Pth1r (parathyroid hormone 1 receptor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Pth1r (parathyroid hormone 1 receptor) Rattus norvegicus
Analyze
Symbol: Pth1r
Name: parathyroid hormone 1 receptor
RGD ID: 3442
Description: Enables parathyroid hormone receptor activity and peptide hormone binding activity. Involved in G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of inositol phosphate biosynthetic process. Located in basolateral plasma membrane and brush border membrane. Part of receptor complex. Used to study hypercalcemia. Human ortholog(s) of this gene implicated in Eiken syndrome; Jansen's metaphyseal chondrodysplasia; chondrodysplasia Blomstrand type; osteochondrodysplasia; and primary failure of tooth eruption. Orthologous to human PTH1R (parathyroid hormone 1 receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; parathyroid hormone signaling pathway; G protein mediated signaling pathway via Galphas family; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: parathyroid hormone receptor; parathyroid hormone receptor 1; Parathyroid hormone/parathyroid hormone-related peptide receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; Pthr; Pthr1; PTHrel
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,572,295 - 119,597,405 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8119,575,868 - 119,598,108 (-)EnsemblGRCr8
mRatBN7.28110,693,910 - 110,725,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,697,485 - 110,719,729 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8116,312,093 - 116,331,737 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,511,292 - 114,530,936 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,354,091 - 112,373,739 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08118,984,531 - 119,012,803 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8118,988,053 - 119,012,671 (-)Ensemblrn6Rnor6.0
Rnor_5.08118,325,190 - 118,353,210 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48115,099,763 - 115,119,362 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8109,981,641 - 110,001,215 (-)NCBICelera
RGSC_v3.18115,119,118 - 115,139,954 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
Azoxymethane  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
cadmium sulfate  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
clofibric acid  (EXP)
cypermethrin  (ISO)
cytarabine  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
fenvalerate  (EXP)
folic acid  (EXP)
FR900359  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
glycerol 2-phosphate  (ISO)
glycitein  (ISO)
glycitin  (ISO)
indometacin  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
losartan  (EXP)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methoxychlor  (EXP)
methylmercury(1+)  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
propiconazole  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium fluoride  (EXP,ISO)
telmisartan  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc dichloride  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Abou-Samra AB, etal., Proc Natl Acad Sci U S A 1992 Apr 1;89(7):2732-6.
2. PTHR1 loss-of-function mutations in familial, nonsyndromic primary failure of tooth eruption. Decker E, etal., Am J Hum Genet. 2008 Dec;83(6):781-6. doi: 10.1016/j.ajhg.2008.11.006.
3. Recessive mutations in PTHR1 cause contrasting skeletal dysplasias in Eiken and Blomstrand syndromes. Duchatelet S, etal., Hum Mol Genet. 2005 Jan 1;14(1):1-5. Epub 2004 Nov 3.
4. Transmembrane residues of the parathyroid hormone (PTH)/PTH-related peptide receptor that specifically affect binding and signaling by agonist ligands. Gardella TJ, etal., J Biol Chem. 1996 May 31;271(22):12820-5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Characterization of PTH/PTHrP receptor in rat duodenum: effects of ageing. Gentili C, etal., J Cell Biochem. 2003 Apr 15;88(6):1157-67.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity. Iida-Klein A, etal., J Biol Chem. 1997 Mar 14;272(11):6882-9.
9. Structure of the parathyroid hormone receptor C terminus bound to the G-protein dimer Gbeta1gamma2. Johnston CA, etal., Structure. 2008 Jul;16(7):1086-94. doi: 10.1016/j.str.2008.04.010.
10. PTHrP and PTH/PTHrP receptor 1 expression in odontogenic cells of normal and HHM model rat incisors. Kato A, etal., Toxicol Pathol. 2005;33(4):456-64.
11. Parathyroid hormone signaling in bone and kidney. Lee M and Partridge NC, Curr Opin Nephrol Hypertens. 2009 Jul;18(4):298-302. doi: 10.1097/MNH.0b013e32832c2264.
12. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Mahon MJ Curr Drug Targets. 2012 Jan;13(1):116-28.
13. The parathyroid hormone 1 receptor directly binds to the FERM domain of ezrin, an interaction that supports apical receptor localization and signaling in LLC-PK1 cells. Mahon MJ Mol Endocrinol. 2009 Oct;23(10):1691-701. doi: 10.1210/me.2009-0164. Epub 2009 Jul 16.
14. Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies. Mannstadt M, etal., J Biol Chem. 1998 Jul 3;273(27):16890-6.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes. Pausova Z, etal., Genomics 1994 Mar 1;20(1):20-6.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Identification of six novel PTH1R mutations in families with a history of primary failure of tooth eruption. Risom L, etal., PLoS One. 2013 Sep 18;8(9):e74601. doi: 10.1371/journal.pone.0074601. eCollection 2013.
21. Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia. Schipani E, etal., N Engl J Med. 1996 Sep 5;335(10):708-14.
22. Molecular basis of parathyroid hormone receptor signaling and trafficking: a family B GPCR paradigm. Vilardaga JP, etal., Cell Mol Life Sci. 2011 Jan;68(1):1-13. doi: 10.1007/s00018-010-0465-9. Epub 2010 Aug 12.
Additional References at PubMed
PMID:8185578   PMID:8397094   PMID:8662561   PMID:8895385   PMID:9832460   PMID:11606467   PMID:12194850   PMID:12787396   PMID:15618618   PMID:15630249   PMID:15670850   PMID:15691895  
PMID:16476422   PMID:16574786   PMID:16672315   PMID:16728497   PMID:17384996   PMID:17627912   PMID:17872377   PMID:18202147   PMID:18450967   PMID:18480546   PMID:19188335   PMID:19574446  
PMID:19674967   PMID:19855984   PMID:20356821   PMID:20843475   PMID:21832055   PMID:22508055   PMID:22554804   PMID:23376485   PMID:23546599   PMID:25278090   PMID:27160269   PMID:27996060  
PMID:30504697   PMID:30926678  


Genomics

Comparative Map Data
Pth1r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,572,295 - 119,597,405 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8119,575,868 - 119,598,108 (-)EnsemblGRCr8
mRatBN7.28110,693,910 - 110,725,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8110,697,485 - 110,719,729 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8116,312,093 - 116,331,737 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,511,292 - 114,530,936 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,354,091 - 112,373,739 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08118,984,531 - 119,012,803 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8118,988,053 - 119,012,671 (-)Ensemblrn6Rnor6.0
Rnor_5.08118,325,190 - 118,353,210 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48115,099,763 - 115,119,362 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8109,981,641 - 110,001,215 (-)NCBICelera
RGSC_v3.18115,119,118 - 115,139,954 (-)NCBI
Cytogenetic Map8q32NCBI
PTH1R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,877,721 - 46,903,799 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,877,721 - 46,903,799 (+)Ensemblhg38GRCh38
GRCh37346,919,211 - 46,945,289 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,894,240 - 46,920,293 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34346,894,239 - 46,920,291NCBI
Celera346,857,742 - 46,883,797 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,962,340 - 46,988,376 (+)NCBIHuRef
CHM1_1346,869,336 - 46,895,385 (+)NCBICHM1_1
T2T-CHM13v2.0346,894,119 - 46,920,191 (+)NCBIT2T-CHM13v2.0
Pth1r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,551,132 - 110,576,213 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,551,153 - 110,576,213 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389110,722,085 - 110,747,145 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,722,085 - 110,747,145 (-)Ensemblmm10GRCm38
MGSCv379110,624,589 - 110,649,649 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369110,567,070 - 110,587,116 (-)NCBIMGSCv36mm8
Celera9110,451,883 - 110,476,939 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.56NCBI
Pth1r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,273,431 - 25,296,471 (-)Ensembl
ChiLan1.0NW_00495542025,274,269 - 25,291,984 (-)NCBIChiLan1.0ChiLan1.0
PTH1R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,838,269 - 46,860,276 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,843,039 - 46,865,045 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,777,945 - 46,804,039 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,882,369 - 47,905,573 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,894,901 - 47,905,431 (+)EnsemblpanPan2panpan1.1
PTH1R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12041,905,265 - 41,924,712 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2041,905,273 - 41,925,794 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2041,821,510 - 41,840,986 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02042,386,625 - 42,411,859 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,387,839 - 42,407,309 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,629,493 - 41,648,962 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,030,456 - 42,049,920 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,311,419 - 42,330,892 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pth1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118201,124,949 - 201,144,052 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936596674,088 - 693,213 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936596674,088 - 693,191 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTH1R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,753,326 - 29,775,348 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11329,749,940 - 29,775,361 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,998,092 - 33,023,626 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTH1R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1228,287,877 - 8,309,736 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl228,289,398 - 8,311,256 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041158,837,510 - 158,863,786 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pth1r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473074,371,294 - 74,390,262 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473074,371,614 - 74,392,344 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Pth1r
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18101,303,428 - 101,323,999 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pth1r
165 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000028435
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
AW532874  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr88119,575,778 - 119,575,952 (+)Marker Load Pipeline
mRatBN7.28110,697,395 - 110,697,569 (+)MAPPERmRatBN7.2
Rnor_6.08118,988,015 - 118,988,188NCBIRnor6.0
Rnor_5.08118,328,671 - 118,328,844UniSTSRnor5.0
RGSC_v3.48115,099,570 - 115,099,743UniSTSRGSC3.4
Celera8109,981,448 - 109,981,621UniSTS
RH 3.4 Map81192.1UniSTS
Cytogenetic Map8q32UniSTS
PMC135637P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr88119,575,693 - 119,576,000 (+)Marker Load Pipeline
mRatBN7.28110,697,310 - 110,697,617 (+)MAPPERmRatBN7.2
Rnor_6.08118,987,930 - 118,988,236NCBIRnor6.0
Rnor_5.08118,328,586 - 118,328,892UniSTSRnor5.0
RGSC_v3.48115,099,485 - 115,099,791UniSTSRGSC3.4
Celera8109,981,363 - 109,981,669UniSTS
Cytogenetic Map8q32UniSTS
UniSTS:498400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28110,697,607 - 110,697,973 (+)MAPPERmRatBN7.2
Rnor_6.08118,988,227 - 118,988,592NCBIRnor6.0
Rnor_5.08118,328,883 - 118,329,248UniSTSRnor5.0
RGSC_v3.48115,099,782 - 115,100,147UniSTSRGSC3.4
Celera8109,981,660 - 109,982,025UniSTS
Cytogenetic Map8q32UniSTS
UniSTS:498482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28110,702,709 - 110,702,777 (+)MAPPERmRatBN7.2
Rnor_6.08118,993,329 - 118,993,396NCBIRnor6.0
Rnor_5.08118,333,845 - 118,333,912UniSTSRnor5.0
RGSC_v3.48115,104,883 - 115,104,950UniSTSRGSC3.4
Celera8109,986,754 - 109,986,821UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 67 153 91 90 59 38 59 6 301 138 11 127 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000028435   ⟹   ENSRNOP00000028435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,575,868 - 119,596,708 (-)Ensembl
mRatBN7.2 Ensembl8110,697,485 - 110,718,329 (-)Ensembl
Rnor_6.0 Ensembl8118,988,053 - 119,012,671 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100155   ⟹   ENSRNOP00000084523
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,575,868 - 119,597,031 (-)Ensembl
mRatBN7.2 Ensembl8110,697,485 - 110,718,502 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100984   ⟹   ENSRNOP00000094940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,575,868 - 119,596,887 (-)Ensembl
mRatBN7.2 Ensembl8110,697,485 - 110,718,502 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108530   ⟹   ENSRNOP00000080822
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,575,868 - 119,598,108 (-)Ensembl
mRatBN7.2 Ensembl8110,697,485 - 110,719,729 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000135570   ⟹   ENSRNOP00000111934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8119,575,868 - 119,595,571 (-)Ensembl
RefSeq Acc Id: NM_020073   ⟹   NP_064458
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,575,972 - 119,595,571 (-)NCBI
mRatBN7.28110,697,589 - 110,717,192 (-)NCBI
Rnor_6.08118,988,208 - 119,007,807 (-)NCBI
Rnor_5.08118,325,190 - 118,353,210 (-)NCBI
RGSC_v3.48115,099,763 - 115,119,362 (-)RGD
Celera8109,981,641 - 110,001,215 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243999   ⟹   XP_006244061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,572,295 - 119,596,821 (-)NCBI
mRatBN7.28110,693,910 - 110,718,516 (-)NCBI
Rnor_6.08118,984,531 - 119,009,104 (-)NCBI
Rnor_5.08118,325,190 - 118,353,210 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006244002   ⟹   XP_006244064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,572,295 - 119,596,384 (-)NCBI
mRatBN7.28110,693,910 - 110,717,192 (-)NCBI
Rnor_6.08118,984,531 - 119,007,778 (-)NCBI
Rnor_5.08118,325,190 - 118,353,210 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082024   ⟹   XP_038937952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,572,295 - 119,597,405 (-)NCBI
mRatBN7.28110,693,910 - 110,718,518 (-)NCBI
RefSeq Acc Id: NP_064458   ⟸   NM_020073
- Peptide Label: precursor
- UniProtKB: P25961 (UniProtKB/Swiss-Prot),   A6I3G4 (UniProtKB/TrEMBL),   A6I3G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244061   ⟸   XM_006243999
- Peptide Label: isoform X2
- UniProtKB: P25961 (UniProtKB/Swiss-Prot),   A6I3G4 (UniProtKB/TrEMBL),   A6I3G5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244064   ⟸   XM_006244002
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZQF2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028435   ⟸   ENSRNOT00000028435
RefSeq Acc Id: XP_038937952   ⟸   XM_039082024
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AIQ2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084523   ⟸   ENSRNOT00000100155
Ensembl Acc Id: ENSRNOP00000094940   ⟸   ENSRNOT00000100984
Ensembl Acc Id: ENSRNOP00000080822   ⟸   ENSRNOT00000108530
Ensembl Acc Id: ENSRNOP00000111934   ⟸   ENSRNOT00000135570
Protein Domains
G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P25961-F1-model_v2 AlphaFold P25961 1-591 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696335
Promoter ID:EPDNEW_R6859
Type:initiation region
Name:Pth1r_1
Description:parathyroid hormone 1 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08119,012,634 - 119,012,694EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3442 AgrOrtholog
BioCyc Gene G2FUF-29059 BioCyc
Ensembl Genes ENSRNOG00000020948 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028435 ENTREZGENE
  ENSRNOT00000028435.5 UniProtKB/Swiss-Prot
  ENSRNOT00000100984 ENTREZGENE
  ENSRNOT00000108530 ENTREZGENE
  ENSRNOT00000135570 ENTREZGENE
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_2 UniProtKB/Swiss-Prot
  GPCR_2-like UniProtKB/Swiss-Prot
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot
  GPCR_2_parathyroid_rcpt UniProtKB/Swiss-Prot
  GPCR_2_secretin-like UniProtKB/Swiss-Prot
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot
KEGG Report rno:56813 UniProtKB/Swiss-Prot
NCBI Gene Pth1r ENTREZGENE
PANTHER PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/Swiss-Prot
  PTHR45620:SF27 UniProtKB/Swiss-Prot
Pfam 7tm_2 UniProtKB/Swiss-Prot
  HRM UniProtKB/Swiss-Prot
PhenoGen Pth1r PhenoGen
PRINTS GPCRSECRETIN UniProtKB/Swiss-Prot
  PTRHORMONER UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020948 RatGTEx
SMART HormR UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
  SSF111418 UniProtKB/Swiss-Prot
UniProt A0A8I5ZQF2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AIQ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GBX8_RAT UniProtKB/TrEMBL
  A0ABK0M1G5_RAT UniProtKB/TrEMBL
  A6I3G4 ENTREZGENE, UniProtKB/TrEMBL
  A6I3G5 ENTREZGENE, UniProtKB/TrEMBL
  P25961 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-23 Pth1r  parathyroid hormone 1 receptor  Pthr1  parathyroid hormone receptor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Pthr1  parathyroid hormone receptor 1  Pthr  parathyroid hormone receptor  Symbol and Name updated 629477 APPROVED
2003-03-11   parathyroid hormone receptor  Pthr  Parathyroid hormone/parathyroid hormone-related peptide receptor  Name updated to reflect Human and Mouse nomenclature 61478 PROVISIONAL
2002-06-10 Pthr  Parathyroid hormone/parathyroid hormone-related peptide receptor      Symbol and Name status set to approved 70586 APPROVED