RGD Reference Report - Phloxine O, a Cosmetic Colorant, Suppresses the Expression of Thymic Stromal Lymphopoietin and Acute Dermatitis Symptoms in Mice. - Rat Genome Database

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Phloxine O, a Cosmetic Colorant, Suppresses the Expression of Thymic Stromal Lymphopoietin and Acute Dermatitis Symptoms in Mice.

Authors: Lee, Hye Eun  Yang, Gabsik  Kim, Kyu-Bong  Lee, Byung-Mu  Lee, Joo Young 
Citation: Lee HE, etal., Biomol Ther (Seoul). 2018 Sep 1;26(5):481-486. doi: 10.4062/biomolther.2017.130.
RGD ID: 38549374
Pubmed: PMID:29310423   (View Abstract at PubMed)
PMCID: PMC6131015   (View Article at PubMed Central)
DOI: DOI:10.4062/biomolther.2017.130   (Journal Full-text)

Cosmetics are primarily applied to the skin; therefore, the association of cosmetic dyes with skin diseases or inflammation is a topic of great interest. Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine that activates dendritic cells to promote Th2 inflammatory immune responses. TSLP is highly expressed in keratinocytes under inflammatory conditions, which suggests that it may play a critical role in the development of skin diseases, such as atopic dermatitis. Therefore, we investigated whether cosmetic dyes influenced the production of TSLP by keratinocytes. Phloxine O, also known as D&C Red No.27, is one of the most common red synthetic pigments and is widely used in colored cosmetics. Our results showed that Phloxine O downregulated phorbol 12-myristate 13-acetate-induced production of TSLP in a murine keratinocyte cell line (PAM212). Phloxine O also suppressed TSLP expression in KCMH-1 cells, which are mouse keratinocytes that constitutively produce high levels of TSLP. To investigate the in vivo effects of Phloxine O, we induced TSLP expression in mouse ear skin by topically applying MC903, a vitamin D3 analogue that is a well-known inducer of atopic dermatitis-like symptoms. Topical application of Phloxine O prevented MC903-induced TSLP production in mouse ear skin, attenuated the acute dermatitis-like symptoms and decreased serum IgE and histamine levels in mice. Suppression of TSLP expression by Phloxine O correlated with reduced expression of OX40 ligand and Th2 cytokines in mouse ear skin. Our results showed that Phloxine O may be beneficial to prevent dermatitis by suppressing the expression of TSLP and Th2 cytokines in skin.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TSLPHumanatopic dermatitis treatmentISOTslp (Mus musculus) RGD 
TslpRatatopic dermatitis treatmentISOTslp (Mus musculus) RGD 
TslpMouseatopic dermatitis treatmentIEP  RGD 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TSLPHumancalcipotriol increases expression ISOTslp (Mus musculus)calcipotriol increases expression of Tslp mRNA and protein in skin of external ear]RGD 
TslpRatcalcipotriol increases expressionISOTslp (Mus musculus)Calcipotriol increases expression of Tslp mRNA and protein in skin of external ear]RGD 
TslpMousecalcipotriol increases expressionEXP Calcipotriol increases expression of Tslp mRNA and protein in skin of external ear]RGD 
TSLPHumandexamethasone multiple interactionsISOTslp (Mus musculus)dexamethasone inhibits the reaction [calcipotriol increases expression of Tslp mRNA in skin of external ear]RGD 
TslpRatdexamethasone multiple interactionsISOTslp (Mus musculus)dexamethasone inhibits the reaction [calcipotriol increases expression of Tslp mRNA in skin of external ear]RGD 
TslpMousedexamethasone multiple interactionsEXP dexamethasone inhibits the reaction [calcipotriol increases expression of Tslp mRNA in skin of external ear]RGD 
TSLPHumanphloxine O multiple interactionsISOTslp (Mus musculus)Phloxine O inhibits the reaction [calcipotriol increases expression of Tslp mRNA and protein in skin of external ear and phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytes]RGD 
TslpRatphloxine O multiple interactionsISOTslp (Mus musculus)Phloxine O inhibits the reaction [calcipotriol increases expression of Tslp mRNA and protein in skin of external ear and phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytes]RGD 
TslpMousephloxine O multiple interactionsEXP Phloxine O inhibits the reaction [calcipotriol increases expression of Tslp mRNA and protein in skin of external ear and phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytes]RGD 
TSLPHumanphorbol 13-acetate 12-myristate multiple interactionsISOTslp (Mus musculus)Phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytesRGD 
TslpRatphorbol 13-acetate 12-myristate multiple interactionsISOTslp (Mus musculus)phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytesRGD 
TslpMousephorbol 13-acetate 12-myristate multiple interactionsEXP Phorbol 12-myristate 13-acetate increases expression of Tslp protein in keratinocytesRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tslp  (thymic stromal lymphopoietin)

Genes (Mus musculus)
Tslp  (thymic stromal lymphopoietin)

Genes (Homo sapiens)
TSLP  (thymic stromal lymphopoietin)


Additional Information