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Gene: Apeh (acylaminoacyl-peptide hydrolase) Rattus norvegicus

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Symbol:

Apeh

Name:

acylaminoacyl-peptide hydrolase

RGD ID:

2125

Description:

Predicted to enable identical protein binding activity; omega peptidase activity; and serine-type endopeptidase activity. Predicted to be involved in amyloid-beta metabolic process and proteolysis. Predicted to be located in cytoplasm. Orthologous to human APEH (acylaminoacyl-peptide hydrolase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

AARE; acyl-peptide hydrolase; acylamino-acid-releasing enzyme; acylaminoacyl-peptidase; acylpeptide hydrolase; Apeh14; Apeh17; APH; N-acylaminoacyl-peptide hydrolase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	APEH (acylaminoacyl-peptide hydrolase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Apeh (acylpeptide hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Apeh (acylaminoacyl-peptide hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	APEH (acylaminoacyl-peptide hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	APEH (acylaminoacyl-peptide hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Apeh (acylaminoacyl-peptide hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	APEH (acylaminoacyl-peptide hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	APEH (acylaminoacyl-peptide hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Apeh (acylaminoacyl-peptide hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Apeh (acylaminoacyl-peptide hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SHISA7 (shisa family member 7)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Apeh (acylpeptide hydrolase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	APEH (acylaminoacyl-peptide hydrolase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	apeh (acylaminoacyl-peptide hydrolase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dpf-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	apeh	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	apeh	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,652,390 - 117,661,502 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	117,652,393 - 117,661,711 (-)	Ensembl				GRCr8
mRatBN7.2	8	108,773,791 - 108,782,903 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	108,773,794 - 108,782,933 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	114,400,007 - 114,409,117 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,599,331 - 112,608,441 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,441,972 - 110,451,082 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,862,664 - 116,871,776 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,862,625 - 116,872,215 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	116,216,745 - 116,225,857 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	113,353,151 - 113,362,263 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	108,078,004 - 108,087,116 (-)	NCBI		Celera
RGSC_v3.1	8	113,372,606 - 113,381,718 (-)	NCBI
RH 3.4 Map	8	1116.3	RGD
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dimethoxyphenol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

atrazine (EXP)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

carbamazepine (ISO)

carbapenems (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

chlorpyrifos (EXP)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dichlorvos (EXP,ISO)

dimethyl sulfoxide (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

eugenol (EXP)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

furfural (ISO)

genistein (EXP)

gentamycin (EXP)

hydrogen peroxide (ISO)

hypochlorous acid (ISO)

indometacin (ISO)

ivermectin (ISO)

lithium chloride (ISO)

methimazole (EXP)

mitomycin C (ISO)

naled (ISO)

nicotine (ISO)

nitrates (ISO)

Nonylphenol (EXP)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

paraoxon (ISO)

paraquat (ISO)

perfluorooctanoic acid (EXP)

pirinixic acid (EXP)

selenium atom (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sulfadimethoxine (EXP)

temozolomide (ISO)

thapsigargin (EXP)

thioacetamide (EXP)

thiram (ISO)

topotecan (EXP)

trovafloxacin (ISO)

urethane (ISO)

valproic acid (ISO)

Valproic acid glucuronide (ISO)

vancomycin (ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amyloid-beta metabolic process (IEA,ISO)

proteolysis (IEA,ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

Molecular Function

hydrolase activity (IEA)

identical protein binding (IEA,ISO)

omega peptidase activity (IEA,ISO)

peptidase activity (IEA)

protein binding (ISO)

serine-type endopeptidase activity (IBA,IEA,ISO)

serine-type peptidase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Cloning and sequence analysis of a rat liver cDNA encoding acyl-peptide hydrolase.	Kobayashi K, etal., J Biol Chem 1989 May 25;264(15):8892-9.
4.	High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence.	Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:2578023	PMID:12477932	PMID:16189514	PMID:17241160	PMID:20458337	PMID:22640895	PMID:22658674	PMID:23533145	PMID:25416956	PMID:31515488

