Lbp (lipopolysaccharide binding protein) - Rat Genome Database

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Gene: Lbp (lipopolysaccharide binding protein) Rattus norvegicus
Analyze
Symbol: Lbp
Name: lipopolysaccharide binding protein
RGD ID: 61865
Description: Enables lipopolysaccharide binding activity. Involved in several processes, including positive regulation of macrophage activation; positive regulation of phagocytosis, engulfment; and response to ethanol. Located in extracellular space. Used to study obesity. Biomarker of liver cirrhosis; metabolic dysfunction and alcohol associated liver disease; obstructive jaundice; and periodontitis. Orthologous to human LBP (lipopolysaccharide binding protein); PARTICIPATES IN interleukin-6 signaling pathway; Toll-like receptor signaling pathway; tuberculosis pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BPI fold containing family D, member 2; Bpifd2; lipopolysaccharide-binding protein; MGC124626
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83167,373,786 - 167,400,941 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3167,373,924 - 167,401,518 (+)EnsemblGRCr8
mRatBN7.23146,953,889 - 146,981,032 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3146,954,015 - 146,981,586 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3150,786,436 - 150,813,463 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03159,285,723 - 159,312,752 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03157,020,490 - 157,047,489 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03154,786,232 - 154,812,910 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3154,786,215 - 154,813,464 (+)Ensemblrn6Rnor6.0
Rnor_5.03160,793,301 - 160,819,979 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43149,016,605 - 149,043,530 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3145,655,280 - 145,682,077 (+)NCBICelera
RGSC_v3.13148,922,500 - 148,949,992 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R,R,R)-alpha-tocopherol  (EXP)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
alpha-amanitin  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acids  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzylpenicillin  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chloroform  (EXP)
ciguatoxin CTX1B  (ISO)
cobalt dichloride  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
diclofenac  (ISO)
diethyl phthalate  (EXP)
diiodine  (ISO)
dimethylarsinic acid  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
erythromycin A  (ISO)
erythromycin estolate  (EXP)
ethanol  (EXP)
fluoranthene  (EXP)
flutamide  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP,ISO)
Ginkgolide A  (ISO)
glafenine  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
graphene oxide  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ketamine  (ISO)
L-ascorbic acid  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (EXP,ISO)
menadione  (ISO)
methimazole  (EXP)
methotrexate  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naloxone  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
Nonylphenol  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
pipoxolan  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
quinidine  (EXP)
resveratrol  (EXP,ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
senecionine  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulindac  (EXP)
Sunset Yellow FCF  (ISO)
tacrolimus hydrate  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
theophylline  (EXP)
tolcapone  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acute-phase response  (IBA,IEA,ISO)
cell surface pattern recognition receptor signaling pathway  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO,ISS)
cellular response to lipoteichoic acid  (ISO)
defense response to bacterium  (IEA)
defense response to Gram-negative bacterium  (IBA,IEA,ISO)
defense response to Gram-positive bacterium  (IBA,IEA,ISO)
detection of molecule of bacterial origin  (IEA,ISO)
immune system process  (IEA)
innate immune response  (IBA,IEA,ISO)
leukocyte chemotaxis involved in inflammatory response  (ISO)
lipid transport  (IEA)
lipopolysaccharide transport  (IEA,ISO)
lipopolysaccharide-mediated signaling pathway  (IBA,IEA,ISO)
liver development  (IEP)
macrophage activation involved in immune response  (IBA,IEA,ISO,ISS)
negative regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of chemokine production  (ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA,ISO)
positive regulation of macrophage activation  (IBA,IDA,IEA,ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of phagocytosis, engulfment  (IDA)
positive regulation of respiratory burst involved in inflammatory response  (IEA,ISO)
positive regulation of toll-like receptor 4 signaling pathway  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA,ISO,ISS)
regulation of membrane permeability  (IMP)
response to ethanol  (IEP)
response to lipopolysaccharide  (IEA,ISO)

Cellular Component
cell surface  (IEA,ISO)
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Lipopolysaccharide-binding protein and lipopolysaccharide receptor CD14 gene expression after thermal injury and its potential mechanism(s). Fang CW, etal., J Trauma. 2002 Nov;53(5):957-67.
