Cyp11b3 (cytochrome P450, family 11, subfamily b, polypeptide 3) - Rat Genome Database

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Gene: Cyp11b3 (cytochrome P450, family 11, subfamily b, polypeptide 3) Rattus norvegicus
Analyze
Symbol: Cyp11b3
Name: cytochrome P450, family 11, subfamily b, polypeptide 3
RGD ID: 727886
Description: Predicted to enable corticosterone 18-monooxygenase activity and steroid 11-beta-monooxygenase activity. Predicted to be involved in cellular response to peptide hormone stimulus and steroid metabolic process. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to human CYP11B1 (cytochrome P450 family 11 subfamily B member 1) and CYP11B2 (cytochrome P450 family 11 subfamily B member 2); PARTICIPATES IN C21-steroid hormone biosynthetic pathway; 11-beta-hydroxylase deficiency pathway; 17-alpha-hydroxylase deficiency pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CYPXIB3; cytochrome P450, subfamily 11B, polypeptide 3
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   LEW.SS-(D7Rat73-D7Rat128)/Ayd   SS.LEW-(D7Rat73-D7Rat128)/Ayd  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,689,319 - 108,694,808 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7108,689,165 - 108,694,921 (-)EnsemblGRCr8
mRatBN7.27106,808,559 - 106,814,048 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,808,559 - 106,814,048 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7108,534,544 - 108,540,024 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,758,218 - 110,763,690 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,704,151 - 110,709,631 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,155,928 - 116,161,781 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,156,219 - 116,255,167 (-)Ensemblrn6Rnor6.0
Rnor_5.07116,059,008 - 116,064,497 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47113,013,335 - 113,018,824 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7103,180,975 - 103,186,464 (-)NCBICelera
RGSC_v3.17113,047,564 - 113,053,054 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
11-deoxycorticosterone  (ISO)
11-deoxycortisol  (ISO)
18-hydroxycortisol  (ISO)
18-hydroxydeoxycorticosterone  (ISO)
18-oxocortisol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenol  (ISO)
2,6-dibromophenol  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
3',4'-dimethoxyflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4,5,3',4',5'-Hexachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acenaphthenes  (ISO)
Acetyl tributyl citrate  (ISO)
aldehydo-D-glucose  (EXP)
aldosterone  (EXP,ISO)
alpha-Zearalanol  (EXP)
alternariol  (ISO)
ammonium chloride  (EXP)
amoxicillin  (ISO)
androgen antagonist  (EXP)
Bay-K-8644  (ISO)
benazepril  (ISO)
benidipine  (ISO)
benzo[a]pyrene  (ISO)
benzofurans  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bucladesine  (ISO)
Butylbenzyl phthalate  (EXP)
C60 fullerene  (EXP)
cadmium telluride  (ISO)
caffeine  (EXP)
calmidazolium  (ISO)
candesartan  (EXP,ISO)
Candesartan cilexetil  (EXP)
carbamazepine  (ISO)
chlorohydrocarbon  (ISO)
clofibrate  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
corticosterone  (ISO)
Cuprizon  (EXP)
cypermethrin  (ISO)
cyproconazole  (EXP)
D-glucose  (EXP)
DDE  (EXP)
deoxynivalenol  (ISO)
Di-n-hexyl phthalate  (EXP)
dibutyl phthalate  (EXP)
Dicyclohexyl phthalate  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dimethyl sulfoxide  (EXP)
dipentyl phthalate  (EXP)
dutasteride  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
epoxiconazole  (EXP)
erythromycin A  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gentamycin  (EXP)
glucose  (EXP)
glycyrrhizinic acid  (EXP)
hydrochlorothiazide  (EXP)
hydroxyitraconazole  (ISO)
imidapril  (ISO)
irbesartan  (ISO)
itraconazole  (ISO)
ketoconazole  (ISO)
KN-93  (ISO)
Methandrostenolone  (ISO)
methylmercury chloride  (ISO)
Mibefradil  (ISO)
Mitotane  (ISO)
mycotoxin  (ISO)
N-acetyl-L-cysteine  (ISO)
naringin  (ISO)
nitroglycerin  (EXP)
paracetamol  (EXP)
perflubron  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (EXP)
posaconazole  (ISO)
potassium atom  (EXP,ISO)
potassium chloride  (ISO)
potassium dichromate  (ISO)
proanthocyanidin  (ISO)
rotenone  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium atom  (ISO)
sodium chloride  (EXP)
spironolactone  (EXP)
streptozocin  (EXP)
testosterone  (ISO)
torasemide  (EXP)
torcetrapib  (ISO)
triadimefon  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
triphenylstannane  (ISO)
Triptolide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains. Cicila GT, etal., Genomics 2001 Feb 15;72(1):51-60.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, developmentally, and hormonally regulated fashion in the rodent adrenal and encodes a protein with both 11-hydroxylase and 18-hydroxylase activities. Mellon SH, etal., J Biol Chem 1995 Jan 27;270(4):1643-9.
4. Isolation and characterization of rat CYP11B genes involved in late steps of mineralo- and glucocorticoid syntheses. Mukai K, etal., J Biol Chem 1993 Apr 25;268(12):9130-7.
5. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. Genetic variation in aldosterone synthase predicts plasma glucose levels. Ranade K, etal., Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13219-24. Epub 2001 Oct 30.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. An aldosterone synthase gene variant is associated with improvement in left ventricular ejection fraction in dilated cardiomyopathy. Tiago AD, etal., Cardiovasc Res. 2002 Jun;54(3):584-9.
14. Cloning and expression of the rat adrenal cytochrome P-450 11B3 (CYP11B3) enzyme cDNA: preferential 18-hydroxylation over 11 beta-hydroxylation of DOC. Zhou MY, etal., Mol Cell Endocrinol 1995 Oct 30;114(1-2):137-45.
Additional References at PubMed
PMID:1686470   PMID:1741400   PMID:2256920   PMID:8645611   PMID:9703385   PMID:9838244   PMID:10224232   PMID:14614232   PMID:18614015   PMID:19342457   PMID:23322723  


