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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621124 Species: Rattus norvegicus RGD Object: Gene Symbol: Cdk7 Name: cyclin-dependent kinase 7

Acc ID: CHEBI:63577 Term: lamivudine Definition: A monothioacetal that consists of cytosine having a (2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl moiety attached at position 1. An inhibitor of HIV-1 reverse transcriptase. CasRN: 134678-17-4 Chemical ID: MESH:D019259

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:734279	6480464	CTD	[Zidovudine co-treated with Lamivudine] results in increased expression of CDK7 mRNA	PMID:15784690