2. Serum LBP levels reflect the impaired synthetic capacity of the remnant liver after partial hepatectomy in rats. Fang H, etal., J Immunol Methods. 2012 Aug 31;382(1-2):68-75. doi: 10.1016/j.jim.2012.05.006. Epub 2012 May 8.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Induction of hepatocyte lipopolysaccharide binding protein in models of sepsis and the acute-phase response. Geller DA, etal., Arch Surg. 1993 Jan;128(1):22-7; discussion 27-8.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Dietary supplementation of n-3 PUFA reduces weight gain and improves postprandial lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat. Hassanali Z, etal., Diabetes Obes Metab. 2010 Feb;12(2):139-47. doi: 10.1111/j.1463-1326.2009.01130.x. Epub 2009 Nov 16.
7. Lipopolysaccharide-binding protein accelerates and augments Escherichia coli phagocytosis by alveolar macrophages. Klein RD, etal., J Surg Res. 2000 Dec;94(2):159-66.
8. Postnatal development of hepatic innate immune response. Le Rouzic V, etal., Inflammation. 2011 Dec;34(6):576-84. doi: 10.1007/s10753-010-9265-5.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Activity of lipopolysaccharide-binding protein-bactericidal/permeability-increasing protein fusion peptide in an experimental model of Pseudomonas sepsis. Opal SM, etal., Antimicrob Agents Chemother. 1995 Dec;39(12):2813-5.
12. Myeloid differentiation 2 as a therapeutic target of inflammatory disorders. Park SH, etal., Pharmacol Ther. 2012 Mar;133(3):291-8. doi: 10.1016/j.pharmthera.2011.11.001. Epub 2011 Nov 19.
13. Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression. Peng JH, etal., J Pharmacol Exp Ther. 2013 Mar;344(3):646-54. doi: 10.1124/jpet.112.201137. Epub 2012 Dec 31.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism. Sheth P, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G308-18. Epub 2007 Apr 19.
20. Altered gene expression in gingival tissues and enhanced bone loss in rats with diabetes with experimental periodontitis. Soboku K, etal., J Periodontol. 2014 Mar;85(3):455-64. doi: 10.1902/jop.2013.120705. Epub 2013 Jun 3.
21. Surfactant protein a inhibits lipopolysaccharide-induced immune cell activation by preventing the interaction of lipopolysaccharide with lipopolysaccharide-binding protein. Stamme C, etal., Am J Respir Cell Mol Biol 2002 Sep;27(3):353-60.
22. Kupffer cell activation by lipopolysaccharide in rats: role for lipopolysaccharide binding protein and toll-like receptor 4. Su GL, etal., Hepatology. 2000 Apr;31(4):932-6.
23. Molecular cloning, characterization, and tissue distribution of rat lipopolysaccharide binding protein. Evidence for extrahepatic expression. Su GL, etal., J Immunol 1994 Jul 15;153(2):743-52.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. High-density lipoprotein administration attenuates liver proinflammatory response, restores liver endothelial nitric oxide synthase activity, and lowers portal pressure in cirrhotic rats. Thabut D, etal., Hepatology. 2007 Dec;46(6):1893-906.
26. The Kinetic Expression of Lipopolysaccharide-Binding Protein and CD14 Gene in Obstructive Jaundice. Tsai CH, etal., J Invest Surg. 2014 Aug 5.
27. Activation of the lipopolysaccharide signaling pathway in hepatic transplantation preservation injury. Tsoulfas G, etal., Transplantation. 2002 Jul 15;74(1):7-13.
28. LBP inhibitory peptide reduces endotoxin-induced macrophage activation and mortality. Wu X, etal., Inflamm Res. 2005 Nov;54(11):451-7.
29. [Role of endotoxin translocation on mesenteric lymph reperfusion aggravating multiple organ injury in SMAO shock rats]. Yang LN, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2012 Jan;28(1):74-8.
