Htr1b (5-hydroxytryptamine receptor 1B) - Rat Genome Database

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Gene: Htr1b (5-hydroxytryptamine receptor 1B) Rattus norvegicus
Analyze
Symbol: Htr1b
Name: 5-hydroxytryptamine receptor 1B
RGD ID: 2846
Description: Enables G protein-coupled serotonin receptor activity; heterocyclic compound binding activity; and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Involved in several processes, including drinking behavior; modulation of chemical synaptic transmission; and regulation of amine transport. Is active in calyx of Held. Used to study anxiety disorder. Biomarker of hypertension; ischemia; and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human HTR1B (5-hydroxytryptamine receptor 1B); INTERACTS WITH (+)-pilocarpine; (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5-HT-1B; 5-HT1B serotonin receptor; 5-hydroxytryptamine (serotonin ) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; Serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; serotonin receptor 1B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD
Candidate Gene For: Alc20
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8891,395,405 - 91,414,815 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl891,052,432 - 91,418,583 (-)EnsemblGRCr8
mRatBN7.2882,513,572 - 82,534,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl882,517,360 - 82,534,549 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx888,140,648 - 88,141,808 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0886,356,378 - 86,357,538 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0884,232,825 - 84,233,985 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0889,113,984 - 89,130,830 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)Ensemblrn6Rnor6.0
Rnor_5.0888,651,220 - 88,667,993 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4886,700,088 - 86,701,248 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera882,222,051 - 82,223,211 (-)NCBICelera
RGSC_v3.1886,719,542 - 86,720,703 (-)NCBI
Cytogenetic Map8q31NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide  (EXP)
(S)-nicotine  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3',5'-cyclic AMP  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline dimaleate  (EXP)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-carboxamidotryptamine  (EXP)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
almotriptan  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
capsaicin  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
citalopram  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
Cuprizon  (EXP)
dextran sulfate  (ISO)
diazinon  (EXP)
Dicyclohexyl phthalate  (EXP)
eletriptan  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
gamma-aminobutyric acid  (EXP)
genistein  (EXP)
gentamycin  (EXP)
GR 127935  (EXP)
hydroquinone  (ISO)
iodocyanopindolol  (EXP)
isotretinoin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
metergoline  (EXP)
methiothepin  (EXP)
methysergide  (EXP)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
naratriptan  (ISO)
nicotine  (EXP)
nitrofen  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
paroxetine  (EXP)
PCB138  (ISO)
pindolol  (EXP)
propranolol  (EXP)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarpogrelate  (EXP)
serotonin  (EXP,ISO)
sodium arsenite  (ISO)
sumatriptan  (EXP)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tertatolol  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
valproic acid  (ISO)
vortioxetine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Analysis of the role of the 5-HT1B receptor in spatial and aversive learning in the rat. Ahlander-Luttgen M, etal., Neuropsychopharmacology 2003 Sep;28(9):1642-55.
2. Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Amato JL, etal., Neuropsychopharmacology. 2007 Apr;32(4):946-54. Epub 2006 Aug 2.
3. Neurokinin-1 receptor antagonism in a rat model of subarachnoid hemorrhage: prevention of upregulation of contractile ETB and 5-HT1B receptors and cerebral blood flow reduction. Ansar S, etal., J Neurosurg. 2007 May;106(5):881-6.
4. Upregulation of arterial serotonin 1B and 2B receptors in deoxycorticosterone acetate-salt hypertension. Banes AK and Watts SW, Hypertension. 2002 Feb;39(2 Pt 2):394-8.
5. 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Barot SK, etal., Eur J Neurosci. 2007 May;25(10):3125-31. Epub 2007 May 17.
6. Contribution of 5-hydroxytryptamine1B receptors and 20-hydroxyeiscosatetraenoic acid to fall in cerebral blood flow after subarachnoid hemorrhage. Cambj-Sapunar L, etal., Stroke 2003 May;34(5):1269-75. Epub 2003 Apr 3.
7. Association between the 5-HTR1B gene polymorphisms and alcohol dependence in a Han Chinese population. Cao JX, etal., Brain Res. 2011 Feb 28;1376:1-9. doi: 10.1016/j.brainres.2010.12.039. Epub 2010 Dec 21.
8. Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. Carta M, etal., Brain. 2007 Jul;130(Pt 7):1819-33. Epub 2007 Apr 23.
9. Different phenotypic and genotypic presentations in alcohol dependence: age at onset matters. Chen YC, etal., J Stud Alcohol Drugs. 2011 Sep;72(5):752-62. doi: 10.15288/jsad.2011.72.752.
