Gpc3 (glypican 3) - Rat Genome Database

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Gene: Gpc3 (glypican 3) Rattus norvegicus
Analyze
Symbol: Gpc3
Name: glypican 3
RGD ID: 2725
Description: Predicted to enable peptidyl-dipeptidase inhibitor activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Simpson-Golabi-Behmel syndrome type 1 and nephroblastoma. Orthologous to human GPC3 (glypican 3); PARTICIPATES IN glypican signaling pathway; Hedgehog signaling pathway; INTERACTS WITH (R)-noradrenaline; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: defective in Simpson-Golabi-Behmel overgrowth syndrome; glypican-3; intestinal protein OCI-5; MGC93606; OCI-5; proteoglycan GPC3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X136,789,770 - 137,157,598 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX136,789,770 - 137,157,639 (-)EnsemblGRCr8
mRatBN7.2X131,868,986 - 132,236,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX131,868,990 - 132,236,798 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX134,029,733 - 134,399,032 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X137,611,682 - 137,980,983 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X135,180,258 - 135,549,530 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X139,579,268 - 139,947,093 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX139,579,268 - 139,916,883 (-)Ensemblrn6Rnor6.0
Rnor_5.0X139,625,383 - 139,993,328 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X139,192,115 - 139,560,649 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX130,783,069 - 131,149,772 (-)NCBICelera
RGSC_v3.1X139,264,617 - 139,634,082 (-)NCBI
Cytogenetic MapXq36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clotrimazole  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinic acid  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
fenvalerate  (EXP)
fulvestrant  (ISO)
furan  (EXP)
gemcitabine  (ISO)
glycerol 2-phosphate  (ISO)
glycidol  (EXP)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indole-3-methanol  (EXP)
L-ascorbic acid  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
raloxifene  (EXP)
SB 431542  (ISO)
scopolamine  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
tolcapone  (EXP)
topotecan  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
anterior/posterior axis specification  (ISO)
biological_process  (ND)
body morphogenesis  (ISO)
bone mineralization  (ISO)
branching involved in ureteric bud morphogenesis  (ISO)
cell migration  (IBA)
cell migration involved in gastrulation  (ISS)
cell proliferation involved in kidney development  (ISO,ISS)
cell proliferation involved in metanephros development  (ISO)
coronary vasculature development  (ISO,ISS)
embryonic hindlimb morphogenesis  (ISO)
kidney development  (ISO)
lung development  (ISO)
mesenchymal cell proliferation involved in ureteric bud development  (IEA,ISO)
mesonephric duct morphogenesis  (ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (IDA,ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of growth  (ISO)
negative regulation of smoothened signaling pathway  (ISO,ISS)
osteoclast differentiation  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of canonical Wnt signaling pathway  (IBA,ISO,ISS)
positive regulation of D-glucose import across plasma membrane  (ISO)
positive regulation of endocytosis  (ISO,ISS)
positive regulation of protein catabolic process  (ISO,ISS)
positive regulation of smoothened signaling pathway  (ISO)
positive regulation of Wnt signaling pathway, planar cell polarity pathway  (IDA,IGI,ISO)
regulation of canonical Wnt signaling pathway  (ISO)
regulation of growth  (ISO)
regulation of non-canonical Wnt signaling pathway  (ISO)
regulation of protein localization to membrane  (IBA)
regulation of signal transduction  (IEA)
response to bacterium  (ISO)

Cellular Component
cell surface  (IBA)
extracellular matrix  (IEA)
lysosome  (IEA,ISO)
plasma membrane  (IBA,IDA,IEA,ISO)
side of membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Assessment of gene expression profiles in peripheral occlusive arterial disease. Bubenek S, etal., Can J Cardiol. 2012 Nov-Dec;28(6):712-20. doi: 10.1016/j.cjca.2012.03.013. Epub 2012 Jun 19.
2. Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. Cano-Gauci DF, etal., J Cell Biol. 1999 Jul 12;146(1):255-64. doi: 10.1083/jcb.146.1.255.
3. Immunohistochemical expression of glypican-3 in pediatric tumors: an analysis of 414 cases. Chan ES, etal., Pediatr Dev Pathol. 2013 Jul-Aug;16(4):272-7. doi: 10.2350/12-06-1216-OA.1. Epub 2013 Mar 26.
