Scnn1b (sodium channel epithelial 1 subunit beta) - Rat Genome Database

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Gene: Scnn1b (sodium channel epithelial 1 subunit beta) Rattus norvegicus
Analyze
Symbol: Scnn1b
Name: sodium channel epithelial 1 subunit beta
RGD ID: 3640
Description: Enables WW domain binding activity and ligand-gated sodium channel activity. Contributes to sodium ion transmembrane transporter activity. Involved in several processes, including intracellular sodium ion homeostasis; sodium ion import across plasma membrane; and wound healing, spreading of epidermal cells. Located in apical plasma membrane and cell surface. Part of sodium channel complex. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amiloride-sensitive sodium channel subunit beta; beta-ENaC; beta-NaCH; epithelial Na(+) channel subunit beta; epithelial sodium channel subunit beta; nonvoltage-gated sodium channel 1 subunit beta; RNENACB; SCNEB; sodium channel epithelial 1 beta subunit; Sodium channel nonvoltage-gated 1 beta (epithelial); sodium channel, non-voltage-gated 1, beta subunit; sodium channel, nonvoltage-gated 1 beta; sodium channel, nonvoltage-gated 1, beta; sodium channel, nonvoltage-gated, type I, beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHR.BN-(D1Mit3-Igf2)/Ipcv
QTLs:   Bp88  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81185,861,326 - 185,915,717 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1185,854,733 - 185,916,049 (+)EnsemblGRCr8
mRatBN7.21176,430,063 - 176,484,451 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,430,103 - 176,484,451 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1184,757,955 - 184,812,267 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01191,943,901 - 191,998,213 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,627,931 - 184,682,270 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01191,829,547 - 191,883,991 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1191,829,555 - 191,884,298 (+)Ensemblrn6Rnor6.0
Rnor_5.01198,932,512 - 198,953,453 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41180,682,622 - 180,748,068 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1174,140,255 - 174,194,462 (+)NCBICelera
RGSC_v3.11180,822,536 - 180,887,983 (+)NCBI
Cytogenetic Map1q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2-hydroxypropanoic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-(4-chlorophenylthio)-cAMP  (EXP)
8-(4-chlorophenylthio)-cGMP  (ISO)
8-bromo-3',5'-cyclic GMP  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldosterone  (ISO)
alpha-Zearalanol  (EXP)
amiloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brefeldin A  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
clothianidin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
cortisol  (ISO)
desmopressin  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diethyl phthalate  (EXP)
dioxygen  (EXP)
diquat  (ISO)
flavonoids  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
hydralazine  (ISO)
iodide salt  (EXP)
lead diacetate  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
methylparaben  (ISO)
nickel atom  (ISO)
nitrates  (EXP)
okadaic acid  (ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (ISO)
potassium atom  (ISO)
progesterone  (EXP)
propylparaben  (ISO)
rac-lactic acid  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium fluoride  (ISO)
sotorasib  (ISO)
terbutaline  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thiourea  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Determination of epithelial Na+ channel subunit stoichiometry from single-channel conductances. Anantharam A and Palmer LG, J Gen Physiol. 2007 Jul;130(1):55-70. doi: 10.1085/jgp.200609716. Epub 2007 Jun 11.
2. Characterization of interactions between Nedd4 and beta and gammaENaC using surface plasmon resonance. Asher C, etal., Biochem Biophys Res Commun. 2001 Sep 7;286(5):1228-31.
3. Cl- interference with the epithelial Na+ channel ENaC. Bachhuber T, etal., J Biol Chem. 2005 Sep 9;280(36):31587-94. Epub 2005 Jul 18.
4. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Canessa CM, etal., Nature 1994 Feb 3;367(6462):463-7.
5. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Chang SS, etal., Nat Genet. 1996 Mar;12(3):248-53.
6. The epithelial sodium channel (ENaC) is intracellularly located as a tetramer. Dijkink L, etal., Pflugers Arch. 2002 Jul;444(4):549-55. doi: 10.1007/s00424-002-0855-4. Epub 2002 May 29.
7. The heterotetrameric architecture of the epithelial sodium channel (ENaC). Firsov D, etal., EMBO J. 1998 Jan 15;17(2):344-52. doi: 10.1093/emboj/17.2.344.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. ENaC proteins contribute to VSMC migration. Grifoni SC, etal., Am J Physiol Heart Circ Physiol. 2006 Dec;291(6):H3076-86. Epub 2006 Jul 14.