10. Ginsenoside Rg1 mitigates morphine dependence via regulation of gut microbiota, tryptophan metabolism, and serotonergic system function. Chen Z, etal., Biomed Pharmacother. 2022 Jun;150:112935. doi: 10.1016/j.biopha.2022.112935. Epub 2022 Apr 18.
11. The effects of long-term adrenalectomy on 5-HT1B receptors mRNA expression in cerebellum, striatum, frontal cortex and hippocampus of rats. Chennaoui M, etal., Neurosci Lett 2003 Apr 10;340(2):131-4.
12. Novel and previously reported single-nucleotide polymorphisms in the human 5-HT(1B) receptor gene: no association with cocaine or alcohol abuse or dependence. Cigler T, etal., Am J Med Genet. 2001 Aug 8;105(6):489-97. doi: 10.1002/ajmg.1473.
13. Overexpression of 5-HT1B receptor in dorsal raphe nucleus using Herpes Simplex Virus gene transfer increases anxiety behavior after inescapable stress. Clark MS, etal., J Neurosci 2002 Jun 1;22(11):4550-62.
14. A haplotype analysis is consistent with the role of functional HTR1B variants in alcohol dependence. Contini V, etal., Drug Alcohol Depend. 2012 Apr 1;122(1-2):100-4. doi: 10.1016/j.drugalcdep.2011.09.020. Epub 2011 Oct 17.
15. CB1 receptors in the paraventricular nucleus of the hypothalamus modulate the release of 5-HT and GABA to stimulate food intake in rats. Cruz-Martínez AM, etal., Eur Neuropsychopharmacol. 2018 Nov;28(11):1247-1259. doi: 10.1016/j.euroneuro.2018.08.002. Epub 2018 Sep 11.
16. The HTR1B 861G>C receptor polymorphism among patients suffering from alcoholism, major depression, anxiety disorders and narcolepsy. Fehr C, etal., Psychiatry Res. 2000 Dec 4;97(1):1-10. doi: 10.1016/s0165-1781(00)00215-8.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Reappraisal of the serotonin 5-HT(1B) receptor gene in alcoholism: of mice and men. Gorwood P, etal., Brain Res Bull. 2002 Jan 1;57(1):103-7. doi: 10.1016/s0361-9230(01)00641-4.
20. Stimulation of the lateral hypothalamus produces antinociception mediated by 5-HT1A, 5-HT1B and 5-HT3 receptors in the rat spinal cord dorsal horn. Holden JE, etal., Neuroscience. 2005;135(4):1255-68. Epub 2005 Sep 13.
21. Serotonin Signaling Through the 5-HT1B Receptor and NADPH Oxidase 1 in Pulmonary Arterial Hypertension. Hood KY, etal., Arterioscler Thromb Vasc Biol. 2017 Jul;37(7):1361-1370. doi: 10.1161/ATVBAHA.116.308929. Epub 2017 May 4.
22. Increased expression of 5-HT1B receptors in rat nucleus accumbens via virally mediated gene transfer increases voluntary alcohol consumption. Hoplight BJ, etal., Alcohol. 2006 Feb;38(2):73-9.
23. Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. Huang YY, etal., Neuropsychopharmacology. 2003 Jan;28(1):163-9. doi: 10.1038/sj.npp.1300000.
24. Serotonin receptor blockade improves distal perfusion after lower limb ischemia in the fatty Zucker rat. Janiak P, etal., Cardiovasc Res. 2002 Nov;56(2):293-302.
25. Contribution of the 5-HT(1B) receptor to hypoxia-induced pulmonary hypertension: converging evidence using 5-HT(1B)-receptor knockout mice and the 5-HT(1B/1D)-receptor antagonist GR127935. Keegan A, etal., Circ Res. 2001 Dec 7;89(12):1231-9.
26. Polymorphism of the 5-HT1B receptor gene (HTR1B): strong within-locus linkage disequilibrium without association to antisocial substance dependence. Kranzler HR, etal., Neuropsychopharmacology. 2002 Jan;26(1):115-22. doi: 10.1016/S0893-133X(01)00283-4.
27. Linkage of antisocial alcoholism to the serotonin 5-HT1B receptor gene in 2 populations. Lappalainen J, etal., Arch Gen Psychiatry. 1998 Nov;55(11):989-94. doi: 10.1001/archpsyc.55.11.989.
28. Serotonergic Modulation of GABAergic and Glutamatergic Synaptic Transmission in Mechanically Isolated Rat Medial Preoptic Area Neurons. Lee JJ, etal., Neuropsychopharmacology. 2007 Mar 28;.
29. 5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253. Lee MD, etal., Psychopharmacology (Berl). 2002 Oct;164(1):49-60. Epub 2002 Jul 19.
30. Selective 5-HT receptor inhibition of glutamatergic and GABAergic synaptic activity in the rat dorsal and median raphe. Lemos JC, etal., Eur J Neurosci. 2006 Dec;24(12):3415-30.
31. Hypothalamic 5-HT1B-receptor changes in anorectic tumor bearing rats. Makarenko IG, etal., Neurosci Lett. 2005 Mar 11;376(2):71-5. Epub 2004 Dec 8.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. 5-HT1B receptor-mediated presynaptic inhibition at the calyx of Held of immature rats. Mizutani H, etal., Eur J Neurosci. 2006 Oct;24(7):1946-54. doi: 10.1111/j.1460-9568.2006.05063.x.
34. Evidence of sexual dimorphism of HTR1B gene on major adult ADHD comorbidities. Müller D, etal., J Psychiatr Res. 2017 Dec;95:269-275. doi: 10.1016/j.jpsychires.2017.09.011. Epub 2017 Sep 8.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. Increased binding at 5-HT(1A), 5-HT(1B), and 5-HT(2A) receptors and 5-HT transporters in diet-induced obese rats. Park S, etal., Brain Res. 1999 Nov 13;847(1):90-7.
37. The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder. Quist JF, etal., Mol Psychiatry 2003 Jan;8(1):98-102.
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Evaluation of an allelic association of the serotonin 5-HT1B G681C polymorphism with antisocial alcoholism in the German population. Sander T, etal., Addict Biol. 2000 Apr 1;5(2):167-72. doi: 10.1080/13556210050003757.
42. SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1- [2'methyl-4'-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): a novel, potent and selective 5-HT1B receptor antagonist. Scott C, etal., Neuropharmacology. 2006 Jun;50(8):984-90. Epub 2006 Mar 20.
43. Association of 5-HT1B receptor gene and antisocial behavior in alcoholism. Soyka M, etal., J Neural Transm 2004 Jan;111(1):101-9. Epub 2003 Dec 3.
44. Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han. Sun HF, etal., Biol Psychiatry. 2002 Jun 1;51(11):896-901. doi: 10.1016/s0006-3223(01)01366-x.
45. The association between HTR1B gene rs13212041 polymorphism and onset of alcohol abuse. Svob Strac D, etal., Neuropsychiatr Dis Treat. 2019 Jan 24;15:339-347. doi: 10.2147/NDT.S191457. eCollection 2019.
46. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. Verge D, etal., J Neurosci. 1986 Dec;6(12):3474-82.
47. Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis. Yan QS, etal., Brain Res 2004 Sep 17;1021(1):82-91.
48. Involvement of 5-HT1B receptors within the ventral tegmental area in ethanol-induced increases in mesolimbic dopaminergic transmission. Yan QS, etal., Brain Res. 2005 Oct 26;1060(1-2):126-37. Epub 2005 Oct 5.
Additional References at PubMed
PMID:1315531   PMID:1836757   PMID:8882600   PMID:9349547   PMID:10234032   PMID:12957218   PMID:16310183   PMID:17074068   PMID:17325130   PMID:17873013   PMID:18207350   PMID:18502320  
PMID:18638459   PMID:18793415   PMID:19041748   PMID:19121358   PMID:19556691   PMID:19819310   PMID:19963045   PMID:20226766   PMID:20385119   PMID:20510890   PMID:20833155   PMID:20843634  
PMID:21047499   PMID:21107539   PMID:21653728   PMID:21681557   PMID:21718722   PMID:21801291   PMID:21982809   PMID:22585122   PMID:22659115   PMID:22848635   PMID:22883081   PMID:23155193  
PMID:23583574   PMID:23609771   PMID:23988741   PMID:24269608   PMID:25871906   PMID:26547948   PMID:28720013   PMID:31468338   PMID:32574671   PMID:34061415   PMID:38750961  


Genomics

Comparative Map Data
Htr1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8891,395,405 - 91,414,815 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl891,052,432 - 91,418,583 (-)EnsemblGRCr8
mRatBN7.2882,513,572 - 82,534,670 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl882,517,360 - 82,534,549 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx888,140,648 - 88,141,808 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0886,356,378 - 86,357,538 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0884,232,825 - 84,233,985 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0889,113,984 - 89,130,830 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)Ensemblrn6Rnor6.0
Rnor_5.0888,651,220 - 88,667,993 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4886,700,088 - 86,701,248 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera882,222,051 - 82,223,211 (-)NCBICelera
RGSC_v3.1886,719,542 - 86,720,703 (-)NCBI
Cytogenetic Map8q31NCBI
HTR1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38677,460,924 - 77,463,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl677,460,924 - 77,463,491 (-)Ensemblhg38GRCh38
GRCh37678,170,641 - 78,173,208 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36678,228,667 - 78,229,839 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34678,228,666 - 78,229,839NCBI
Celera678,559,593 - 78,560,765 (-)NCBICelera
Cytogenetic Map6q14.1NCBI
HuRef675,364,405 - 75,365,577 (-)NCBIHuRef
CHM1_1678,338,190 - 78,339,362 (-)NCBICHM1_1
T2T-CHM13v2.0678,638,386 - 78,640,951 (-)NCBIT2T-CHM13v2.0
Htr1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39981,510,344 - 81,515,885 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl981,510,344 - 81,515,881 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38981,628,291 - 81,633,832 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl981,628,291 - 81,633,828 (-)Ensemblmm10GRCm38
MGSCv37981,524,999 - 81,526,159 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36981,428,110 - 81,429,270 (-)NCBIMGSCv36mm8
Celera978,725,698 - 78,726,858 (-)NCBICelera
Cytogenetic Map9E1NCBI
cM Map944.61NCBI
Htr1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555025,645,644 - 5,646,816 (-)Ensembl
ChiLan1.0NW_0049555025,640,919 - 5,646,899 (-)NCBIChiLan1.0ChiLan1.0
HTR1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2597,481,591 - 97,517,530 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1695,362,194 - 95,398,144 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0675,309,078 - 75,313,747 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1678,594,870 - 78,598,204 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl678,596,408 - 78,597,580 (-)EnsemblpanPan2panpan1.1
HTR1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11238,659,088 - 38,659,546 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1238,541,798 - 38,542,967 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01239,430,205 - 39,431,374 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1239,430,205 - 39,431,374 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11238,755,029 - 38,756,198 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01238,739,892 - 38,741,061 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01238,869,413 - 38,870,583 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Htr1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494674,024,237 - 74,029,424 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936890155,233 - 156,408 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936890154,252 - 157,044 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,596,237 - 88,601,757 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1188,597,510 - 88,598,682 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2199,465,592 - 99,466,764 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1132,143,646 - 2,145,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl132,144,313 - 2,145,485 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040178,365,080 - 178,420,109 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Htr1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248194,427,827 - 4,428,999 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248194,425,271 - 4,429,165 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Htr1b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1875,877,269 - 75,879,465 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Htr1b
186 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:38
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000017411
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat

Markers in Region
PMC166422P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2882,533,078 - 82,533,410 (+)MAPPERmRatBN7.2
Rnor_6.0889,130,477 - 89,130,808NCBIRnor6.0
Rnor_5.0888,667,644 - 88,667,975UniSTSRnor5.0
RGSC_v3.4886,700,913 - 86,701,244UniSTSRGSC3.4
Celera882,222,876 - 82,223,207UniSTS
Cytogenetic Map8q31UniSTS
GDB:580614  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2882,532,623 - 82,532,824 (+)MAPPERmRatBN7.2
Rnor_6.0889,130,022 - 89,130,222NCBIRnor6.0
Rnor_5.0888,667,189 - 88,667,389UniSTSRnor5.0
RGSC_v3.4886,700,458 - 86,700,658UniSTSRGSC3.4
Celera882,222,421 - 82,222,621UniSTS
Cytogenetic Map8q31UniSTS
UniSTS:491331  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2882,532,198 - 82,533,477 (+)MAPPERmRatBN7.2
Rnor_6.0889,129,597 - 89,130,875NCBIRnor6.0
Rnor_5.0888,666,764 - 88,668,042UniSTSRnor5.0
RGSC_v3.4886,700,033 - 86,701,311UniSTSRGSC3.4
Celera882,221,996 - 82,223,274UniSTS
Cytogenetic Map8q31UniSTS


Related Rat Strains
The following Strains have been annotated to Htr1b
SD    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 64 162 56 55 24 54 24 6 269 151 11 141 70 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017411   ⟹   ENSRNOP00000017411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl891,052,432 - 91,415,002 (-)Ensembl
