Plp1 (proteolipid protein 1) - Rat Genome Database

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Gene: Plp1 (proteolipid protein 1) Rattus norvegicus
Analyze
Symbol: Plp1
Name: proteolipid protein 1
RGD ID: 3354
Description: A structural constituent of myelin sheath. Involved in several processes, including AMPA selective glutamate receptor signaling pathway; nervous system development; and positive regulation of calcium ion transmembrane transport. Located in myelin sheath. Part of integrin alphav-beta3 complex. Used to study epilepsy. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lipophilin; myelin proteolipid protein; Plp; proteolipid protein; proteolipid protein (myelin); proteolipid protein (myelin) 1; Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated); Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Plp1md
Genetic Models: W-Plp1md/Nya
Is Marker For: Strains:   W-Plp1md/Nya
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X104,933,921 - 104,993,317 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX104,975,780 - 104,993,314 (+)EnsemblGRCr8
mRatBN7.2X100,184,039 - 100,201,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX100,185,767 - 100,201,032 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX102,315,950 - 102,331,220 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X105,814,627 - 105,829,894 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X103,383,798 - 103,399,065 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X107,494,326 - 107,511,355 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX107,496,072 - 107,511,348 (+)Ensemblrn6Rnor6.0
Rnor_5.0X107,379,831 - 107,394,881 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X124,488,627 - 124,503,639 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX101,020,110 - 101,035,276 (+)NCBICelera
RGSC_v3.1X124,562,059 - 124,577,072 (+)NCBI
Cytogenetic MapXq32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trimethylbenzene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
AMPA receptor agonist  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
capsaicin  (EXP)
carbofuran  (EXP)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
clozapine  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
Cuprizon  (EXP,ISO)
cycloheximide  (EXP)
cytarabine  (ISO)
dabigatran  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
etoposide  (ISO)
fenvalerate  (EXP)
genistein  (ISO)
glyphosate  (ISO)
haloperidol  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (EXP)
hydrogen sulfide  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
lidocaine  (EXP)
linagliptin  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
malathion  (ISO)
mechlorethamine  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
nickel atom  (ISO)
nitrofen  (EXP)
olanzapine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
PCB138  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
sarin  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
undecane  (EXP)
valproic acid  (ISO)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
integrin alphav-beta3 complex  (IDA)
membrane  (IEA)
myelin sheath  (IBA,IDA,IEA,ISO)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
premature death  (IAGP)
seizures  (IAGP)
tremors  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Myelin-deficient rat: a point mutation in exon III (A----C, Thr75----Pro) of the myelin proteolipid protein causes dysmyelination and oligodendrocyte death. Boison D and Stoffel W, EMBO J 1989 Nov;8(11):3295-302.
2. Proteolipid protein gene modulates viability and phenotype of neurons. Boucher SE, etal., J Neurosci 2002 Mar 1;22(5):1772-83.
3. Myelin deficiency (md): a neurologic mutant in the Wistar rat. Csiza CK and de Lahunta A, Am J Pathol 1979 Apr;95(1):215-23.
4. Molecular cloning and nucleotide sequence of a cDNA clone coding for rat brain myelin proteolipid. Dautigny A, etal., FEBS Lett 1985 Aug 19;188(1):33-6.
5. Abnormal compact myelin in the myelin-deficient rat: absence of proteolipid protein correlates with a defect in the intraperiod line. Duncan ID, etal., Proc Natl Acad Sci U S A 1987 Sep;84(17):6287-91.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Ontogeny of glycerol phosphate dehydrogenase-positive oligodendrocytes in rat brain. Impaired differentiation of oligodendrocytes in the myelin deficient mutant rat. Gordon MN, etal., Int J Dev Neurosci 1992 Aug;10(4):243-53.
8. Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes. Gudz TI, etal., J Neurosci 2002 Sep 1;22(17):7398-407.
9. Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex. Gudz TI, etal., J Neurosci. 2006 Mar 1;26(9):2458-66. doi: 10.1523/JNEUROSCI.4054-05.2006.
10. Pelizaeus-Merzbacher disease and spastic paraplegia type 2: two faces of myelin loss from mutations in the same gene. Hudson LD J Child Neurol 2003 Sep;18(9):616-24.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein. Milner RJ, etal., Cell 1985 Oct;42(3):931-9.
13. Gene expression and oligodendrocyte development in the myelin deficient rat. Nadon NL and Duncan ID, J Neurosci Res 1995 May 1;41(1):96-104.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Exacerbation of experimental autoimmune encephalomyelitis in rodents infected with murine gammaherpesvirus-68. Peacock JW, etal., Eur J Immunol. 2003 Jul;33(7):1849-58. doi: 10.1002/eji.200323148.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Cloned proteolipid protein and myelin basic protein cDNA. Transcription of the two genes during myelination. Schaich M, etal., Biol Chem Hoppe Seyler 1986 Aug;367(8):825-34.
21. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. Yamaguchi Y, etal., J Neurosci Res. 2008 Mar;86(4):766-75.
22. A novel mutation (A246T) in exon 6 of the proteolipid protein gene associated with connatal Pelizaeus-Merzbacher disease. Yamamoto T and Nanba E, Hum Mutat 1999 Aug 19;14(2):182.
23. Downregulation of microRNA-199a-5p alleviated lidocaine-induced sensory dysfunction and spinal cord myelin lesions in a rat model. Zhang Z, etal., Toxicol Lett. 2021 Jan 1;336:1-10. doi: 10.1016/j.toxlet.2020.11.001. Epub 2020 Nov 6.
24. [Effect of Yishen Daluo Decoction on the expression of PLP, Olig1, and Olig2 in mice with experimental autoimmune encephalomyelitis]. Zhu WH, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2014 May;34(5):562-5.
Additional References at PubMed
PMID:1150661   PMID:1373175   PMID:1689377   PMID:1694232   PMID:1702593   PMID:2432393   PMID:2441390   PMID:11746780   PMID:12477932   PMID:14169723   PMID:16288477   PMID:17634366  
PMID:17962415   PMID:19808102   PMID:20578039   PMID:21784154   PMID:22871113   PMID:22926577   PMID:24038504   PMID:24103481   PMID:25003183   PMID:25368380   PMID:25936639   PMID:26002313  
PMID:26563642   PMID:28251676   PMID:29476059   PMID:31885393   PMID:32357304  


Genomics

Comparative Map Data
Plp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X104,933,921 - 104,993,317 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX104,975,780 - 104,993,314 (+)EnsemblGRCr8
mRatBN7.2X100,184,039 - 100,201,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX100,185,767 - 100,201,032 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX102,315,950 - 102,331,220 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X105,814,627 - 105,829,894 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X103,383,798 - 103,399,065 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X107,494,326 - 107,511,355 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX107,496,072 - 107,511,348 (+)Ensemblrn6Rnor6.0
Rnor_5.0X107,379,831 - 107,394,881 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X124,488,627 - 124,503,639 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX101,020,110 - 101,035,276 (+)NCBICelera
RGSC_v3.1X124,562,059 - 124,577,072 (+)NCBI
Cytogenetic MapXq32NCBI
PLP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X103,776,506 - 103,792,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX103,769,047 - 103,792,677 (+)Ensemblhg38GRCh38
GRCh37X103,031,434 - 103,047,548 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X102,918,410 - 102,934,204 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X102,837,898 - 102,853,690NCBI
CeleraX103,470,449 - 103,486,558 (+)NCBICelera
Cytogenetic MapXq22.2NCBI
HuRefX92,687,547 - 92,703,609 (+)NCBIHuRef
CHM1_1X102,924,426 - 102,940,535 (+)NCBICHM1_1
T2T-CHM13v2.0X102,223,463 - 102,239,585 (+)NCBIT2T-CHM13v2.0
Plp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X135,720,897 - 135,739,331 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX135,723,420 - 135,740,482 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X136,820,148 - 136,838,582 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX136,822,671 - 136,839,733 (+)Ensemblmm10GRCm38
MGSCv37X133,357,375 - 133,372,282 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X132,169,200 - 132,184,107 (+)NCBIMGSCv36mm8
CeleraX120,104,727 - 120,119,592 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX59.1NCBI
Plp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955548781,015 - 797,935 (+)Ensembl
ChiLan1.0NW_004955548781,522 - 797,246 (+)NCBIChiLan1.0ChiLan1.0
PLP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X103,397,682 - 103,413,776 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X103,401,283 - 103,417,377 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X93,015,098 - 93,031,193 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X103,353,181 - 103,412,513 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX103,353,184 - 103,412,513 (+)EnsemblpanPan2panpan1.1
PLP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X77,191,112 - 77,207,772 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX77,191,150 - 77,205,964 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX63,420,093 - 63,434,914 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X78,808,649 - 78,825,317 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX78,808,262 - 78,825,306 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X76,287,255 - 76,302,076 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X77,974,000 - 77,988,806 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X77,741,107 - 77,755,923 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Plp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X77,107,149 - 77,123,012 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649910,534,950 - 