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Gene: Dhrs1 (dehydrogenase/reductase 1) Rattus norvegicus

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Symbol:

Dhrs1

Name:

dehydrogenase/reductase 1

RGD ID:

1359172

Description:

Predicted to enable carbonyl reductase (NADPH) activity. Predicted to be located in endoplasmic reticulum. Orthologous to human DHRS1 (dehydrogenase/reductase 1); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

dehydrogenase/reductase (SDR family) member 1; dehydrogenase/reductase SDR family member 1; MGC94370

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DHRS1 (dehydrogenase/reductase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Dhrs1 (dehydrogenase/reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dhrs1 (dehydrogenase/reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DHRS1 (dehydrogenase/reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DHRS1 (dehydrogenase/reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dhrs1 (dehydrogenase/reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DHRS1 (dehydrogenase/reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DHRS1 (dehydrogenase/reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dhrs1 (dehydrogenase/reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Dhrs1 (dehydrogenase/reductase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	C1QTNF7 (C1q and TNF related 7)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	DHRS1 (dehydrogenase/reductase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dhrs1 (dehydrogenase/reductase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dhrs1 (dehydrogenase/reductase (SDR family) member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F59E11.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dhs-26	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	dhs-9	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	33,206,449 - 33,213,776 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	33,206,451 - 33,213,734 (-)	Ensembl				GRCr8
mRatBN7.2	15	29,236,522 - 29,243,807 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	29,236,522 - 29,243,838 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	31,082,199 - 31,089,484 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	32,229,411 - 32,236,696 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	30,471,759 - 30,479,044 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	34,424,017 - 34,431,302 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	34,424,016 - 34,431,325 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	38,313,182 - 38,320,490 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	33,900,694 - 33,907,979 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	28,812,169 - 28,819,454 (-)	NCBI		Celera
RGSC_v3.1	15	33,916,395 - 33,923,679 (-)	NCBI
Cytogenetic Map	15	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-alpha-phellandrene (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-methylcholine (ISO)

3-chloropropane-1,2-diol (EXP)

acrylamide (ISO)

alpha-phellandrene (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

curcumin (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dibenzofurans (ISO)

dibutyl phthalate (ISO)

diuron (EXP,ISO)

ethanol (ISO)

eugenol (EXP)

folic acid (ISO)

glyphosate (ISO)

ivermectin (ISO)

leflunomide (ISO)

methylmercury chloride (ISO)

NADP zwitterion (ISO)

NADP(+) (ISO)

okadaic acid (ISO)

p-toluidine (EXP)

paracetamol (EXP,ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

resveratrol (ISO)

sodium arsenite (EXP,ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thimerosal (ISO)

thioacetamide (EXP)

trichloroethene (EXP)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

endoplasmic reticulum (IEA,ISO)

Molecular Function

carbonyl reductase (NADPH) activity (IEA,ISO)

oxidoreductase activity (IEA)

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
6.	Molecular cloning and characterization of a novel Dehydrogenase/reductase (SDR family) member 1 genea from human fetal brain.	Wu Q, etal., Mol Biol Rep 2001;28(4):193-8.

Additional References at PubMed

PMID:12865426	PMID:18614015

Genomics

Comparative Map Data

Dhrs1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	33,206,449 - 33,213,776 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	33,206,451 - 33,213,734 (-)	Ensembl				GRCr8
mRatBN7.2	15	29,236,522 - 29,243,807 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	29,236,522 - 29,243,838 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	31,082,199 - 31,089,484 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	32,229,411 - 32,236,696 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	30,471,759 - 30,479,044 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	34,424,017 - 34,431,302 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	34,424,016 - 34,431,325 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	38,313,182 - 38,320,490 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	33,900,694 - 33,907,979 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	28,812,169 - 28,819,454 (-)	NCBI		Celera
RGSC_v3.1	15	33,916,395 - 33,923,679 (-)	NCBI
Cytogenetic Map	15	p13	NCBI

DHRS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	24,290,598 - 24,299,780 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	24,290,598 - 24,300,136 (-)	Ensembl			hg38	GRCh38
GRCh37	14	24,759,804 - 24,768,986 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	23,829,646 - 23,838,506 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	14	23,829,645 - 23,838,506	NCBI
Celera	14	4,624,421 - 4,633,663 (-)	NCBI		Celera
Cytogenetic Map	14	q12	NCBI
HuRef	14	4,874,961 - 4,884,201 (-)	NCBI		HuRef
CHM1_1	14	24,758,405 - 24,767,639 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	18,488,942 - 18,498,124 (-)	NCBI		T2T-CHM13v2.0

