Pak2 (p21 (RAC1) activated kinase 2) - Rat Genome Database

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Gene: Pak2 (p21 (RAC1) activated kinase 2) Rattus norvegicus
Analyze
Symbol: Pak2
Name: p21 (RAC1) activated kinase 2
RGD ID: 61953
Description: Predicted to enable several functions, including enzyme binding activity; identical protein binding activity; and protein tyrosine kinase activator activity. Involved in cardiac muscle hypertrophy and cellular response to transforming growth factor beta stimulus. Located in secretory granule. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2); PARTICIPATES IN vascular endothelial growth factor signaling pathway; epidermal growth factor/neuregulin signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: gamma-PAK; LOC100910732; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; PAK-2; serine/threonine-protein kinase PAK 2; serine/threonine-protein kinase PAK 2-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,212,896 - 82,273,803 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1182,212,951 - 82,273,803 (+)EnsemblGRCr8
mRatBN7.21168,707,940 - 68,768,816 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,707,969 - 68,768,816 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1177,545,003 - 77,605,878 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,206,629 - 70,267,901 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01169,234,099 - 69,294,967 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01172,829,407 - 72,865,815 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,959,228 - 72,021,224 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1172,829,238 - 72,865,902 (+)Ensemblrn6Rnor6.0
Rnor_5.01175,895,329 - 75,939,106 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41170,529,961 - 70,588,511 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1168,130,464 - 68,189,144 (+)NCBICelera
RGSC_v3.11170,587,549 - 70,646,100 (+)NCBI
Cytogenetic Map11q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dimethylarsinic acid  (EXP)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
Ethylenethiourea  (EXP)
folic acid  (ISO)
FR900359  (ISO)
genistein  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N(4)-hydroxycytidine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
ochratoxin A  (ISO)
oxaliplatin  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
tamibarotene  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell-cell junction  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
glutamatergic synapse  (IEA,ISO)
membrane  (IEA)
nuclear speck  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
organelle  (IEA)
perinuclear region of cytoplasm  (IEA)
postsynaptic density  (IEA,ISO)
secretory granule  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
4. Identification and validation of new autoantibodies for the diagnosis of DCIS and node negative early-stage breast cancers. Lacombe J, etal., Int J Cancer. 2013 Mar 1;132(5):1105-13. doi: 10.1002/ijc.27766. Epub 2012 Aug 28.
5. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Manser E, etal., Nature 1994 Jan 6;367(6458):40-6.
6. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. Martin GA, etal., EMBO J 1995 May 1;14(9):1970-8.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. p21-activated protein kinase gamma-PAK in pituitary secretory granules phosphorylates prolactin. Tuazon PT, etal., FEBS Lett. 2002 Mar 27;515(1-3):84-8.
14. A novel player in cellular hypertrophy: Gibetagamma/PI3K-dependent activation of the RacGEF TIAM-1 is required for alpha(1)-adrenoceptor induced hypertrophy in neonatal rat cardiomyocytes. Vettel C, etal., J Mol Cell Cardiol. 2012 Aug;53(2):165-75. doi: 10.1016/j.yjmcc.2012.04.015. Epub 2012 May 4.
15. Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo. Wang S, etal., FASEB J. 2005 Jan;19(1):1-11.
16. Cell-type-specific activation of PAK2 by transforming growth factor beta independent of Smad2 and Smad3. Wilkes MC, etal., Mol Cell Biol. 2003 Dec;23(23):8878-89.
17. p21-activated kinases regulate actin remodeling in glomerular podocytes. Zhu J, etal., Am J Physiol Renal Physiol. 2010 Apr;298(4):F951-61. doi: 10.1152/ajprenal.00536.2009. Epub 2010 Jan 13.
