Nck1 (NCK adaptor protein 1) - Rat Genome Database

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Gene: Nck1 (NCK adaptor protein 1) Rattus norvegicus
Analyze
Symbol: Nck1
Name: NCK adaptor protein 1
RGD ID: 1310688
Description: Enables eukaryotic initiation factor eIF2 binding activity. Predicted to be involved in several processes, including antiviral innate immune response; regulation of gene expression; and regulation of signal transduction. Predicted to act upstream of or within several processes, including T cell receptor signaling pathway; plasma membrane bounded cell projection assembly; and positive regulation of cellular component organization. Predicted to be located in several cellular components, including cell-cell junction; endoplasmic reticulum; and ribosome. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in cytoplasm. Orthologous to human NCK1 (NCK adaptor protein 1); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cytoplasmic protein NCK1; LOC300955; non-catalytic region of tyrosine kinase adaptor protein 1; SH2/SH3 adapter protein NCK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88109,897,723 - 109,958,247 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8109,897,724 - 109,958,247 (-)EnsemblGRCr8
mRatBN7.28101,018,610 - 101,079,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8101,018,702 - 101,079,300 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8106,689,323 - 106,743,736 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08104,888,640 - 104,943,070 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08102,731,183 - 102,785,617 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08108,787,797 - 108,847,779 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8108,787,798 - 108,847,779 (-)Ensemblrn6Rnor6.0
Rnor_5.08108,204,372 - 108,264,127 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48105,346,933 - 105,409,843 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8100,416,045 - 100,476,576 (-)NCBICelera
RGSC_v3.18105,365,785 - 105,380,767 (-)NCBI
Cytogenetic Map8q31NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IEA,ISO)
antiviral innate immune response  (IEA,ISO)
cell migration  (IBA,ISO)
ephrin receptor signaling pathway  (IBA,IEA,ISO)
lamellipodium assembly  (IEA,ISO)
negative regulation of insulin receptor signaling pathway  (IEA,ISO)
negative regulation of PERK-mediated unfolded protein response  (IBA,IEA,ISO)
negative regulation of T cell receptor signaling pathway  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of actin filament polymerization  (IEA,ISO)
positive regulation of cap-dependent translational initiation  (IEA,ISO)
positive regulation of cap-independent translational initiation  (IEA,ISO)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IBA,IEA,ISO)
positive regulation of intracellular signal transduction  (IEA)
positive regulation of neuron projection development  (ISO)
positive regulation of T cell proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of translation in response to endoplasmic reticulum stress  (IBA,IEA,ISO)
regulation of cell migration  (ISO)
regulation of transcription by RNA polymerase II  (IEA)
regulation of translation  (IEA)
regulation of translation initiation in response to endoplasmic reticulum stress  (IEA,ISO)
response to endoplasmic reticulum stress  (IEA,ISO)
response to other organism  (ISO)
substrate-dependent cell migration, cell extension  (ISO)
T cell activation  (IEA,ISO)

Cellular Component
cell-cell junction  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO)
protein phosphatase type 1 complex  (IEA,ISO)
ribosome  (IEA,ISO)
vesicle membrane  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Holmes K, etal., Cell Signal. 2007 Oct;19(10):2003-12. Epub 2007 Jun 12.