11. A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel. Gründer S, etal., EMBO J. 1997 Mar 3;16(5):899-907. doi: 10.1093/emboj/16.5.899.
12. Trafficking and cell surface stability of the epithelial Na+ channel expressed in epithelial Madin-Darby canine kidney cells. Hanwell D, etal., J Biol Chem 2002 Mar 22;277(12):9772-9.
13. δ ENaC: a novel divergent amiloride-inhibitable sodium channel. Ji HL, etal., Am J Physiol Lung Cell Mol Physiol. 2012 Dec 15;303(12):L1013-26. doi: 10.1152/ajplung.00206.2012. Epub 2012 Sep 14.
14. NMR studies of tandem WW domains of Nedd4 in complex with a PY motif-containing region of the epithelial sodium channel. Kanelis V, etal., Biochem Cell Biol. 1998;76(2-3):341-50.
15. Increased expression and apical targeting of renal ENaC subunits in puromycin aminonucleoside-induced nephrotic syndrome in rats. Kim SW, etal., Am J Physiol Renal Physiol. 2004 May;286(5):F922-35. Epub 2004 Jan 6.
16. Role of the alpha-, beta-, and gamma-subunits of epithelial sodium channel in a model of polygenic hypertension. Kreutz R, etal., Hypertension 1997 Jan;29(1 Pt 1):131-6.
17. The carboxyl terminus of the alpha-subunit of the amiloride-sensitive epithelial sodium channel binds to F-actin. Mazzochi C, etal., J Biol Chem. 2006 Mar 10;281(10):6528-38. Epub 2005 Dec 14.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism. Michlig S, etal., J Biol Chem. 2005 Nov 18;280(46):38264-70. Epub 2005 Sep 19.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. Planes C, etal., J Biol Chem 2002 Dec 6;277(49):47318-24.
25. A mouse model for Liddle's syndrome. Pradervand S, etal., J Am Soc Nephrol 1999 Dec;10(12):2527-33.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation. Shi H, etal., J Biol Chem 2002 Apr 19;277(16):13539-47.
30. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Shimkets RA, etal., Cell. 1994 Nov 4;79(3):407-14.
31. WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. Staub O, etal., EMBO J 1996 May 15;15(10):2371-80.
32. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
33. Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells. Warnock DG, etal., Nat Rev Nephrol. 2014 Mar;10(3):146-57. doi: 10.1038/nrneph.2013.275. Epub 2014 Jan 14.
34. Stimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's beta- and gamma-subunit. Yang LM, etal., J Biol Chem. 2006 Apr 14;281(15):9859-68. Epub 2006 Feb 13.
Additional References at PubMed
PMID:9501257   PMID:10212229   PMID:10409305   PMID:10642508   PMID:11323714   PMID:12548398   PMID:12654927   PMID:12759227   PMID:12876281   PMID:12928314   PMID:12967915   PMID:14514522  
PMID:14567502   PMID:14576089   PMID:14672917   PMID:15161604   PMID:15219314   PMID:15326289   PMID:15381679   PMID:15956070   PMID:16020936   PMID:16554417   PMID:16941024   PMID:17200158  
PMID:17605762   PMID:17715136   PMID:17724164   PMID:17926064   PMID:18024548   PMID:18504317   PMID:18806814   PMID:18990692   PMID:19202345   PMID:19224431   PMID:19420735   PMID:19426735  
PMID:21423289   PMID:22045317   PMID:22090066   PMID:22830999   PMID:24093724   PMID:24124190   PMID:24553299   PMID:26297031   PMID:27215035   PMID:27941075  


Genomics

Comparative Map Data
Scnn1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81185,861,326 - 185,915,717 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1185,854,733 - 185,916,049 (+)EnsemblGRCr8
mRatBN7.21176,430,063 - 176,484,451 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1176,430,103 - 176,484,451 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1184,757,955 - 184,812,267 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01191,943,901 - 191,998,213 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01184,627,931 - 184,682,270 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01191,829,547 - 191,883,991 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1191,829,555 - 191,884,298 (+)Ensemblrn6Rnor6.0
Rnor_5.01198,932,512 - 198,953,453 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41180,682,622 - 180,748,068 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1174,140,255 - 174,194,462 (+)NCBICelera
RGSC_v3.11180,822,536 - 180,887,983 (+)NCBI
Cytogenetic Map1q36NCBI
SCNN1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381623,278,231 - 23,381,294 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1623,278,231 - 23,381,299 (+)Ensemblhg38GRCh38