Additional References at PubMed
PMID:2402637   PMID:8409400   PMID:8985160   PMID:9338787   PMID:11079463   PMID:11528597   PMID:11739189   PMID:12055258   PMID:12477932   PMID:12594207   PMID:12932360   PMID:14739326  
PMID:15294986   PMID:15828022   PMID:17254389   PMID:19056867   PMID:23376485   PMID:23437199   PMID:23533145   PMID:23958732   PMID:24120359   PMID:24380872   PMID:25874537   PMID:31714656  
PMID:38114435  


Genomics

Comparative Map Data
Lbp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83167,373,786 - 167,400,941 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3167,373,924 - 167,401,518 (+)EnsemblGRCr8
mRatBN7.23146,953,889 - 146,981,032 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3146,954,015 - 146,981,586 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3150,786,436 - 150,813,463 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03159,285,723 - 159,312,752 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03157,020,490 - 157,047,489 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03154,786,232 - 154,812,910 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3154,786,215 - 154,813,464 (+)Ensemblrn6Rnor6.0
Rnor_5.03160,793,301 - 160,819,979 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43149,016,605 - 149,043,530 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3145,655,280 - 145,682,077 (+)NCBICelera
RGSC_v3.13148,922,500 - 148,949,992 (+)NCBI
Cytogenetic Map3q42NCBI
LBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382038,346,482 - 38,377,013 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2038,346,482 - 38,377,511 (+)Ensemblhg38GRCh38
GRCh372036,974,885 - 37,005,655 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362036,408,299 - 36,439,067 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342036,408,298 - 36,439,067NCBI
Celera2033,683,680 - 33,714,456 (+)NCBICelera
Cytogenetic Map20q11.23NCBI
HuRef2033,709,729 - 33,740,760 (+)NCBIHuRef
CHM1_12036,878,602 - 36,909,384 (+)NCBICHM1_1
T2T-CHM13v2.02040,072,800 - 40,104,597 (+)NCBIT2T-CHM13v2.0
Lbp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392158,148,413 - 158,174,772 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2158,148,413 - 158,174,772 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382158,306,493 - 158,332,852 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2158,306,493 - 158,332,852 (+)Ensemblmm10GRCm38
MGSCv372158,132,229 - 158,158,588 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362157,997,986 - 158,023,737 (+)NCBIMGSCv36mm8
Celera2164,244,570 - 164,269,152 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.72NCBI
LBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22144,070,881 - 44,103,778 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12044,063,979 - 44,096,876 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02034,670,128 - 34,703,046 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12035,780,768 - 35,813,188 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2035,780,768 - 35,813,188 (+)EnsemblpanPan2panpan1.1
LBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12426,810,369 - 26,833,515 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2426,809,843 - 26,833,434 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2426,456,134 - 26,479,256 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02427,506,422 - 27,529,551 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2427,506,460 - 27,529,472 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12426,780,778 - 26,803,800 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02426,888,642 - 26,911,780 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02427,377,130 - 27,400,265 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lbp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640175,713,998 - 175,732,560 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365613,016,926 - 3,035,552 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365613,017,471 - 3,035,481 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1741,398,791 - 41,429,551 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11741,398,935 - 41,429,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21746,838,042 - 46,868,577 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1225,375,364 - 25,407,181 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl225,374,755 - 25,406,839 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605074,213,568 - 74,246,762 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lbp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248421,301,831 - 1,332,346 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248421,306,299 - 1,332,269 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lbp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15137,646,061 - 137,673,279 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lbp
342 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:94
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000019787
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat

Markers in Region
D3Got121  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83167,395,778 - 167,395,989 (+)Marker Load Pipeline
mRatBN7.23146,975,869 - 146,976,080 (+)MAPPERmRatBN7.2
Rnor_6.03154,807,748 - 154,807,958NCBIRnor6.0
Rnor_5.03160,798,253 - 160,798,463UniSTSRnor5.0
RGSC_v3.43149,038,367 - 149,038,578RGDRGSC3.4
RGSC_v3.43149,038,368 - 149,038,578UniSTSRGSC3.4
Celera3145,676,915 - 145,677,125UniSTS
RGSC_v3.13148,944,277 - 148,944,487RGD
RH 3.4 Map31357.9UniSTS
RH 3.4 Map31357.9RGD
Cytogenetic Map3q42UniSTS
D3Got125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23146,975,873 - 146,976,091 (+)MAPPERmRatBN7.2
Rnor_6.03154,807,752 - 154,807,969NCBIRnor6.0
Rnor_5.03160,798,242 - 160,798,459UniSTSRnor5.0
RGSC_v3.43149,038,371 - 149,038,589RGDRGSC3.4
RGSC_v3.43149,038,372 - 149,038,589UniSTSRGSC3.4
Celera3145,676,919 - 145,677,136UniSTS
RGSC_v3.13148,944,281 - 148,944,498RGD
RH 3.4 Map31357.6RGD
RH 3.4 Map31357.6UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 149 91 90 59 92 59 6 355 192 11 124 80 92 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000019787   ⟹   ENSRNOP00000019787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3167,373,929 - 167,401,518 (+)Ensembl
mRatBN7.2 Ensembl3146,954,015 - 146,981,586 (+)Ensembl
Rnor_6.0 Ensembl3154,786,215 - 154,813,464 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096776   ⟹   ENSRNOP00000095950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3167,373,924 - 167,398,524 (+)Ensembl
mRatBN7.2 Ensembl3146,954,015 - 146,978,615 (+)Ensembl
RefSeq Acc Id: NM_017208   ⟹   NP_058904
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83167,373,941 - 167,400,941 (+)NCBI
mRatBN7.23146,954,032 - 146,981,032 (+)NCBI
Rnor_6.03154,786,232 - 154,812,910 (+)NCBI
Rnor_5.03160,793,301 - 160,819,979 (-)NCBI
RGSC_v3.43149,016,605 - 149,043,530 (+)RGD
Celera3145,655,280 - 145,682,077 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104446   ⟹   XP_038960374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83167,380,486 - 167,400,936 (+)NCBI
mRatBN7.23146,960,578 - 146,981,032 (+)NCBI
RefSeq Acc Id: XM_039104447   ⟹   XP_038960375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83167,373,786 - 167,390,903 (+)NCBI
mRatBN7.23146,953,889 - 146,970,988 (+)NCBI
RefSeq Acc Id: XM_039104448   ⟹   XP_038960376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83167,382,830 - 167,400,936 (+)NCBI
mRatBN7.23146,962,939 - 146,981,032 (+)NCBI
Protein Sequences
Protein RefSeqs NP_058904 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960374 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960375 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960376 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI01907 (Get FASTA)   NCBI Sequence Viewer  
  EDL96653 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019787
GenBank Protein Q63313 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058904   ⟸   NM_017208
- Peptide Label: precursor
- UniProtKB: Q63313 (UniProtKB/Swiss-Prot),   Q3MID7 (UniProtKB/TrEMBL),   F7FLI1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019787   ⟸   ENSRNOT00000019787
RefSeq Acc Id: XP_038960375   ⟸   XM_039104447
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038960374   ⟸   XM_039104446
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038960376   ⟸   XM_039104448
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000095950   ⟸   ENSRNOT00000096776
Protein Domains
Lipid-binding serum glycoprotein C-terminal   Lipid-binding serum glycoprotein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63313-F1-model_v2 AlphaFold Q63313 1-481 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692620
Promoter ID:EPDNEW_R3144
Type:multiple initiation site
Name:Lbp_1
Description:lipopolysaccharide binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03154,786,219 - 154,786,279EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61865 AgrOrtholog
BioCyc Gene G2FUF-47034 BioCyc
Ensembl Genes ENSRNOG00000014532 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019787 ENTREZGENE
Gene3D-CATH Bactericidal permeability-increasing protein, domain 1 UniProtKB/Swiss-Prot
  Bactericidal permeability-increasing protein, domain 2 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7933709 IMAGE-MGC_LOAD
InterPro Bactericidal_perm-incr_a/b_dom UniProtKB/Swiss-Prot
  BPI/LBP UniProtKB/Swiss-Prot
  BPI/LBP/Plunc UniProtKB/Swiss-Prot
  Lipid-bd_serum_glycop_C UniProtKB/Swiss-Prot
  Lipid-bd_serum_glycop_CS UniProtKB/Swiss-Prot
  Lipid-bd_serum_glycop_N UniProtKB/Swiss-Prot
MGC_CLONE MGC:124626 IMAGE-MGC_LOAD
NCBI Gene 29469 ENTREZGENE
PANTHER PTHR10504 UniProtKB/Swiss-Prot
  PTHR10504:SF66 UniProtKB/Swiss-Prot
Pfam LBP_BPI_CETP UniProtKB/Swiss-Prot
  LBP_BPI_CETP_C UniProtKB/Swiss-Prot
PhenoGen Lbp PhenoGen
PIRSF Lipid_binding_protein UniProtKB/Swiss-Prot
PROSITE LBP_BPI_CETP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014532 RatGTEx
SMART BPI1 UniProtKB/Swiss-Prot
  BPI2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55394 UniProtKB/Swiss-Prot
TIGR TC216800
UniProt A0A8I6AMU5_RAT UniProtKB/TrEMBL
  F7FLI1 ENTREZGENE, UniProtKB/TrEMBL
  LBP_RAT UniProtKB/Swiss-Prot
  Q3MID7 ENTREZGENE, UniProtKB/TrEMBL
  Q63313 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Lbp  lipopolysaccharide binding protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation interaction with lipopolysaccharide is inhibited by Pulmonary surfactant protein (SP)-A binding to lipopolysaccharide 727417