Genomics

Comparative Map Data

Apeh
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,652,390 - 117,661,502 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	117,652,393 - 117,661,711 (-)	Ensembl				GRCr8
mRatBN7.2	8	108,773,791 - 108,782,903 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	108,773,794 - 108,782,933 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	114,400,007 - 114,409,117 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,599,331 - 112,608,441 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	110,441,972 - 110,451,082 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,862,664 - 116,871,776 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,862,625 - 116,872,215 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	116,216,745 - 116,225,857 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	113,353,151 - 113,362,263 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	108,078,004 - 108,087,116 (-)	NCBI		Celera
RGSC_v3.1	8	113,372,606 - 113,381,718 (-)	NCBI
RH 3.4 Map	8	1116.3	RGD
Cytogenetic Map	8	q32	NCBI

APEH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	49,673,117 - 49,683,971 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	49,673,981 - 49,683,971 (+)	Ensembl			hg38	GRCh38
GRCh37	3	49,711,784 - 49,721,404 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	49,686,439 - 49,695,938 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	49,686,438 - 49,695,937	NCBI
Celera	3	49,676,127 - 49,685,626 (+)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	49,770,415 - 49,779,914 (+)	NCBI		HuRef
CHM1_1	3	49,663,491 - 49,672,990 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	49,702,408 - 49,713,255 (+)	NCBI		T2T-CHM13v2.0

Apeh
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	107,962,613 - 107,971,736 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	107,962,612 - 107,971,805 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	108,085,413 - 108,094,490 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	108,085,413 - 108,094,606 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	107,987,745 - 107,996,811 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	107,943,514 - 107,952,552 (-)	NCBI		MGSCv36	mm8
Celera	9	107,695,183 - 107,704,249 (-)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	59.07	NCBI

Apeh
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	1,580,553 - 1,590,138 (+)	Ensembl
ChiLan1.0	NW_004955532	1,580,473 - 1,590,274 (+)	NCBI	ChiLan1.0	ChiLan1.0

APEH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	49,659,511 - 49,670,341 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	49,665,230 - 49,675,114 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	49,606,294 - 49,615,896 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	50,843,968 - 50,853,516 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	50,843,220 - 50,853,516 (+)	Ensembl			panPan2	panpan1.1

APEH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	39,587,316 - 39,596,324 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	39,587,279 - 39,596,228 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	39,508,241 - 39,517,291 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	39,944,841 - 39,953,890 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	39,944,843 - 39,953,810 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	39,311,923 - 39,320,973 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	39,715,279 - 39,724,328 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	39,995,110 - 40,004,158 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Apeh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	64,529,248 - 64,538,312 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	1,289,827 - 1,298,798 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	1,289,810 - 1,298,798 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

APEH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	32,205,609 - 32,214,518 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	32,205,863 - 32,214,517 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	35,385,067 - 35,393,717 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

APEH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	11,067,966 - 11,078,258 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666041	155,922,305 - 155,931,881 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Apeh
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	3,601,714 - 3,612,048 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624730	3,601,792 - 3,612,048 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Apeh
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	99,414,830 - 99,424,433 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Apeh
74 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	100
Count of miRNA genes:	86
Interacting mature miRNAs:	95
Transcripts:	ENSRNOT00000045410
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	105462581	132782436	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	82352698	127352698	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	61019838	121662124	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	80768445	125768445	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	80768445	125768445	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	70041301	121080908	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	68690349	119799881	Rat
10450865	Bw175	Body weight QTL 175	4.1		total fat pad mass (VT:0015008)	adipose tissue molecular composition measurement (CMO:0000484)	8	84192326	129192326	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	103375781	129871912	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	102413464	132782436	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
634332	Pia18	Pristane induced arthritis QTL 18	4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	84192326	132782436	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	85348065	130348065	Rat
631217	Activ1	Activity QTL 1	15.9		voluntary movement trait (VT:0003491)	number of photobeam interruptions in an experimental apparatus (CMO:0001517)	8	111249511	117802327	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	79394435	132782436	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	98145073	122898010	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	80768445	125768445	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	80768445	125768445	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	91340911	131690273	Rat

