Vav3 (vav guanine nucleotide exchange factor 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Vav3 (vav guanine nucleotide exchange factor 3) Rattus norvegicus
Analyze
Symbol: Vav3
Name: vav guanine nucleotide exchange factor 3
RGD ID: 1565941
Description: Predicted to enable epidermal growth factor receptor binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; positive regulation of B cell proliferation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to act upstream of or within several processes, including integrin-mediated signaling pathway; lamellipodium assembly; and neutrophil chemotaxis. Predicted to be located in immunological synapse. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human VAV3 (vav guanine nucleotide exchange factor 3); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; Fc epsilon receptor mediated signaling pathway; B cell receptor signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: guanine nucleotide exchange factor VAV3; LOC295378; RGD1565941; similar to Vav 3 oncogene; vav 3 guanine nucleotide exchange factor; vav 3 oncogene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82199,699,861 - 200,042,344 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2199,700,445 - 200,042,343 (+)EnsemblGRCr8
mRatBN7.22197,011,901 - 197,354,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2197,011,831 - 197,354,321 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2204,649,909 - 204,985,041 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02202,536,978 - 202,872,292 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02197,354,079 - 197,689,388 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02212,247,061 - 212,585,818 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2212,247,451 - 212,585,818 (+)Ensemblrn6Rnor6.0
Rnor_5.02231,716,228 - 232,053,965 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42204,982,222 - 205,326,505 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2189,650,820 - 189,990,562 (+)NCBICelera
Cytogenetic Map2q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amphotericin B  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
fipronil  (EXP)
genistein  (ISO)
glycidol  (EXP)
glyphosate  (EXP)
GSK-J4  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
luteolin  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP)
Pf-06840003  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
immunological synapse  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8990121   PMID:15249579   PMID:15708849   PMID:15728722   PMID:17875758   PMID:19969623   PMID:21178006   PMID:22467863   PMID:23376485   PMID:37591108  


Genomics

Comparative Map Data
Vav3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82199,699,861 - 200,042,344 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2199,700,445 - 200,042,343 (+)EnsemblGRCr8
mRatBN7.22197,011,901 - 197,354,321 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2197,011,831 - 197,354,321 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2204,649,909 - 204,985,041 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02202,536,978 - 202,872,292 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02197,354,079 - 197,689,388 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02212,247,061 - 212,585,818 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2212,247,451 - 212,585,818 (+)Ensemblrn6Rnor6.0
Rnor_5.02231,716,228 - 232,053,965 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42204,982,222 - 205,326,505 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2189,650,820 - 189,990,562 (+)NCBICelera
Cytogenetic Map2q41NCBI
VAV3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381107,571,161 - 107,965,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1107,571,161 - 107,965,180 (-)Ensemblhg38GRCh38
GRCh371108,113,783 - 108,507,802 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361107,915,305 - 108,309,068 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341107,825,831 - 108,219,580NCBI
Celera1106,288,518 - 106,682,258 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1106,059,691 - 106,453,322 (-)NCBIHuRef
CHM1_11108,228,649 - 108,622,362 (-)NCBICHM1_1
T2T-CHM13v2.01107,608,692 - 108,002,653 (-)NCBIT2T-CHM13v2.0
Vav3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393109,247,757 - 109,593,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3109,247,969 - 109,593,014 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383109,340,465 - 109,685,694 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3109,340,653 - 109,685,698 (+)Ensemblmm10GRCm38
MGSCv373109,143,601 - 109,488,612 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363109,468,739 - 109,813,750 (+)NCBIMGSCv36mm8
Celera3111,676,271 - 112,018,586 (+)NCBICelera
Cytogenetic Map3F3NCBI