Genomics

Comparative Map Data
Cyp11b3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87108,689,319 - 108,694,808 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7108,689,165 - 108,694,921 (-)EnsemblGRCr8
mRatBN7.27106,808,559 - 106,814,048 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7106,808,559 - 106,814,048 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7108,534,544 - 108,540,024 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07110,758,218 - 110,763,690 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07110,704,151 - 110,709,631 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,155,928 - 116,161,781 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,156,219 - 116,255,167 (-)Ensemblrn6Rnor6.0
Rnor_5.07116,059,008 - 116,064,497 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47113,013,335 - 113,018,824 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7103,180,975 - 103,186,464 (-)NCBICelera
RGSC_v3.17113,047,564 - 113,053,054 (-)NCBI
Cytogenetic Map7q34NCBI
CYP11B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388142,910,559 - 142,917,843 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8142,910,559 - 142,917,850 (-)Ensemblhg38GRCh38
GRCh378143,991,975 - 143,999,259 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368143,988,977 - 143,996,261 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348143,988,976 - 143,996,261NCBI
Celera8140,301,421 - 140,308,694 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8139,244,244 - 139,251,515 (-)NCBIHuRef
CHM1_18144,032,236 - 144,039,525 (-)NCBICHM1_1
T2T-CHM13v2.08144,053,900 - 144,061,172 (-)NCBIT2T-CHM13v2.0
Cyp11b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391574,722,467 - 74,728,080 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1574,722,467 - 74,728,167 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381574,850,618 - 74,856,231 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1574,851,010 - 74,856,318 (-)Ensemblmm10GRCm38
MGSCv371574,681,440 - 74,686,748 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361574,678,294 - 74,683,480 (-)NCBIMGSCv36mm8
Celera1576,357,529 - 76,362,843 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.29NCBI
CYP11B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27160,346,798 - 160,354,193 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18135,873,004 - 135,880,399 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08139,622,632 - 139,630,014 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18142,666,534 - 142,672,575 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8142,666,534 - 142,672,575 (-)EnsemblpanPan2panpan1.1
CYP11B1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11336,866,476 - 36,880,625 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1336,823,864 - 36,833,784 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01337,342,302 - 37,352,691 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1337,325,993 - 37,354,777 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11337,015,530 - 37,025,564 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01337,134,290 - 37,144,097 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01337,610,637 - 37,619,980 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
CYP11B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.141,365,725 - 1,373,138 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CYP11B2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18137,160,919 - 137,168,332 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8137,162,325 - 137,168,350 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660392,778,493 - 2,785,353 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101700701
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473513,701,382 - 13,708,750 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp11b3
30 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:107
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000038109, ENSRNOT00000068707
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)763889858108889858Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)763889858108889858Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Related Rat Strains
The following Strains have been annotated to Cyp11b3
LEW.SS-(D7Rat73-D7Rat128)/Ayd     SS.LEW-(D7Rat73-D7Rat128)/Ayd    


