Slc1a2 (solute carrier family 1 member 2) - Rat Genome Database

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Gene: Slc1a2 (solute carrier family 1 member 2) Rattus norvegicus
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Symbol: Slc1a2
Name: solute carrier family 1 member 2
RGD ID: 3697
Description: Enables high-affinity L-glutamate transmembrane transporter activity. Involved in L-glutamate transmembrane transport; response to antibiotic; and response to ethanol. Acts upstream of or within L-glutamate import across plasma membrane. Located in several cellular components, including astrocyte projection; dendrite; and presynaptic membrane. Part of membrane protein complex. Used to study alcohol dependence and nicotine dependence. Biomarker of Alzheimer's disease; alcohol use disorder; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2); PARTICIPATES IN amyotrophic lateral sclerosis pathway; glutamate signaling pathway; INTERACTS WITH (+)-schisandrin B; (4-chloro-2-methylphenoxy)acetic acid; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Eaat2; excitatory amino acid transporter 2; glial glutamate transporter GLT1/V1; glial glutamate transporter GLT1/V2; glial glutamate transporter GLT1/V3; glial glutamate transporter GLT1/V4; Glt; GLT-1; GluT; GluT-R; glutamate transporter; glutamate transporter 1; high affinity glucose transporter; sodium-dependent glutamate/aspartate transporter 2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; solute carrier family 1, member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83109,460,109 - 109,590,445 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3109,459,630 - 109,605,249 (+)EnsemblGRCr8
mRatBN7.2389,005,129 - 89,135,469 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl389,005,129 - 89,126,498 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx392,504,212 - 92,634,668 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03101,103,236 - 101,233,691 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0398,927,305 - 99,057,642 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0392,518,679 - 92,665,731 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl392,640,752 - 92,665,644 (+)Ensemblrn6Rnor6.0
Rnor_5.0399,168,111 - 99,308,723 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4387,870,558 - 87,992,401 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera388,087,285 - 88,206,296 (+)NCBICelera
RGSC_v3.1387,766,997 - 87,888,821 (+)NCBI
Cytogenetic Map3q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(4-chloro-2-methylphenoxy)acetic acid  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-chloroethanol  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
all-trans-retinol  (ISO)
ammonium chloride  (EXP)
amoxicillin  (EXP)
ampicillin  (EXP,ISO)
Ampicillin Sodium Mixture With Sulbactam Sodium  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
Augmentin  (EXP)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylparaben  (EXP)
butyric acid  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
cannabigerol  (ISO)
carbon nanotube  (ISO)
cefazolin  (EXP)
cefoperazone  (EXP)
ceftezole  (EXP)
ceftriaxone  (EXP)
CGP 52608  (ISO)
chelerythrine  (EXP)
chlorpyrifos  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP)
cocaine  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
coumarin  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDE  (EXP)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
fentin chloride  (EXP)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
genistein  (EXP)
guanosine  (ISO)
haloperidol  (EXP)
hesperidin  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
ivermectin  (ISO)
kainic acid  (EXP,ISO)
ketamine  (EXP,ISO)
KT 5720  (EXP)
L-serine  (EXP)
lanthanum trichloride  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
linuron  (EXP)
lipopolysaccharide  (ISO)
LY294002  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mercury dibromide  (ISO)
metacetamol  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (EXP,ISO)
Moniliformin  (ISO)
morphine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
naloxone  (EXP)
nicotine  (EXP,ISO)
nifedipine  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxidopamine  (EXP)
oxybenzone  (EXP)
oxycodone  (EXP)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
pregabalin  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
propanal  (ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (ISO)
quinazolines  (EXP)
raloxifene  (EXP)
resveratrol  (EXP)
rifampicin  (ISO)
Riluzole  (EXP)
romidepsin  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silmitasertib  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
staurosporine  (EXP)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP,ISO)
thiamphenicol  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
Tungsten carbide  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (EXP)
WIN 55212-2  (EXP)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
astrocyte projection  (IDA,IEA,ISO)
axolemma  (IEA,ISO)
axon  (IEA,ISO)
cell body  (IDA,IEA,ISO)
cell surface  (IDA,IEA,ISO)
dendritic shaft  (IDA)
dendritic spine  (IDA)
glutamatergic synapse  (IEA,ISO)
membrane  (IEA,ISO)
membrane protein complex  (IDA,IEA,ISO)
membrane raft  (IEA,ISO)
neuron projection terminus  (IEA,ISO)
plasma membrane  (IBA,IEA,IMP,ISO,ISS)
presynaptic membrane  (IDA,IEA,ISO)
synapse  (IEA,ISO)
vesicle  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ampicillin/Sulbactam Treatment Modulates NMDA Receptor NR2B Subunit and Attenuates Neuroinflammation and Alcohol Intake in Male High Alcohol Drinking Rats. Alasmari F, etal., Biomolecules. 2020 Jul 10;10(7):1030. doi: 10.3390/biom10071030.