4. Modulation of protein translation by Nck-1. Kebache S, etal., Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5406-11.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8438166   PMID:10026169   PMID:11489946   PMID:12110186   PMID:12147689   PMID:12477932   PMID:12637565   PMID:12808099   PMID:14676213   PMID:16835242   PMID:16934223   PMID:17923684  
PMID:18835251   PMID:19414610   PMID:19443634   PMID:19505147   PMID:21707536   PMID:22966049   PMID:23358419   PMID:23793062   PMID:25468996  


Genomics

Comparative Map Data
Nck1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88109,897,723 - 109,958,247 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8109,897,724 - 109,958,247 (-)EnsemblGRCr8
mRatBN7.28101,018,610 - 101,079,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8101,018,702 - 101,079,300 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8106,689,323 - 106,743,736 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08104,888,640 - 104,943,070 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08102,731,183 - 102,785,617 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08108,787,797 - 108,847,779 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8108,787,798 - 108,847,779 (-)Ensemblrn6Rnor6.0
Rnor_5.08108,204,372 - 108,264,127 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48105,346,933 - 105,409,843 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8100,416,045 - 100,476,576 (-)NCBICelera
RGSC_v3.18105,365,785 - 105,380,767 (-)NCBI
Cytogenetic Map8q31NCBI
NCK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383136,862,208 - 136,951,606 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3136,862,177 - 136,951,606 (+)Ensemblhg38GRCh38
GRCh373136,581,050 - 136,670,448 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363138,063,763 - 138,150,658 (+)NCBIBuild 36Build 36hg18NCBI36
Build 343138,063,770 - 138,150,665NCBI
Celera3135,007,352 - 135,094,246 (+)NCBICelera
Cytogenetic Map3q22.3NCBI
HuRef3133,957,144 - 134,043,755 (+)NCBIHuRef
CHM1_13136,544,712 - 136,631,607 (+)NCBICHM1_1
T2T-CHM13v2.03139,602,861 - 139,692,274 (+)NCBIT2T-CHM13v2.0
Nck1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399100,376,047 - 100,428,187 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9100,374,346 - 100,428,187 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389100,494,302 - 100,546,134 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9100,492,293 - 100,546,134 (-)Ensemblmm10GRCm38
MGSCv379100,395,422 - 100,446,472 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369100,304,355 - 100,355,405 (-)NCBIMGSCv36mm8
Celera9100,033,773 - 100,084,727 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
cM Map952.69NCBI
Nck1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555011,874,449 - 1,901,223 (-)Ensembl
ChiLan1.0NW_0049555011,867,956 - 1,963,091 (-)NCBIChiLan1.0ChiLan1.0
NCK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22134,779,250 - 134,866,238 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13134,783,966 - 134,872,031 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03133,902,463 - 133,990,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13141,362,407 - 141,451,444 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3141,427,870 - 141,451,444 (+)EnsemblpanPan2panpan1.1
NCK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12333,297,660 - 33,374,025 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2333,297,756 - 33,372,534 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2333,281,832 - 33,358,413 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02333,827,357 - 33,903,748 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2333,827,416 - 33,905,987 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12333,509,571 - 33,586,142 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02333,575,236 - 33,651,579 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02333,819,866 - 33,896,593 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nck1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560272,886,653 - 72,961,283 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365299,701,530 - 9,721,869 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365299,647,161 - 9,718,512 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1377,863,701 - 77,945,468 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11377,863,655 - 77,940,944 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21385,560,199 - 85,580,490 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NCK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11553,501,152 - 53,595,500 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1553,500,623 - 53,523,576 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604126,543,119 - 26,636,848 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nck1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473013,226,315 - 13,366,661 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473013,271,575 - 13,366,930 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nck1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1891,795,481 - 91,854,741 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nck1