Dhrs1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	55,976,477 - 55,983,147 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	55,976,477 - 55,983,147 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	14	55,739,020 - 55,745,684 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	55,739,020 - 55,745,690 (-)	Ensembl			mm10	GRCm38
MGSCv37	14	56,357,857 - 56,364,521 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	14	54,693,091 - 54,699,663 (-)	NCBI		MGSCv36	mm8
Celera	14	53,544,068 - 53,550,732 (-)	NCBI		Celera
Cytogenetic Map	14	C3	NCBI
cM Map	14	28.19	NCBI

Dhrs1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	36,002,576 - 36,009,513 (+)	Ensembl
ChiLan1.0	NW_004955409	36,002,576 - 36,040,595 (+)	NCBI	ChiLan1.0	ChiLan1.0

DHRS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,645,629 - 25,654,191 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	24,862,121 - 24,871,292 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	5,066,996 - 5,076,229 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,190,323 - 23,199,587 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	23,190,323 - 23,199,587 (-)	Ensembl			panPan2	panpan1.1

DHRS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,263,707 - 4,269,453 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,263,700 - 4,270,271 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	4,184,055 - 4,191,794 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,373,191 - 4,380,933 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,373,194 - 4,380,816 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	4,063,544 - 4,071,277 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	4,125,376 - 4,133,107 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,387,953 - 4,395,691 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Dhrs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	36,123,012 - 36,133,015 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936722	256,192 - 265,985 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936722	255,977 - 265,980 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DHRS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	74,992,115 - 75,002,148 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	7	74,992,120 - 75,002,154 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	80,263,079 - 80,273,096 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DHRS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	1,273,717 - 1,282,761 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	1,273,659 - 1,282,812 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666036	12,958,265 - 12,967,291 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dhrs1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624820	8,204,627 - 8,213,512 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Dhrs1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	12	69,256,369 - 69,263,782 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Dhrs1
14 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	201
Count of miRNA genes:	140
Interacting mature miRNAs:	154
Transcripts:	ENSRNOT00000027511
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	15	2315759	47315759	Rat
5684946	Bss98	Bone structure and strength QTL 98	3.9	0.0026	tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	15	1	39411584	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	44836456	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2315759	53331089	Rat
152025253	Hrtrt24	Heart rate QTL 24	3.82		heart pumping trait (VT:2000009)		15	31855803	92671517	Rat
10755503	Bp391	Blood pressure QTL 391	2.37		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	22728353	42072050	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	28527732	73527732	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	25285835	104695021	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	22336351	52597086	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	25285835	104695021	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	19155762	87086765	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	2785923	47785923	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	14926594	71614418	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	22336351	67336351	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	25285835	104695021	Rat

Markers in Region

RH130624

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	15	33,206,515 - 33,206,710 (+)	Marker Load Pipeline
mRatBN7.2	15	29,236,587 - 29,236,783 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	34,424,083 - 34,424,278	NCBI	Rnor6.0
Rnor_5.0	15	38,313,248 - 38,313,443	UniSTS	Rnor5.0
RGSC_v3.4	15	33,900,760 - 33,900,955	UniSTS	RGSC3.4
Celera	15	28,812,235 - 28,812,430	UniSTS
RH 3.4 Map	15	260.91	UniSTS
Cytogenetic Map	15	p13	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001007621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274128	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274129	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063274130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC116083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000027511 ⟹ ENSRNOP00000027511

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	33,206,451 - 33,213,734 (-)	Ensembl
mRatBN7.2 Ensembl	15	29,236,522 - 29,243,728 (-)	Ensembl
Rnor_6.0 Ensembl	15	34,424,016 - 34,431,325 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096138 ⟹ ENSRNOP00000097862

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	29,236,523 - 29,243,838 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101030 ⟹ ENSRNOP00000081174

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	33,206,709 - 33,213,734 (-)	Ensembl
mRatBN7.2 Ensembl	15	29,236,782 - 29,243,795 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116632 ⟹ ENSRNOP00000082526

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	33,206,451 - 33,213,734 (-)	Ensembl
mRatBN7.2 Ensembl	15	29,236,535 - 29,243,606 (-)	Ensembl

RefSeq Acc Id:

NM_001007621 ⟹ NP_001007622

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,206,449 - 33,213,734 (-)	NCBI
mRatBN7.2	15	29,236,522 - 29,243,807 (-)	NCBI
Rnor_6.0	15	34,424,017 - 34,431,302 (-)	NCBI
Rnor_5.0	15	38,313,182 - 38,320,490 (-)	NCBI
RGSC_v3.4	15	33,900,694 - 33,907,979 (-)	RGD
Celera	15	28,812,169 - 28,819,454 (-)	RGD

Sequence:

show sequence

GGTCGCCCTTCCCCATTTGCGGGTTCCACCCCCGGGTCTGAGCCTGCAACTCCGGGGCTAGCCT
CGACTCATCCTCACCCGCACCCGGACTTCCATCCAGGCAAGCACTCCGACGAGGCTAGAATCAA
AGTTCTCGAACTATAGAACTGGCGATCTGGGCAGAAAGAAACCCAGAGGCTGTGTCTGCTGCAG
GTAAGGCTCTGTTAACTTACAGTTCAGGGCTTCGCGGTTCTTCGTGGGACTGGACGGATAGCCA
CGGGTAGCCAGAACTCCAGAGAGCCCAGGACTCTTCGTGGACATACCCTGTTAGACTACATCGC
CAGATTCCCCATCGAATTATCCCCACTCAGAGATACCCCTTTGGTGTGAGTCATGATAATGACT
ATGAAGGGCCAAGTGTGTGTGGTAACTGGGGCCTCCAGGGGTATTGGCCGTGGCATTGCCTTAC
AGCTTTGCCAAGCAGGTGCTACAGTTTACATTACCGGCCGCCATTTGGACACCCTTAGAGCTAC
TGCCCAGGAGGCACAATCCCTCGGGGGCCGGTGTGTACCAGTGGTGTGTGATTCAAGCCAGGAG
AGTGAGGTGAAAAGCCTGTTTGAGCAAGTAGATCGGGAACAGCAGGGGCGGCTAGATGTTCTGG
TCAATAATGCCTATGCTGGTGTACAGGCAATCCTGAACACCACCACCAAGTCATTCTGGGAAGC
ACCTGCCTCCCTTTGGGATGATATAAACAATGTTGGACTCAGAGGCCACTACTTATGCTCTGTG
TATGGGGCACGGCTGATGGTACCAGCTGGCAAAGGACTTATCGTGGTTGTCTCTTCCCCCGGGG
GGCTGCAGCATATGTTCAATGTCCCTTATGGTGTGGGCAAAGCTGCGTGCGACAAACTGGCTGC
TGACTGTGCCCATGAGCTACGGCGTCATGGAGTCAGCTACGTATCTCTGTGGCCAGGCCTGGTG
CAAACAGAAATGGTGAAGGAGTATGTAGCAAAAGAGGAGCAGCCTGAAGATCCTCTGTTTAAGA
AGATGAAATCAGTTCTCTCATCGGCCGAAACTACAGAGATGAGTGGCAAGTGTGTGGTGGCCTT
GGCAACAGACCCCAATATCCTGAGCCTGAGTGGGAAGGTGCTGCCGTCCTGTGACCTTGCTCGG
CGTTACGGCCTTAAGGATGTCGATGGACGCCCTGTCCAAGACTACTTTTCTTTGGGCTATGCCC
TCTCACAAGTCTCCAGCTTGAGATGGCTGGCCTCCTACTTGCCCGGCTTCCTCCGTGTACCTAA
GTGGATCGTCACCCTCTACACCAGCAAATTCTAACCTCCTGACCTGATATCCCAGCCCTTCCAG
AACCTCATCTCACTGAGGCTCAGGTGGGTGGGGCTCTTGGGAAACAAACCACTTTCCCACATCC
CATGTCCTCACCATGAAGAGAAGGTGGCTGCTGGGCATCTAGTGCATCTTGGGGGTTCTGGTAG
GTTCTTGGTGCCTTGGTGTTCCCTGTCCCTACATCTTAATAGCTTGCTTGAGTCATAAGTGGTT
ATAAGTAGAAGTTAATAAAAGTCTCATCTCCCCTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AA

hide sequence

RefSeq Acc Id:

XM_039093132 ⟹ XP_038949060

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,206,449 - 33,213,523 (-)	NCBI
mRatBN7.2	15	29,236,522 - 29,243,801 (-)	NCBI

RefSeq Acc Id:

XM_039093133 ⟹ XP_038949061

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,206,449 - 33,213,523 (-)	NCBI
mRatBN7.2	15	29,236,522 - 29,243,775 (-)	NCBI

RefSeq Acc Id:

XM_039093134 ⟹ XP_038949062

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,208,094 - 33,213,148 (-)	NCBI
mRatBN7.2	15	29,238,167 - 29,243,801 (-)	NCBI

RefSeq Acc Id:

XM_063274127 ⟹ XP_063130197

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,206,449 - 33,213,776 (-)	NCBI

RefSeq Acc Id:

XM_063274128 ⟹ XP_063130198

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,206,449 - 33,213,761 (-)	NCBI

RefSeq Acc Id:

XM_063274129 ⟹ XP_063130199

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,206,449 - 33,213,679 (-)	NCBI

RefSeq Acc Id:

