Ldhb (lactate dehydrogenase B) - Rat Genome Database

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Gene: Ldhb (lactate dehydrogenase B) Rattus norvegicus
Analyze
Symbol: Ldhb
Name: lactate dehydrogenase B
RGD ID: 2997
Description: Enables several functions, including L-lactate dehydrogenase (NAD+) activity; NAD binding activity; and identical protein binding activity. Involved in NAD+ metabolic process and lactate metabolic process. Predicted to be located in membrane raft and mitochondrial inner membrane. Predicted to be part of oxidoreductase complex. Predicted to be active in cytosol and mitochondrion. Orthologous to human LDHB (lactate dehydrogenase B); PARTICIPATES IN cysteine and methionine metabolic pathway; gluconeogenesis pathway; glycolysis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: L-lactate dehydrogenase B; L-lactate dehydrogenase B chain; Lactate dehydrogenease B; LDH heart subunit; LDH-B; LDH-H; Ldh2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ldhb-ps1  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84177,159,389 - 177,177,408 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4177,159,392 - 177,177,408 (-)EnsemblGRCr8
mRatBN7.24175,428,382 - 175,446,403 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,428,385 - 175,446,403 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4181,723,217 - 181,741,234 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,507,488 - 177,525,505 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,128,058 - 176,146,075 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,701,980 - 176,719,999 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,701,983 - 176,720,012 (-)Ensemblrn6Rnor6.0
Rnor_5.04240,918,027 - 240,936,014 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44180,061,567 - 180,079,473 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4163,963,498 - 163,981,517 (-)NCBICelera
RGSC_v3.14180,306,690 - 180,322,406 (-)NCBI
Cytogenetic Map4q44NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
chlorite  (ISO)
chloropicrin  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dihydroartemisinin  (ISO)
dihydroxyacetone  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenofibrate  (ISO)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
gallic acid  (EXP)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
glucose  (ISO)
haloperidol  (EXP,ISO)
heparin  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
indometacin  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lanthanum trichloride  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
Monobutylphthalate  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naphthalene  (ISO)
naringin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylpropanolamine  (ISO)
picrotoxin  (EXP)
pirinixic acid  (ISO)
progesterone  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sodium nitrite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
tamoxifen  (ISO)
tanespimycin  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toxaphene  (EXP)
triphenylstannane  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
membrane raft  (IEA,ISO)
mitochondrial inner membrane  (IEA,ISO,ISS)
mitochondrion  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Purification and radioimmunoassay of rat lactate dehydrogenase A and B subunits. Beebee TJ and Carty DS, Biochem J. 1982 Aug 1;205(2):313-20.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. M-LDH serves as a regulatory subunit of the cytosolic substrate-channelling complex in vivo. Jovanovic S, etal., J Mol Biol. 2007 Aug 10;371(2):349-61. Epub 2007 Jun 2.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer. Tan WL, etal., Cancer Biol Ther. 2011 Mar 15;11(6):599-608. Epub 2011 Mar 15.
13. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
14. Evolutionary relationships of lactate dehydrogenases (LDHs) from mammals, birds, an amphibian, fish, barley, and bacteria: LDH cDNA sequences from Xenopus, pig, and rat. Tsuji S, etal., Proc Natl Acad Sci U S A 1994 Sep 27;91(20):9392-6.
15. Effect of Anabolic Steroid Nandrolone Decanoate on the Properties of Certain Enzymes in the Heart, Liver, and Muscle of Rats, and their Effect on Rats' Cardiac Electrophysiology. Tylicki A, etal., Horm Metab Res. 2007 Apr;39(4):268-72.
Additional References at PubMed
PMID:1914521   PMID:1996957   PMID:5764873   PMID:8889548   PMID:11276087   PMID:11726686   PMID:15489334   PMID:17634366   PMID:18614015   PMID:19056867   PMID:19946888   PMID:20458337  
PMID:21416482   PMID:22871113   PMID:23376485   PMID:23533145   PMID:24625528   PMID:24835193   PMID:25204797   PMID:25247702   PMID:25340584   PMID:25416956   PMID:25502805   PMID:25931508  
PMID:26316108   PMID:28131823   PMID:30618075   PMID:31515488   PMID:32357304   PMID:33450132  


Genomics

Comparative Map Data
Ldhb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84177,159,389 - 177,177,408 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4177,159,392 - 177,177,408 (-)EnsemblGRCr8
mRatBN7.24175,428,382 - 175,446,403 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4175,428,385 - 175,446,403 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4181,723,217 - 181,741,234 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04177,507,488 - 177,525,505 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04176,128,058 - 176,146,075 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04176,701,980 - 176,719,999 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4176,701,983 - 176,720,012 (-)Ensemblrn6Rnor6.0
Rnor_5.04240,918,027 - 240,936,014 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44180,061,567 - 180,079,473 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4163,963,498 - 163,981,517 (-)NCBICelera
RGSC_v3.14180,306,690 - 180,322,406 (-)NCBI
Cytogenetic Map4q44NCBI
LDHB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381221,635,342 - 21,657,842 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1221,635,340 - 21,757,890 (-)Ensemblhg38GRCh38
GRCh371221,788,276 - 21,810,776 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,679,543 - 21,702,043 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341221,679,544 - 21,702,042NCBI
Celera1226,943,264 - 26,965,789 (-)NCBICelera
Cytogenetic Map12p12.1NCBI
HuRef1221,561,869 - 21,584,405 (-)NCBIHuRef
CHM1_11221,753,523 - 21,776,056 (-)NCBICHM1_1
T2T-CHM13v2.01221,513,920 - 21,536,444 (-)NCBIT2T-CHM13v2.0
Ldhb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396142,435,975 - 142,453,683 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6142,435,975 - 142,453,683 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386142,490,249 - 142,507,957 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6142,490,249 - 142,507,957 (-)Ensemblmm10GRCm38
MGSCv376142,438,769 - 142,456,463 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366142,447,471 - 142,465,165 (-)NCBIMGSCv36mm8
Celera6145,551,908 - 145,569,602 (-)NCBICelera
Cytogenetic Map6G2NCBI
cM Map674.17NCBI
Ldhb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541317,261,118 - 17,283,593 (-)Ensembl
ChiLan1.0NW_00495541317,264,337 - 17,283,530 (-)NCBIChiLan1.0ChiLan1.0
LDHB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21075,145,106 - 75,167,533 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11275,141,504 - 75,163,931 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01264,640,994 - 64,663,418 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11267,245,012 - 67,267,487 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1267,245,130 - 67,267,487 (+)EnsemblpanPan2panpan1.1
LDHB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12725,470,666 - 25,493,114 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2725,470,665 - 25,492,920 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2720,864,321 - 20,886,793 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02725,693,648 - 25,716,172 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2725,693,609 - 25,716,160 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12725,492,290 - 25,514,750 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02725,515,724 - 25,538,195 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02721,035,083 - 21,057,566 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ldhb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494587,301,989 - 87,321,822 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365485,227,666 - 5,244,525 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365485,224,905 - 5,244,708 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LDHB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1551,810,932 - 51,831,218 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2555,086,895 - 55,106,892 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LDHB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,489,815 - 21,511,892 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,488,814 - 21,511,938 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606913,631,514 - 13,654,346 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ldhb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475217,049,296 - 17,069,553 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475217,046,640 - 17,065,910 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ldhb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16233,908 - 252,038 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ldhb