mRatBN7.2 Ensembl882,517,360 - 82,534,549 (-)Ensembl
Rnor_6.0 Ensembl889,129,453 - 89,130,991 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123084   ⟹   ENSRNOP00000112035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl891,411,150 - 91,414,643 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000145729   ⟹   ENSRNOP00000105377
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl891,397,463 - 91,418,583 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146843   ⟹   ENSRNOP00000103273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl891,378,395 - 91,414,586 (-)Ensembl
RefSeq Acc Id: NM_022225   ⟹   NP_071561
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8891,409,291 - 91,414,815 (-)NCBI
mRatBN7.2882,529,144 - 82,534,670 (-)NCBI
Rnor_6.0889,129,652 - 89,130,812 (-)NCBI
Rnor_5.0888,651,220 - 88,667,993 (-)NCBI
RGSC_v3.4886,700,088 - 86,701,248 (-)RGD
Celera882,222,051 - 82,223,211 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264941   ⟹   XP_063121011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8891,409,291 - 91,414,782 (-)NCBI
RefSeq Acc Id: XR_356450
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8891,395,405 - 91,414,516 (-)NCBI
mRatBN7.2882,513,572 - 82,534,386 (-)NCBI
Rnor_6.0889,113,984 - 89,130,830 (-)NCBI
Rnor_5.0888,651,220 - 88,667,993 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_071561 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121011 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40613 (Get FASTA)   NCBI Sequence Viewer  
  EDL77686 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017411
  ENSRNOP00000017411.1
GenBank Protein P28564 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071561   ⟸   NM_022225
- UniProtKB: P28564 (UniProtKB/Swiss-Prot),   A6I1P1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017411   ⟸   ENSRNOT00000017411
RefSeq Acc Id: XP_063121011   ⟸   XM_063264941
- Peptide Label: isoform X1
- UniProtKB: P28564 (UniProtKB/Swiss-Prot),   A6I1P1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000105377   ⟸   ENSRNOT00000145729
Ensembl Acc Id: ENSRNOP00000112035   ⟸   ENSRNOT00000123084
Ensembl Acc Id: ENSRNOP00000103273   ⟸   ENSRNOT00000146843
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P28564-F1-model_v2 AlphaFold P28564 1-386 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2846 AgrOrtholog
BioCyc Gene G2FUF-29731 BioCyc
Ensembl Genes ENSRNOG00000013042 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017411 ENTREZGENE
  ENSRNOT00000017411.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro 5HT1B_rcpt UniProtKB/Swiss-Prot
  5HT_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:25075 UniProtKB/Swiss-Prot
NCBI Gene 25075 ENTREZGENE
PANTHER 5-HYDROXYTRYPTAMINE RECEPTOR 1B UniProtKB/Swiss-Prot
  ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB HTR1B RGD
PhenoGen Htr1b PhenoGen
PRINTS 5HT1BRECEPTR UniProtKB/Swiss-Prot
  5HTRECEPTOR UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013042 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt 5HT1B_RAT UniProtKB/Swiss-Prot
  A6I1P1 ENTREZGENE, UniProtKB/TrEMBL
  P28564 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr1b  5-hydroxytryptamine receptor 1B  Htr1b  5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr1b  5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled  Htr1b  5-hydroxytryptamine (serotonin) receptor 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2001-07-23 Htr1b  5-hydroxytryptamine (serotonin) receptor 1B      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Htr1b  Serotonin (5-hydroxytryptamine (5HT)) receptor, type 1B      Name withdrawn 67952 WITHDRAWN
2001-07-23 Htr1b  5-hydroxytryptamine (serotonin ) receptor 1B      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease associated with stress, depression and anxiety behaviors 625756
gene_drugs antidepressants downregulate the receptor activity and normalize serotonergic neurotransmission; fluoxetine or paroxetine acts on a time-dependent and reversible manner resulting in decrease of receptor expression in striatum 625756
gene_expression expressed in the midbrain raphe nuclei and dorsal raphe nucleus (DRN) and serotonergic neurons of brain 625756
gene_mutations_overexpression receptor overexpression in dorsal raphe nucleus mediates pathological response to behavioural disorders such as anxiety and stress 625756
gene_mutations_overexpression overexpression in dorsal raphe nucleus causes an increase in anxiety behavior 625756
gene_process involved in the negative feedback system regulating extracellular serotonin [ 5-HT ] neurotransmission 625756
gene_regulation upregulated in animals during behavior related learning periods and downregulated by antidepressants 625756
gene_regulation activated by subarachnoid hemorrhage 737621