Serpinb1a (serpin family B member 1A) - Rat Genome Database

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Gene: Serpinb1a (serpin family B member 1A) Rattus norvegicus
Analyze
Symbol: Serpinb1a
Name: serpin family B member 1A
RGD ID: 1306203
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cell migration; negative regulation of interleukin-1 beta production; and type B pancreatic cell proliferation. Predicted to act upstream of or within regulation of protein catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human SERPINB1 (serpin family B member 1); PARTICIPATES IN Entamoebiasis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leukocyte elastase inhibitor A; LOC291091; MGC112650; serine (or cysteine) proteinase inhibitor, clade B, member 1a; serine protease inhibitor EIA; serpin B1a; serpin family B member 1; Serpinb1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,799,446 - 31,807,853 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1731,799,415 - 31,808,166 (+)EnsemblGRCr8
mRatBN7.21731,590,695 - 31,599,102 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1731,590,677 - 31,599,102 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1731,425,819 - 31,434,247 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01733,029,593 - 33,038,021 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01731,421,586 - 31,430,014 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,903,089 - 32,911,498 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,904,119 - 32,911,495 (+)Ensemblrn6Rnor6.0
Rnor_5.01734,795,295 - 34,803,704 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41737,950,875 - 37,959,284 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1731,153,059 - 31,161,466 (+)NCBICelera
RGSC_v3.11737,905,219 - 37,962,230 (+)NCBI
Cytogenetic Map17p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-(N,N-hexamethylene)amiloride  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chlordecone  (ISO)
chromium atom  (ISO)
chrysene  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (EXP,ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
flavone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP,ISO)
furfural  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
ketoconazole  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
morphine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
nitrates  (ISO)
nitrofen  (EXP)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phytoestrogen  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinoline  (ISO)
resveratrol  (EXP)
rifampicin  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP)
Soman  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
topotecan  (EXP,ISO)
triamcinolone acetonide  (EXP,ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12189154   PMID:12477932   PMID:16502470   PMID:17664292   PMID:19056867   PMID:19946888   PMID:20551380   PMID:21683252   PMID:22344266   PMID:22664934   PMID:23376485   PMID:23533145  
PMID:23580065   PMID:24899316   PMID:26701651   PMID:27068509   PMID:27559042   PMID:30692621   PMID:35291946  


Genomics

Comparative Map Data
Serpinb1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81731,799,446 - 31,807,853 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1731,799,415 - 31,808,166 (+)EnsemblGRCr8
mRatBN7.21731,590,695 - 31,599,102 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1731,590,677 - 31,599,102 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1731,425,819 - 31,434,247 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01733,029,593 - 33,038,021 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01731,421,586 - 31,430,014 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01732,903,089 - 32,911,498 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1732,904,119 - 32,911,495 (+)Ensemblrn6Rnor6.0
Rnor_5.01734,795,295 - 34,803,704 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41737,950,875 - 37,959,284 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1731,153,059 - 31,161,466 (+)NCBICelera
RGSC_v3.11737,905,219 - 37,962,230 (+)NCBI
Cytogenetic Map17p12NCBI
SERPINB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3862,832,332 - 2,841,863 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl62,832,332 - 2,842,001 (-)Ensemblhg38GRCh38
GRCh3762,832,566 - 2,842,097 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3662,778,732 - 2,787,080 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3462,778,734 - 2,787,080NCBI
Celera64,062,686 - 4,071,034 (-)NCBICelera
Cytogenetic Map6p25.2NCBI
HuRef62,705,973 - 2,715,695 (-)NCBIHuRef
CHM1_162,835,084 - 2,844,765 (-)NCBICHM1_1
T2T-CHM13v2.062,698,484 - 2,708,154 (-)NCBIT2T-CHM13v2.0
Serpinb1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391333,026,075 - 33,037,189 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1333,026,075 - 33,035,168 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381332,842,092 - 32,853,206 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1332,842,092 - 32,851,185 (-)Ensemblmm10GRCm38
MGSCv371332,933,961 - 32,943,054 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361332,849,591 - 32,858,650 (-)NCBIMGSCv36mm8
Celera1333,052,332 - 33,062,299 (-)NCBICelera
Cytogenetic Map13A3.2NCBI
cM Map1313.75NCBI
Serpinb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546510,541,485 - 10,550,290 (+)Ensembl
ChiLan1.0NW_00495546510,541,562 - 10,551,417 (+)NCBIChiLan1.0ChiLan1.0
SERPINB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2517,458,189 - 17,467,186 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1613,437,056 - 13,459,495 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v062,655,244 - 2,664,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.162,758,173 - 2,766,984 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl62,758,173 - 2,766,650 (-)EnsemblpanPan2panpan1.1
SERPINB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,147,140 - 3,151,747 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,147,170 - 3,153,915 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha353,154,221 - 3,162,902 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0353,201,536 - 3,210,182 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,201,544 - 3,211,067 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,077,400 - 3,086,040 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,099,914 - 3,108,812 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,432,360 - 4,441,097 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Serpinb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494622,694,570 - 22,703,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366333,916,572 - 3,926,176 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366333,917,430 - 3,926,046 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl71,684,215 - 1,693,299 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.171,684,212 - 1,693,313 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.271,783,253 - 1,792,454 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11769,318,919 - 69,327,733 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1769,319,302 - 69,328,865 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660442,771,546 - 2,781,061 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpinb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475621,994,769 - 22,002,065 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475621,993,777 - 22,003,715 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Serpinb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11451,877,210 - 51,885,975 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Serpinb1a
34 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:71
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000059854
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)173006647275066472Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172413612784432719Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172266079955604694Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172149899450592236Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172723344583975845Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172328632264246472Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)172652205171522051Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172201970567019705Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
152025238Slep14Serum leptin concentration QTL 144.62blood leptin amount (VT:0005667)172439059584432719Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172385892668858926Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172385892668858926Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172723344565155015Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172723344572233445Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172385892668858926Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172385892668858926Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172385892668858926Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
152023740Bp406Blood pressure QTL 4066.06arterial blood pressure trait (VT:2000000)172413612784432719Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172385892668858926Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
152023737Bp405Blood pressure QTL 4055.06arterial blood pressure trait (VT:2000000)2413612784432719Rat
152023736Bp404Blood pressure QTL 4043.78arterial blood pressure trait (VT:2000000)172413612784432719Rat

Markers in Region
BE100150  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21731,594,543 - 31,594,696 (+)MAPPERmRatBN7.2
Rnor_6.01732,906,940 - 32,907,092NCBIRnor6.0
Rnor_5.01734,799,146 - 34,799,298UniSTSRnor5.0
RGSC_v3.41737,954,726 - 37,954,878UniSTSRGSC3.4
Celera1731,156,908 - 31,157,060UniSTS
RH 3.4 Map17324.81UniSTS
Cytogenetic Map17p12UniSTS
RH132528  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21731,598,727 - 31,598,926 (+)MAPPERmRatBN7.2
Rnor_6.01732,911,124 - 32,911,322NCBIRnor6.0
Rnor_5.01734,803,330 - 34,803,528UniSTSRnor5.0
RGSC_v3.41737,958,910 - 37,959,108UniSTSRGSC3.4
Celera1731,161,092 - 31,161,290UniSTS
RH 3.4 Map17356.7UniSTS
Cytogenetic Map17p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000059854   ⟹   ENSRNOP00000056600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1731,799,415 - 31,808,166 (+)Ensembl
mRatBN7.2 Ensembl1731,590,677 - 31,599,102 (+)Ensembl
Rnor_6.0 Ensembl1732,904,119 - 32,911,495 (+)Ensembl
RefSeq Acc Id: NM_001031642   ⟹   NP_001026812
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81731,799,446 - 31,807,853 (+)NCBI
mRatBN7.21731,590,695 - 31,599,102 (+)NCBI
Rnor_6.01732,903,089 - 32,911,498 (+)NCBI
Rnor_5.01734,795,295 - 34,803,704 (+)NCBI
RGSC_v3.41737,950,875 - 37,959,284 (+)RGD
Celera1731,153,059 - 31,161,466 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001026812 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98686 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056600
  ENSRNOP00000056600.2
GenBank Protein Q4G075 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001026812   ⟸   NM_001031642
- UniProtKB: Q4G075 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056600   ⟸   ENSRNOT00000059854

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4G075-F1-model_v2 AlphaFold Q4G075 1-379 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306203 AgrOrtholog
BioCyc Gene G2FUF-9573 BioCyc
Ensembl Genes ENSRNOG00000016581 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000059854 ENTREZGENE
  ENSRNOT00000059854.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot
  3.30.497.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7385870 IMAGE-MGC_LOAD
InterPro Serpin_CS UniProtKB/Swiss-Prot
  Serpin_dom UniProtKB/Swiss-Prot
  Serpin_fam UniProtKB/Swiss-Prot
  Serpin_sf UniProtKB/Swiss-Prot
  Serpin_sf_1 UniProtKB/Swiss-Prot
  Serpin_sf_2 UniProtKB/Swiss-Prot
KEGG Report rno:291091 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112650 IMAGE-MGC_LOAD
NCBI Gene 291091 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot
  PTHR11461:SF180 UniProtKB/Swiss-Prot
Pfam Serpin UniProtKB/Swiss-Prot
PhenoGen Serpinb1a PhenoGen
PROSITE SERPIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016581 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot
UniProt ILEUA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-09 Serpinb1a  serpin family B member 1A  Serpinb1a  serpin family B member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-29 Serpinb1a  serpin family B member 1  Serpinb1  serpin family B member 1a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-08-23 Serpinb1  serpin family B member 1a  Serpinb1a  serine (or cysteine) proteinase inhibitor, clade B, member 1a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Serpinb1a  serine (or cysteine) proteinase inhibitor, clade B, member 1a  Serpinb1a_predicted  serine (or cysteine) proteinase inhibitor, clade B, member 1a (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Serpinb1a_predicted  serine (or cysteine) proteinase inhibitor, clade B, member 1a (predicted)      Symbol and Name status set to approved 70820 APPROVED