Additional References at PubMed
PMID:7592896   PMID:8625410   PMID:10075701   PMID:11121037   PMID:11278486   PMID:11805089   PMID:15182717   PMID:16396499   PMID:16641100   PMID:16837009   PMID:17060906   PMID:17224451  
PMID:19103160   PMID:19240112   PMID:21555521   PMID:22871113   PMID:23509247   PMID:25468996   PMID:25753039   PMID:25979836   PMID:26912410   PMID:28408623   PMID:30620686   PMID:31505169  


Genomics

Comparative Map Data
Pak2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,212,896 - 82,273,803 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1182,212,951 - 82,273,803 (+)EnsemblGRCr8
mRatBN7.21168,707,940 - 68,768,816 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,707,969 - 68,768,816 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1177,545,003 - 77,605,878 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,206,629 - 70,267,901 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01169,234,099 - 69,294,967 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01172,829,407 - 72,865,815 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1171,959,228 - 72,021,224 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1172,829,238 - 72,865,902 (+)Ensemblrn6Rnor6.0
Rnor_5.01175,895,329 - 75,939,106 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41170,529,961 - 70,588,511 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1168,130,464 - 68,189,144 (+)NCBICelera
RGSC_v3.11170,587,549 - 70,646,100 (+)NCBI
Cytogenetic Map11q22NCBI
PAK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,739,857 - 196,832,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3196,739,743 - 196,832,647 (+)Ensemblhg38GRCh38
GRCh373196,466,728 - 196,559,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,951,312 - 198,043,756 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343197,955,224 - 198,047,662NCBI
Celera3195,047,767 - 195,144,272 (+)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3193,763,319 - 193,859,670 (+)NCBIHuRef
CHM1_13196,437,954 - 196,530,860 (+)NCBICHM1_1
T2T-CHM13v2.03199,459,234 - 199,558,334 (+)NCBIT2T-CHM13v2.0
Pak2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391631,835,108 - 31,898,160 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1631,835,108 - 31,898,160 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381632,016,290 - 32,079,342 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1632,016,290 - 32,079,342 (-)Ensemblmm10GRCm38
MGSCv371632,017,949 - 32,079,359 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361631,937,610 - 31,999,020 (-)NCBIMGSCv36mm8
Celera1632,511,700 - 32,575,354 (-)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1622.4NCBI
Pak2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542012,892,845 - 12,930,955 (+)Ensembl
ChiLan1.0NW_00495542012,893,760 - 12,930,955 (+)NCBIChiLan1.0ChiLan1.0
PAK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22194,609,641 - 194,699,725 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13194,614,360 - 194,704,443 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03194,084,037 - 194,174,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13204,023,357 - 204,111,515 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3204,023,357 - 204,111,507 (+)EnsemblpanPan2panpan1.1
PAK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,774,645 - 29,863,661 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,774,593 - 29,987,478 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3329,798,837 - 29,887,939 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03330,018,726 - 30,108,342 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3330,018,587 - 30,235,797 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13329,795,936 - 29,906,532 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03329,850,899 - 29,940,690 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03330,473,517 - 30,563,048 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pak2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602124,493,276 - 124,572,628 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367841,351,039 - 1,391,992 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367841,351,034 - 1,391,992 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,273,112 - 133,389,458 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113133,276,122 - 133,383,506 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213142,923,496 - 142,963,953 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PAK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11590,474,367 - 90,488,814 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1590,398,660 - 90,449,346 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ChlSab1.1 Ensembl1590,398,660 - 90,449,346 (-)NCBIChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604164,177,811 - 64,268,335 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pak2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,817,300 - 61,879,755 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473061,809,876 - 61,879,755 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pak2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1416,846,603 - 16,907,483 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pak2