2. Effects of cefazolin and cefoperazone on glutamate transporter 1 isoforms and cystine/glutamate exchanger as well as alcohol drinking behavior in male alcohol-preferring rats. Alasmari F, etal., Brain Res. 2016 Mar 1;1634:150-157. doi: 10.1016/j.brainres.2016.01.007. Epub 2016 Jan 11.
3. E-cigarette aerosols containing nicotine modulate nicotinic acetylcholine receptors and astroglial glutamate transporters in mesocorticolimbic brain regions of chronically exposed mice. Alasmari F, etal., Chem Biol Interact. 2021 Jan 5;333:109308. doi: 10.1016/j.cbi.2020.109308. Epub 2020 Nov 23.
4. Peri-adolescent drinking of ethanol and/or nicotine modulates astroglial glutamate transporters and metabotropic glutamate receptor-1 in female alcohol-preferring rats. Alasmari F, etal., Pharmacol Biochem Behav. 2018 Jul;170:44-55. doi: 10.1016/j.pbb.2018.05.006. Epub 2018 May 10.
5. Effects of chronic ethanol consumption on the expression of GLT-1 and neuroplasticity-related proteins in the nucleus accumbens of alcohol-preferring rats. Alhaddad H, etal., Brain Res Bull. 2020 Dec;165:272-280. doi: 10.1016/j.brainresbull.2020.10.012. Epub 2020 Oct 16.
6. Effects of MS-153 on chronic ethanol consumption and GLT1 modulation of glutamate levels in male alcohol-preferring rats. Alhaddad H, etal., Front Behav Neurosci. 2014 Oct 30;8:366. doi: 10.3389/fnbeh.2014.00366. eCollection 2014.
7. Effects of a Novel Beta Lactam Compound, MC-100093, on the Expression of Glutamate Transporters/Receptors and Ethanol Drinking Behavior of Alcohol-Preferring Rats. Alhaddad H, etal., J Pharmacol Exp Ther. 2022 Dec;383(3):208-216. doi: 10.1124/jpet.122.001147. Epub 2022 Sep 24.
8. Effects of ceftriaxone on ethanol intake: a possible role for xCT and GLT-1 isoforms modulation of glutamate levels in P rats. Alhaddad H, etal., Psychopharmacology (Berl). 2014 Oct;231(20):4049-57. doi: 10.1007/s00213-014-3545-y. Epub 2014 Apr 1.
9. Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats. Arasteh A, etal., Avicenna J Med Biotechnol. 2023 Oct-Dec;15(4):223-231. doi: 10.18502/ajmb.v15i4.13492.
10. Changes of NMDA receptor subunit (NR1, NR2B) and glutamate transporter (GLT1) mRNA expression in Huntington's disease--an in situ hybridization study. Arzberger T, etal., J Neuropathol Exp Neurol. 1997 Apr;56(4):440-54.
11. Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and function. Butchbach ME, etal., J Biol Chem. 2004 Aug 13;279(33):34388-96. doi: 10.1074/jbc.M403938200. Epub 2004 Jun 8.
12. Expression of a variant form of the glutamate transporter GLT1 in neuronal cultures and in neurons and astrocytes in the rat brain. Chen W, etal., J Neurosci 2002 Mar 15;22(6):2142-52.
13. Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex. Cholet N, etal., Cereb Cortex 2002 May;12(5):515-25.
14. Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats. Das SC, etal., Neuropharmacology. 2015 Oct;97:67-74. doi: 10.1016/j.neuropharm.2015.05.009. Epub 2015 May 19.
