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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3697
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc1a2
Name: solute carrier family 1 member 2
Acc ID: CHEBI:63949
Term: 2,3-bis(4-hydroxyphenyl)propionitrile
Definition: A nitrile that is acetonitrile in which one of the hydrogens is replaced by a 4-hydroxyphenyl group while a second hydrogen is replaced by a 4-hydroxybenzyl group. It is a specific agonist for estrogen receptor beta (ERbeta).
Chemical ID: MESH:C486182
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc1a2multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of SLC1A2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of SLC1A2 protein]; [2,3-bis(4-hydroxyphenyl)-propionitrile binds to and results in increased activity of ESR2 protein] which results in increased expression of SLC1A2 protein; Fulvestrant inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of SLC1A2 protein]; RTKI cpd inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of SLC1A2 protein]PMID:24782323
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