Hcn4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4) - Rat Genome Database

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Gene: Hcn4 (hyperpolarization activated cyclic nucleotide-gated potassium channel 4) Rattus norvegicus
Analyze
Symbol: Hcn4
Name: hyperpolarization activated cyclic nucleotide-gated potassium channel 4
RGD ID: 71065
Description: Predicted to enable identical protein binding activity and monoatomic cation channel activity. Involved in cellular response to aldosterone. Located in basolateral plasma membrane; neuronal cell body; and terminal bouton. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hyperpolarization-activated cyclic nucleotide-gated potassium channel 4 (HCN4); hyperpolarization-activated, cyclic nucleotide-gated K+ 4; hyperpolarization-activated, cyclic nucleotide-gated potassium channel 4 (HCN4); potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8868,118,062 - 68,155,482 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl868,118,062 - 68,155,495 (+)EnsemblGRCr8
mRatBN7.2859,222,206 - 59,259,626 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl859,221,653 - 59,259,639 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx864,753,125 - 64,790,548 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0863,030,680 - 63,068,103 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0860,895,392 - 60,932,815 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0863,599,907 - 63,637,327 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl863,600,663 - 63,639,654 (+)Ensemblrn6Rnor6.0
Rnor_5.0863,367,893 - 63,405,313 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4862,629,828 - 62,667,248 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera858,680,131 - 58,717,545 (+)NCBICelera
RGSC_v3.1862,648,881 - 62,686,299 (+)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Transcriptional control of pacemaker channel genes HCN2 and HCN4 by Sp1 and implications in re-expression of these genes in hypertrophied myocytes. Lin H, etal., Cell Physiol Biochem. 2009;23(4-6):317-26. doi: 10.1159/000218178. Epub 2009 May 6.
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Monteggia LM, etal., Brain Res Mol Brain Res 2000 Sep 30;81(1-2):129-39.
7. HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals. Muller F, etal., Eur J Neurosci 2003 May;17(10):2084-96.
8. Aldosterone modulates I(f) current through gene expression in cultured neonatal rat ventricular myocytes. Muto T, etal., Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2710-8. Epub 2007 Jul 20.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain. Notomi T and Shigemoto R, J Comp Neurol. 2004 Apr 5;471(3):241-76.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues. Shi W, etal., Circ Res 1999 Jul 9;85(1):e1-6.
17. Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli. Stevens DR, etal., Nature. 2001 Oct 11;413(6856):631-5.
18. Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells. Stradleigh TW, etal., J Comp Neurol. 2011 Sep 1;519(13):2546-73. doi: 10.1002/cne.22638.
19. HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. Whitaker GM, etal., J Biol Chem. 2007 Aug 3;282(31):22900-9. Epub 2007 Jun 6.
20. Hyperpolarisation-activated cyclic nucleotide channel 4 (HCN4) involvement in Tourette's syndrome autoimmunity. Yeh CB, etal., J Neuroimmunol. 2012 Sep 15;250(1-2):18-26. doi: 10.1016/j.jneuroim.2012.05.009. Epub 2012 Jun 7.
21. Declines in levels of hyperpolarization-activated cation (HCN) channels in the rat ovary after cisplatin exposure. Yeh J, etal., Reprod Sci. 2009 Oct;16(10):986-94. Epub 2009 Jul 7.
Additional References at PubMed
PMID:10228147   PMID:12750403   PMID:14657344   PMID:15056713   PMID:16407510   PMID:16648453   PMID:17065201   PMID:17173866   PMID:17311321   PMID:18255311   PMID:18282314   PMID:18326556  
PMID:19236845   PMID:19477969   PMID:19820968   PMID:20220080   PMID:21753027   PMID:21798320   PMID:22006928   PMID:22281825   PMID:22403875   PMID:22694806   PMID:22748890   PMID:23172916  
PMID:23357121   PMID:24776929   PMID:26065643   PMID:26695361   PMID:27496876   PMID:27569278   PMID:31409881   PMID:36214984   PMID:36574099   PMID:37643180  


Genomics

Comparative Map Data
Hcn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8868,118,062 - 68,155,482 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl868,118,062 - 68,155,495 (+)EnsemblGRCr8
mRatBN7.2859,222,206 - 59,259,626 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl859,221,653 - 59,259,639 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx864,753,125 - 64,790,548 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0863,030,680 - 63,068,103 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0860,895,392 - 60,932,815 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0863,599,907 - 63,637,327 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl863,600,663 - 63,639,654 (+)Ensemblrn6Rnor6.0
Rnor_5.0863,367,893 - 63,405,313 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4862,629,828 - 62,667,248 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera858,680,131 - 58,717,545 (+)NCBICelera
RGSC_v3.1862,648,881 - 62,686,299 (+)NCBI
Cytogenetic Map8q24NCBI
HCN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381573,319,859 - 73,368,958 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1573,319,859 - 73,368,958 (-)Ensemblhg38GRCh38
GRCh371573,612,200 - 73,661,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361571,400,988 - 71,448,230 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341571,400,987 - 71,448,230NCBI
Celera1550,490,801 - 50,540,207 (-)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1550,443,643 - 50,492,812 (-)NCBIHuRef
CHM1_11573,730,167 - 73,779,572 (-)NCBICHM1_1
T2T-CHM13v2.01571,136,994 - 71,186,091 (-)NCBIT2T-CHM13v2.0
Hcn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39958,730,232 - 58,770,458 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl958,730,695 - 58,770,458 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38958,822,949 - 58,863,175 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl958,823,412 - 58,863,175 (+)Ensemblmm10GRCm38
MGSCv37958,671,319 - 58,708,762 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36958,621,649 - 58,659,092 (+)NCBIMGSCv36mm8
Celera956,052,112 - 56,089,597 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.8NCBI
Hcn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554504,139,852 - 4,181,377 (+)Ensembl
ChiLan1.0NW_0049554504,139,852 - 4,181,377 (+)NCBIChiLan1.0ChiLan1.0
HCN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21662,549,462 - 62,598,928 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11566,713,883 - 66,763,353 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01552,231,906 - 52,285,220 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11570,994,405 - 71,043,256 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1570,997,020 - 71,042,285 (-)EnsemblpanPan2panpan1.1
HCN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13036,637,492 - 36,656,194 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3036,639,908 - 36,656,406 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3036,573,522 - 36,617,524 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03036,844,740 - 36,888,776 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3036,844,723 - 36,889,181 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13036,796,738 - 36,840,679 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03036,822,594 - 36,866,568 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03037,078,286 - 37,122,259 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hcn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640114,675,949 - 114,722,220 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647132,529,847 - 32,570,284 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647132,527,551 - 32,570,548 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl760,010,283 - 60,050,689 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1760,010,396 - 60,052,258 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2764,633,705 - 64,677,047 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HCN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12610,107,342 - 10,158,885 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2610,110,579 - 10,156,292 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048131,447,372 - 131,496,994 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hcn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624781968,748 - 1,008,200 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624781968,608 - 1,007,969 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hcn4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1852,683,812 - 52,723,504 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hcn4
294 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir1rno-miR-1-3pMirtarbaseexternal_infoReporter assay//real-timeRT-PCR//Western blotFunctional MTI17516552

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:20
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000012644
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84961020468373388Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 66 152 48 47 17 11 17 6 207 103 3 137 63 91 30 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000012644   ⟹   ENSRNOP00000012644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl868,118,062 - 68,155,495 (+)Ensembl
mRatBN7.2 Ensembl859,222,206 - 59,259,639 (+)Ensembl
Rnor_6.0 Ensembl863,600,663 - 63,639,654 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103911   ⟹   ENSRNOP00000080600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl868,118,088 - 68,155,495 (+)Ensembl
mRatBN7.2 Ensembl859,221,653 - 59,259,639 (+)Ensembl
RefSeq Acc Id: NM_021658   ⟹   NP_067690
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8868,118,062 - 68,155,482 (+)NCBI
mRatBN7.2859,222,206 - 59,259,626 (+)NCBI
Rnor_6.0863,599,907 - 63,637,327 (+)NCBI
Rnor_5.0863,367,893 - 63,405,313 (+)NCBI
RGSC_v3.4862,629,828 - 62,667,248 (+)RGD
Celera858,680,131 - 58,717,545 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_067690 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF01493 (Get FASTA)   NCBI Sequence Viewer  
  AAF62176 (Get FASTA)   NCBI Sequence Viewer  
  EDL95687 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012644
  ENSRNOP00000012644.5
GenBank Protein Q9JKA7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067690   ⟸   NM_021658
- UniProtKB: Q9QZW4 (UniProtKB/Swiss-Prot),   Q9JKA7 (UniProtKB/Swiss-Prot),   A6J514 (UniProtKB/TrEMBL),   A0A8I5ZPZ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012644   ⟸   ENSRNOT00000012644
Ensembl Acc Id: ENSRNOP00000080600   ⟸   ENSRNOT00000103911
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JKA7-F1-model_v2 AlphaFold Q9JKA7 1-1198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71065 AgrOrtholog
BioCyc Gene G2FUF-30253 BioCyc
Ensembl Genes ENSRNOG00000009450 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012644 ENTREZGENE
  ENSRNOT00000012644.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  2.60.120.10 UniProtKB/Swiss-Prot
  Helix hairpin bin UniProtKB/Swiss-Prot
InterPro cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_CS UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  Ion_trans_N UniProtKB/Swiss-Prot
  K/Na_HCN_channel UniProtKB/Swiss-Prot
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
KEGG Report rno:59266 UniProtKB/Swiss-Prot
NCBI Gene 59266 ENTREZGENE
PANTHER I[[H]] CHANNEL, ISOFORM E UniProtKB/Swiss-Prot
  POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4 UniProtKB/Swiss-Prot
Pfam cNMP_binding UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  Ion_trans_N UniProtKB/Swiss-Prot
PharmGKB HCN4 RGD
PhenoGen Hcn4 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot
  CNMP_BINDING_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009450 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A0H2UHH6_RAT UniProtKB/TrEMBL
  A0A8I5ZPZ1 ENTREZGENE, UniProtKB/TrEMBL
  A6J514 ENTREZGENE, UniProtKB/TrEMBL
  HCN4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9QZW4 ENTREZGENE
UniProt Secondary Q9QZW4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-03 Hcn4  hyperpolarization activated cyclic nucleotide-gated potassium channel 4  Hcn4  hyperpolarization-activated, cyclic nucleotide-gated K+ 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Hcn4  hyperpolarization-activated, cyclic nucleotide-gated K+ 4      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_product member of a family of hyperpolarization -activated, cyclic nucleotide-gated channels 70760