4. [Expression of glypican-3, hepatocyte antigen, alpha-fetoprotein, CD34 and CD10 in hepatocellular carcinoma: a clinicopathologic analysis of 375 cases]. Du JL, etal., Zhonghua Bing Li Xue Za Zhi. 2012 May;41(5):309-13. doi: 10.3760/cma.j.issn.0529-5807.2012.05.006.
5. Identification of a new membrane-bound heparan sulphate proteoglycan. Filmus J, etal., Biochem J. 1995 Oct 15;311 ( Pt 2):561-5.
6. Isolation of a cDNA corresponding to a developmentally regulated transcript in rat intestine. Filmus J, etal., Mol Cell Biol 1988 Oct;8(10):4243-9.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development. Ng A, etal., Dev Biol. 2009 Nov 1;335(1):208-15. doi: 10.1016/j.ydbio.2009.08.029. Epub 2009 Sep 4.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
14. Expression of glypican 3 in placental site trophoblastic tumor. Ou-Yang RJ, etal., Diagn Pathol. 2010 Sep 25;5:64. doi: 10.1186/1746-1596-5-64.
15. Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. Pilia G, etal., Nat Genet 1996 Mar;12(3):241-7.
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma. Shirakawa H, etal., Cancer Sci. 2009 Aug;100(8):1403-7. doi: 10.1111/j.1349-7006.2009.01206.x. Epub 2009 May 4.
22. The loss of glypican-3 induces alterations in Wnt signaling. Song HH, etal., J Biol Chem. 2005 Jan 21;280(3):2116-25. Epub 2004 Nov 10.
23. [Value of detection of serum glypican-3 level in diagnosis and therapeutic effect evaluation of primary hepatocellular carcinoma]. Wang YY, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2017 Aug 20;37(8):1060-1065. doi: 10.3969/j.issn.1673-4254.2017.08.10.
24. K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. Watanabe K, etal., J Cell Biol 1995 Sep;130(5):1207-18.
25. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Williams EH, etal., Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5869-74. Epub 2010 Mar 15.
26. Detection of α-fetoprotein and glypican-3 mRNAs in the peripheral blood of hepatocellular carcinoma patients by using multiple FQ-RT-PCR. Yan D, etal., J Clin Lab Anal. 2011;25(2):113-7. doi: 10.1002/jcla.20443.
27. Values of circulating GPC-3 mRNA and alpha-fetoprotein in detecting patients with hepatocellular carcinoma. Yao M, etal., Hepatobiliary Pancreat Dis Int. 2013 Apr;12(2):171-9. doi: 10.1016/s1499-3872(13)60028-4.
28. Evaluation of antiglypican-3 therapy as a promising target for amelioration of hepatic tissue damage in hepatocellular carcinoma. Zaghloul RA, etal., Eur J Pharmacol. 2015 Jan 5;746:353-62. doi: 10.1016/j.ejphar.2014.11.008. Epub 2014 Nov 18.
Additional References at PubMed
PMID:9853964   PMID:10964473   PMID:11180950   PMID:11846487   PMID:12477932   PMID:14610063   PMID:15489334   PMID:15925496   PMID:15936336   PMID:17117158   PMID:17549790   PMID:18343214  
PMID:18477453   PMID:19574424   PMID:19590577   PMID:21669573   PMID:23012479   PMID:23376485   PMID:24496449   PMID:25931508  


Genomics

Comparative Map Data
Gpc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X136,789,770 - 137,157,598 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX136,789,770 - 137,157,639 (-)EnsemblGRCr8
mRatBN7.2X131,868,986 - 132,236,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX131,868,990 - 132,236,798 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX134,029,733 - 134,399,032 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X137,611,682 - 137,980,983 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X135,180,258 - 135,549,530 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X139,579,268 - 139,947,093 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX139,579,268 - 139,916,883 (-)Ensemblrn6Rnor6.0
Rnor_5.0X139,625,383 - 139,993,328 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X139,192,115 - 139,560,649 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX130,783,069 - 131,149,772 (-)NCBICelera
RGSC_v3.1X139,264,617 - 139,634,082 (-)NCBI
Cytogenetic MapXq36NCBI
GPC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X133,535,745 - 133,985,594 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX133,535,745 - 133,987,100 (-)Ensemblhg38GRCh38
GRCh37X132,669,773 - 133,119,621 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X132,497,439 - 132,947,332 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X132,395,297 - 132,845,186NCBI
CeleraX133,056,670 - 133,506,461 (-)NCBICelera
Cytogenetic MapXq26.2NCBI
HuRefX122,070,349 - 122,518,471 (-)NCBIHuRef
CHM1_1X132,581,479 - 133,031,377 (-)NCBICHM1_1
T2T-CHM13v2.0X131,860,879 - 132,310,724 (-)NCBIT2T-CHM13v2.0
Gpc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X51,361,303 - 51,702,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX51,361,303 - 51,702,827 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X52,272,426 - 52,613,974 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX52,272,426 - 52,613,950 (-)Ensemblmm10GRCm38
MGSCv37X49,625,603 - 49,967,151 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X48,517,053 - 48,858,548 (-)NCBIMGSCv36mm8
CeleraX39,684,455 - 40,028,880 (-)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX28.74NCBI
Gpc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955473969,800 - 1,431,483 (+)Ensembl
ChiLan1.0NW_004955473969,627 - 1,431,706 (+)NCBIChiLan1.0ChiLan1.0
GPC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X132,962,618 - 133,417,727 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X132,966,213 - 133,421,264 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X122,677,072 - 123,131,511 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X132,979,890 - 133,432,266 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX132,979,612 - 133,432,441 (-)EnsemblpanPan2panpan1.1
GPC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X104,313,426 - 104,751,215 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX104,313,591 - 104,751,756 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX90,423,525 - 90,861,387 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X106,172,656 - 106,610,807 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX106,172,666 - 106,610,973 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X103,586,071 - 104,023,982 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X105,451,609 - 105,889,924 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X105,234,374 - 105,675,118 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gpc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X102,497,623 - 102,897,321 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366911,059,994 - 1,459,740 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366911,060,013 - 1,459,736 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX109,536,504 - 109,973,607 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X109,536,495 - 109,973,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X125,676,131 - 126,059,402 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X108,688,706 - 109,143,653 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606546,279,325 - 46,740,727 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479713,230,932 - 13,678,742 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479713,234,741 - 13,678,542 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Gpc3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X115,450,239 - 115,803,102 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gpc3
2047 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:146
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000040122
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X97528096142528096Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X120028026141353710Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X120028026141353710Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX105359969157758123Rat
10059603Bw174Body weight QTL 1743.40.025body mass (VT:0001259)body weight (CMO:0000012)X118973754157758123Rat
2302047Pia34Pristane induced arthritis QTL 345.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1996916163141916163Rat

Markers in Region
DXWox36  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X137,158,302 - 137,158,520 (+)Marker Load Pipeline
mRatBN7.2X132,237,528 - 132,237,746 (+)MAPPERmRatBN7.2
Rnor_6.0X139,948,240 - 139,948,457NCBIRnor6.0
Rnor_5.0X139,994,475 - 139,994,692UniSTSRnor5.0
RGSC_v3.4X139,561,395 - 139,561,612UniSTSRGSC3.4
CeleraX131,150,518 - 131,150,733UniSTS
Cytogenetic MapXq36UniSTS
RH138426  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2325,194,287 - 25,194,478 (+)MAPPERmRatBN7.2
mRatBN7.2X131,869,048 - 131,869,238 (+)MAPPERmRatBN7.2
Rnor_6.0X139,579,331 - 139,579,520NCBIRnor6.0
Rnor_6.0325,813,337 - 25,813,526NCBIRnor6.0
Rnor_5.0331,021,019 - 31,021,208UniSTSRnor5.0
Rnor_5.0X139,625,446 - 139,625,635UniSTSRnor5.0
RGSC_v3.4X139,192,178 - 139,192,367UniSTSRGSC3.4
RGSC_v3.4321,381,930 - 21,382,119UniSTSRGSC3.4
Celera323,577,159 - 23,577,348UniSTS
CeleraX130,783,132 - 130,783,321UniSTS
RH 3.4 Map51174.5UniSTS
Cytogenetic MapXq36UniSTS
Cytogenetic Map3q12UniSTS
L77880  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X136,948,471 - 136,948,547 (+)Marker Load Pipeline
mRatBN7.2X132,027,685 - 132,027,760 (+)MAPPERmRatBN7.2
Rnor_6.0X139,737,092 - 139,737,166NCBIRnor6.0
Rnor_5.0X139,783,307 - 139,783,381UniSTSRnor5.0
RGSC_v3.4X139,351,933 - 139,352,007UniSTSRGSC3.4
CeleraX130,942,471 - 130,942,545UniSTS
Cytogenetic MapXq36UniSTS
AL032586  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X132,233,292 - 132,233,467 (+)MAPPERmRatBN7.2
Rnor_6.0X139,943,605 - 139,943,779NCBIRnor6.0
Rnor_5.0X139,989,840 - 139,990,014UniSTSRnor5.0
RGSC_v3.4X139,557,161 - 139,557,335UniSTSRGSC3.4
CeleraX131,146,283 - 131,146,457UniSTS
Cytogenetic MapXq36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 150 91 90 59 35 59 6 299 135 10 129 81 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000090442   ⟹   ENSRNOP00000075712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX136,789,770 - 137,157,598 (-)Ensembl
mRatBN7.2 EnsemblX131,868,990 - 132,236,798 (-)Ensembl
Rnor_6.0 EnsemblX139,579,268 - 139,916,883 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000133825   ⟹   ENSRNOP00000111623
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX136,789,770 - 137,157,639 (-)Ensembl
RefSeq Acc Id: NM_012774   ⟹   NP_036906
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X136,789,770 - 137,157,598 (-)NCBI
mRatBN7.2X131,868,986 - 132,236,824 (-)NCBI
Rnor_6.0X139,579,268 - 139,947,093 (-)NCBI
Rnor_5.0X139,625,383 - 139,993,328 (-)NCBI
RGSC_v3.4X139,192,115 - 139,560,649 (-)RGD
CeleraX130,783,069 - 131,149,772 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036906 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41735 (Get FASTA)   NCBI Sequence Viewer  
  AAB17866 (Get FASTA)   NCBI Sequence Viewer  
  AAH85756 (Get FASTA)   NCBI Sequence Viewer  
  EDM10952 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075712
GenBank Protein P13265 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036906   ⟸   NM_012774
- Peptide Label: precursor
- UniProtKB: Q5U326 (UniProtKB/Swiss-Prot),   P13265 (UniProtKB/Swiss-Prot),   A0A0G2KBA2 (UniProtKB/TrEMBL),   A6JMU0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075712   ⟸   ENSRNOT00000090442
Ensembl Acc Id: ENSRNOP00000111623   ⟸   ENSRNOT00000133825

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13265-F1-model_v2 AlphaFold P13265 1-597 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2725 AgrOrtholog
BioCyc Gene G2FUF-1030 BioCyc
Ensembl Genes ENSRNOG00000060179 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000090442 ENTREZGENE
IMAGE_CLONE IMAGE:7122343 IMAGE-MGC_LOAD
InterPro Glypican UniProtKB/Swiss-Prot
  Glypican_CS UniProtKB/Swiss-Prot
KEGG Report rno:25236 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93606 IMAGE-MGC_LOAD
NCBI Gene 25236 ENTREZGENE
PANTHER PTHR10822 UniProtKB/Swiss-Prot
  PTHR10822:SF4 UniProtKB/Swiss-Prot
Pfam Glypican UniProtKB/Swiss-Prot
PhenoGen Gpc3 PhenoGen
PROSITE GLYPICAN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000060179 RatGTEx
UniProt A0A0G2KBA2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M3B4_RAT UniProtKB/TrEMBL
  A6JMU0 ENTREZGENE, UniProtKB/TrEMBL
  GPC3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5U326 ENTREZGENE
UniProt Secondary Q5U326 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gpc3  Glypican 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in fetal rat intestine between E15 and E19, undetectable after weaning 728561