Wasl (WASP like actin nucleation promoting factor) - Rat Genome Database

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Gene: Wasl (WASP like actin nucleation promoting factor) Rattus norvegicus
Analyze
Symbol: Wasl
Name: WASP like actin nucleation promoting factor
RGD ID: 735144
Description: Enables cytoskeletal protein binding activity and identical protein binding activity. Involved in several processes, including plasma membrane tubulation; positive regulation of cellular component organization; and postsynaptic actin cytoskeleton organization. Located in Golgi membrane; cell leading edge; and cytoplasmic vesicle. Is active in glutamatergic synapse and postsynapse. Orthologous to human WASL (WASP like actin nucleation promoting factor); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: actin nucleation-promoting factor WASL; hypothetical protein LOC685687; IQ motif and ubiquitin domain containing; Iqub; LOC682507; MGC116166; N-WASP; neural Wiskott-Aldrich syndrome protein; similar to Neural Wiskott-Aldrich syndrome protein (N-WASP); TRS4; Wiskott-Aldrich syndrome-like; Wiskott-Aldrich syndrome-like (human)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8454,049,081 - 54,097,653 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl454,049,082 - 54,097,570 (-)EnsemblGRCr8
mRatBN7.2453,083,536 - 53,132,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl453,083,536 - 53,132,022 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx458,070,385 - 58,118,872 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0453,977,276 - 54,025,972 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0452,411,758 - 52,460,472 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0451,677,722 - 51,726,212 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl451,677,722 - 51,726,212 (-)Ensemblrn6Rnor6.0
Rnor_5.0451,455,978 - 51,504,496 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4451,063,710 - 51,092,848 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera448,249,249 - 48,297,692 (-)NCBICelera
RGSC_v3.1451,294,288 - 51,323,128 (-)NCBI
Cytogenetic Map4q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
chloroprene  (EXP)
chromium(6+)  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dextran sulfate  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
Evodiamine  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
gentamycin  (EXP)
irinotecan  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
levofloxacin  (EXP)
MeIQx  (ISO)
Mesaconitine  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nefazodone  (EXP)
ozone  (EXP)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
testosterone enanthate  (ISO)
tetraphene  (ISO)
thimerosal  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
actin cap  (ISO)
cell leading edge  (IDA)
cytoplasm  (IEA)
cytoplasmic vesicle  (IDA)
cytoskeleton  (IEA)
cytosol  (ISO,TAS)
glutamatergic synapse  (EXP,IDA,IMP,ISO)
Golgi membrane  (IDA)
lamellipodium  (ISO)
nucleus  (IEA,ISO,ISS)
plasma membrane  (IBA)
postsynapse  (IDA,IMP)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Abl silencing inhibits CAS-mediated process and constriction in resistance arteries. Anfinogenova Y, etal., Circ Res. 2007 Aug 17;101(4):420-8. Epub 2007 Jul 5.
2. Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis. Bu W, etal., PLoS One. 2010 Aug 13;5(8):e12153. doi: 10.1371/journal.pone.0012153.
3. EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly. Campellone KG, etal., Dev Cell. 2004 Aug;7(2):217-28. doi: 10.1016/j.devcel.2004.07.004.
4. Repetitive N-WASP-binding elements of the enterohemorrhagic Escherichia coli effector EspF(U) synergistically activate actin assembly. Campellone KG, etal., PLoS Pathog. 2008 Oct;4(10):e1000191. doi: 10.1371/journal.ppat.1000191. Epub 2008 Oct 31.
5. Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP. Cantarelli VV, etal., Cell Microbiol. 2007 Jul;9(7):1782-95. doi: 10.1111/j.1462-5822.2007.00913.x. Epub 2007 Apr 19.
6. Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes. Chen JL, etal., FEBS Lett. 2004 May 21;566(1-3):281-6.
7. N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. Desmarais V, etal., Cell Motil Cytoskeleton. 2009 Jun;66(6):303-16. doi: 10.1002/cm.20361.
8. Identification of N-WASP homologs in human and rat brain. Fukuoka M, etal., Gene 1997 Sep 1;196(1-2):43-8.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. Icking A, etal., J Cell Sci. 2005 Nov 1;118(Pt 21):5059-69. Epub 2005 Oct 18.
12. Syndapins integrate N-WASP in receptor-mediated endocytosis. Kessels MM and Qualmann B, EMBO J 2002 Nov 15;21(22):6083-94.
