Gene:	Cdc42 ( Rattus norvegicus ) cell division cycle 42 (GTP binding protein)
Description:	small GTPase; involved in formation of cellular asymmetry
Synonyms:	cell division cycle 42 homolog (S. cerevisiae);  (details...)
ArrayIDs:	6394088; 6399488; 6356578; rc_AI227887_g_at; rc_AI176308_at; rc_AA925473_at; GE21484; rc_AI227887_at; 1370825_a_at; 1367475_at; 6564007; 1391127_at; 5845270; rc_AI227676_at; A_44_P555019; 6404212; rc_AA925473_g_at; 6266801; 5636612; 6197050; 6350360; A_44_P555021;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: CDC42     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Cdc42     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Cdc42 Rat Celera Assembly 5 147953333 - 147971185     RGSC genome assembly v3.4 5 156106122 - 156124006     Cytogenetic 5 q36     genome assembly 3.1 5 156116164 - 156153079 Mus musculus Cdc42 Mouse genome assembly build 36.1 4 136875618 - 136892044     Cytogenetic 4 4 D3 Homo sapiens CDC42 human genome assembly 1 22124487 - 22164741     Human genome assembly build 36.2 1 22251707 - 22292023     Cytogenetic 1 p36.1   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology GTP binding,  protein binding,  GTP-dependent protein binding ...  (details...)
Biological Process	Note Reference involved in reduction of the expression of dystrophin-glycoprotein complex (DGC) in muscle atrophy 625642 regulates cell polarity through the spatial regulation of GSK-3beta and Apc 632398 Gene Ontology positive regulation of pseudopodium assembly,  positive regulation of JNK cascade,  establishment of cell polarity ...  (details...)
Cellular Component	Gene Ontology filopodium,  cell projection,  cytoplasm ...  (details...)
Pathway	Ontology c-Jun N-terminal kinases MAPK signaling pathway,  Rho/Rac/Cdc42 mediated signaling pathway,  insulin secretion pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: RHO IPI PROSITE: RHO IPI UNIPARC: UPI0000000356 IPI UNIPARC: UPI0000EADF14 IPI KEGG Report: rno:64465 ENTREZGENE HomoloGene Group ID: 1357 ENTREZGENE Germonline: 71043 Pfam: Ras IPI KEGG Pathway: 04062 ENTREZGENE KEGG Pathway: 04144 ENTREZGENE KEGG Pathway: 04666 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 04670 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 04810 ENTREZGENE KEGG Pathway: 05211 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04530 ENTREZGENE KEGG Pathway: 04370 ENTREZGENE KEGG Pathway: 04360 ENTREZGENE KEGG Pathway: 04520 ENTREZGENE InterPro: Ras_GTPase. IPI InterPro: Ras. IPI InterPro: GTPase_Rho. IPI InterPro: Small_GTP_bd. IPI Ensembl Protein: ENSRNOP00000030928 IPI Ensembl Protein: ENSRNOP00000018118 IPI IPI: IPI00388289 IPI IPI: IPI00285606 IPI Entrez Gene: Cdc42 ENTREZGENE IMAGE_CLONE: IMAGE:6920523 IMAGE-MGC_LOAD MGC_CLONE: MGC:72646 IMAGE-MGC_LOAD UniProt: CDC42_RAT IPI UniProt: CDC42_RAT IPI Ensembl Genes: ENSRNOG00000013536 IPI TIGRFAMs: small_GTP IPI PRINTS: RASTRNSFRMNG. IPI
Sequences	Nucleotide: AF205635 Get FASTA Search GEO Profiles Nucleotide: AF491841 Get FASTA Search GEO Profiles Nucleotide: BC060535 Get FASTA Search GEO Profiles Nucleotide: CH473968 Get FASTA Search GEO Profiles Nucleotide: NM_171994 Get FASTA Search GEO Profiles (View all 5 Nucleotide Accessions) Protein: AAN63806 Get FASTA Protein: NP_741991 Get FASTA Protein: EDL80834 Get FASTA Protein: Q8CFN2 Get FASTA Protein: AAH60535 Get FASTA Protein: AAF15538 Get FASTA Protein: EDL80835 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 60067
References
Curated References	15 references in RGD related to Cdc42
Other References	33 other references at PubMed related to Cdc42
Database Information
RGD ID	71043
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 26-SEP-08: Cdc42 cell division cycle 42 (GTP binding protein) Cdc42 cell division cycle 42 homolog (S. cerevisiae) APPROVED Nomenclature updated to reflect human and mouse nomenclature 1299863 09-JUL-02: Cdc42 cell division cycle 42 homolog (S. cerevisiae) APPROVED Symbol and Name updated to reflect Human and Mouse nomenclature 70877