cM Map348.13NCBI
Vav3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543511,326,910 - 11,599,043 (-)Ensembl
ChiLan1.0NW_00495543511,326,910 - 11,599,043 (-)NCBIChiLan1.0ChiLan1.0
VAV3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21119,178,596 - 119,579,566 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11118,341,662 - 118,742,435 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01110,101,651 - 110,531,294 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11109,216,867 - 109,617,658 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1109,210,813 - 109,617,658 (-)EnsemblpanPan2panpan1.1
VAV3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1643,663,787 - 44,002,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl643,559,985 - 44,000,811 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha646,430,623 - 46,782,296 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0643,923,858 - 44,276,352 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl643,923,610 - 44,276,343 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1643,658,033 - 44,009,951 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0643,628,551 - 43,981,239 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0644,059,178 - 44,411,293 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vav3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058116,810,838 - 117,160,637 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936731417,322 - 767,429 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936731417,610 - 767,427 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VAV3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4111,824,896 - 112,202,825 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14111,825,071 - 112,202,833 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24122,945,014 - 122,967,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VAV3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12025,631,104 - 26,023,854 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2025,631,171 - 26,023,849 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603832,217,599 - 32,613,494 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vav3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247723,604,165 - 4,022,990 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247723,604,553 - 4,022,986 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Vav3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1348,730,040 - 49,061,535 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Vav3
4378 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:310
Count of miRNA genes:172
Interacting mature miRNAs:233
Transcripts:ENSRNOT00000027813
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
AI145306  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22197,353,911 - 197,354,092 (+)MAPPERmRatBN7.2
Rnor_6.02212,585,409 - 212,585,589NCBIRnor6.0
Rnor_5.02232,053,556 - 232,053,736UniSTSRnor5.0
RGSC_v3.42205,326,096 - 205,326,276UniSTSRGSC3.4
Celera2189,990,153 - 189,990,333UniSTS
RH 3.4 Map21418.01UniSTS
Cytogenetic Map2q34-q41UniSTS
BF403608  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22197,273,440 - 197,273,561 (+)MAPPERmRatBN7.2
Rnor_6.02212,504,940 - 212,505,060NCBIRnor6.0
Rnor_5.02231,973,087 - 231,973,207UniSTSRnor5.0
RGSC_v3.42205,245,636 - 205,245,756UniSTSRGSC3.4
Celera2189,909,872 - 189,909,992UniSTS
RH 3.4 Map21417.71UniSTS
Cytogenetic Map2q34-q41UniSTS
AU048068  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82199,745,922 - 199,746,251 (+)Marker Load Pipeline
mRatBN7.22197,057,882 - 197,058,211 (+)MAPPERmRatBN7.2
mRatBN7.26112,690,410 - 112,690,443 (+)MAPPERmRatBN7.2
Rnor_6.02212,292,139 - 212,292,729NCBIRnor6.0
Rnor_6.02212,292,139 - 212,292,467NCBIRnor6.0
Rnor_5.02231,760,456 - 231,761,046UniSTSRnor5.0
Rnor_5.02231,760,456 - 231,760,784UniSTSRnor5.0
RGSC_v3.42205,027,960 - 205,028,288UniSTSRGSC3.4
Celera2189,695,853 - 189,696,159UniSTS
Cytogenetic Map2q34-q41UniSTS
AI102699  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82200,024,086 - 200,024,279 (+)Marker Load Pipeline
mRatBN7.22197,336,060 - 197,336,253 (+)MAPPERmRatBN7.2
Rnor_6.02212,567,562 - 212,567,754NCBIRnor6.0
Rnor_5.02232,035,709 - 232,035,901UniSTSRnor5.0
RGSC_v3.42205,308,248 - 205,308,440UniSTSRGSC3.4
Celera2189,972,481 - 189,972,673UniSTS
RH 3.4 Map21418.01UniSTS
Cytogenetic Map2q34-q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000027813   ⟹   ENSRNOP00000027813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2199,700,445 - 200,042,343 (+)Ensembl
mRatBN7.2 Ensembl2197,012,735 - 197,354,321 (+)Ensembl
Rnor_6.0 Ensembl2212,247,451 - 212,585,818 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077883   ⟹   ENSRNOP00000073138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2199,700,445 - 200,042,343 (+)Ensembl
mRatBN7.2 Ensembl2197,091,794 - 197,354,321 (+)Ensembl
Rnor_6.0 Ensembl2212,257,225 - 212,585,818 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098387   ⟹   ENSRNOP00000080097
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2199,700,445 - 200,042,343 (+)Ensembl
mRatBN7.2 Ensembl2197,011,831 - 197,354,321 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106503   ⟹   ENSRNOP00000088576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2199,700,445 - 200,042,343 (+)Ensembl
mRatBN7.2 Ensembl2197,011,831 - 197,354,321 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000137916   ⟹   ENSRNOP00000101463
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2199,700,445 - 200,042,343 (+)Ensembl
RefSeq Acc Id: NM_001191714   ⟹   NP_001178643
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82199,700,778 - 200,042,344 (+)NCBI
mRatBN7.22197,012,735 - 197,354,321 (+)NCBI
Rnor_6.02212,247,451 - 212,585,818 (+)NCBI
Rnor_5.02231,716,228 - 232,053,965 (+)NCBI
Celera2189,650,820 - 189,990,562 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590775   ⟹   XP_017446264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82199,699,861 - 200,042,344 (+)NCBI
mRatBN7.22197,011,901 - 197,354,321 (+)NCBI
Rnor_6.02212,247,061 - 212,585,818 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063281659   ⟹   XP_063137729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82199,699,861 - 200,014,574 (+)NCBI
RefSeq Acc Id: NP_001178643   ⟸   NM_001191714
- UniProtKB: A0A8I5ZPB5 (UniProtKB/TrEMBL),   A0A8I6A8C8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446264   ⟸   XM_017590775
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A8C8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073138   ⟸   ENSRNOT00000077883
Ensembl Acc Id: ENSRNOP00000027813   ⟸   ENSRNOT00000027813
Ensembl Acc Id: ENSRNOP00000088576   ⟸   ENSRNOT00000106503
Ensembl Acc Id: ENSRNOP00000080097   ⟸   ENSRNOT00000098387
RefSeq Acc Id: XP_063137729   ⟸   XM_063281659
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000101463   ⟸   ENSRNOT00000137916
Protein Domains
Calponin-homology (CH)   DH   PH   Phorbol-ester/DAG-type   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LWB1-F1-model_v2 AlphaFold F1LWB1 1-847 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565941 AgrOrtholog
BioCyc Gene G2FUF-51577 BioCyc
Ensembl Genes ENSRNOG00000020485 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027813 ENTREZGENE
  ENSRNOT00000027813.8 UniProtKB/TrEMBL
  ENSRNOT00000077883.3 UniProtKB/TrEMBL
  ENSRNOT00000098387 ENTREZGENE
  ENSRNOT00000098387.2 UniProtKB/TrEMBL
  ENSRNOT00000106503.2 UniProtKB/TrEMBL
  ENSRNOT00000137916.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Calponin-like_dom_sf UniProtKB/TrEMBL
  CAMSAP_CH UniProtKB/TrEMBL
  CH-domain UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Filamin/ABP280_repeat-like UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH_like_dom UniProtKB/TrEMBL
  PH_Vav UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  SM22_calponin UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
  VAV3_SH2 UniProtKB/TrEMBL
  VAV3_SH3_1 UniProtKB/TrEMBL
  VAV3_SH3_2 UniProtKB/TrEMBL
KEGG Report rno:295378 UniProtKB/TrEMBL
NCBI Gene 295378 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV3 UniProtKB/TrEMBL
  PROTEIN VAV UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  CAMSAP_CH UniProtKB/TrEMBL
  PF00307 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PhenoGen Vav3 PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
  SM22CALPONIN UniProtKB/TrEMBL
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  FILAMIN_REPEAT UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  PS50021 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020485 RatGTEx
SMART RhoGEF UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP Calponin-homology UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0G2K4R0_RAT UniProtKB/TrEMBL
  A0A8I5ZPB5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A8C8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L0N5_RAT UniProtKB/TrEMBL
  F1LWB1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Vav3  vav guanine nucleotide exchange factor 3  Vav3  vav 3 guanine nucleotide exchange factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Vav3  vav 3 guanine nucleotide exchange factor  Vav3  vav 3 oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Vav3  vav 3 oncogene  RGD1565941_predicted  similar to Vav 3 oncogene (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565941_predicted  similar to Vav 3 oncogene (predicted)  LOC295378  similar to Vav 3 oncogene  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC295378  similar to Vav 3 oncogene      Symbol and Name status set to provisional 70820 PROVISIONAL