Tslp (thymic stromal lymphopoietin) - Rat Genome Database

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Gene: Tslp (thymic stromal lymphopoietin) Rattus norvegicus
Analyze
Symbol: Tslp
Name: thymic stromal lymphopoietin
RGD ID: 1586479
Description: Predicted to enable cytokine activity and interleukin-7 receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Predicted to be active in extracellular space. Orthologous to human TSLP (thymic stromal lymphopoietin); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC688621; similar to thymic stromal lymphopoietin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81824,723,990 - 24,728,419 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1824,720,257 - 24,728,420 (+)EnsemblGRCr8
mRatBN7.21824,447,409 - 24,454,244 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1824,449,844 - 24,453,548 (+)EnsemblmRatBN7.2
Rnor_6.01825,613,601 - 25,618,066 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1825,613,831 - 25,617,361 (+)Ensemblrn6Rnor6.0
Rnor_5.01825,326,396 - 25,333,230 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41825,268,082 - 25,274,214 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1824,198,059 - 24,202,524 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->3)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aluminium hydroxide  (ISO)
amiodarone  (ISO)
amorolfine  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benomyl  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-eudesmol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butenafine  (ISO)
Butylbenzyl phthalate  (ISO)
Calcimycin  (ISO)
calcipotriol  (ISO)
calcitriol  (ISO)
ceric oxide  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP,ISO)
Didecyldimethylammonium  (ISO)
diethyl malate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethylparaben  (ISO)
ferric oxide  (ISO)
fluorescein 5-isothiocyanate  (ISO)
formaldehyde  (EXP,ISO)
furan  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (ISO)
GW 4064  (ISO)
helenalin  (ISO)
hydroquinone  (ISO)
itraconazole  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
lipopolysaccharide  (ISO)
Liranaftate  (ISO)
Luliconazole  (ISO)
Maxacalcitol  (ISO)
melatonin  (ISO)
methoxychlor  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
naringin  (ISO)
nickel dichloride  (ISO)
Nonylphenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (ISO)
parthenolide  (ISO)
perfluorobutyric acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoropentanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phloxine O  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (ISO)
progesterone  (ISO)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
terbinafine  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
toluene 2,4-diisocyanate  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. TSLP Protects Corneas From Pseudomonas aeruginosa Infection by Regulating Dendritic Cells and IL-23-IL-17 Pathway. Cui X, etal., Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4228-4237. doi: 10.1167/iovs.18-24672.
2. Interactions of thymic stromal lymphopoietin with TLR2 and TLR4 regulate anti-fungal innate immunity in Aspergillus fumigatus-induced corneal infection. Dai C, etal., Exp Eye Res. 2019 May;182:19-29. doi: 10.1016/j.exer.2019.02.020. Epub 2019 Mar 8.
3. Adjuvant selection for vaccination against murine schistosomiasis. El Ridi R and Tallima H, Scand J Immunol. 2012 Dec;76(6):552-8. doi: 10.1111/j.1365-3083.2012.02768.x.
4. Thymic stromal lymphopoietin, IL-33, and periostin in hospitalized infants with viral bronchiolitis. García-García ML, etal., Medicine (Baltimore). 2017 May;96(18):e6787. doi: 10.1097/MD.0000000000006787.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection. Giacomin PR, etal., J Immunol. 2012 Nov 1;189(9):4371-8. doi: 10.4049/jimmunol.1200691. Epub 2012 Sep 28.
7. The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice. Han M, etal., J Immunol. 2017 Aug 15;199(4):1308-1318. doi: 10.4049/jimmunol.1700216. Epub 2017 Jul 12.
8. Alteration of cytokine production during visceral larva migrans by Toxascaris leonina in mice. Kang SA, etal., Korean J Parasitol. 2013 Oct;51(5):583-8. doi: 10.3347/kjp.2013.51.5.583. Epub 2013 Oct 31.
9. Thymic stromal lymphopoietin mediates the host response and increases mortality during sepsis. Kuethe JW, etal., J Surg Res. 2014 Sep;191(1):19-24. doi: 10.1016/j.jss.2014.05.024. Epub 2014 May 20.
10. Phloxine O, a Cosmetic Colorant, Suppresses the Expression of Thymic Stromal Lymphopoietin and Acute Dermatitis Symptoms in Mice. Lee HE, etal., Biomol Ther (Seoul). 2018 Sep 1;26(5):481-486. doi: 10.4062/biomolther.2017.130.
11. Sex-associated TSLP-induced immune alterations following early-life RSV infection leads to enhanced allergic disease. Malinczak CA, etal., Mucosal Immunol. 2019 Jul;12(4):969-979. doi: 10.1038/s41385-019-0171-3. Epub 2019 May 11.
12. Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33. Mehta AK, etal., J Allergy Clin Immunol. 2016 Jan;137(1):278-88.e6. doi: 10.1016/j.jaci.2015.05.007. Epub 2015 Jun 19.
13. Itching in a trichophytin contact dermatitis mouse model and the antipruritic effect of antifungal agents. Nakamura T, etal., Clin Exp Dermatol. 2019 Jun;44(4):381-389. doi: 10.1111/ced.13719. Epub 2018 Sep 6.
14. Thymic Stromal Lymphopoietin Is Critical for Regulation of Proinflammatory Cytokine Response and Resistance to Experimental Trypanosoma congolense Infection. Onyilagha C, etal., Front Immunol. 2017 Jul 14;8:803. doi: 10.3389/fimmu.2017.00803. eCollection 2017.
15. Thymic Stromal Lymphopoietin Improves Survival and Reduces Inflammation in Sepsis. Piliponsky AM, etal., Am J Respir Cell Mol Biol. 2016 Aug;55(2):264-74. doi: 10.1165/rcmb.2015-0380OC.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. A potential link between TSLP/TSLPR/STAT5 and TLR2/MyD88/NFκB-p65 in human corneal epithelial cells for Aspergillus fumigatus tolerance. Ren X, etal., Mol Immunol. 2016 Mar;71:98-106. doi: 10.1016/j.molimm.2015.12.014. Epub 2016 Feb 11.
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Thymic stromal lymphopoietin in hepatitis C virus-related cryoglobulinemic vasculitis: gene expression level and protein distribution. Sansonno D, etal., Arthritis Res Ther. 2015 Mar 15;17:62. doi: 10.1186/s13075-015-0581-x.
20. Repurposing the psoriasis drug Oxarol to an ointment adjuvant for the influenza vaccine. Sato R, etal., Int Immunol. 2020 Jul 28;32(8):499-507. doi: 10.1093/intimm/dxaa012.
21. Oral interferon-alpha treatment of mice with cryoglobulinemic glomerulonephritis. Segerer S, etal., Am J Kidney Dis. 2002 Apr;39(4):876-88. doi: 10.1053/ajkd.2002.32011.
22. IL-25, IL-33 and TSLP receptor are not critical for development of experimental murine malaria. Shibui A, etal., Biochem Biophys Rep. 2015 Dec 14;5:191-195. doi: 10.1016/j.bbrep.2015.12.007. eCollection 2016 Mar.
23. Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietin. Stier MT, etal., J Allergy Clin Immunol. 2016 Sep;138(3):814-824.e11. doi: 10.1016/j.jaci.2016.01.050. Epub 2016 Apr 9.
24. TSLP-activated dendritic cells induce T helper type 2 inflammation in Aspergillus fumigatus keratitis. Sun L, etal., Exp Eye Res. 2018 Jun;171:120-130. doi: 10.1016/j.exer.2018.03.014. Epub 2018 Mar 14.
25. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. Taylor BC, etal., J Exp Med. 2009 Mar 16;206(3):655-67. doi: 10.1084/jem.20081499. Epub 2009 Mar 9.
Additional References at PubMed
PMID:10974033   PMID:11418668   PMID:11480573   PMID:17242164   PMID:20603637   PMID:21038685   PMID:23154814   PMID:24668732   PMID:24850429   PMID:27492484   PMID:29257253   PMID:34281158  
PMID:37660072  


Genomics

Comparative Map Data
Tslp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81824,723,990 - 24,728,419 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1824,720,257 - 24,728,420 (+)EnsemblGRCr8
mRatBN7.21824,447,409 - 24,454,244 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1824,449,844 - 24,453,548 (+)EnsemblmRatBN7.2
Rnor_6.01825,613,601 - 25,618,066 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1825,613,831 - 25,617,361 (+)Ensemblrn6Rnor6.0
Rnor_5.01825,326,396 - 25,333,230 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41825,268,082 - 25,274,214 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1824,198,059 - 24,202,524 (+)NCBICelera
Cytogenetic Map18p12NCBI
TSLP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385111,070,062 - 111,078,026 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5111,070,062 - 111,078,026 (+)Ensemblhg38GRCh38
GRCh375110,405,760 - 110,413,724 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365110,435,289 - 110,441,623 (+)NCBIBuild 36Build 36hg18NCBI36
Celera5106,353,329 - 106,359,661 (+)NCBICelera
Cytogenetic Map5q22.1NCBI
HuRef5105,584,896 - 105,592,841 (+)NCBIHuRef
CHM1_15109,839,103 - 109,847,047 (+)NCBICHM1_1
T2T-CHM13v2.05111,580,695 - 111,588,660 (+)NCBIT2T-CHM13v2.0
Tslp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391832,948,436 - 32,952,852 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1832,948,436 - 32,952,850 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381832,815,383 - 32,819,799 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1832,815,383 - 32,819,797 (+)Ensemblmm10GRCm38
MGSCv371832,975,037 - 32,979,453 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361832,958,393 - 32,962,802 (+)NCBIMGSCv36mm8
Celera1833,286,509 - 33,290,920 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.12NCBI
Tslp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554184,041,529 - 4,045,534 (-)NCBIChiLan1.0ChiLan1.0
TSLP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24106,340,561 - 106,348,525 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15104,494,184 - 104,502,180 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05106,440,136 - 106,446,849 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15112,242,490 - 112,249,200 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5112,242,490 - 112,250,130 (+)EnsemblpanPan2panpan1.1
TSLP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.131,502,469 - 1,507,696 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl31,503,188 - 1,507,696 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha32,907,296 - 2,971,755 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.031,393,149 - 1,400,425 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl31,393,868 - 1,398,504 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.131,339,901 - 1,404,345 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.031,341,683 - 1,348,998 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.031,506,469 - 1,571,642 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tslp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213156,110,394 - 156,115,633 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365315,495,872 - 5,500,462 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSLP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.12115,832,152 - 115,837,572 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22120,289,894 - 120,323,977 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TSLP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12314,419,820 - 14,423,331 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603464,056,775 - 64,060,255 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tslp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11511,440,205 - 11,445,795 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tslp
31 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181221923726822399Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)182201556261600538Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181564228031610627Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181221668431644508Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18126032889Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)18125071266Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181522610142690662Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181221668431644508Rat
1331775Bp235Blood pressure QTL 2353.201arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228031610627Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181221923726822399Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181206648257066482Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18125022372Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181221923726822399Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181221923726822399Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181221923726822399Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181221923726822399Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181221923726822399Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18126032889Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 66 163 78 79 48 36 48 6 280 131 11 144 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000091040   ⟹   ENSRNOP00000069118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1824,723,992 - 24,728,420 (+)Ensembl
mRatBN7.2 Ensembl1824,449,844 - 24,453,548 (+)Ensembl
Rnor_6.0 Ensembl1825,613,831 - 25,617,361 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170831   ⟹   ENSRNOP00000111544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1824,720,257 - 24,728,420 (+)Ensembl
RefSeq Acc Id: XM_063277692   ⟹   XP_063133762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81824,723,990 - 24,728,419 (+)NCBI
RefSeq Acc Id: XM_063277693   ⟹   XP_063133763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81824,725,094 - 24,725,763 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001419476 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133762 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133763 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069118
  ENSRNOP00000069118.3
  ENSRNOP00000111544.1
Ensembl Acc Id: ENSRNOP00000069118   ⟸   ENSRNOT00000091040
RefSeq Acc Id: XP_063133762   ⟸   XM_063277692
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063133763   ⟸   XM_063277693
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000111544   ⟸   ENSRNOT00000170831

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JUJ3-F1-model_v2 AlphaFold A0A0G2JUJ3 1-135 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586479 AgrOrtholog
BioCyc Gene G2FUF-8010 BioCyc
Ensembl Genes ENSRNOG00000058856 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091040 ENTREZGENE
  ENSRNOT00000091040.3 UniProtKB/TrEMBL
  ENSRNOT00000170831.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.90 UniProtKB/TrEMBL
InterPro TSLP UniProtKB/TrEMBL
  TSLP_sf UniProtKB/TrEMBL
NCBI Gene 688621 ENTREZGENE
PANTHER PTHR38003 UniProtKB/TrEMBL
  THYMIC STROMAL LYMPHOPOIETIN UniProtKB/TrEMBL
Pfam TSLP UniProtKB/TrEMBL
PhenoGen Tslp PhenoGen
RatGTEx ENSRNOG00000058856 RatGTEx
UniProt A0A0G2JUJ3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M738_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Tslp  thymic stromal lymphopoietin  LOC682183  similar to thymic stromal lymphopoietin  Data merged from RGD:1586907 1643240 APPROVED
2008-03-05 Tslp  thymic stromal lymphopoietin  LOC688621  similar to thymic stromal lymphopoietin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC688621  similar to thymic stromal lymphopoietin      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682183  similar to thymic stromal lymphopoietin      Symbol and Name status set to provisional 70820 PROVISIONAL