RGD Reference Report - Alteration of cytokine production during visceral larva migrans by Toxascaris leonina in mice. - Rat Genome Database

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Alteration of cytokine production during visceral larva migrans by Toxascaris leonina in mice.

Authors: Kang, Shin Ae  Park, Mi-Kyung  Cho, Min Kyoung  Yu, Hak Sun 
Citation: Kang SA, etal., Korean J Parasitol. 2013 Oct;51(5):583-8. doi: 10.3347/kjp.2013.51.5.583. Epub 2013 Oct 31.
RGD ID: 38596353
Pubmed: PMID:24327787   (View Abstract at PubMed)
PMCID: PMC3857509   (View Article at PubMed Central)
DOI: DOI:10.3347/kjp.2013.51.5.583   (Journal Full-text)

To determine alteration of immune responses during visceral larva migrans (VLM) caused by Toxascaris leonina at several time points, we experimentally infected mice with embryonated eggs of T. leonina and measured T-helper (Th) cell-related serial cytokine production after infection. At day 5 post infection (PI), most larvae were detected from the lungs, spleen, intestine, and muscle. Expression of thymic stromal lymphopoietin (TSLP) and CCL11 (eotaxin) showed a significant increase in most infected organs, except the intestine. However, expression of the CXCL1 (Gro-α) gene was most highly enhanced in the intestine at day 14 PI. Th1-related cytokine secretion of splenocytes showed increases at day 28 PI, and the level showed a decrease at day 42 PI. Th2-related cytokine secretion of splenocytes also showed an increase after infection; in particular, IL-5 level showed a significant increase at day 14 PI, and the level showed a decrease at day 28 PI. However, levels of Th17-related cytokines, IL-6 and IL-17A, showed gradual increases until day 42 PI. In conclusion, Th1, Th2, and Th17-related cytokine production might be important in immune responses against T. leonina VLM in experimental mice.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TSLPHumantoxascariasis  ISOTslp (Mus musculus)mRNA:increased expression:multiple (mouse)RGD 
TslpRattoxascariasis  ISOTslp (Mus musculus)mRNA:increased expression:multiple (mouse)RGD 
TslpMousetoxascariasis  IEP mRNA:increased expression:multiple (mouse)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tslp  (thymic stromal lymphopoietin)

Genes (Mus musculus)
Tslp  (thymic stromal lymphopoietin)

Genes (Homo sapiens)
TSLP  (thymic stromal lymphopoietin)


Additional Information