392 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:26
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000049862
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)115893182292356038Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 7 23 72 21 24 6 84 6 189 124 11 64 44 44 18 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000049862   ⟹   ENSRNOP00000040162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1182,212,951 - 82,273,795 (+)Ensembl
mRatBN7.2 Ensembl1168,707,969 - 68,767,873 (+)Ensembl
Rnor_6.0 Ensembl1171,959,228 - 72,017,463 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000071060   ⟹   ENSRNOP00000065949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1172,829,238 - 72,865,902 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077269   ⟹   ENSRNOP00000072644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1182,235,230 - 82,273,803 (+)Ensembl
mRatBN7.2 Ensembl1168,730,236 - 68,768,816 (+)Ensembl
Rnor_6.0 Ensembl1171,981,060 - 72,021,224 (+)Ensembl
RefSeq Acc Id: NM_001393703   ⟹   NP_001380632
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,212,935 - 82,273,803 (+)NCBI
mRatBN7.21168,707,940 - 68,768,816 (+)NCBI
RefSeq Acc Id: NM_053306   ⟹   NP_445758
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,212,935 - 82,273,803 (+)NCBI
mRatBN7.21168,707,940 - 68,768,816 (+)NCBI
Rnor_6.01172,829,407 - 72,865,815 (+)NCBI
Rnor_5.01175,895,329 - 75,939,106 (+)NCBI
RGSC_v3.41170,529,961 - 70,588,511 (+)RGD
Celera1168,130,464 - 68,189,144 (+)RGD
Sequence:
RefSeq Acc Id: XM_063270441   ⟹   XP_063126511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,212,896 - 82,273,803 (+)NCBI
RefSeq Acc Id: NP_445758   ⟸   NM_053306
- UniProtKB: Q64303 (UniProtKB/Swiss-Prot),   Q9QYU0 (UniProtKB/Swiss-Prot),   A6IRU5 (UniProtKB/TrEMBL),   A0A8L2R675 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065949   ⟸   ENSRNOT00000071060
Ensembl Acc Id: ENSRNOP00000072644   ⟸   ENSRNOT00000077269
Ensembl Acc Id: ENSRNOP00000040162   ⟸   ENSRNOT00000049862
RefSeq Acc Id: NP_001380632   ⟸   NM_001393703
- UniProtKB: Q64303 (UniProtKB/Swiss-Prot),   Q9QYU0 (UniProtKB/Swiss-Prot),   A6IRU5 (UniProtKB/TrEMBL),   A0A8L2R675 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126511   ⟸   XM_063270441
- Peptide Label: isoform X1
- UniProtKB: Q9QYU0 (UniProtKB/Swiss-Prot),   Q64303 (UniProtKB/Swiss-Prot),   A6IRU5 (UniProtKB/TrEMBL),   A0A8L2R675 (UniProtKB/TrEMBL)
Protein Domains
CRIB   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64303-F1-model_v2 AlphaFold Q64303 1-524 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61953 AgrOrtholog
BioCyc Gene G2FUF-21079 BioCyc
Ensembl Genes ENSRNOG00000001747 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000048597 Ensembl
Ensembl Transcript ENSRNOT00000049862 ENTREZGENE
  ENSRNOT00000049862.4 UniProtKB/Swiss-Prot
  ENSRNOT00000077269 ENTREZGENE
Gene3D-CATH 3.90.810.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro CRIB_dom UniProtKB/Swiss-Prot
  CRIB_dom_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PAK3-like UniProtKB/Swiss-Prot
  PAK_BD UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STK_PAK2 UniProtKB/Swiss-Prot
KEGG Report rno:29432 UniProtKB/Swiss-Prot
NCBI Gene 29432 ENTREZGENE
PANTHER NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot
  SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED UniProtKB/Swiss-Prot
Pfam PBD UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Pak2 PhenoGen
PROSITE CRIB UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001747 RatGTEx
  ENSRNOG00000048597 RatGTEx
SMART PBD UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8L2R675 ENTREZGENE, UniProtKB/TrEMBL
  A6IRU5 ENTREZGENE, UniProtKB/TrEMBL
  PAK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QYU0 ENTREZGENE
UniProt Secondary Q9QYU0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pak2  p21 (RAC1) activated kinase 2  LOC100910732  serine/threonine-protein kinase PAK 2-like  Data merged from RGD:6497075 737654 PROVISIONAL
2017-06-20 Pak2  p21 (RAC1) activated kinase 2  Pak2  p21 protein (Cdc42/Rac)-activated kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-03-27 Pak2  p21 protein (Cdc42/Rac)-activated kinase 2  Pak2  p21 (RAC1) activated kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-12 Pak2  p21 (RAC1) activated kinase 2  Pak2  p21 protein (Cdc42/Rac)-activated kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910732  serine/threonine-protein kinase PAK 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-05-27 Pak2  p21 protein (Cdc42/Rac)-activated kinase 2  Pak2  p21 (CDKN1A)-activated kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pak2  p21 (CDKN1A)-activated kinase 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in many tissues 61685
gene_expression expressed in many tissues 70317
gene_function phosphorylates protein serine/threonine residues 61685
gene_function phosphorylates protein serine/threonine residues 70317