GRCh371623,313,623 - 23,392,615 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361623,221,092 - 23,300,121 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341623,221,140 - 23,300,117NCBI
Celera1622,091,376 - 22,169,881 (+)NCBICelera
Cytogenetic Map16p12.2NCBI
HuRef1621,402,990 - 21,480,744 (+)NCBIHuRef
CHM1_11624,325,334 - 24,404,340 (+)NCBICHM1_1
T2T-CHM13v2.01623,554,125 - 23,657,344 (+)NCBIT2T-CHM13v2.0
Scnn1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397121,464,261 - 121,517,951 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7121,464,261 - 121,517,737 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387121,865,038 - 121,918,728 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7121,865,038 - 121,918,514 (+)Ensemblmm10GRCm38
MGSCv377129,008,625 - 129,062,030 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367121,656,259 - 121,709,664 (+)NCBIMGSCv36mm8
Celera7121,788,233 - 121,808,466 (+)NCBICelera
Cytogenetic Map7F2NCBI
cM Map765.07NCBI
Scnn1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554931,904,220 - 1,956,303 (+)Ensembl
ChiLan1.0NW_0049554931,937,507 - 1,956,248 (+)NCBIChiLan1.0ChiLan1.0
SCNN1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21824,712,414 - 24,794,054 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11629,231,645 - 29,312,685 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01614,728,834 - 14,809,072 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11623,555,391 - 23,634,873 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1623,555,388 - 23,634,873 (+)EnsemblpanPan2panpan1.1
SCNN1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1622,439,643 - 22,481,349 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl622,439,643 - 22,481,349 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha624,003,147 - 24,044,601 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0622,579,419 - 22,621,104 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl622,579,419 - 22,621,104 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1622,383,826 - 22,425,285 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0622,286,935 - 22,328,601 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0622,681,830 - 22,723,544 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Scnn1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344119,923,171 - 119,968,392 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365018,020,316 - 8,065,332 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365018,021,090 - 8,065,245 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCNN1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl322,832,262 - 22,902,063 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1322,832,259 - 22,902,592 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.210271,050 - 337,906 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SCNN1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1521,021,181 - 21,107,746 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl521,022,133 - 21,107,824 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660688,719,000 - 8,805,239 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scnn1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247828,549,583 - 8,581,819 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247828,521,639 - 8,580,099 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Scnn1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1279,897,501 - 79,957,456 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Scnn1b
419 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:121
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000067138
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
61326Eae6Experimental allergic encephalomyelitis QTL 65.3body mass (VT:0001259)change in body weight (CMO:0002045)1182383862191260518Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
D1Smu8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,447,349 - 176,447,478 (+)MAPPERmRatBN7.2
Rnor_6.01191,846,830 - 191,846,958NCBIRnor6.0
Rnor_5.01198,817,904 - 198,818,032UniSTSRnor5.0
RGSC_v3.41180,699,898 - 180,700,026UniSTSRGSC3.4
Celera1174,157,501 - 174,157,629UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map1q36-q41UniSTS
D1Smu7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21176,447,730 - 176,447,875 (+)MAPPERmRatBN7.2
Rnor_6.01191,847,211 - 191,847,353NCBIRnor6.0
Rnor_5.01198,818,285 - 198,818,427UniSTSRnor5.0
RGSC_v3.41180,700,279 - 180,700,421UniSTSRGSC3.4
Celera1174,157,882 - 174,158,024UniSTS
Cytogenetic Map1q36-q41UniSTS
Cytogenetic Map1q36UniSTS


Related Rat Strains
The following Strains have been annotated to Scnn1b
SHR.BN-(D1Mit3-Igf2)/Ipcv    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 30 95 56 55 24 65 24 6 253 124 6 73 81 90 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000067138   ⟹   ENSRNOP00000063755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1185,861,340 - 185,916,049 (+)Ensembl
mRatBN7.2 Ensembl1176,430,103 - 176,484,451 (+)Ensembl
Rnor_6.0 Ensembl1191,829,555 - 191,884,298 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000152824   ⟹   ENSRNOP00000107794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1185,854,733 - 185,916,049 (+)Ensembl
RefSeq Acc Id: NM_012648   ⟹   NP_036780
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81185,861,376 - 185,915,715 (+)NCBI
mRatBN7.21176,430,105 - 176,484,451 (+)NCBI
Rnor_6.01191,829,587 - 191,883,989 (+)NCBI
Rnor_5.01198,932,512 - 198,953,453 (-)NCBI
RGSC_v3.41180,682,622 - 180,748,068 (+)RGD
Celera1174,140,255 - 174,194,462 (+)RGD
Sequence:
RefSeq Acc Id: XM_008759682   ⟹   XP_008757904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81185,861,326 - 185,915,717 (+)NCBI
mRatBN7.21176,430,063 - 176,484,287 (+)NCBI
Rnor_6.01191,829,556 - 191,883,991 (+)NCBI
Sequence:
RefSeq Acc Id: NP_036780   ⟸   NM_012648
- UniProtKB: O09183 (UniProtKB/Swiss-Prot),   P37090 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757904   ⟸   XM_008759682
- Peptide Label: isoform X1
- UniProtKB: P37090 (UniProtKB/Swiss-Prot),   O09183 (UniProtKB/Swiss-Prot),   B8QP48 (UniProtKB/TrEMBL),   F1LQG4 (UniProtKB/TrEMBL),   A0A9K3Y6R5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063755   ⟸   ENSRNOT00000067138
Ensembl Acc Id: ENSRNOP00000107794   ⟸   ENSRNOT00000152824

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P37090-F1-model_v2 AlphaFold P37090 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690368
Promoter ID:EPDNEW_R893
Type:multiple initiation site
Name:Scnn1b_1
Description:sodium channel epithelial 1 beta subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01191,829,572 - 191,829,632EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3640 AgrOrtholog
BioCyc Gene G2FUF-57554 BioCyc
Ensembl Genes ENSRNOG00000030981 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000067138 ENTREZGENE
Gene3D-CATH Acid-sensing ion channel domain UniProtKB/Swiss-Prot
  Acid-sensing ion channels like domains UniProtKB/Swiss-Prot
InterPro ENaC UniProtKB/Swiss-Prot
  ENaC_chordates UniProtKB/Swiss-Prot
  ENaC_CS UniProtKB/Swiss-Prot
KEGG Report rno:24767 UniProtKB/Swiss-Prot
NCBI Gene 24767 ENTREZGENE
PANTHER AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT BETA UniProtKB/Swiss-Prot
  PTHR11690 UniProtKB/Swiss-Prot
Pfam ASC UniProtKB/Swiss-Prot
PharmGKB SCNN1B RGD
PhenoGen Scnn1b PhenoGen
PRINTS AMINACHANNEL UniProtKB/Swiss-Prot
PROSITE ASC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000030981 RatGTEx
TIGR TC236653
UniProt A0A9K3Y6R5 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LUX7_RAT UniProtKB/TrEMBL
  B8QP48 ENTREZGENE, UniProtKB/TrEMBL
  F1LQG4 ENTREZGENE
  O09183 ENTREZGENE
  P37090 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O09183 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Scnn1b  sodium channel epithelial 1 subunit beta  Scnn1b  sodium channel epithelial 1 beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Scnn1b  sodium channel epithelial 1 beta subunit  Scnn1b  sodium channel, non-voltage-gated 1, beta subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-11-11 Scnn1b  sodium channel, non-voltage-gated 1, beta subunit  Scnn1b  sodium channel, nonvoltage-gated 1, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-07 Scnn1b  sodium channel, nonvoltage-gated 1, beta  Scnn1b  sodium channel, nonvoltage-gated, type I, beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Scnn1b  sodium channel, nonvoltage-gated, type I, beta  Scnn1b  sodium channel, nonvoltage-gated 1 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Scnn1b  Sodium channel, nonvoltage-gated 1, beta (epithelial)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function beta subunit, with alpha and gamma subunits forms the amiloride-sensitive epithelial Na+ channel 729911