10,551,012 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649910,534,953 - 10,553,411 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX84,666,733 - 84,685,058 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X84,676,627 - 84,683,517 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X98,648,731 - 98,655,621 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X91,671,535 - 91,687,693 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX91,671,878 - 91,687,878 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606516,533,357 - 16,552,347 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624954133,105 - 150,953 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624954135,065 - 150,911 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Plp1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X88,583,148 - 88,598,071 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Plp1
232 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:485
Count of miRNA genes:263
Interacting mature miRNAs:327
Transcripts:ENSRNOT00000003283
Prediction methods:Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X80434318125434318Rat
738029Stresp2Stress response QTL 23.40.0004stress-related behavior trait (VT:0010451)defensive burying - approachX92979612117740458Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
DXWox26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,203,334 - 100,203,482 (+)MAPPERmRatBN7.2
Rnor_6.0X107,513,655 - 107,513,802NCBIRnor6.0
Rnor_5.0X107,397,181 - 107,397,328UniSTSRnor5.0
RGSC_v3.4X124,505,946 - 124,506,093UniSTSRGSC3.4
CeleraX101,037,576 - 101,037,723UniSTS
Cytogenetic MapXq35UniSTS
D4Ulb4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXq35UniSTS
DXMit9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,200,819 - 100,200,920 (+)MAPPERmRatBN7.2
Rnor_6.0X107,511,140 - 107,511,240NCBIRnor6.0
Rnor_5.0X107,394,666 - 107,394,766UniSTSRnor5.0
RGSC_v3.4X124,503,431 - 124,503,531UniSTSRGSC3.4
CeleraX101,035,061 - 101,035,161UniSTS
Cytogenetic MapXq35UniSTS
PMC311008P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,194,197 - 100,195,139 (+)MAPPERmRatBN7.2
Rnor_6.0X107,504,519 - 107,505,460NCBIRnor6.0
Rnor_5.0X107,388,045 - 107,388,986UniSTSRnor5.0
RGSC_v3.4X124,496,811 - 124,497,752UniSTSRGSC3.4
CeleraX101,028,440 - 101,029,381UniSTS
Cytogenetic MapXq35UniSTS
D573  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,200,676 - 100,200,920 (+)MAPPERmRatBN7.2
Rnor_6.0X107,510,997 - 107,511,240NCBIRnor6.0
Rnor_5.0X107,394,523 - 107,394,766UniSTSRnor5.0
RGSC_v3.4X124,503,288 - 124,503,531UniSTSRGSC3.4
CeleraX101,034,918 - 101,035,161UniSTS
Cytogenetic MapXq35UniSTS
RH140080  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,200,230 - 100,200,435 (+)MAPPERmRatBN7.2
Rnor_6.0X107,510,551 - 107,510,755NCBIRnor6.0
Rnor_5.0X107,394,077 - 107,394,281UniSTSRnor5.0
RGSC_v3.4X124,502,843 - 124,503,047UniSTSRGSC3.4
CeleraX101,034,472 - 101,034,676UniSTS
RH 3.4 Map71131.62UniSTS
Cytogenetic MapXq35UniSTS
RH141820  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X100,199,170 - 100,199,372 (+)MAPPERmRatBN7.2
Rnor_6.0X107,509,491 - 107,509,692NCBIRnor6.0
Rnor_5.0X107,393,017 - 107,393,218UniSTSRnor5.0
RGSC_v3.4X124,501,783 - 124,501,984UniSTSRGSC3.4
CeleraX101,033,412 - 101,033,613UniSTS
RH 3.4 Map71128.32UniSTS
Cytogenetic MapXq35UniSTS


Related Rat Strains
The following Strains have been annotated to Plp1
W-Plp1md/Nya    


Genetic Models
This gene Plp1 is modified in the following models/strains:
W-Plp1md/Nya    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_030990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC093596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB697155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ841934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11185 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M14126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000003283   ⟹   ENSRNOP00000003283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX104,978,074 - 104,993,314 (+)Ensembl
mRatBN7.2 EnsemblX100,185,767 - 100,201,032 (+)Ensembl
Rnor_6.0 EnsemblX107,496,072 - 107,511,348 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126862   ⟹   ENSRNOP00000106004
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX104,975,780 - 104,993,314 (+)Ensembl
RefSeq Acc Id: NM_030990   ⟹   NP_112252
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X104,978,053 - 104,993,317 (+)NCBI
mRatBN7.2X100,185,767 - 100,201,035 (+)NCBI
Rnor_6.0X107,496,072 - 107,511,355 (+)NCBI
Rnor_5.0X107,379,831 - 107,394,881 (+)NCBI
RGSC_v3.4X124,488,627 - 124,503,639 (+)RGD
CeleraX101,020,110 - 101,035,276 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601913   ⟹   XP_017457402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X104,961,445 - 104,993,317 (+)NCBI
mRatBN7.2X100,184,040 - 100,201,035 (+)NCBI
Rnor_6.0X107,494,332 - 107,511,355 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601914   ⟹   XP_017457403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X104,961,445 - 104,993,317 (+)NCBI
mRatBN7.2X100,184,039 - 100,201,035 (+)NCBI
Rnor_6.0X107,494,326 - 107,511,355 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063279807   ⟹   XP_063135877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X104,975,785 - 104,993,317 (+)NCBI
RefSeq Acc Id: XM_063279808   ⟹   XP_063135878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X104,975,785 - 104,993,317 (+)NCBI
RefSeq Acc Id: XM_063279809   ⟹   XP_063135879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X104,977,633 - 104,993,317 (+)NCBI
RefSeq Acc Id: XM_063279810   ⟹   XP_063135880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X104,975,785 - 104,993,317 (+)NCBI
RefSeq Acc Id: XM_063279811   ⟹   XP_063135881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X104,975,785 - 104,993,317 (+)NCBI
RefSeq Acc Id: XM_063279812   ⟹   XP_063135882
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X104,933,921 - 104,993,317 (+)NCBI
RefSeq Acc Id: NP_112252   ⟸   NM_030990
- UniProtKB: Q561K5 (UniProtKB/Swiss-Prot),   P60203 (UniProtKB/Swiss-Prot),   A6KNU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457403   ⟸   XM_017601914
- Peptide Label: isoform X2
- UniProtKB: A0A097BVK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457402   ⟸   XM_017601913
- Peptide Label: isoform X1
- UniProtKB: Q561K5 (UniProtKB/Swiss-Prot),   P60203 (UniProtKB/Swiss-Prot),   A6KNU2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003283   ⟸   ENSRNOT00000003283
RefSeq Acc Id: XP_063135882   ⟸   XM_063279812
- Peptide Label: isoform X2
- UniProtKB: A0A097BVK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135878   ⟸   XM_063279808
- Peptide Label: isoform X1
- UniProtKB: Q561K5 (UniProtKB/Swiss-Prot),   P60203 (UniProtKB/Swiss-Prot),   A6KNU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135880   ⟸   XM_063279810
- Peptide Label: isoform X2
- UniProtKB: A0A097BVK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135877   ⟸   XM_063279807
- Peptide Label: isoform X1
- UniProtKB: Q561K5 (UniProtKB/Swiss-Prot),   P60203 (UniProtKB/Swiss-Prot),   A6KNU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135881   ⟸   XM_063279811
- Peptide Label: isoform X2
- UniProtKB: A0A097BVK2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135879   ⟸   XM_063279809
- Peptide Label: isoform X1
- UniProtKB: Q561K5 (UniProtKB/Swiss-Prot),   P60203 (UniProtKB/Swiss-Prot),   A6KNU2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106004   ⟸   ENSRNOT00000126862

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P60203-F1-model_v2 AlphaFold P60203 1-277 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701946
Promoter ID:EPDNEW_R12469
Type:initiation region
Name:Plp1_1
Description:proteolipid protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X107,496,063 - 107,496,123EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3354 AgrOrtholog
BioCyc Gene G2FUF-1608 BioCyc
Ensembl Genes ENSRNOG00000002419 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003283 ENTREZGENE
  ENSRNOT00000003283.7 UniProtKB/Swiss-Prot
  ENSRNOT00000126862 ENTREZGENE
InterPro Myelin_PLP UniProtKB/Swiss-Prot
  Myelin_PLP_CS UniProtKB/Swiss-Prot
KEGG Report rno:24943 UniProtKB/Swiss-Prot
NCBI Gene 24943 ENTREZGENE
PANTHER MYELIN PROTEOLIPID PROTEIN UniProtKB/Swiss-Prot
  PTHR11683 UniProtKB/Swiss-Prot
Pfam Myelin_PLP UniProtKB/Swiss-Prot
PhenoGen Plp1 PhenoGen
PRINTS MYELINPLP UniProtKB/Swiss-Prot
PROSITE MYELIN_PLP_1 UniProtKB/Swiss-Prot
  MYELIN_PLP_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002419 RatGTEx
SMART PLP UniProtKB/Swiss-Prot
UniProt A0A097BVK2 ENTREZGENE, UniProtKB/TrEMBL
  A6KNU2 ENTREZGENE, UniProtKB/TrEMBL
  MYPR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q561K5 ENTREZGENE
UniProt Secondary P04400 UniProtKB/Swiss-Prot
  P06905 UniProtKB/Swiss-Prot
  Q561K5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Plp1  proteolipid protein 1  Plp1  proteolipid protein (myelin) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Plp1  proteolipid protein (myelin) 1  Plp  proteolipid protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Plp  proteolipid protein      Symbol and Name updated 629477 APPROVED
2003-03-06 Plp  proteolipid protein  Plp1    Data merged from RGD:621371 628472 PROVISIONAL
2002-08-07 Plp1        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Plp  Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression altered expression (over or under) by oligodendrocytes causes axonal pathology and is directly responsible for neuron viability 1298599
gene_expression expressed during development under strict regulation 729337
gene_function major integral myelin membrane protein 729337