XM_063274130 ⟹ XP_063130200

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	33,206,449 - 33,213,679 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001007622	(Get FASTA)	NCBI Sequence Viewer
	XP_038949060	(Get FASTA)	NCBI Sequence Viewer
	XP_038949061	(Get FASTA)	NCBI Sequence Viewer
	XP_038949062	(Get FASTA)	NCBI Sequence Viewer
	XP_063130197	(Get FASTA)	NCBI Sequence Viewer
	XP_063130198	(Get FASTA)	NCBI Sequence Viewer
	XP_063130199	(Get FASTA)	NCBI Sequence Viewer
	XP_063130200	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79263	(Get FASTA)	NCBI Sequence Viewer
	EDM14274	(Get FASTA)	NCBI Sequence Viewer
	EDM14275	(Get FASTA)	NCBI Sequence Viewer
	EDM14276	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000027511
	ENSRNOP00000027511.3
	ENSRNOP00000081174.1
	ENSRNOP00000082526.1

RefSeq Acc Id:

NP_001007622 ⟸ NM_001007621

- UniProtKB:

Q6AXY8 (UniProtKB/TrEMBL), F7F1T8 (UniProtKB/TrEMBL), A0A8I5ZRF1 (UniProtKB/TrEMBL), A0A8I5ZVF5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MIMTMKGQVCVVTGASRGIGRGIALQLCQAGATVYITGRHLDTLRATAQEAQSLGGRCVPVVCD
SSQESEVKSLFEQVDREQQGRLDVLVNNAYAGVQAILNTTTKSFWEAPASLWDDINNVGLRGHY
LCSVYGARLMVPAGKGLIVVVSSPGGLQHMFNVPYGVGKAACDKLAADCAHELRRHGVSYVSLW
PGLVQTEMVKEYVAKEEQPEDPLFKKMKSVLSSAETTEMSGKCVVALATDPNILSLSGKVLPSC
DLARRYGLKDVDGRPVQDYFSLGYALSQVSSLRWLASYLPGFLRVPKWIVTLYTSKF

hide sequence

Ensembl Acc Id:

ENSRNOP00000027511 ⟸ ENSRNOT00000027511

RefSeq Acc Id:	XP_038949060 ⟸ XM_039093132
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZRF1 (UniProtKB/TrEMBL), A0A8I5ZVF5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038949061 ⟸ XM_039093133
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038949062 ⟸ XM_039093134
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSRNOP00000097862 ⟸ ENSRNOT00000096138

Ensembl Acc Id:

ENSRNOP00000082526 ⟸ ENSRNOT00000116632

Ensembl Acc Id:

ENSRNOP00000081174 ⟸ ENSRNOT00000101030

RefSeq Acc Id:	XP_063130197 ⟸ XM_063274127
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZRF1 (UniProtKB/TrEMBL), A0A8I5ZVF5 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063130198 ⟸ XM_063274128
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063130200 ⟸ XM_063274130
- Peptide Label:	isoform X5

RefSeq Acc Id:	XP_063130199 ⟸ XM_063274129
- Peptide Label:	isoform X4

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AXY8-F1-model_v2	AlphaFold	Q6AXY8	1-313	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699688

Promoter ID:

EPDNEW_R10210

Type:

initiation region

Name:

Dhrs1_1

Description:

dehydrogenase/reductase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	34,431,226 - 34,431,286	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359172	AgrOrtholog
BioCyc Gene	G2FUF-13693	BioCyc
Ensembl Genes	ENSRNOG00000020264	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000027511	ENTREZGENE
	ENSRNOT00000027511.7	UniProtKB/TrEMBL
	ENSRNOT00000101030.2	UniProtKB/TrEMBL
	ENSRNOT00000116632.2	UniProtKB/TrEMBL
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7133513	IMAGE-MGC_LOAD
InterPro	Glc/ribitol_DH	UniProtKB/TrEMBL
	NAD(P)-bd_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:290234	UniProtKB/TrEMBL
MGC_CLONE	MGC:94370	IMAGE-MGC_LOAD
NCBI Gene	290234	ENTREZGENE
PANTHER	DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1	UniProtKB/TrEMBL
	DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1	UniProtKB/TrEMBL
Pfam	adh_short	UniProtKB/TrEMBL
PhenoGen	Dhrs1	PhenoGen
PRINTS	GDHRDH	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020264	RatGTEx
Superfamily-SCOP	SSF51735	UniProtKB/TrEMBL
UniProt	A0A8I5ZRF1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZVF5	ENTREZGENE, UniProtKB/TrEMBL
	A6KH46_RAT	UniProtKB/TrEMBL
	A6KH47_RAT	UniProtKB/TrEMBL
	F7F1T8	ENTREZGENE, UniProtKB/TrEMBL
	Q6AXY8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-01	Dhrs1	dehydrogenase/reductase 1	Dhrs1	dehydrogenase/reductase (SDR family) member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Dhrs1	dehydrogenase/reductase (SDR family) member 1	MGC94370		Symbol updated	1299863	APPROVED
2005-07-29	MGC94370	dehydrogenase/reductase (SDR family) member 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD