HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4) - Rat Genome Database

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Gene: HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4) Pan paniscus
Analyze
Symbol: HCN4
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 4
RGD ID: 11794993
Description: ENCODES a protein that exhibits cAMP binding (inferred); identical protein binding (inferred); intracellularly cAMP-activated cation channel activity (inferred); INVOLVED IN cellular response to aldosterone (ortholog); in utero embryonic development (ortholog); monoatomic cation transport (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); atrial fibrillation (ortholog); Bardet-Biedl syndrome (ortholog); FOUND IN basolateral plasma membrane (ortholog); neuronal cell body (ortholog); terminal bouton (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21662,549,462 - 62,598,928 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11566,713,883 - 66,763,353 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01552,231,906 - 52,285,220 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11570,994,405 - 71,043,256 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1570,997,020 - 71,042,285 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HCN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21662,549,462 - 62,598,928 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11566,713,883 - 66,763,353 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01552,231,906 - 52,285,220 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11570,994,405 - 71,043,256 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1570,997,020 - 71,042,285 (-)Ensemblpanpan1.1panPan2
HCN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381573,319,859 - 73,368,958 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1573,319,859 - 73,368,958 (-)EnsemblGRCh38hg38GRCh38
GRCh371573,612,200 - 73,661,299 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361571,400,988 - 71,448,230 (-)NCBINCBI36Build 36hg18NCBI36
Build 341571,400,987 - 71,448,230NCBI
Celera1550,490,801 - 50,540,207 (-)NCBICelera
Cytogenetic Map15q24.1NCBI
HuRef1550,443,643 - 50,492,812 (-)NCBIHuRef
CHM1_11573,730,167 - 73,779,572 (-)NCBICHM1_1
T2T-CHM13v2.01571,136,994 - 71,186,091 (-)NCBIT2T-CHM13v2.0
Hcn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39958,730,232 - 58,770,458 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl958,730,695 - 58,770,458 (+)EnsemblGRCm39 Ensembl
GRCm38958,822,949 - 58,863,175 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl958,823,412 - 58,863,175 (+)EnsemblGRCm38mm10GRCm38
MGSCv37958,671,319 - 58,708,762 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36958,621,649 - 58,659,092 (+)NCBIMGSCv36mm8
Celera956,052,112 - 56,089,597 (+)NCBICelera
Cytogenetic Map9BNCBI
cM Map931.8NCBI
Hcn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8868,118,062 - 68,155,482 (+)NCBIGRCr8
mRatBN7.2859,222,206 - 59,259,626 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl859,221,653 - 59,259,639 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx864,753,125 - 64,790,548 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0863,030,680 - 63,068,103 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0860,895,392 - 60,932,815 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0863,599,907 - 63,637,327 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl863,600,663 - 63,639,654 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0863,367,893 - 63,405,313 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4862,629,828 - 62,667,248 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1862,648,881 - 62,686,299 (+)NCBI
Celera858,680,131 - 58,717,545 (+)NCBICelera
Cytogenetic Map8q24NCBI
Hcn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554504,139,852 - 4,181,377 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554504,139,852 - 4,181,377 (+)NCBIChiLan1.0ChiLan1.0
HCN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13036,637,492 - 36,656,194 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3036,639,908 - 36,656,406 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3036,573,522 - 36,617,524 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03036,844,740 - 36,888,776 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3036,844,723 - 36,889,181 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13036,796,738 - 36,840,679 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03036,822,594 - 36,866,568 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03037,078,286 - 37,122,259 (-)NCBIUU_Cfam_GSD_1.0
Hcn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640114,675,949 - 114,722,220 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647132,529,847 - 32,570,284 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647132,527,551 - 32,570,548 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl760,010,283 - 60,050,689 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1760,010,396 - 60,052,258 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2764,633,705 - 64,677,047 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HCN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12610,107,342 - 10,158,885 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2610,110,579 - 10,156,292 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048131,447,372 - 131,496,994 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hcn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624781968,748 - 1,008,200 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624781968,608 - 1,007,969 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034939102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000042684   ⟹   ENSPPAP00000019904
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1570,997,020 - 71,042,285 (-)Ensembl
RefSeq Acc Id: XM_034939102   ⟹   XP_034794993
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21662,549,462 - 62,598,928 (-)NCBI
NHGRI_mPanPan11566,713,883 - 66,763,353 (-)NCBI
Mhudiblu_PPA_v01552,231,906 - 52,285,220 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034794993 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000019904.1
Reference Protein Sequences
RefSeq Acc Id: XP_034794993   ⟸   XM_034939102
RefSeq Acc Id: ENSPPAP00000019904   ⟸   ENSPPAT00000042684
Protein Domains
Cyclic nucleotide-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033171 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000042684.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
NCBI Gene HCN4 ENTREZGENE
PANTHER I[[H]] CHANNEL, ISOFORM E UniProtKB/TrEMBL
  POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 4 UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  Ion_trans_N UniProtKB/TrEMBL
PRINTS EAGCHANLFMLY UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A2R9AXY2_PANPA UniProtKB/TrEMBL