Expression

RNA-SEQ Expression

mesenchyme
renal system
1 1

Sequence


Ensembl Acc Id: ENSRNOT00000038109   ⟹   ENSRNOP00000035538
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7108,689,165 - 108,694,921 (-)Ensembl
Rnor_6.0 Ensembl7116,196,239 - 116,255,167 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000041774   ⟹   ENSRNOP00000049722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,838,590 - 106,845,004 (-)Ensembl
Rnor_6.0 Ensembl7116,248,759 - 116,255,167 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000068707   ⟹   ENSRNOP00000062325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7116,156,219 - 116,161,708 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091401   ⟹   ENSRNOP00000075065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7116,156,219 - 116,201,756 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7106,808,559 - 106,814,048 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101557   ⟹   ENSRNOP00000079048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7108,719,349 - 108,725,763 (-)Ensembl
mRatBN7.2 Ensembl7106,838,590 - 106,845,004 (-)Ensembl
RefSeq Acc Id: NM_181824   ⟹   NP_861545
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87108,689,319 - 108,694,808 (-)NCBI
mRatBN7.27106,808,559 - 106,814,048 (-)NCBI
Rnor_6.07116,156,219 - 116,161,708 (-)NCBI
Rnor_5.07116,059,008 - 116,064,497 (-)NCBI
RGSC_v3.47113,013,335 - 113,018,824 (-)RGD
Celera7103,180,975 - 103,186,464 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_861545 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA66363 (Get FASTA)   NCBI Sequence Viewer  
  AAB17633 (Get FASTA)   NCBI Sequence Viewer  
  BAA03173 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035538
  ENSRNOP00000079048.1
RefSeq Acc Id: NP_861545   ⟸   NM_181824
- UniProtKB: Q64586 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035538   ⟸   ENSRNOT00000038109
Ensembl Acc Id: ENSRNOP00000049722   ⟸   ENSRNOT00000041774
Ensembl Acc Id: ENSRNOP00000062325   ⟸   ENSRNOT00000068707
Ensembl Acc Id: ENSRNOP00000075065   ⟸   ENSRNOT00000091401
Ensembl Acc Id: ENSRNOP00000079048   ⟸   ENSRNOT00000101557

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727886 AgrOrtholog
BioCyc Gene G2FUF-33007 BioCyc
Ensembl Genes ENSRNOG00000030111 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000068978 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000038109 ENTREZGENE
  ENSRNOT00000101557.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro CYP11_CYP27_families UniProtKB/TrEMBL
  Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_mitochondrial UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report rno:353498 UniProtKB/TrEMBL
NCBI Gene 353498 ENTREZGENE
PANTHER CYTOCHROME P450 11B2, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR24279 UniProtKB/TrEMBL
  STEROID 11-BETA-MONOOXYGENASE UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp11b3 PhenoGen
PRINTS MITP450 UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030111 RatGTEx
  ENSRNOG00000068978 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A8I5ZMM4_RAT UniProtKB/TrEMBL
  Q64539_RAT UniProtKB/TrEMBL
  Q64546_RAT UniProtKB/TrEMBL
  Q64586 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp11b3  cytochrome P450, family 11, subfamily b, polypeptide 3  Cyp11b3  cytochrome P450, subfamily 11B, polypeptide 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-10-12 Cyp11b3        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the adrenal gland several days after birth and in the zona fasciculata/reticularis but not in the zona glomerulosa 1299585