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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2997
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ldhb
Name: lactate dehydrogenase B
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ldhbincreases expressionEXP 6480464CTDIsoproterenol results in increased expression of LDHB proteinPMID:17188415 PMID:21322096 PMID:21472895 PMID:21671307
Ldhbincreases secretionEXP 6480464CTDIsoproterenol results in increased secretion of LDHB proteinPMID:19146839
Ldhbmultiple interactionsEXP 6480464CTD[Quercetin co-treated with alpha-Tocopherol] inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]; Acetylcysteine inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]; caffeic acid inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]; Gallic Acid inhibits the reaction [Isoproterenol results in increased secretion of LDHB protein]; naringin inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]PMID:17188415 PMID:19146839 PMID:21322096 PMID:21472895 PMID:21671307
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