13. SPIN90/WISH interacts with PSD-95 and regulates dendritic spinogenesis via an N-WASP-independent mechanism. Lee S, etal., EMBO J. 2006 Oct 18;25(20):4983-95. Epub 2006 Sep 21.
14. Focal adhesion kinase-Tyr407 and -Tyr397 exhibit antagonistic effects on blood-testis barrier dynamics in the rat. Lie PP, etal., Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12562-7. doi: 10.1073/pnas.1202316109. Epub 2012 Jul 12.
15. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Martinez-Quiles N, etal., Mol Cell Biol. 2004 Jun;24(12):5269-80. doi: 10.1128/MCB.24.12.5269-5280.2004.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP. Miki H, etal., Nature. 1998 Jan 1;391(6662):93-6.
18. SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane. Park J, etal., J Cell Sci. 2010 May 15;123(Pt 10):1742-50. doi: 10.1242/jcs.064170. Epub 2010 Apr 27.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
21. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Prehoda KE, etal., Science. 2000 Oct 27;290(5492):801-6.
22. GOA pipeline RGD automated data pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency. Sallee NA, etal., Nature. 2008 Aug 21;454(7207):1005-8. doi: 10.1038/nature07170. Epub 2008 Jul 23.
25. The essential role of profilin in the assembly of actin for microspike formation. Suetsugu S, etal., EMBO J. 1998 Nov 16;17(22):6516-26.
26. Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization. To C, etal., J Biol Chem. 2010 Sep 3;285(36):27944-57. doi: 10.1074/jbc.M110.103036. Epub 2010 Jun 21.
27. Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Volkman BF, etal., Cell 2002 Nov 15;111(4):565-76.
28. N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses. Wegner AM, etal., J Biol Chem. 2008 Jun 6;283(23):15912-20. Epub 2008 Apr 21.
Additional References at PubMed
PMID:9950691   PMID:10704453   PMID:11559594   PMID:11584276   PMID:12477932   PMID:14732713   PMID:15148305   PMID:15489334   PMID:15664188   PMID:15791211   PMID:15797550   PMID:16767080  
PMID:16885158   PMID:17049400   PMID:17092940   PMID:17229736   PMID:17350575   PMID:17405146   PMID:17635999   PMID:17681954   PMID:18362183   PMID:18388313   PMID:19056867   PMID:19379711  
PMID:19509061   PMID:19759398   PMID:21464958   PMID:21874009   PMID:22250195   PMID:22389406   PMID:22585739   PMID:22966049   PMID:23376485   PMID:23750457   PMID:23843614   PMID:25321392  
PMID:25851601   PMID:26554011   PMID:31859439   PMID:37296607  


Genomics

Comparative Map Data
Wasl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8454,049,081 - 54,097,653 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl454,049,082 - 54,097,570 (-)EnsemblGRCr8
mRatBN7.2453,083,536 - 53,132,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl453,083,536 - 53,132,022 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx458,070,385 - 58,118,872 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0453,977,276 - 54,025,972 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0452,411,758 - 52,460,472 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0451,677,722 - 51,726,212 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl451,677,722 - 51,726,212 (-)Ensemblrn6Rnor6.0
Rnor_5.0451,455,978 - 51,504,496 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4451,063,710 - 51,092,848 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera448,249,249 - 48,297,692 (-)NCBICelera
RGSC_v3.1451,294,288 - 51,323,128 (-)NCBI
Cytogenetic Map4q22NCBI
WASL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387123,681,943 - 123,749,003 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7123,681,938 - 123,749,003 (-)Ensemblhg38GRCh38
GRCh377123,321,997 - 123,389,057 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367123,109,233 - 123,176,352 (-)NCBIBuild 36Build 36hg18NCBI36
Build 347122,915,949 - 122,983,067NCBI
Celera7118,125,741 - 118,192,900 (-)NCBICelera
Cytogenetic Map7q31.32NCBI
HuRef7117,685,121 - 117,752,321 (-)NCBIHuRef
CHM1_17123,255,296 - 123,322,481 (-)NCBICHM1_1
T2T-CHM13v2.07124,998,697 - 125,065,742 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27122,710,608 - 122,777,749 (-)NCBI
Wasl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39624,613,809 - 24,665,185 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl624,613,804 - 24,665,008 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38624,613,810 - 24,664,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl624,613,805 - 24,665,009 (-)Ensemblmm10GRCm38
MGSCv37624,563,810 - 24,614,995 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36624,563,815 - 24,614,981 (-)NCBIMGSCv36mm8
Celera624,624,846 - 24,676,054 (-)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map611.28NCBI
Wasl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554795,166,393 - 5,200,512 (-)Ensembl
ChiLan1.0NW_0049554795,167,851 - 5,200,512 (-)NCBIChiLan1.0ChiLan1.0
WASL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26160,537,416 - 160,606,388 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1712,550,222 - 12,614,145 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07115,675,170 - 115,741,498 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17128,357,909 - 128,388,395 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7128,360,495 - 128,385,393 (-)EnsemblpanPan2panpan1.1
WASL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11411,828,298 - 11,901,190 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1411,828,687 - 11,899,788 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1411,512,373 - 11,585,271 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01411,605,958 - 11,678,914 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1411,606,343 - 11,678,904 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11411,795,524 - 11,868,439 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01411,533,495 - 11,606,377 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01411,774,079 - 11,846,981 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wasl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511850,387,234 - 50,461,160 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366051,742,776 - 1,816,690 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366051,741,832 - 1,816,694 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WASL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1823,722,188 - 23,789,506 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11823,722,188 - 23,789,516 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21825,318,931 - 25,386,518 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WASL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12192,480,392 - 92,546,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2192,482,918 - 92,546,481 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604210,917,558 - 10,985,328 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wasl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478312,254,715 - 12,323,232 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478312,239,467 - 12,322,403 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Wasl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16114,678,779 - 114,727,518 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Wasl
377 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:599
Count of miRNA genes:262
Interacting mature miRNAs:340
Transcripts:ENSRNOT00000009261
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
10450825Scl78Serum cholesterol level QTL 783.70.01blood VLDL cholesterol amount (VT:0005144)blood low density lipoprotein cholesterol level (CMO:0000053)45014392658080146Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
10450821Scl77Serum cholesterol level QTL 774.10.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)45014392658080146Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
10450818Scl76Serum cholesterol level QTL 763.60.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)45014392658080146Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat

Markers in Region
RH128038  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2453,085,580 - 53,085,797 (+)MAPPERmRatBN7.2
Rnor_6.0451,679,767 - 51,679,983NCBIRnor6.0
Rnor_5.0451,458,023 - 51,458,239UniSTSRnor5.0
Celera448,251,294 - 48,251,510UniSTS
RH 3.4 Map4288.5UniSTS
AI231276  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2453,085,097 - 53,085,268 (+)MAPPERmRatBN7.2
Rnor_6.0451,679,284 - 51,679,454NCBIRnor6.0
Rnor_5.0451,457,540 - 51,457,710UniSTSRnor5.0
Celera448,250,811 - 48,250,981UniSTS
RH 3.4 Map4288.9UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009261   ⟹   ENSRNOP00000009261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl454,049,082 - 54,097,570 (-)Ensembl
mRatBN7.2 Ensembl453,083,536 - 53,132,022 (-)Ensembl
Rnor_6.0 Ensembl451,677,722 - 51,726,212 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106852   ⟹   ENSRNOP00000097692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl454,052,412 - 54,097,570 (-)Ensembl
mRatBN7.2 Ensembl453,086,866 - 53,132,022 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114717   ⟹   ENSRNOP00000091229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl454,049,082 - 54,097,570 (-)Ensembl
mRatBN7.2 Ensembl453,083,550 - 53,131,984 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116006   ⟹   ENSRNOP00000090815
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl454,067,509 - 54,097,570 (-)Ensembl
mRatBN7.2 Ensembl453,101,963 - 53,132,022 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000140623   ⟹   ENSRNOP00000103171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl454,049,082 - 54,097,570 (-)Ensembl
RefSeq Acc Id: NM_001110365   ⟹   NP_001103835
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8454,049,082 - 54,097,570 (-)NCBI
mRatBN7.2453,083,536 - 53,132,022 (-)NCBI
Rnor_6.0451,677,722 - 51,726,212 (-)NCBI
Rnor_5.0451,455,978 - 51,504,496 (-)NCBI
RGSC_v3.4451,063,710 - 51,092,848 (-)RGD
Celera448,249,249 - 48,297,692 (-)RGD
Sequence:
RefSeq Acc Id: XM_039108349   ⟹   XP_038964277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8454,049,081 - 54,097,653 (-)NCBI
mRatBN7.2453,083,540 - 53,132,061 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001103835 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964277 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM15175 (Get FASTA)   NCBI Sequence Viewer  
  EDM15176 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009261
  ENSRNOP00000103171
GenBank Protein O08816 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001103835   ⟸   NM_001110365
- UniProtKB: O08816 (UniProtKB/Swiss-Prot),   F1LSG0 (UniProtKB/TrEMBL),   A6IE88 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009261   ⟸   ENSRNOT00000009261
RefSeq Acc Id: XP_038964277   ⟸   XM_039108349
- Peptide Label: isoform X1
- UniProtKB: O08816 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000097692   ⟸   ENSRNOT00000106852
Ensembl Acc Id: ENSRNOP00000090815   ⟸   ENSRNOT00000116006
Ensembl Acc Id: ENSRNOP00000091229   ⟸   ENSRNOT00000114717
Ensembl Acc Id: ENSRNOP00000103171   ⟸   ENSRNOT00000140623
Protein Domains
CRIB   WH1   WH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08816-F1-model_v2 AlphaFold O08816 1-501 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692906
Promoter ID:EPDNEW_R3431
Type:initiation region
Name:Wasl_1
Description:Wiskott-Aldrich syndrome-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0451,726,177 - 51,726,237EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735144 AgrOrtholog
BioCyc Gene G2FUF-45479 BioCyc
Ensembl Genes ENSRNOG00000006975 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000009261 ENTREZGENE
  ENSRNOT00000140623 ENTREZGENE
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot
  3.90.810.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7454794 IMAGE-MGC_LOAD
InterPro CRIB_dom UniProtKB/Swiss-Prot
  CRIB_dom_sf UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  WASP_C UniProtKB/Swiss-Prot
  WASPfam_EVH1 UniProtKB/Swiss-Prot
  WH1/EVH1_dom UniProtKB/Swiss-Prot
  WH2_dom UniProtKB/Swiss-Prot
MGC_CLONE MGC:116166 IMAGE-MGC_LOAD
NCBI Gene 682507 ENTREZGENE
PANTHER NEURAL WISKOTT-ALDRICH SYNDROME PROTEIN UniProtKB/Swiss-Prot
  SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER UniProtKB/Swiss-Prot
Pfam PBD UniProtKB/Swiss-Prot
  WH1 UniProtKB/Swiss-Prot
  WH2 UniProtKB/Swiss-Prot
PhenoGen Wasl PhenoGen
PROSITE CRIB UniProtKB/Swiss-Prot
  WH1 UniProtKB/Swiss-Prot
  WH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006975 RatGTEx
SMART PBD UniProtKB/Swiss-Prot
  WH1 UniProtKB/Swiss-Prot
  WH2 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
  SSF47912 UniProtKB/Swiss-Prot
UniProt A0A8I6ABN7_RAT UniProtKB/TrEMBL
  A0A8I6AE95_RAT UniProtKB/TrEMBL
  A0A8I6B641_RAT UniProtKB/TrEMBL
  A0ABK0LFP8_RAT UniProtKB/TrEMBL
  A6IE81_RAT UniProtKB/TrEMBL
  A6IE88 ENTREZGENE, UniProtKB/TrEMBL
  F1LSG0 ENTREZGENE, UniProtKB/TrEMBL
  O08816 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Wasl  WASP like actin nucleation promoting factor  Wasl  Wiskott-Aldrich syndrome-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Wasl  Wiskott-Aldrich syndrome-like  LOC685687  hypothetical protein LOC685687  Data merged from RGD:1591326 1643240 APPROVED
2009-12-15 Wasl  Wiskott-Aldrich syndrome-like  Iqub  IQ motif and ubiquitin domain containing  Data merged from RGD:2300151 737654 APPROVED
2008-09-22 Wasl  Wiskott-Aldrich syndrome-like  LOC682507  similar to Neural Wiskott-Aldrich syndrome protein (N-WASP)  Data merged from RGD:1597967 737654 APPROVED
2008-03-04 Wasl  Wiskott-Aldrich syndrome-like  Iqub  IQ motif and ubiquitin domain containing  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-11-07 Iqub  IQ motif and ubiquitin domain containing  Wasl  Wiskott-Aldrich syndrome-like (human)  Symbol and Name updated 1299863 APPROVED
2006-11-20 LOC682507  similar to Neural Wiskott-Aldrich syndrome protein (N-WASP)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC685687  hypothetical protein LOC685687      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-07-08 Wasl  Wiskott-Aldrich syndrome-like (human)  N-WASP  neural Wiskott-Aldrich syndrome protein  Symbol and Name updated 1299863 APPROVED