Markers in Region

D8Wox5

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	66,977,803 - 66,978,050 (+)	Marker Load Pipeline
mRatBN7.2	8	58,081,909 - 58,082,156 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	62,457,899 - 62,458,145	NCBI	Rnor6.0
Rnor_5.0	8	62,234,858 - 62,235,104	UniSTS	Rnor5.0
Celera	8	57,547,607 - 57,547,857	UniSTS
Cytogenetic Map	8	q24	UniSTS
Cytogenetic Map	8	q32	UniSTS

D8Wox11

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RGSC_v3.4	8	113,364,040 - 113,364,148	UniSTS	RGSC3.4
Celera	8	108,088,893 - 108,089,001	UniSTS
RH 3.4 Map	8	1120.8	UniSTS
RH 3.4 Map	8	1120.8	RGD
RH 2.0 Map	8	873.1	RGD
Cytogenetic Map	8	q32	UniSTS

D8Arb20

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	117,655,424 - 117,655,829 (+)	Marker Load Pipeline
mRatBN7.2	8	108,776,825 - 108,777,230 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	116,865,699 - 116,866,103	NCBI	Rnor6.0
Rnor_5.0	8	116,219,780 - 116,220,184	UniSTS	Rnor5.0
RGSC_v3.4	8	113,356,185 - 113,356,590	RGD	RGSC3.4
RGSC_v3.4	8	113,356,186 - 113,356,590	UniSTS	RGSC3.4
Celera	8	108,081,039 - 108,081,443	UniSTS
RGSC_v3.1	8	113,375,640 - 113,376,045	RGD
RH 3.4 Map	8	1119.3	UniSTS
RH 3.4 Map	8	1119.3	RGD
RH 2.0 Map	8	889.4	RGD
SHRSP x BN Map	8	71.89	RGD
Cytogenetic Map	8	q32	UniSTS

D8Wox7

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	117,655,479 - 117,655,674 (+)	Marker Load Pipeline
mRatBN7.2	8	108,776,880 - 108,777,075 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	116,865,754 - 116,865,948	NCBI	Rnor6.0
Rnor_5.0	8	116,219,835 - 116,220,029	UniSTS	Rnor5.0
RGSC_v3.4	8	113,356,240 - 113,356,435	RGD	RGSC3.4
RGSC_v3.4	8	113,356,241 - 113,356,435	UniSTS	RGSC3.4
Celera	8	108,081,094 - 108,081,288	UniSTS
RGSC_v3.1	8	113,375,695 - 113,375,890	RGD
RH 3.4 Map	8	1119.5	UniSTS
RH 3.4 Map	8	1119.5	RGD
RH 2.0 Map	8	875.4	RGD
Cytogenetic Map	8	q32	UniSTS

RH94462

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	108,773,819 - 108,773,919 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	116,862,693 - 116,862,792	NCBI	Rnor6.0
Rnor_5.0	8	116,216,774 - 116,216,873	UniSTS	Rnor5.0
RGSC_v3.4	8	113,353,180 - 113,353,279	UniSTS	RGSC3.4
Celera	8	108,078,033 - 108,078,132	UniSTS
RH 3.4 Map	8	1116.3	UniSTS
Cytogenetic Map	8	q32	UniSTS

RH132558

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	117,652,755 - 117,653,040 (+)	Marker Load Pipeline
Cytogenetic Map	8	q32	UniSTS

D8Wox11

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	8	117,663,278 - 117,663,387 (+)	Marker Load Pipeline
mRatBN7.2	8	108,784,680 - 108,784,789 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	116,873,553 - 116,873,661	NCBI	Rnor6.0
Rnor_5.0	8	116,227,634 - 116,227,742	UniSTS	Rnor5.0
RGSC_v3.4	8	113,364,040 - 113,364,148	UniSTS	RGSC3.4
Celera	8	108,088,893 - 108,089,001	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128059	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC107565	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC166605	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	J04733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MW394930	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	MW394953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X14915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000045410 ⟹ ENSRNOP00000043843

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	117,652,393 - 117,661,711 (-)	Ensembl
mRatBN7.2 Ensembl	8	108,773,794 - 108,782,927 (-)	Ensembl
Rnor_6.0 Ensembl	8	116,862,625 - 116,872,215 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095731 ⟹ ENSRNOP00000080692

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	108,773,794 - 108,782,933 (-)	Ensembl

RefSeq Acc Id:

NM_012500 ⟹ NP_036632

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	117,652,390 - 117,661,502 (-)	NCBI
mRatBN7.2	8	108,773,791 - 108,782,903 (-)	NCBI
Rnor_6.0	8	116,862,664 - 116,871,776 (-)	NCBI
Rnor_5.0	8	116,216,745 - 116,225,857 (-)	NCBI
RGSC_v3.4	8	113,353,151 - 113,362,263 (-)	RGD
Celera	8	108,078,004 - 108,087,116 (-)	RGD

Sequence:

show sequence

CGACTATGGAGCGTCAGGTGCTGCTGAGTGAGCCCCAGGAGGCGGCAGCGCTGTACCGGGGCCT
TAGCCGCCAGCCTTCGCTGAGCGCCGCCTGCCTGGGTCCGGAGGTCACCACGCAGTATGGGGGC
CTCTATCGGACCGTGCACACTGAGTGGACTCAGAGGGACTTGGAGCGAATGGAGAACATCCGAT
TCTGCCGCCAGTACCTAGTGTTTCATGACGGAGACTCGGTGGTGTTTGCCGGGCCTGCAGGCAA
CAGTGTGGAAACCCGGGGGGAGCTGCTGAGCAGAGAGTCTCCTTCAGGCACCATGAAAGCTGTG
CTTCGCAAGGCCGGAGGCACAGTCTCAGGAGAGGAAAAACAGTTCTTGGAGGTCTGGGAGAAGA
ACCGGAAGCTCAAGAGTTTCAACCTGTCAGCGCTGGAGAAGCATGGGCCTGTCTATGAGGATGA
CTGCTTTGGCTGCCTTTCCTGGTCACACTCAGAGACACACTTGTTGTATGTGGCGGAGAAGAAG
CGTCCCAAGGCTGAGTCCTTCTTTCAGACCAAAGCCTTGGACATCAGTGCCAGCGATGATGAGA
TGGCCAGGCCGAAGAAGCCAGACCAGGCCATCAAGGGGGACCAGTTTGTATTTTATGAAGACTG
GGGAGAAACGATGGTTTCCAAAAGCATCCCTGTGCTCTGCGTGCTAGATATCGACAGTGGCAAC
ATCTCTGTGCTTGAGGGAGTCCCTGAAAATGTGTCACCTGGTCAGGCTTTTTGGGCCCCTGGAG
ACACGGGGGTGGTGTTTGTGGGCTGGTGGCATGAACCCTTCAGGCTCGGCATCCGCTATTGCAC
CAATCGCAGATCAGCTCTGTACTATGTGGACCTGAGCGGAGGGAAGTGTGAACTACTCTCGGAT
GGTTCCCTGGCCATCTGTTCTCCTCGGCTCAGCCCAGACCAGTGTCGCATCGTCTACCTACAGT
ATCCATGTCTAGCCCCTCATCACCAATGCAGCCAGCTCTGCCTGTACGACTGGTACACCAAGGT
CACCTCAGTGGTGGTGGACATTGTACCCCGGCAGCTGGGAGAGAGCTTCTCTGGAATCTACTGC
AGTCTTCTTCCTTTGGGATGCTGGTCAGCTGACAGCCAGAGAGTAGTCTTTGACTCTGCCCAGC
GCAGTCGGCAGGACCTGTTTGCTGTGGACACCCAGACGGGCAGCATCACCTCCCTGACAGCTGC
GGGGTCAGCAGGAAGCTGGAAGCTGCTTACAATTGACAAAGACCTTATGGTTGCCCAGTTCTCC
ACACCCAGTTTGCCCCCAAGCCTGAAAGTTGGGTTCCTGCCTCCTCCTGGGAAGGAGCAGTCTG
TGTCATGGGTGTCCCTGGAGGAGGCTGAACCTATTCCTGGCATCCACTGGGGCGTCCGTGTGCT
ACACCCACCTCCAGACCAAGAGAATGTACAATATGCTGACCTTGACTTTGAAGCAATCCTTTTG
CAGCCCAGCAATCCTCCAGATAAGACCCAGGTCCCCATGGTAGTCATGCCCCATGGGGGACCCC
ATTCGTCCTTCGTCACTGCCTGGATGCTGTTCCCAGCCATGCTCTGCAAGATGGGCTTTGCAGT
ACTTCTGGTGAACTATCGTGGCTCCACTGGCTTTGGCCAAGACAGCATCCTTTCTCTCCCAGGC
AATGTGGGCCACCAGGATGTGAAGGATGTCCAGTTTGCAGTGGAGCAGGTACTCCAGGAGGAAC
ACTTTGATGCAAGACGCGTGGCCCTTATGGGTGGTTCCCATGGTGGGTTCCTCTCCTGCCACCT
GATTGGTCAATACCCGGAGACCTACAGTGCTTGTATAGCCCGGAACCCAGTGATCAACATTGCC
TCCATGATGGGCTCCACTGACATCCCTGATTGGTGTATGGTGGAGACTGGCTTCCCTTATAGCA
ACAGCTGCCTCCCAGATCTGAATGTGTGGGAGGAGATGCTGGATAAGTCACCCATCAAATACAT
CCCTCAGGTAAAGACACCAGTGTTACTGATGCTGGGCCAGGAGGACCGACGGGTACCCTTCAAG
CAGGGTATGGAGTATTACCGTGCCCTCAAGGCCCGGAATGTGCCTGTCCGGCTCCTGCTGTACC
CCAAGAGCAACCACGCGCTGTCAGAGGTGGAGGCGGAGTCAGACAGCTTCATGAACGCTGTGCT
TTGGCTGCACACACACTTGGGCAGCTGAAGCCCTATGTTCTTCTTGAGCTGGGCAGCCCGTCTT
GCACTTTGCTCTTGGTAAGCTCCAGGATCTGACCGAACAGCCAAACAGTCTCCTAGGCTGTGGA
CTCAGTGAATGGGCAGAGGACTAAGAACTATGTTATCATAATAAAGGAAGACACAGAAAAAAAA
AAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_036632	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA88506	(Get FASTA)	NCBI Sequence Viewer
	AAI66605	(Get FASTA)	NCBI Sequence Viewer
	CAA33040	(Get FASTA)	NCBI Sequence Viewer
	EDL77191	(Get FASTA)	NCBI Sequence Viewer
	EDL77192	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000043843
GenBank Protein	P13676	(Get FASTA)	NCBI Sequence Viewer
	QST77014	(Get FASTA)	NCBI Sequence Viewer
	QST77036	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_036632 ⟸ NM_012500

- UniProtKB:

P14320 (UniProtKB/Swiss-Prot), P70479 (UniProtKB/Swiss-Prot), P13676 (UniProtKB/Swiss-Prot), B2GVB7 (UniProtKB/TrEMBL), A6I335 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MERQVLLSEPQEAAALYRGLSRQPSLSAACLGPEVTTQYGGLYRTVHTEWTQRDLERMENIRFC
RQYLVFHDGDSVVFAGPAGNSVETRGELLSRESPSGTMKAVLRKAGGTVSGEEKQFLEVWEKNR
KLKSFNLSALEKHGPVYEDDCFGCLSWSHSETHLLYVAEKKRPKAESFFQTKALDISASDDEMA
RPKKPDQAIKGDQFVFYEDWGETMVSKSIPVLCVLDIDSGNISVLEGVPENVSPGQAFWAPGDT
GVVFVGWWHEPFRLGIRYCTNRRSALYYVDLSGGKCELLSDGSLAICSPRLSPDQCRIVYLQYP
CLAPHHQCSQLCLYDWYTKVTSVVVDIVPRQLGESFSGIYCSLLPLGCWSADSQRVVFDSAQRS
RQDLFAVDTQTGSITSLTAAGSAGSWKLLTIDKDLMVAQFSTPSLPPSLKVGFLPPPGKEQSVS
WVSLEEAEPIPGIHWGVRVLHPPPDQENVQYADLDFEAILLQPSNPPDKTQVPMVVMPHGGPHS
SFVTAWMLFPAMLCKMGFAVLLVNYRGSTGFGQDSILSLPGNVGHQDVKDVQFAVEQVLQEEHF
DARRVALMGGSHGGFLSCHLIGQYPETYSACIARNPVINIASMMGSTDIPDWCMVETGFPYSNS
CLPDLNVWEEMLDKSPIKYIPQVKTPVLLMLGQEDRRVPFKQGMEYYRALKARNVPVRLLLYPK
SNHALSEVEAESDSFMNAVLWLHTHLGS

hide sequence

Ensembl Acc Id:

ENSRNOP00000043843 ⟸ ENSRNOT00000045410

Ensembl Acc Id:

ENSRNOP00000080692 ⟸ ENSRNOT00000095731

Protein Domains

Acylamino-acid-releasing enzyme N-terminal Peptidase S9 prolyl oligopeptidase catalytic

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P13676-F1-model_v2	AlphaFold	P13676	1-732	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696290

Promoter ID:

EPDNEW_R6815

Type:

multiple initiation site

Name:

Apeh_1

Description:

acylaminoacyl-peptide hydrolase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	116,871,806 - 116,871,866	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2125	AgrOrtholog
BioCyc Gene	G2FUF-29157	BioCyc
BioCyc Pathway	PWY-7799 [Arg/N-end rule pathway (eukaryotic)]	BioCyc
BioCyc Pathway Image	PWY-7799	BioCyc
Ensembl Genes	ENSRNOG00000029572	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000045410	ENTREZGENE
Gene3D-CATH	2.120.10.30	UniProtKB/Swiss-Prot
	3.40.50.1820	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7937766	IMAGE-MGC_LOAD
InterPro	6-blade_b-propeller_TolB-like	UniProtKB/Swiss-Prot
	AARE_N	UniProtKB/Swiss-Prot
	AB_hydrolase	UniProtKB/Swiss-Prot
	Pept_S9_AS	UniProtKB/Swiss-Prot
	Peptidase_S9	UniProtKB/Swiss-Prot
KEGG Report	rno:24206	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:188384	IMAGE-MGC_LOAD
NCBI Gene	24206	ENTREZGENE
PANTHER	ACYLAMINO-ACID-RELEASING ENZYME	UniProtKB/Swiss-Prot
	SERINE PEPTIDASE S9 FAMILY MEMBER	UniProtKB/Swiss-Prot
Pfam	APEH_N	UniProtKB/Swiss-Prot
	Peptidase_S9	UniProtKB/Swiss-Prot
PhenoGen	Apeh	PhenoGen
PROSITE	PRO_ENDOPEP_SER	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000029572	RatGTEx
Superfamily-SCOP	Peptidase/esterase 'gauge' domain	UniProtKB/Swiss-Prot
	SSF53474	UniProtKB/Swiss-Prot
TIGR	TC219864
UniProt	A6I335	ENTREZGENE, UniProtKB/TrEMBL
	A6I336_RAT	UniProtKB/TrEMBL
	ACPH_RAT	UniProtKB/Swiss-Prot
	B2GVB7	ENTREZGENE, UniProtKB/TrEMBL
	G3V9E4_RAT	UniProtKB/TrEMBL
	P13676	ENTREZGENE
	P14320	ENTREZGENE
	P70479	ENTREZGENE
UniProt Secondary	P14320	UniProtKB/Swiss-Prot
	P70479	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-06-05	Apeh	acylaminoacyl-peptide hydrolase	Apeh	N-acylaminoacyl-peptide hydrolase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-25	Apeh	N-acylaminoacyl-peptide hydrolase	Apeh	acylpeptide hydrolase	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Apeh	acylpeptide hydrolase		N-acylaminoacyl-peptide hydrolase	Name updated	1299863	APPROVED
2002-06-10	Apeh	N-acylaminoacyl-peptide hydrolase			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_function	catalyzes the removal of an N alpha-acetylated amino acid residue from a peptide	634651
gene_transcript	2.7 kb transcript is detected	634651

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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