DHRS1 (dehydrogenase/reductase 1) - Rat Genome Database

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Gene: DHRS1 (dehydrogenase/reductase 1) Canis lupus familiaris
Analyze
Symbol: DHRS1
Name: dehydrogenase/reductase 1
RGD ID: 12185794
Description: ENCODES a protein that exhibits carbonyl reductase (NADPH) activity (inferred); oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); Brain-Lung-Thyroid Syndrome (ortholog); lysinuric protein intolerance (ortholog); FOUND IN endoplasmic reticulum (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dehydrogenase/reductase SDR family member 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,263,707 - 4,269,453 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,263,700 - 4,270,271 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,184,055 - 4,191,794 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,373,191 - 4,380,933 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,373,194 - 4,380,816 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,063,544 - 4,071,277 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,125,376 - 4,133,107 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,387,953 - 4,395,691 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
DHRS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,263,707 - 4,269,453 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,263,700 - 4,270,271 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,184,055 - 4,191,794 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,373,191 - 4,380,933 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,373,194 - 4,380,816 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,063,544 - 4,071,277 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,125,376 - 4,133,107 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,387,953 - 4,395,691 (-)NCBIUU_Cfam_GSD_1.0
DHRS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,290,598 - 24,299,780 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,290,598 - 24,299,780 (-)EnsemblGRCh38hg38GRCh38
GRCh371424,759,804 - 24,768,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,829,646 - 23,838,506 (-)NCBINCBI36Build 36hg18NCBI36
Build 341423,829,645 - 23,838,506NCBI
Celera144,624,421 - 4,633,663 (-)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,874,961 - 4,884,201 (-)NCBIHuRef
CHM1_11424,758,405 - 24,767,639 (-)NCBICHM1_1
T2T-CHM13v2.01418,488,942 - 18,498,124 (-)NCBIT2T-CHM13v2.0
Dhrs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391455,976,477 - 55,983,147 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1455,976,477 - 55,983,147 (-)EnsemblGRCm39 Ensembl
GRCm381455,739,020 - 55,745,684 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,739,020 - 55,745,690 (-)EnsemblGRCm38mm10GRCm38
MGSCv371456,357,857 - 56,364,521 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,693,091 - 54,699,663 (-)NCBIMGSCv36mm8
Celera1453,544,068 - 53,550,732 (-)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Dhrs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,206,449 - 33,213,776 (-)NCBIGRCr8
mRatBN7.21529,236,522 - 29,243,807 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,236,522 - 29,243,838 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,082,199 - 31,089,484 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,229,411 - 32,236,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,471,759 - 30,479,044 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,424,017 - 34,431,302 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,424,016 - 34,431,325 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,313,182 - 38,320,490 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,900,694 - 33,907,979 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,916,395 - 33,923,679 (-)NCBI
Celera1528,812,169 - 28,819,454 (-)NCBICelera
Cytogenetic Map15p13NCBI
Dhrs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540936,002,576 - 36,009,513 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540936,002,576 - 36,040,595 (+)NCBIChiLan1.0ChiLan1.0
DHRS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,645,629 - 25,654,191 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,862,121 - 24,871,292 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,066,996 - 5,076,229 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,190,323 - 23,199,587 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,190,323 - 23,199,587 (-)Ensemblpanpan1.1panPan2
Dhrs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,123,012 - 36,133,015 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722256,192 - 265,985 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722255,977 - 265,980 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHRS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,992,115 - 75,002,148 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1774,992,120 - 75,002,154 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,263,079 - 80,273,096 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DHRS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,273,717 - 1,282,761 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,273,659 - 1,282,812 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603612,958,265 - 12,967,291 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhrs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248208,204,627 - 8,213,512 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DHRS1
53 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 22 6 6 6 6 10 8 10 6
Low 5 6 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022421852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038482877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038482878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038544311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038544312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038584210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038608428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038608429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038673239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038673240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005329201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005363070 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005384350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005397541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005430821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000043307   ⟹   ENSCAFP00000041724
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,263,700 - 4,269,431 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000081431   ⟹   ENSCAFP00000049468
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl84,263,700 - 4,270,271 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845011981   ⟹   ENSCAFP00845009349
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl84,373,194 - 4,380,816 (-)Ensembl
RefSeq Acc Id: XM_022421852   ⟹   XP_022277560
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.184,263,707 - 4,269,453 (-)NCBI
Dog10K_Boxer_Tasha84,185,374 - 4,191,794 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038482877   ⟹   XP_038338805
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.184,064,863 - 4,071,277 (-)NCBI
RefSeq Acc Id: XM_038482878   ⟹   XP_038338806
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.184,063,544 - 4,071,277 (-)NCBI
RefSeq Acc Id: XM_038544311   ⟹   XP_038400239
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.084,389,272 - 4,395,691 (-)NCBI
RefSeq Acc Id: XM_038544312   ⟹   XP_038400240
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.084,387,953 - 4,395,691 (-)NCBI
RefSeq Acc Id: XM_038584210   ⟹   XP_038440138
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha84,184,055 - 4,191,794 (-)NCBI
RefSeq Acc Id: XM_038608428   ⟹   XP_038464356
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.084,126,695 - 4,133,107 (-)NCBI
RefSeq Acc Id: XM_038608429   ⟹   XP_038464357
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.084,125,376 - 4,133,107 (-)NCBI
RefSeq Acc Id: XM_038673239   ⟹   XP_038529167
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.084,374,510 - 4,380,933 (-)NCBI
RefSeq Acc Id: XM_038673240   ⟹   XP_038529168
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.084,373,191 - 4,380,933 (-)NCBI
RefSeq Acc Id: XR_005329201
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.184,063,544 - 4,071,277 (-)NCBI
RefSeq Acc Id: XR_005363070
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.084,387,953 - 4,395,691 (-)NCBI
RefSeq Acc Id: XR_005384350
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha84,184,055 - 4,191,794 (-)NCBI
RefSeq Acc Id: XR_005397541
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.084,125,376 - 4,133,107 (-)NCBI
RefSeq Acc Id: XR_005430821
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.084,373,191 - 4,380,933 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_022277560   ⟸   XM_022421852
- UniProtKB: A0A8I3MTA9 (UniProtKB/TrEMBL),   A0A8P0SVD5 (UniProtKB/TrEMBL),   A0A8C0QGC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000041724   ⟸   ENSCAFT00000043307
RefSeq Acc Id: ENSCAFP00000049468   ⟸   ENSCAFT00000081431
RefSeq Acc Id: XP_038338806   ⟸   XM_038482878
RefSeq Acc Id: XP_038338805   ⟸   XM_038482877
RefSeq Acc Id: XP_038464357   ⟸   XM_038608429
RefSeq Acc Id: XP_038464356   ⟸   XM_038608428
RefSeq Acc Id: XP_038529168   ⟸   XM_038673240
- UniProtKB: A0A8I3MTA9 (UniProtKB/TrEMBL),   A0A8P0SVD5 (UniProtKB/TrEMBL),   A0A8C0QGC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038529167   ⟸   XM_038673239
- UniProtKB: A0A8I3MTA9 (UniProtKB/TrEMBL),   A0A8P0SVD5 (UniProtKB/TrEMBL),   A0A8C0QGC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038440138   ⟸   XM_038584210
- UniProtKB: A0A8I3MTA9 (UniProtKB/TrEMBL),   A0A8P0SVD5 (UniProtKB/TrEMBL),   A0A8C0QGC6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400240   ⟸   XM_038544312
- UniProtKB: A0A8C0QGC6 (UniProtKB/TrEMBL),   A0A8I3MTA9 (UniProtKB/TrEMBL),   A0A8P0SVD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038400239   ⟸   XM_038544311
- UniProtKB: A0A8C0QGC6 (UniProtKB/TrEMBL),   A0A8I3MTA9 (UniProtKB/TrEMBL),   A0A8P0SVD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845009349   ⟸   ENSCAFT00845011981


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000032262 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013794 UniProtKB/TrEMBL
  ENSCAFG00040004113 UniProtKB/TrEMBL
  ENSCAFG00845006762 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000043307.3 UniProtKB/TrEMBL
  ENSCAFT00030025540.1 UniProtKB/TrEMBL
  ENSCAFT00040007863.1 UniProtKB/TrEMBL
  ENSCAFT00845011981 ENTREZGENE
  ENSCAFT00845011981.1 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  SDR_fam UniProtKB/TrEMBL
NCBI Gene DHRS1 ENTREZGENE
PANTHER DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1 UniProtKB/TrEMBL
  DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 1 UniProtKB/TrEMBL
Pfam adh_short UniProtKB/TrEMBL
PRINTS GDHRDH UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
UniProt A0A8C0QGC6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MTA9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SVD5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:56058 ENTREZGENE