15. Preconditioning with cortical spreading depression decreases intraischemic cerebral glutamate levels and down-regulates excitatory amino acid transporters EAAT1 and EAAT2 from rat cerebal cortex plasma membranes. Douen AG, etal., J Neurochem. 2000 Aug;75(2):812-8.
16. Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease. Fan MM, etal., J Neurosci. 2007 Apr 4;27(14):3768-79.
17. Glutamate transporter protein subtypes are expressed differentially during rat CNS development. Furuta A, etal., J Neurosci. 1997 Nov 1;17(21):8363-75.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
20. Amoxicillin and amoxicillin/clavulanate reduce ethanol intake and increase GLT-1 expression as well as AKT phosphorylation in mesocorticolimbic regions. Goodwani S, etal., Brain Res. 2015 Oct 5;1622:397-408. doi: 10.1016/j.brainres.2015.07.008. Epub 2015 Jul 10.
21. Effects of orally administered Augmentin on glutamate transporter 1, cystine-glutamate exchanger expression and ethanol intake in alcohol-preferring rats. Hakami AY, etal., Behav Brain Res. 2017 Mar 1;320:316-322. doi: 10.1016/j.bbr.2016.12.016. Epub 2016 Dec 16.
22. Effects of Amoxicillin and Augmentin on Cystine-Glutamate Exchanger and Glutamate Transporter 1 Isoforms as well as Ethanol Intake in Alcohol-Preferring Rats. Hakami AY, etal., Front Neurosci. 2016 Apr 25;10:171. doi: 10.3389/fnins.2016.00171. eCollection 2016.
23. Effect of amoxicillin/clavulanic acid in attenuating pregabalin-induced condition place preference. Hammad AM, etal., Behav Brain Res. 2023 Feb 15;439:114244. doi: 10.1016/j.bbr.2022.114244. Epub 2022 Dec 2.
24. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Howland DS, etal., Proc Natl Acad Sci U S A 2002 Feb 5;99(3):1604-1609.
25. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
26. The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. Lehre KP and Danbolt NC, J Neurosci. 1998 Nov 1;18(21):8751-7.
27. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Lin CL, etal., Neuron 1998 Mar;20(3):589-602.
28. The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba. Marie H, etal., Mol Cell Neurosci 2002 Feb;19(2):152-64.
29. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
30. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
31. Changes in the glutamate biomarker expression in rats vulnerable or resistant to the rewarding effects of cocaine and their reversal by ceftriaxone. Niedzielska-Andres E, etal., Behav Brain Res. 2019 Sep 16;370:111945. doi: 10.1016/j.bbr.2019.111945. Epub 2019 May 14.
32. Effect of gene transfer of GLT-1, a glutamate transporter, into the locus coeruleus by recombinant adenoviruses on morphine physical dependence in rats. Ozawa T, etal., Eur J Neurosci. 2004 Jan;19(1):221-6. doi: 10.1111/j.1460-9568.2004.03101.x.
33. Cloning and expression of a rat brain L-glutamate transporter. Pines G, etal., Nature 1992 Dec 3;360(6403):464-7.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. The rat hepatoma cell line H4-II-E-C3 expresses high activities of the high-affinity glutamate transporter GLT-1A. Pollard M and McGivan J, FEBS Lett 2000 Nov 3;484(2):74-6.
36. Ceftriaxone, a beta-lactam antibiotic, attenuates relapse-like ethanol-drinking behavior in alcohol-preferring rats. Qrunfleh AM, etal., J Psychopharmacol. 2013 Jun;27(6):541-9. doi: 10.1177/0269881113482529. Epub 2013 Mar 21.
37. Effects of ceftriaxone on chronic ethanol consumption: a potential role for xCT and GLT1 modulation of glutamate levels in male P rats. Rao PS and Sari Y, J Mol Neurosci. 2014 Sep;54(1):71-7. doi: 10.1007/s12031-014-0251-5. Epub 2014 Feb 18.
38. Effects of ampicillin, cefazolin and cefoperazone treatments on GLT-1 expressions in the mesocorticolimbic system and ethanol intake in alcohol-preferring rats. Rao PS, etal., Neuroscience. 2015 Jun 4;295:164-74. doi: 10.1016/j.neuroscience.2015.03.038. Epub 2015 Mar 24.
39. Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol. Rao PS, etal., Psychopharmacology (Berl). 2015 Jul;232(13):2333-42. doi: 10.1007/s00213-015-3868-3. Epub 2015 Jan 27.
40. Chronic administration of the methylxanthine propentofylline impairs reinstatement to cocaine by a GLT-1-dependent mechanism. Reissner KJ, etal., Neuropsychopharmacology. 2014 Jan;39(2):499-506. doi: 10.1038/npp.2013.223. Epub 2013 Aug 29.
41. GOA pipeline RGD automated data pipeline
42. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
44. Ceftriaxone treatment affects the levels of GLT1 and ENT1 as well as ethanol intake in alcohol-preferring rats. Sari Y, etal., J Mol Neurosci. 2013 Nov;51(3):779-87. doi: 10.1007/s12031-013-0064-y. Epub 2013 Jul 27.
45. Effects of ceftriaxone on ethanol, nicotine or sucrose intake by alcohol-preferring (P) rats and its association with GLT-1 expression. Sari Y, etal., Neuroscience. 2016 Jun 21;326:117-125. doi: 10.1016/j.neuroscience.2016.04.004. Epub 2016 Apr 7.
46. A splice variant of glutamate transporter GLT1/EAAT2 expressed in neurons: cloning and localization in rat nervous system. Schmitt A, etal., Neuroscience 2002;109(1):45-61.
47. Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia/reperfusion injury. Verma R, etal., Eur J Pharmacol. 2010 Jul 25;638(1-3):65-71. doi: 10.1016/j.ejphar.2010.04.021. Epub 2010 Apr 24.
48. Aquaporin 4 Forms a Macromolecular Complex with Glutamate Transporter 1 and Mu Opioid Receptor in Astrocytes and Participates in Morphine Dependence. Wang H, etal., J Mol Neurosci. 2017 May;62(1):17-27. doi: 10.1007/s12031-017-0905-1. Epub 2017 Mar 24.
49. SLC1A2 Gene Polymorphism Influences Methamphetamine-Induced Psychosis. Yahya DN, etal., J Pers Med. 2023 Jan 31;13(2):270. doi: 10.3390/jpm13020270.
Additional References at PubMed
PMID:7521911   PMID:7698742   PMID:7913472   PMID:8099882   PMID:9180080   PMID:9373176   PMID:9539795   PMID:9671661   PMID:11744157   PMID:12420313   PMID:12535941   PMID:12957496  
PMID:14766991   PMID:15009636   PMID:15265858   PMID:15337309   PMID:15337311   PMID:15390098   PMID:15483603   PMID:15494979   PMID:15739191   PMID:15755674   PMID:15789431   PMID:15892126  
PMID:16024041   PMID:16079146   PMID:16175560   PMID:16197522   PMID:16292503   PMID:16324108   PMID:16474996   PMID:16718509   PMID:16738240   PMID:16868771   PMID:16950847   PMID:16987241  
PMID:17028421   PMID:17122424   PMID:17138558   PMID:17213861   PMID:17254611   PMID:17346885   PMID:17442809   PMID:17680651   PMID:17701165   PMID:17981401   PMID:18079058   PMID:18248606  
PMID:18381652   PMID:18384122   PMID:18428036   PMID:18671901   PMID:18720407   PMID:18720515   PMID:18805448   PMID:18973588   PMID:19200233   PMID:19323820   PMID:19323997   PMID:19328838  
PMID:19428804   PMID:19428805   PMID:19457061   PMID:19551376   PMID:19570219   PMID:19614985   PMID:19625514   PMID:19651762   PMID:19706515   PMID:19728998   PMID:19747495   PMID:19804828  
PMID:19806886   PMID:19998491   PMID:20072121   PMID:20152809   PMID:20193040   PMID:20375134   PMID:20547213   PMID:20685337   PMID:21098017   PMID:21110225   PMID:21233495   PMID:21258616  
PMID:21371514   PMID:21399631   PMID:21426345   PMID:21693777   PMID:21700703   PMID:21730107   PMID:21781120   PMID:21853027   PMID:21853059   PMID:21925558   PMID:21964391   PMID:22052455  
PMID:22069320   PMID:22171032   PMID:22266516   PMID:22266730   PMID:22593010   PMID:22645130   PMID:22710775   PMID:22871113   PMID:22895544   PMID:23020698   PMID:23392471   PMID:23602887  
PMID:23638698   PMID:23665075   PMID:23694703   PMID:23697999   PMID:23936321   PMID:24307171   PMID:24442982   PMID:24469401   PMID:24611756   PMID:24650590   PMID:24735535   PMID:24753081  
PMID:24836816   PMID:24866234   PMID:24907601   PMID:25059512   PMID:25454285   PMID:25480579   PMID:25716834   PMID:25834045   PMID:26031379   PMID:26037264   PMID:26301411   PMID:26459476  
PMID:26464063   PMID:26690923   PMID:26732590   PMID:26861954   PMID:26920805   PMID:27189737   PMID:27226528   PMID:27247047   PMID:27430327   PMID:27438618   PMID:27769869   PMID:27837432  
PMID:28104249   PMID:28461494   PMID:28677303   PMID:28771710   PMID:29045497   PMID:29350434   PMID:29375045   PMID:29431649   PMID:29476059   PMID:29603414   PMID:30360015   PMID:30558468  
PMID:30590449   PMID:30799685   PMID:30915775   PMID:31004734   PMID:31019528   PMID:31872442   PMID:32008166   PMID:32170887   PMID:32357304   PMID:32433937   PMID:32621862   PMID:32650029  
PMID:32847971   PMID:33619583   PMID:33860761   PMID:34197892   PMID:34719508   PMID:35451738   PMID:36725696   PMID:37061176   PMID:37975223  


Genomics

Comparative Map Data
Slc1a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83109,460,109 - 109,590,445 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3109,459,630 - 109,605,249 (+)EnsemblGRCr8
mRatBN7.2389,005,129 - 89,135,469 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl389,005,129 - 89,126,498 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx392,504,212 - 92,634,668 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03101,103,236 - 101,233,691 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0398,927,305 - 99,057,642 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0392,518,679 - 92,665,731 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl392,640,752 - 92,665,644 (+)Ensemblrn6Rnor6.0
Rnor_5.0399,168,111 - 99,308,723 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4387,870,558 - 87,992,401 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera388,087,285 - 88,206,296 (+)NCBICelera
RGSC_v3.1387,766,997 - 87,888,821 (+)NCBI
Cytogenetic Map3q32NCBI
SLC1A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381135,251,205 - 35,420,507 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1135,251,205 - 35,420,063 (-)Ensemblhg38GRCh38
GRCh371135,272,752 - 35,441,605 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361135,229,328 - 35,397,681 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341135,229,328 - 35,397,372NCBI
Celera1135,420,071 - 35,588,420 (-)NCBICelera
Cytogenetic Map11p13NCBI
HuRef1134,972,036 - 35,140,670 (-)NCBIHuRef
CHM1_11135,271,219 - 35,439,999 (-)NCBICHM1_1
T2T-CHM13v2.01135,389,505 - 35,559,339 (-)NCBIT2T-CHM13v2.0
Slc1a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392102,488,584 - 102,621,129 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2102,489,004 - 102,621,129 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382102,658,239 - 102,790,784 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2102,658,659 - 102,790,784 (+)Ensemblmm10GRCm38
MGSCv372102,498,840 - 102,630,941 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362102,507,277 - 102,578,945 (+)NCBIMGSCv36mm8
Celera2103,898,008 - 104,034,664 (+)NCBICelera
Cytogenetic Map2E2NCBI
cM Map254.13NCBI
Slc1a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542210,930,296 - 11,073,032 (+)Ensembl
ChiLan1.0NW_00495542210,929,987 - 11,082,220 (+)NCBIChiLan1.0ChiLan1.0
SLC1A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2937,471,506 - 37,639,909 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11137,476,132 - 37,644,775 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,223,811 - 35,392,799 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,098,291 - 35,266,940 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,107,920 - 35,265,878 (-)EnsemblpanPan2panpan1.1
SLC1A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11832,565,258 - 32,717,052 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1832,565,258 - 32,709,225 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1832,172,140 - 32,315,018 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01833,175,536 - 33,327,487 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1833,175,537 - 33,319,660 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11832,737,141 - 32,880,123 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01832,322,154 - 32,465,264 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01832,967,648 - 33,106,043 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc1a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494729,654,306 - 29,802,620 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365332,779,518 - 2,918,298 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365332,779,650 - 2,918,640 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC1A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl225,604,950 - 25,848,276 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1225,603,892 - 25,771,840 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2227,968,216 - 28,136,634 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC1A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,845,512 - 30,012,261 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,847,043 - 29,989,975 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038126,963,701 - 127,135,271 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc1a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476711,768,951 - 11,911,017 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476711,768,942 - 11,919,315 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc1a2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1580,500,333 - 80,619,335 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc1a2
3902 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:518
Count of miRNA genes:243
Interacting mature miRNAs:300
Transcripts:ENSRNOT00000007604
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
D3Rat27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2389,115,068 - 89,115,240 (+)MAPPERmRatBN7.2
Rnor_6.0392,654,302 - 92,654,473NCBIRnor6.0
Rnor_5.0399,297,509 - 99,297,680UniSTSRnor5.0
RGSC_v3.4387,981,086 - 87,981,257UniSTSRGSC3.4
RGSC_v3.4387,981,062 - 87,981,257RGDRGSC3.4
Celera388,194,883 - 88,195,054UniSTS
RGSC_v3.1387,877,514 - 87,877,685RGD
RH 3.4 Map3669.6RGD
RH 3.4 Map3669.6UniSTS
RH 2.0 Map3440.8RGD
SHRSP x BN Map347.2698RGD
Cytogenetic Map3q31UniSTS
BF386143  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2389,112,161 - 89,112,321 (+)MAPPERmRatBN7.2
Rnor_6.0392,651,395 - 92,651,554NCBIRnor6.0
Rnor_5.0399,294,602 - 99,294,761UniSTSRnor5.0
RGSC_v3.4387,978,179 - 87,978,338UniSTSRGSC3.4
Celera388,191,976 - 88,192,135UniSTS
RH 3.4 Map3669.7UniSTS
Cytogenetic Map3q31UniSTS
D43796  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2389,126,535 - 89,126,702 (+)MAPPERmRatBN7.2
Rnor_6.0392,665,769 - 92,665,935NCBIRnor6.0
Rnor_5.0399,308,761 - 99,308,927UniSTSRnor5.0
RGSC_v3.4387,992,439 - 87,992,605UniSTSRGSC3.4
Celera388,206,334 - 88,206,500UniSTS
Cytogenetic Map3q31UniSTS
RH138571  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2389,122,654 - 89,122,802 (+)MAPPERmRatBN7.2
Rnor_6.0392,661,888 - 92,662,035NCBIRnor6.0
Rnor_5.0399,304,880 - 99,305,027UniSTSRnor5.0
RGSC_v3.4387,988,558 - 87,988,705UniSTSRGSC3.4
Celera388,202,453 - 88,202,600UniSTS
RH 3.4 Map3670.4UniSTS
Cytogenetic Map3q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 12 67 206 91 90 59 112 59 6 388 213 14 187 85 113 31 32 32

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001035233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283236 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC113891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF297648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF451299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF465909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY035551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY044832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY069978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY578981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY643513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY643514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY643515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY643516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY643517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB760876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ489741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF017228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JN132400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KP966087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KR006257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U15098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X67857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000007604   ⟹   ENSRNOP00000007604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3109,536,005 - 109,580,497 (+)Ensembl
mRatBN7.2 Ensembl389,081,028 - 89,125,521 (+)Ensembl
Rnor_6.0 Ensembl392,640,752 - 92,665,644 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098273   ⟹   ENSRNOP00000091331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,005,178 - 89,122,959 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099140   ⟹   ENSRNOP00000097282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3109,459,630 - 109,605,249 (+)Ensembl
mRatBN7.2 Ensembl389,005,178 - 89,126,498 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106964   ⟹   ENSRNOP00000093236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl389,081,028 - 89,122,959 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109994   ⟹   ENSRNOP00000094162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3109,460,068 - 109,577,945 (+)Ensembl
mRatBN7.2 Ensembl389,005,129 - 89,122,959 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118194   ⟹   ENSRNOP00000100271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3109,507,947 - 109,590,445 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119447   ⟹   ENSRNOP00000097017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3109,460,089 - 109,581,438 (+)Ensembl
mRatBN7.2 Ensembl389,005,178 - 89,126,434 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119905   ⟹   ENSRNOP00000093496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3109,460,081 - 109,577,934 (+)Ensembl
mRatBN7.2 Ensembl389,053,004 - 89,122,959 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000155256   ⟹   ENSRNOP00000112804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3109,459,630 - 109,590,440 (+)Ensembl
RefSeq Acc Id: NM_001035233   ⟹   NP_001030310
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,460,109 - 109,577,946 (+)NCBI
mRatBN7.2389,005,129 - 89,122,970 (+)NCBI
Rnor_6.0392,518,679 - 92,662,194 (+)NCBI
Rnor_5.0399,168,111 - 99,308,723 (+)NCBI
RGSC_v3.4387,870,558 - 87,992,401 (+)RGD
Celera388,087,285 - 88,202,759 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302089   ⟹   NP_001289018
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,507,947 - 109,590,445 (+)NCBI
mRatBN7.2389,052,970 - 89,135,469 (+)NCBI
Rnor_6.0392,640,766 - 92,665,731 (+)NCBI
Celera388,161,302 - 88,206,296 (+)NCBI
Sequence:
RefSeq Acc Id: NM_017215   ⟹   NP_058911
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,460,109 - 109,590,445 (+)NCBI
mRatBN7.2389,005,129 - 89,135,469 (+)NCBI
Rnor_6.0392,518,679 - 92,665,731 (+)NCBI
Rnor_5.0399,168,111 - 99,308,723 (+)NCBI
RGSC_v3.4387,870,558 - 87,992,401 (+)RGD
Celera388,087,285 - 88,206,296 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283235   ⟹   XP_063139305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,496,562 - 109,590,440 (+)NCBI
RefSeq Acc Id: XM_063283236   ⟹   XP_063139306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,496,562 - 109,581,384 (+)NCBI
RefSeq Acc Id: XM_063283237   ⟹   XP_063139307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83109,476,098 - 109,590,440 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001030310 (Get FASTA)   NCBI Sequence Viewer  
  NP_001289018 (Get FASTA)   NCBI Sequence Viewer  
  NP_058911 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139305 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139306 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139307 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA93061 (Get FASTA)   NCBI Sequence Viewer  
  AAA93062 (Get FASTA)   NCBI Sequence Viewer  
  AAG13411 (Get FASTA)   NCBI Sequence Viewer  
  AAK98779 (Get FASTA)   NCBI Sequence Viewer  
  AAL55405 (Get FASTA)   NCBI Sequence Viewer  
  AAL86765 (Get FASTA)   NCBI Sequence Viewer  
  AAM21604 (Get FASTA)   NCBI Sequence Viewer  
  AAS89003 (Get FASTA)   NCBI Sequence Viewer  
  AAT66426 (Get FASTA)   NCBI Sequence Viewer  
  AAT66427 (Get FASTA)   NCBI Sequence Viewer  
  AAT66428 (Get FASTA)   NCBI Sequence Viewer  
  AAT66429 (Get FASTA)   NCBI Sequence Viewer  
  AAT66430 (Get FASTA)   NCBI Sequence Viewer  
  ABF47217 (Get FASTA)   NCBI Sequence Viewer  
  AEO52639 (Get FASTA)   NCBI Sequence Viewer  
  AMD11600 (Get FASTA)   NCBI Sequence Viewer  
  AMD11602 (Get FASTA)   NCBI Sequence Viewer  
  CAA48042 (Get FASTA)   NCBI Sequence Viewer  
  EDL79643 (Get FASTA)   NCBI Sequence Viewer  
  EDL79644 (Get FASTA)   NCBI Sequence Viewer  
  EDL79645 (Get FASTA)   NCBI Sequence Viewer  
  EDL79646 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000094162
  ENSRNOP00000100271
  ENSRNOP00000112804
GenBank Protein P31596 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058911   ⟸   NM_017215
- Peptide Label: isoform a
- UniProtKB: P31596 (UniProtKB/Swiss-Prot),   A6HNP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001030310   ⟸   NM_001035233
- Peptide Label: isoform b
- UniProtKB: A0A8I6AL04 (UniProtKB/TrEMBL),   A6HNP3 (UniProtKB/TrEMBL),   Q8K5B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289018   ⟸   NM_001302089
- Peptide Label: isoform c
- UniProtKB: P31596 (UniProtKB/Swiss-Prot),   A6HNP4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007604   ⟸   ENSRNOT00000007604
Ensembl Acc Id: ENSRNOP00000094162   ⟸   ENSRNOT00000109994
Ensembl Acc Id: ENSRNOP00000091331   ⟸   ENSRNOT00000098273
Ensembl Acc Id: ENSRNOP00000093236   ⟸   ENSRNOT00000106964
Ensembl Acc Id: ENSRNOP00000097282   ⟸   ENSRNOT00000099140
Ensembl Acc Id: ENSRNOP00000097017   ⟸   ENSRNOT00000119447
Ensembl Acc Id: ENSRNOP00000093496   ⟸   ENSRNOT00000119905
RefSeq Acc Id: XP_063139307   ⟸   XM_063283237
- Peptide Label: isoform X3
- UniProtKB: P31596 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063139305   ⟸   XM_063283235
- Peptide Label: isoform X1
- UniProtKB: P31596 (UniProtKB/Swiss-Prot),   A0A8I6B5J7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139306   ⟸   XM_063283236
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AS41 (UniProtKB/TrEMBL),   A0A8I6GIX2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100271   ⟸   ENSRNOT00000118194
Ensembl Acc Id: ENSRNOP00000112804   ⟸   ENSRNOT00000155256

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31596-F1-model_v2 AlphaFold P31596 1-573 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3697 AgrOrtholog
BioCyc Gene G2FUF-48594 BioCyc
Ensembl Genes ENSRNOG00000005479 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000109994 ENTREZGENE
  ENSRNOT00000118194 ENTREZGENE
  ENSRNOT00000155256 ENTREZGENE
Gene3D-CATH 1.10.3860.10 UniProtKB/Swiss-Prot
InterPro DAACS UniProtKB/Swiss-Prot
  Na-dicarboxylate_symporter UniProtKB/Swiss-Prot
  Na-dicarboxylate_symporter_CS UniProtKB/Swiss-Prot
  Na:dicarbo_symporter_sf UniProtKB/Swiss-Prot
KEGG Report rno:29482 UniProtKB/Swiss-Prot
NCBI Gene 29482 ENTREZGENE
PANTHER EXCITATORY AMINO ACID TRANSPORTER 2 UniProtKB/Swiss-Prot
  SODIUM/DICARBOXYLATE SYMPORTER-RELATED UniProtKB/Swiss-Prot
Pfam SDF UniProtKB/Swiss-Prot
PhenoGen Slc1a2 PhenoGen
PRINTS EDTRNSPORT UniProtKB/Swiss-Prot
PROSITE NA_DICARBOXYL_SYMP_1 UniProtKB/Swiss-Prot
  NA_DICARBOXYL_SYMP_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005479 RatGTEx
Superfamily-SCOP SSF118215 UniProtKB/Swiss-Prot
UniProt A0A8I6AL04 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AS41 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B5J7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GIX2 ENTREZGENE
  A0A8I6GKB5_RAT UniProtKB/TrEMBL
  A0ABK0KYQ9_RAT UniProtKB/TrEMBL
  A0ABK0M9V6_RAT UniProtKB/TrEMBL
  A6HNP2 ENTREZGENE, UniProtKB/TrEMBL
  A6HNP3 ENTREZGENE, UniProtKB/TrEMBL
  A6HNP4 ENTREZGENE, UniProtKB/TrEMBL
  A6HNP5_RAT UniProtKB/TrEMBL
  EAA2_RAT UniProtKB/Swiss-Prot
  G3V6R0_RAT UniProtKB/TrEMBL
  P31596 ENTREZGENE
  Q6DUJ4_RAT UniProtKB/TrEMBL
  Q6DUJ5_RAT UniProtKB/TrEMBL
  Q8K5B5 ENTREZGENE, UniProtKB/TrEMBL
  Q8R4I5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc1a2  solute carrier family 1 member 2  Slc1a2  solute carrier family 1 (glial high affinity glutamate transporter), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc1a2  solute carrier family 1 (glial high affinity glutamate transporter), member 2    solute carrier family 1, member 2  Name updated 1299863 APPROVED
2002-06-10 Slc1a2  solute carrier family 1, member 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease significantly decreased in ventral horn of amyotrophic lateral sclerosis patients 70237
gene_disease loss may lead to cell death in amyotrophic lateral sclerosis 70237
gene_expression expressed in astrocytes 70237
gene_function central nervous system glutamate transporter 70237
gene_protein variant forms GLT1a and GLT1b differ at the C terminal region 619547