303 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:330
Count of miRNA genes:186
Interacting mature miRNAs:208
Transcripts:ENSRNOT00000020330
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020330   ⟹   ENSRNOP00000020330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8109,897,724 - 109,958,247 (-)Ensembl
mRatBN7.2 Ensembl8101,018,702 - 101,079,242 (-)Ensembl
Rnor_6.0 Ensembl8108,787,798 - 108,847,779 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091593   ⟹   ENSRNOP00000069028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8109,897,724 - 109,914,022 (-)Ensembl
mRatBN7.2 Ensembl8101,018,702 - 101,079,300 (-)Ensembl
Rnor_6.0 Ensembl8108,788,284 - 108,801,570 (-)Ensembl
RefSeq Acc Id: NM_001106851   ⟹   NP_001100321
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88109,897,723 - 109,958,247 (-)NCBI
mRatBN7.28101,018,702 - 101,079,237 (-)NCBI
Rnor_6.08108,787,797 - 108,847,779 (-)NCBI
Rnor_5.08108,204,372 - 108,264,127 (-)NCBI
RGSC_v3.48105,346,933 - 105,409,843 (-)RGD
Celera8100,416,045 - 100,476,576 (-)RGD
Sequence:
RefSeq Acc Id: XM_039081189   ⟹   XP_038937117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88109,897,723 - 109,958,087 (-)NCBI
mRatBN7.28101,018,610 - 101,079,101 (-)NCBI
RefSeq Acc Id: XM_039081190   ⟹   XP_038937118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88109,897,723 - 109,913,740 (-)NCBI
mRatBN7.28101,018,610 - 101,034,719 (-)NCBI
RefSeq Acc Id: XM_063265225   ⟹   XP_063121295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88109,897,723 - 109,957,904 (-)NCBI
RefSeq Acc Id: XM_063265226   ⟹   XP_063121296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88109,897,723 - 109,957,904 (-)NCBI
RefSeq Acc Id: NP_001100321   ⟸   NM_001106851
- UniProtKB: B2RZ33 (UniProtKB/TrEMBL),   G3V7X3 (UniProtKB/TrEMBL),   A0A9K3Y859 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020330   ⟸   ENSRNOT00000020330
Ensembl Acc Id: ENSRNOP00000069028   ⟸   ENSRNOT00000091593
RefSeq Acc Id: XP_038937117   ⟸   XM_039081189
- Peptide Label: isoform X1
- UniProtKB: G3V7X3 (UniProtKB/TrEMBL),   B2RZ33 (UniProtKB/TrEMBL),   A0A9K3Y859 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038937118   ⟸   XM_039081190
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JUA7 (UniProtKB/TrEMBL),   A6I2F5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121296   ⟸   XM_063265226
- Peptide Label: isoform X1
- UniProtKB: A0A9K3Y859 (UniProtKB/TrEMBL),   B2RZ33 (UniProtKB/TrEMBL),   G3V7X3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121295   ⟸   XM_063265225
- Peptide Label: isoform X1
- UniProtKB: A0A9K3Y859 (UniProtKB/TrEMBL),   B2RZ33 (UniProtKB/TrEMBL),   G3V7X3 (UniProtKB/TrEMBL)
Protein Domains
SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JUA7-F1-model_v2 AlphaFold A0A0G2JUA7 1-374 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696217
Promoter ID:EPDNEW_R6742
Type:initiation region
Name:Nck1_1
Description:NCK adaptor protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08108,847,777 - 108,847,837EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310688 AgrOrtholog
BioCyc Gene G2FUF-29373 BioCyc
Ensembl Genes ENSRNOG00000014917 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020330 ENTREZGENE
  ENSRNOT00000020330.9 UniProtKB/TrEMBL
  ENSRNOT00000091593 ENTREZGENE
  ENSRNOT00000091593.3 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9034703 IMAGE-MGC_LOAD
InterPro Cytoplasmic_NCK UniProtKB/TrEMBL
  Nck1_SH2 UniProtKB/TrEMBL
  Nck1_SH3_1 UniProtKB/TrEMBL
  Nck1_SH3_2 UniProtKB/TrEMBL
  Nck1_SH3_3 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyrosine-phos_adapter UniProtKB/TrEMBL
KEGG Report rno:300955 UniProtKB/TrEMBL
MGC_CLONE MGC:189191 IMAGE-MGC_LOAD
NCBI Gene 300955 ENTREZGENE
PANTHER PTHR19969:SF16 UniProtKB/TrEMBL
  SH2-SH3 ADAPTOR PROTEIN-RELATED UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Nck1 PhenoGen
PIRSF Cytoplasmic_NCK UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014917 RatGTEx
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SH3 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A0G2JUA7 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y859 ENTREZGENE, UniProtKB/TrEMBL
  A6I2F5 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ33 ENTREZGENE, UniProtKB/TrEMBL
  G3V7X3 ENTREZGENE
UniProt Secondary G3V7X3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Nck1  NCK adaptor protein 1  Nck1  non-catalytic region of tyrosine kinase adaptor protein 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Nck1  non-catalytic region of tyrosine kinase adaptor protein 1   Nck1_predicted  non-catalytic region of tyrosine kinase adaptor protein 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Nck1_predicted  non-catalytic region of tyrosine kinase adaptor protein 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED