Or2l5 (olfactory receptor family 2 subfamily L member 5) - Rat Genome Database

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Gene: Or2l5 (olfactory receptor family 2 subfamily L member 5) Rattus norvegicus
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Symbol: Or2l5
Name: olfactory receptor family 2 subfamily L member 5
RGD ID: 1334380
Description: Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including OR2L2 (olfactory receptor family 2 subfamily L member 2); INTERACTS WITH bisphenol A; benzo[a]pyrene (ortholog); paracetamol (ortholog).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: LOC100911043; olfactory receptor 1568; olfactory receptor 2L3-like; olfactory receptor 2L8-like; olfactory receptor gene Olr1568; olfactory receptor Olr1568; Olr1568
RGD Orthologs
Human
Bonobo
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81194,880,257 - 94,881,195 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1194,880,257 - 94,881,195 (+)EnsemblGRCr8
mRatBN7.21181,375,886 - 81,376,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,368,820 - 81,382,532 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1190,113,769 - 90,114,707 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01182,774,965 - 82,775,903 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,828,252 - 81,829,190 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01185,288,783 - 85,289,721 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1185,030,872 - 85,031,810 (+)Ensemblrn6Rnor6.0
Rnor_5.01188,346,276 - 88,347,214 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41183,643,287 - 83,644,225 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,206,724 - 80,207,662 (+)NCBICelera
RGSC_v3.11183,701,207 - 83,702,146 (+)NCBI
Cytogenetic Map11q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, etal., Nature 2004 Apr 1;428(6982):493-521.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Or2l5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81194,880,257 - 94,881,195 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1194,880,257 - 94,881,195 (+)EnsemblGRCr8
mRatBN7.21181,375,886 - 81,376,824 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1181,368,820 - 81,382,532 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1190,113,769 - 90,114,707 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01182,774,965 - 82,775,903 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01181,828,252 - 81,829,190 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01185,288,783 - 85,289,721 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1185,030,872 - 85,031,810 (+)Ensemblrn6Rnor6.0
Rnor_5.01188,346,276 - 88,347,214 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41183,643,287 - 83,644,225 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,206,724 - 80,207,662 (+)NCBICelera
RGSC_v3.11183,701,207 - 83,702,146 (+)NCBI
Cytogenetic Map11q23NCBI
OR2L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381248,030,070 - 248,042,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1248,030,070 - 248,042,305 (+)Ensemblhg38GRCh38
GRCh371248,193,372 - 248,205,607 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,268,097 - 246,269,230 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341244,527,610 - 244,528,549NCBI
Celera1221,486,878 - 221,488,011 (+)NCBICelera
Cytogenetic Map1q44NCBI
HuRef1218,585,191 - 218,586,324 (+)NCBIHuRef
CHM1_11249,473,811 - 249,474,944 (+)NCBICHM1_1
T2T-CHM13v2.01247,456,121 - 247,468,355 (+)NCBIT2T-CHM13v2.0
LOC100976999
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21997,113 - 1,004,546 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111,273,292 - 1,280,721 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01223,683,642 - 223,684,959 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11229,129,871 - 229,130,808 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1229,129,871 - 229,130,808 (+)EnsemblpanPan2panpan1.1
OR2L3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1141,341,098 - 1,342,036 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl141,341,098 - 1,342,036 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha14980,716 - 981,654 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0141,061,981 - 1,062,919 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl141,061,981 - 1,062,919 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1141,271,442 - 1,272,380 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0141,033,195 - 1,034,133 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0141,021,451 - 1,022,389 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:12
Interacting mature miRNAs:12
Transcripts:ENSRNOT00000072275, ENSRNOT00000074815
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)117330848796070872Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)119046178196556255Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)118295102896351019Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)115827236396350770Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
renal system
reproductive system
2 1 1 1 5 1 18 7 2 10 5

Sequence


Ensembl Acc Id: ENSRNOT00000074815   ⟹   ENSRNOP00000066133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1185,030,872 - 85,031,810 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113240   ⟹   ENSRNOP00000086941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1181,368,820 - 81,382,532 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000122569   ⟹   ENSRNOP00000100290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1194,880,257 - 94,881,195 (+)Ensembl
RefSeq Acc Id: NM_001000532   ⟹   NP_001000532
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81194,880,257 - 94,881,195 (+)NCBI
mRatBN7.21181,375,886 - 81,376,824 (+)NCBI
Rnor_6.01185,288,783 - 85,289,721 (+)NCBI
Rnor_5.01188,346,276 - 88,347,214 (+)NCBI
RGSC_v3.41183,643,287 - 83,644,225 (+)RGD
Celera1180,206,724 - 80,207,662 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001000532 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77977 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000100290
  ENSRNOP00000100290.1
RefSeq Acc Id: NP_001000532   ⟸   NM_001000532
- UniProtKB: D3ZSQ8 (UniProtKB/TrEMBL),   A6JSD0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066133   ⟸   ENSRNOT00000074815
Ensembl Acc Id: ENSRNOP00000086941   ⟸   ENSRNOT00000113240
Ensembl Acc Id: ENSRNOP00000100290   ⟸   ENSRNOT00000122569
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZSQ8-F1-model_v2 AlphaFold D3ZSQ8 1-312 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1334380 AgrOrtholog
BioCyc Gene G2FUF-20692 BioCyc
Ensembl Genes ENSRNOG00000046589 Ensembl
  ENSRNOG00000062641 Ensembl
  ENSRNOG00000081703 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000122569 ENTREZGENE
  ENSRNOT00000122569.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Olfact_rcpt UniProtKB/TrEMBL
KEGG Report rno:363826 UniProtKB/TrEMBL
NCBI Gene 363826 ENTREZGENE
PANTHER OLFACTORY RECEPTOR UniProtKB/TrEMBL
Pfam 7tm_4 UniProtKB/TrEMBL
PhenoGen Or2l5 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  OLFACTORYR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046589 RatGTEx
  ENSRNOG00000062641 RatGTEx
  ENSRNOG00000081703 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0ABK0LG58_RAT UniProtKB/TrEMBL
  A6JSD0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZSQ8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-08-16 Or2l5  olfactory receptor family 2 subfamily L member 5  Olr1568  olfactory receptor 1568  Symbol and Name Changed 1299863 APPROVED
2021-03-09 Olr1568  olfactory receptor 1568  LOC100911043  olfactory receptor 2L3-like  Data merged from RGD:6495384 737654 PROVISIONAL
2012-07-05 LOC100911043  olfactory receptor 2L3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Olr1568  olfactory receptor 1568   Olr1568_predicted  olfactory receptor 1568 (predicted)  'predicted' is removed 2292626 APPROVED
2005-02-04 Olr1568_predicted  olfactory receptor 1568 (predicted)      Symbol and Name status set to approved 70820 APPROVED