Vamp2 (vesicle-associated membrane protein 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Vamp2 (vesicle-associated membrane protein 2) Rattus norvegicus
Analyze
Symbol: Vamp2
Name: vesicle-associated membrane protein 2
RGD ID: 3949
Description: Enables several functions, including calcium-dependent protein binding activity; syntaxin-1 binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; regulation of delayed rectifier potassium channel activity; and synaptic vesicle docking. Located in neuron projection terminus; plasma membrane; and secretory vesicle. Part of several cellular components, including synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in postsynaptic cytosol; postsynaptic density; and synaptic vesicle membrane. Orthologous to human VAMP2 (vesicle associated membrane protein 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin secretion pathway; vasopressin signaling pathway; INTERACTS WITH 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: RATVAMPB; RATVAMPIR; SYB; Syb2; synaptobrevin 2; Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2); synaptobrevin-2; VAMP-2; Vesicle-associated membrane protein (synaptobrevin 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SS.MNS-(Vamp2-D10M11Mit84)/Mco ; WKY.SHRSP-(Asgr1-Vamp2)/Bbb ; SS.MNS-(D10Mit11-Vamp2)/Mco
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,292,423 - 54,296,657 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,292,806 - 54,296,654 (+)EnsemblGRCr8
mRatBN7.21053,793,581 - 53,797,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,793,923 - 53,797,809 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1058,455,722 - 58,459,585 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,944,320 - 57,948,183 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,452,495 - 53,456,350 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,675,171 - 55,679,405 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,675,575 - 55,679,450 (+)Ensemblrn6Rnor6.0
Rnor_5.01055,418,231 - 55,422,465 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41055,848,264 - 55,852,132 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1052,959,486 - 52,963,354 (+)NCBICelera
RGSC_v3.11055,861,886 - 55,865,753 (+)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
cisplatin  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
D-gluconic acid  (EXP)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gamma-tocopherol  (ISO)
GSK-J4  (ISO)
haloperidol  (EXP)
hydrazines  (ISO)
hypochlorous acid  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nicotinamide  (EXP)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
propiconazole  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
trichloroethene  (EXP)
trimethylamine N-oxide  (EXP)
triphenyl phosphate  (ISO)
urethane  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. The SNARE Vti1a-beta is localized to small synaptic vesicles and participates in a novel SNARE complex. Antonin W, etal., J Neurosci 2000 Aug 1;20(15):5724-32.
2. Role of SNAP-23 in trafficking of H+-ATPase in cultured inner medullary collecting duct cells. Banerjee A, etal., Am J Physiol Cell Physiol. 2001 Apr;280(4):C775-81.
3. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. Boone M and Deen PM, Pflugers Arch. 2008 Sep;456(6):1005-24. Epub 2008 Apr 23.
4. Mutational analysis of synaptobrevin transmembrane domain oligomerization. Bowen ME, etal., Biochemistry 2002 Dec 31;41(52):15861-6.
5. Negative regulation of syntaxin4/SNAP-23/VAMP2-mediated membrane fusion by Munc18c in vitro. Brandie FM, etal., PLoS One. 2008;3(12):e4074. doi: 10.1371/journal.pone.0004074. Epub 2008 Dec 31.
6. Changes in mRNA for VAMPs following facial nerve transection. Che YH, etal., J Chem Neuroanat 2002 Jul;24(2):147-52.
7. Single-molecule FRET-derived model of the synaptotagmin 1-SNARE fusion complex. Choi UB, etal., Nat Struct Mol Biol. 2010 Mar;17(3):318-24. doi: 10.1038/nsmb.1763. Epub 2010 Feb 21.
8. Expression of two membrane fusion proteins, synaptosome-associated protein of 25 kDa and vesicle-associated membrane protein, in choroid plexus epithelium. Chung I, etal., Neuroscience 2003;116(2):349-57.
9. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
10. Two vesicle-associated membrane protein genes are differentially expressed in the rat central nervous system. Elferink LA, etal., J Biol Chem 1989 Jul 5;264(19):11061-4.
11. Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation. Ellena JF, etal., Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20306-11. doi: 10.1073/pnas.0908317106. Epub 2009 Nov 16.
12. Identification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly. Fasshauer D, etal., Biochemistry. 1998 Jul 21;37(29):10354-62.
13. The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are associated on synaptic vesicles in a Triton X-100-resistant, freeze-thawing sensitive, complex. Galli T, etal., J Biol Chem. 1996 Jan 26;271(4):2193-8.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Differential vesicular sorting of AMPA and GABAA receptors. Gu Y, etal., Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E922-31. doi: 10.1073/pnas.1525726113. Epub 2016 Feb 2.
16. Effect of mutations in vesicle-associated membrane protein (VAMP) on the assembly of multimeric protein complexes. Hao JC, etal., J Neurosci. 1997 Mar 1;17(5):1596-603. doi: 10.1523/JNEUROSCI.17-05-01596.1997.
17. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Hu SH, etal., Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1040-5. doi: 10.1073/pnas.0914906108. Epub 2010 Dec 30.
18. Postsynaptic VAMP/Synaptobrevin Facilitates Differential Vesicle Trafficking of GluA1 and GluA2 AMPA Receptor Subunits. Hussain S and Davanger S, PLoS One. 2015 Oct 21;10(10):e0140868. doi: 10.1371/journal.pone.0140868. eCollection 2015.
19. Antibodies raised against aldehyde-fixed antigens improve sensitivity for postembedding electron microscopy. Hussain S, etal., J Neurosci Methods. 2019 Apr 1;317:1-10. doi: 10.1016/j.jneumeth.2019.01.015. Epub 2019 Jan 28.
20. Rapid fusion of synaptic vesicles with reconstituted target SNARE membranes. Kiessling V, etal., Biophys J. 2013 May 7;104(9):1950-8. doi: 10.1016/j.bpj.2013.03.038.
21. Insulin stimulates syntaxin4 SNARE complex assembly via a novel regulatory mechanism. Kioumourtzoglou D, etal., Mol Cell Biol. 2014 Apr;34(7):1271-9. doi: 10.1128/MCB.01203-13. Epub 2014 Jan 27.
22. SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses. Koo SJ, etal., Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13540-5. doi: 10.1073/pnas.1107067108. Epub 2011 Aug 1.
23. SNAREs in native plasma membranes are active and readily form core complexes with endogenous and exogenous SNAREs. Lang T, etal., J Cell Biol 2002 Aug 19;158(4):751-60.
24. The GLUT4 code. Larance M, etal., Mol Endocrinol. 2008 Feb;22(2):226-33. Epub 2007 Aug 23.
25. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Li H, etal., Nat Cell Biol. 2013 Jul;15(7):773-85. doi: 10.1038/ncb2791. Epub 2013 Jun 23.
26. Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2. Lu G, etal., Cell Signal. 2007 Apr;19(4):867-79. Epub 2006 Nov 16.
27. Rearrangements in the relative orientation of cytoplasmic domains induced by a membrane-anchored protein mediate modulations in Kv channel gating. Lvov A, etal., J Biol Chem. 2009 Oct 9;284(41):28276-91. doi: 10.1074/jbc.M109.028761. Epub 2009 Aug 18.
28. A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytes. Maienschein V, etal., Glia. 1999 May;26(3):233-44.
29. The Habc domain and the SNARE core complex are connected by a highly flexible linker. Margittai M, etal., Biochemistry. 2003 Apr 15;42(14):4009-14.
30. Isolation and characterization of a dual prenylated Rab and VAMP2 receptor. Martincic I, etal., J Biol Chem 1997 Oct 24;272(43):26991-8.
31. Complexins: cytosolic proteins that regulate SNAP receptor function. McMahon HT, etal., Cell 1995 Oct 6;83(1):111-9.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis. Nevins AK and Thurmond DC, J Biol Chem. 2005 Jan 21;280(3):1944-52. Epub 2004 Nov 9.
35. Protein oligomerization mediated by the transmembrane carboxyl terminal domain of Bcl-XL. Ospina A, etal., FEBS Lett. 2011 Oct 3;585(19):2935-42. doi: 10.1016/j.febslet.2011.08.012. Epub 2011 Aug 16.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
38. GOA pipeline RGD automated data pipeline
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover. Ryu JK, etal., Science. 2015 Mar 27;347(6229):1485-9. doi: 10.1126/science.aaa5267.
41. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin. Schiavo G, etal., Nature. 1992 Oct 29;359(6398):832-5. doi: 10.1038/359832a0.
42. Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions. Shin OH, etal., Neuron. 2003 Jan 9;37(1):99-108.
43. SNAP-23 participates in SNARE complex assembly in rat adipose cells. St-Denis JF, etal., Biochem J 1999 Mar 15;338 ( Pt 3):709-15.
44. Helical extension of the neuronal SNARE complex into the membrane. Stein A, etal., Nature. 2009 Jul 23;460(7254):525-8. doi: 10.1038/nature08156. Epub 2009 Jul 1.
45. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
46. Molecular anatomy of a trafficking organelle. Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
47. Isoproterenol stimulates transient SNAP23-VAMP2 interaction in rat parotid glands. Takuma T, etal., FEBS Lett. 2013 Mar 18;587(6):583-9. doi: 10.1016/j.febslet.2013.01.039. Epub 2013 Feb 1.
48. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
49. Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1. Tokumaru H, etal., Brain Cell Biol. 2008 Dec;36(5-6):173-89. doi: 10.1007/s11068-008-9032-9. Epub 2009 Jan 9.
50. Cis- and trans-membrane interactions of synaptotagmin-1. Vennekate W, etal., Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):11037-42. doi: 10.1073/pnas.1116326109. Epub 2012 Jun 18.
51. Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly. Wang C, etal., Nat Commun. 2020 Mar 24;11(1):1531. doi: 10.1038/s41467-020-15270-4.
52. Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins. Wang Z and Thurmond DC, J Cell Sci. 2009 Apr 1;122(Pt 7):893-903.
53. Myosin-Va regulates exocytosis through the submicromolar Ca2+-dependent binding of syntaxin-1A. Watanabe M, etal., Mol Biol Cell. 2005 Oct;16(10):4519-30. Epub 2005 Jul 19.
54. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
55. Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. Worst TJ, etal., J Neurosci Res 2005 May 15;80(4):529-38.
56. The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity. Yao H, etal., J Neurochem. 2009 Feb;108(4):909-19. doi: 10.1111/j.1471-4159.2008.05834.x. Epub 2008 Dec 10.
57. LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25. Yun HJ, etal., Exp Mol Med. 2013 Aug 16;45:e36. doi: 10.1038/emm.2013.68.
58. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
59. Mechanistic insights into the recycling machine of the SNARE complex. Zhao M, etal., Nature. 2015 Feb 5;518(7537):61-7. doi: 10.1038/nature14148. Epub 2015 Jan 12.
Additional References at PubMed
PMID:8760387   PMID:9759724   PMID:10371166   PMID:10644763   PMID:11691998   PMID:11832227   PMID:12130530   PMID:12145198   PMID:12181340   PMID:12192047   PMID:12490950   PMID:12496247  
PMID:12730201   PMID:12855681   PMID:14528015   PMID:14983476   PMID:15071120   PMID:15086514   PMID:15109254   PMID:15145078   PMID:15327778   PMID:15489334   PMID:15920476   PMID:16144963  
PMID:16169186   PMID:16322057   PMID:16677249   PMID:16888141   PMID:17272274   PMID:17313651   PMID:17468895   PMID:17548353   PMID:18042464   PMID:18086678   PMID:18227281   PMID:18253931  
PMID:18385322   PMID:18505797   PMID:18508917   PMID:18511418   PMID:18535671   PMID:18542995   PMID:18570252   PMID:18703708   PMID:18706977   PMID:18827011   PMID:19253017   PMID:19478182  
PMID:19546860   PMID:19603498   PMID:19675279   PMID:19843696   PMID:20005125   PMID:20186959   PMID:20582536   PMID:20633536   PMID:20801128   PMID:20829354   PMID:20937897   PMID:20943658  
PMID:21040848   PMID:21266332   PMID:21556117   PMID:21646859   PMID:21730064   PMID:21768342   PMID:21828338   PMID:22094010   PMID:22144578   PMID:22375059   PMID:22411134   PMID:22571236  
PMID:22905234   PMID:23009845   PMID:23376485   PMID:23395379   PMID:23641074   PMID:23643538   PMID:23791195   PMID:24356748   PMID:24534378   PMID:24794856   PMID:24878716   PMID:25008321  
PMID:25374362   PMID:25481410   PMID:26851777   PMID:26854222   PMID:28483813   PMID:28588281   PMID:29476059   PMID:29949059   PMID:30929742   PMID:31686426   PMID:31962145   PMID:32467162  
PMID:33513363   PMID:34496238  


Genomics

Comparative Map Data
Vamp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,292,423 - 54,296,657 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,292,806 - 54,296,654 (+)EnsemblGRCr8
mRatBN7.21053,793,581 - 53,797,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1053,793,923 - 53,797,809 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1058,455,722 - 58,459,585 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01057,944,320 - 57,948,183 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,452,495 - 53,456,350 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01055,675,171 - 55,679,405 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1055,675,575 - 55,679,450 (+)Ensemblrn6Rnor6.0
Rnor_5.01055,418,231 - 55,422,465 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41055,848,264 - 55,852,132 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1052,959,486 - 52,963,354 (+)NCBICelera
RGSC_v3.11055,861,886 - 55,865,753 (+)NCBI
Cytogenetic Map10q24NCBI
VAMP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,159,147 - 8,162,948 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,159,149 - 8,163,546 (-)Ensemblhg38GRCh38
GRCh37178,062,465 - 8,066,266 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,003,189 - 8,007,017 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34178,003,188 - 8,007,017NCBI
Celera178,089,806 - 8,093,640 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,957,475 - 7,960,724 (-)NCBIHuRef
CHM1_1178,071,269 - 8,075,097 (-)NCBICHM1_1
T2T-CHM13v2.0178,064,587 - 8,068,400 (-)NCBIT2T-CHM13v2.0
Vamp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391168,979,354 - 68,983,207 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1168,979,316 - 68,983,210 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381169,088,528 - 69,092,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,088,490 - 69,092,384 (+)Ensemblmm10GRCm38
MGSCv371168,902,030 - 68,905,883 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361168,904,723 - 68,908,576 (+)NCBIMGSCv36mm8
Celera1176,032,081 - 76,035,943 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.36NCBI
Vamp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554678,793,296 - 8,796,771 (+)Ensembl
ChiLan1.0NW_0049554678,793,296 - 8,796,771 (+)NCBIChiLan1.0ChiLan1.0
VAMP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21965,589,912 - 65,594,126 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11770,399,645 - 70,403,527 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01743,495,464 - 43,499,348 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11748,228,253 - 48,231,948 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1748,228,253 - 48,231,948 (+)EnsemblpanPan2panpan1.1
VAMP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,975,372 - 32,977,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha533,111,535 - 33,114,048 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0533,078,395 - 33,080,876 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl533,077,052 - 33,080,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1533,045,188 - 33,047,701 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0533,000,996 - 33,003,510 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0533,180,938 - 33,183,450 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vamp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,911,504 - 47,915,326 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365951,385,695 - 1,389,552 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365951,385,692 - 1,389,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAMP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1253,378,409 - 53,382,240 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11253,378,407 - 53,382,243 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,853,614 - 55,857,435 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VAMP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,539,098 - 7,542,466 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605913,862,312 - 13,866,164 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vamp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,724,964 - 10,727,649 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478610,723,791 - 10,727,654 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Vamp2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1948,688,380 - 48,690,978 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Vamp2
28 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:519
Count of miRNA genes:235
Interacting mature miRNAs:304
Transcripts:ENSRNOT00000057295
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Mit8  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81054,296,227 - 54,296,336 (+)Marker Load Pipeline
mRatBN7.21053,797,385 - 53,797,494 (+)MAPPERmRatBN7.2
Rnor_6.01055,678,976 - 55,679,084NCBIRnor6.0
Rnor_5.01055,422,036 - 55,422,144UniSTSRnor5.0
RGSC_v3.41055,851,702 - 55,851,811RGDRGSC3.4
RGSC_v3.41055,851,703 - 55,851,811UniSTSRGSC3.4
Celera1052,962,925 - 52,963,033UniSTS
RGSC_v3.11055,865,325 - 55,865,434RGD
SHRSP x BN Map1046.5699UniSTS
SHRSP x BN Map1046.5699RGD
Cytogenetic Map10q24UniSTS
D10Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10 RGD
D10Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81054,296,092 - 54,296,393 (+)Marker Load Pipeline
mRatBN7.21053,797,250 - 53,797,551 (+)MAPPERmRatBN7.2
Rnor_6.01055,678,841 - 55,679,141NCBIRnor6.0
Rnor_5.01055,421,901 - 55,422,201UniSTSRnor5.0
RGSC_v3.41055,851,567 - 55,851,868RGDRGSC3.4
RGSC_v3.41055,851,568 - 55,851,868UniSTSRGSC3.4
Celera1052,962,790 - 52,963,090UniSTS
RGSC_v3.11055,865,190 - 55,865,491RGD
SHRSP x BN Map1046.5699RGD
SHRSP x BN Map1046.5699UniSTS
Cytogenetic Map10q24UniSTS


Related Rat Strains
The following Strains have been annotated to Vamp2
SS.MNS-(D10Mit11-Vamp2)/Mco     SS.MNS-(Vamp2-D10M11Mit84)/Mco     WKY.SHRSP-(Asgr1-Vamp2)/Bbb    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000057295   ⟹   ENSRNOP00000054114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,292,985 - 54,296,654 (+)Ensembl
mRatBN7.2 Ensembl1053,793,923 - 53,797,809 (+)Ensembl
Rnor_6.0 Ensembl1055,675,575 - 55,679,450 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111022   ⟹   ENSRNOP00000096610
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1053,794,183 - 53,796,102 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112363   ⟹   ENSRNOP00000079371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,292,806 - 54,294,944 (+)Ensembl
mRatBN7.2 Ensembl1053,793,964 - 53,796,102 (+)Ensembl
RefSeq Acc Id: NM_012663   ⟹   NP_036795
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,292,789 - 54,296,657 (+)NCBI
mRatBN7.21053,793,947 - 53,797,815 (+)NCBI
Rnor_6.01055,675,537 - 55,679,405 (+)NCBI
Rnor_5.01055,418,231 - 55,422,465 (+)NCBI
RGSC_v3.41055,848,264 - 55,852,132 (+)RGD
Celera1052,959,486 - 52,963,354 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246593   ⟹   XP_006246655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,292,423 - 54,296,657 (+)NCBI
mRatBN7.21053,793,581 - 53,796,052 (+)NCBI
Rnor_6.01055,675,171 - 55,677,643 (+)NCBI
Rnor_5.01055,418,231 - 55,422,465 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036795   ⟸   NM_012663
- UniProtKB: P63045 (UniProtKB/Swiss-Prot),   A6HFN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246655   ⟸   XM_006246593
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZNB8 (UniProtKB/TrEMBL),   A6HFN6 (UniProtKB/TrEMBL),   Q9WUW2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000054114   ⟸   ENSRNOT00000057295
Ensembl Acc Id: ENSRNOP00000079371   ⟸   ENSRNOT00000112363
Ensembl Acc Id: ENSRNOP00000096610   ⟸   ENSRNOT00000111022
Protein Domains
v-SNARE coiled-coil homology

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63045-F1-model_v2 AlphaFold P63045 1-116 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697309
Promoter ID:EPDNEW_R7832
Type:initiation region
Name:Vamp2_1
Description:vesicle-associated membrane protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01055,675,530 - 55,675,590EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3949 AgrOrtholog
BIND 134142
  134143
  134144
  134145
BioCyc Gene G2FUF-24587 BioCyc
Ensembl Genes ENSRNOG00000006989 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000057295 ENTREZGENE
  ENSRNOT00000057295.4 UniProtKB/Swiss-Prot
  ENSRNOT00000112363 ENTREZGENE
Gene3D-CATH 1.20.5.110 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7097683 IMAGE-MGC_LOAD
InterPro Synaptobrevin UniProtKB/Swiss-Prot
  Synaptobrevin/VAMP UniProtKB/Swiss-Prot
  V_SNARE_CC UniProtKB/Swiss-Prot
KEGG Report rno:24803 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91770 IMAGE-MGC_LOAD
NCBI Gene 24803 ENTREZGENE
PANTHER PTHR45701 UniProtKB/Swiss-Prot
Pfam Synaptobrevin UniProtKB/Swiss-Prot
PhenoGen Vamp2 PhenoGen
PIRSF Synaptobrevin_euk UniProtKB/Swiss-Prot
PRINTS SYNAPTOBREVN UniProtKB/Swiss-Prot
PROSITE SYNAPTOBREVIN UniProtKB/Swiss-Prot
  V_SNARE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006989 RatGTEx
Superfamily-SCOP SNARE fusion complex UniProtKB/Swiss-Prot
TIGR TC204053
  TC204847
UniProt A0A8I5ZNB8 ENTREZGENE, UniProtKB/TrEMBL
  A6HFN5 ENTREZGENE, UniProtKB/TrEMBL
  A6HFN6 ENTREZGENE, UniProtKB/TrEMBL
  A6HFN7_RAT UniProtKB/TrEMBL
  P63045 ENTREZGENE
  Q9WUW2 ENTREZGENE, UniProtKB/TrEMBL
  VAMP2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q64357 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Vamp2  vesicle-associated membrane protein 2      Symbol and Name status set to approved 70586 APPROVED
2001-06-22 Syb2  Synaptobrevin 2 (vesicle-associated membrane protein, VAMP-2)      Symbol witdrawn, duplicate of Vamp2 (RGD:3949) 67952 WITHDRAWN
2001-06-22 Vamp2  Vesicle-associated membrane protein 2      Name updated, removed withdrawn gene name text 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction forms a complex with soluble NSF attachment protein (SNAP) receptors syntaxin 1A and SNAP25 730202
gene_transcript mRNA upregulated in frontal cortex of AA rat strain compared to ANA rat strain 1358772
gene_transcript mRNA upregulated in frontal cortex of P(alcohol preferring) rat strain compared to NP (alcohol non-preferring) rat strain 1358772