114 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:91
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000017965
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4176806581181925369Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat

Markers in Region
AI790582  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24175,430,710 - 175,430,819 (+)MAPPERmRatBN7.2
Rnor_6.04176,704,309 - 176,704,417NCBIRnor6.0
Rnor_5.04240,920,356 - 240,920,464UniSTSRnor5.0
RGSC_v3.44180,063,891 - 180,063,999UniSTSRGSC3.4
Celera4163,965,827 - 163,965,935UniSTS
Cytogenetic Map4q44UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 90 59 6 354 190 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017965   ⟹   ENSRNOP00000017965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4177,159,392 - 177,177,408 (-)Ensembl
mRatBN7.2 Ensembl4175,428,385 - 175,446,403 (-)Ensembl
Rnor_6.0 Ensembl4176,701,983 - 176,720,012 (-)Ensembl
RefSeq Acc Id: NM_001316333   ⟹   NP_001303262
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,159,389 - 177,177,408 (-)NCBI
mRatBN7.24175,428,382 - 175,446,403 (-)NCBI
Rnor_6.04176,701,980 - 176,719,999 (-)NCBI
Celera4163,963,498 - 163,981,517 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001316334   ⟹   NP_001303263
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,159,389 - 177,177,408 (-)NCBI
mRatBN7.24175,428,382 - 175,446,403 (-)NCBI
Rnor_6.04176,701,980 - 176,719,999 (-)NCBI
Celera4163,963,498 - 163,981,517 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012595   ⟹   NP_036727
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84177,159,389 - 177,177,408 (-)NCBI
mRatBN7.24175,428,382 - 175,446,403 (-)NCBI
Rnor_6.04176,701,980 - 176,719,999 (-)NCBI
Rnor_5.04240,918,027 - 240,936,014 (-)NCBI
RGSC_v3.44180,061,567 - 180,079,473 (-)RGD
Celera4163,963,498 - 163,981,517 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036727   ⟸   NM_012595
- Peptide Label: isoform Ldhb
- UniProtKB: P42123 (UniProtKB/Swiss-Prot),   A6IMU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001303262   ⟸   NM_001316333
- Peptide Label: isoform Ldhbx
- UniProtKB: P42123 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001303263   ⟸   NM_001316334
- Peptide Label: isoform Ldhb
- UniProtKB: P42123 (UniProtKB/Swiss-Prot),   A6IMU4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017965   ⟸   ENSRNOT00000017965
Protein Domains
Lactate/malate dehydrogenase C-terminal   Lactate/malate dehydrogenase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P42123-F1-model_v2 AlphaFold P42123 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693490
Promoter ID:EPDNEW_R4014
Type:initiation region
Name:Ldhb_1
Description:lactate dehydrogenase B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04176,719,962 - 176,720,022EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2997 AgrOrtholog
BioCyc Gene G2FUF-42491 BioCyc
BioCyc Pathway PWY-5031 [L-histidine degradation V] BioCyc
BioCyc Pathway Image PWY-5031 BioCyc
Ensembl Genes ENSRNOG00000013000 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017965 ENTREZGENE
  ENSRNOT00000017965.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.110.10 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6919339 IMAGE-MGC_LOAD
InterPro L-lactate/malate_DH UniProtKB/Swiss-Prot
  L-lactate_DH UniProtKB/Swiss-Prot
  L-lactate_DH_AS UniProtKB/Swiss-Prot
  Lactate/malate_DH_C UniProtKB/Swiss-Prot
  Lactate/malate_DH_N UniProtKB/Swiss-Prot
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:24534 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72914 IMAGE-MGC_LOAD
NCBI Gene 24534 ENTREZGENE
PANTHER L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)) UniProtKB/Swiss-Prot
  L-LACTATE DEHYDROGENASE B CHAIN UniProtKB/Swiss-Prot
Pfam Ldh_1_C UniProtKB/Swiss-Prot
  Ldh_1_N UniProtKB/Swiss-Prot
PhenoGen Ldhb PhenoGen
PIRSF Lac_mal_DH UniProtKB/Swiss-Prot
PRINTS LLDHDRGNASE UniProtKB/Swiss-Prot
PROSITE L_LDH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013000 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot
  SSF56327 UniProtKB/Swiss-Prot
TIGR TC216522
UniProt A6IMU4 ENTREZGENE, UniProtKB/TrEMBL
  A6IMU6_RAT UniProtKB/TrEMBL
  LDHB_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Ldhb  lactate dehydrogenase B    Lactate dehydrogenease B  Name updated 625702 APPROVED
2002-06-10 Ldhb  Lactate dehydrogenease B      Symbol and Name status set to approved 70586 APPROVED