Adcy3 (adenylate cyclase 3) - Rat Genome Database

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Gene: Adcy3 (adenylate cyclase 3) Rattus norvegicus
Analyze
Symbol: Adcy3
Name: adenylate cyclase 3
RGD ID: 71009
Description: Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in cAMP biosynthetic process and cellular response to forskolin. Located in Golgi apparatus and plasma membrane. Orthologous to human ADCY3 (adenylate cyclase 3); PARTICIPATES IN endothelin signaling pathway; G protein mediated signaling pathway via Galphas family; protein kinase A (PKA) signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AC-III; AC3; adenylate cyclase type 3; adenylate cyclase type III; adenylate cyclase, olfactive type; adenylyl cyclase 3; ATP pyrophosphate-lyase 3; type III adenylyl cyclase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,819,602 - 32,923,174 (+)NCBIGRCr8
mRatBN7.2627,100,089 - 27,203,686 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,124,828 - 27,203,686 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx627,417,094 - 27,495,948 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,732,977 - 27,811,837 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,210,479 - 27,289,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,570,941 - 28,648,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,571,351 - 28,650,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0638,378,060 - 38,454,926 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4627,118,325 - 27,202,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1627,121,352 - 27,205,228 (+)NCBI
Celera626,598,414 - 26,676,272 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
disulfiram  (ISO)
divanadium pentaoxide  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
FR900359  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
Licarin A  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
N-nitrosodiethylamine  (EXP)
Octicizer  (ISO)
ozone  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
rotenone  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (EXP)
toluene  (EXP)
triclosan  (EXP)
undecane  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
ciliary membrane  (IEA,ISO)
cilium  (ISO,ISS)
cytoplasm  (IEA,ISO)
Golgi apparatus  (IDA)
membrane  (ISO,ISS)
plasma membrane  (IBA,IDA,ISO,TAS)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Identification of a specialized adenylyl cyclase that may mediate odorant detection. Bakalyar HA and Reed RR, Science 1990 Dec 7;250(4986):1403-6.
2. Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms. Bogard AS, etal., Naunyn Schmiedebergs Arch Pharmacol. 2014 Apr;387(4):329-39. doi: 10.1007/s00210-013-0950-4. Epub 2013 Dec 22.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rodent oocytes express an active adenylyl cyclase required for meiotic arrest. Horner K, etal., Dev Biol 2003 Jun 15;258(2):385-96.
6. Characterization of adenylyl cyclase isoforms in rat peripheral pulmonary arteries. Jourdan KB, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1359-69.
7. Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats. Keele GR, etal., Obesity (Silver Spring). 2018 Jan;26(1):213-222. doi: 10.1002/oby.22075. Epub 2017 Nov 28.
8. Inactivation of the mouse adenylyl cyclase 3 gene disrupts male fertility and spermatozoon function. Livera G, etal., Mol Endocrinol. 2005 May;19(5):1277-90. Epub 2005 Feb 10.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Nicotinic acetylcholine receptor alpha 7 regulates cAMP signal within lipid rafts. Oshikawa J, etal., Am J Physiol Cell Physiol. 2003 Sep;285(3):C567-74. Epub 2003 May 14.
13. Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts. Ostrom RS, etal., J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.
14. A nuclear location for Ca2+-activated adenylyl cyclases I and III in neurones. Parkinson NA and Bolsover SR, Brain Res Mol Brain Res. 2001 Jul 13;91(1-2):43-9.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Physiological roles for G protein-regulated adenylyl cyclase isoforms: insights from knockout and overexpression studies. Sadana R and Dessauer CW, Neurosignals. 2009;17(1):5-22. Epub 2008 Oct 24.
Additional References at PubMed
PMID:8889548   PMID:11055432   PMID:11549699   PMID:15499025   PMID:18596612   PMID:19946888   PMID:22179047   PMID:22531884   PMID:22871113   PMID:23018249   PMID:23077041   PMID:26393535  
PMID:26934374   PMID:28154160   PMID:30366013   PMID:35625651  


Genomics

Comparative Map Data
Adcy3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,819,602 - 32,923,174 (+)NCBIGRCr8
mRatBN7.2627,100,089 - 27,203,686 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl627,124,828 - 27,203,686 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx627,417,094 - 27,495,948 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,732,977 - 27,811,837 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,210,479 - 27,289,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,570,941 - 28,648,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,571,351 - 28,650,148 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0638,378,060 - 38,454,926 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4627,118,325 - 27,202,275 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1627,121,352 - 27,205,228 (+)NCBI
Celera626,598,414 - 26,676,272 (+)NCBICelera
Cytogenetic Map6q14NCBI
ADCY3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38224,819,169 - 24,920,237 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl224,819,169 - 24,920,237 (-)EnsemblGRCh38hg38GRCh38
GRCh37225,042,038 - 25,143,106 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36224,895,542 - 24,995,559 (-)NCBINCBI36Build 36hg18NCBI36
Build 34224,953,691 - 25,053,654NCBI
Celera224,882,356 - 24,982,363 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef224,779,864 - 24,880,170 (-)NCBIHuRef
CHM1_1224,971,569 - 25,071,569 (-)NCBICHM1_1
T2T-CHM13v2.0224,853,918 - 24,954,979 (-)NCBIT2T-CHM13v2.0
Adcy3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,183,397 - 4,263,525 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,183,103 - 4,263,525 (+)EnsemblGRCm39 Ensembl
GRCm38124,133,116 - 4,213,525 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl124,133,103 - 4,213,525 (+)EnsemblGRCm38mm10GRCm38
MGSCv37124,133,397 - 4,213,524 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36124,134,076 - 4,214,096 (+)NCBIMGSCv36mm8
Celera124,061,963 - 4,140,655 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
Adcy3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554696,929,092 - 7,026,758 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554696,933,208 - 7,026,179 (-)NCBIChiLan1.0ChiLan1.0
ADCY3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212101,605,337 - 101,706,428 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A101,609,330 - 101,710,392 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A24,812,729 - 24,913,539 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A24,908,108 - 25,009,163 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A24,908,108 - 25,009,163 (-)Ensemblpanpan1.1panPan2
ADCY3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,153,732 - 19,231,943 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1719,154,571 - 19,232,411 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1719,050,504 - 19,129,367 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01719,426,953 - 19,505,567 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,426,958 - 19,505,153 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11719,163,469 - 19,242,122 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01719,172,925 - 19,251,551 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01719,212,943 - 19,298,018 (-)NCBIUU_Cfam_GSD_1.0
Adcy3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,506,132 - 63,589,371 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364937,250,194 - 7,335,691 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364937,250,194 - 7,333,433 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADCY3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3113,876,339 - 113,982,369 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13113,875,005 - 113,969,053 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23121,107,146 - 121,199,908 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADCY3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,752,786 - 82,858,727 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1482,753,177 - 82,859,415 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604529,309,587 - 29,414,423 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adcy3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,163,354 - 7,249,190 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247387,163,189 - 7,249,249 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adcy3
527 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:72
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000005389
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
RH134597  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,203,769 - 27,203,964 (+)MAPPERmRatBN7.2
Rnor_6.0628,648,932 - 28,649,126NCBIRnor6.0
Rnor_5.0638,455,009 - 38,455,203UniSTSRnor5.0
Celera626,676,356 - 26,676,550UniSTS
RH 3.4 Map6116.9UniSTS
Cytogenetic Map6q14UniSTS
UniSTS:496038  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,186,204 - 27,186,925 (+)MAPPERmRatBN7.2
Rnor_6.0628,631,368 - 28,632,088NCBIRnor6.0
Rnor_5.0638,437,445 - 38,438,165UniSTSRnor5.0
RGSC_v3.4627,184,795 - 27,185,515UniSTSRGSC3.4
Celera626,658,792 - 26,659,512UniSTS
Cytogenetic Map6q14UniSTS
ADCY3_1034  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2627,202,796 - 27,203,615 (+)MAPPERmRatBN7.2
Rnor_6.0628,647,959 - 28,648,777NCBIRnor6.0
Rnor_5.0638,454,036 - 38,454,854UniSTSRnor5.0
RGSC_v3.4627,201,386 - 27,202,204UniSTSRGSC3.4
Celera626,675,383 - 26,676,201UniSTS
Cytogenetic Map6q14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 8 50 14 1
Low 3 43 44 31 11 31 8 11 24 35 27 10 8
Below cutoff 10 10 10

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005389   ⟹   ENSRNOP00000005389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl627,124,828 - 27,203,686 (+)Ensembl
Rnor_6.0 Ensembl628,571,351 - 28,650,148 (+)Ensembl
RefSeq Acc Id: NM_130779   ⟹   NP_570135
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,844,320 - 32,923,173 (+)NCBI
mRatBN7.2627,124,828 - 27,203,686 (+)NCBI
Rnor_6.0628,571,133 - 28,648,848 (+)NCBI
Rnor_5.0638,378,060 - 38,454,926 (+)NCBI
RGSC_v3.4627,118,325 - 27,202,275 (+)RGD
Celera626,598,414 - 26,676,272 (+)RGD
Sequence:
RefSeq Acc Id: XM_006239847   ⟹   XP_006239909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,844,441 - 32,923,174 (+)NCBI
mRatBN7.2627,124,951 - 27,202,951 (+)NCBI
Rnor_6.0628,571,305 - 28,648,237 (+)NCBI
Rnor_5.0638,378,060 - 38,454,926 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239848   ⟹   XP_006239910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,844,500 - 32,923,174 (+)NCBI
mRatBN7.2627,125,005 - 27,202,951 (+)NCBI
Rnor_6.0628,571,380 - 28,648,237 (+)NCBI
Rnor_5.0638,378,060 - 38,454,926 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239849   ⟹   XP_006239911
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,844,510 - 32,923,174 (+)NCBI
mRatBN7.2627,125,002 - 27,202,951 (+)NCBI
Rnor_6.0628,570,941 - 28,648,237 (+)NCBI
Rnor_5.0638,378,060 - 38,454,926 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239850   ⟹   XP_006239912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,844,510 - 32,923,174 (+)NCBI
mRatBN7.2627,125,697 - 27,202,951 (+)NCBI
Rnor_6.0628,571,305 - 28,648,237 (+)NCBI
Rnor_5.0638,378,060 - 38,454,926 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112876   ⟹   XP_038968804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,819,602 - 32,923,174 (+)NCBI
mRatBN7.2627,100,089 - 27,202,951 (+)NCBI
RefSeq Acc Id: XM_063262445   ⟹   XP_063118515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,844,443 - 32,923,174 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_570135   ⟸   NM_130779
- UniProtKB: P21932 (UniProtKB/Swiss-Prot),   G3V6I2 (UniProtKB/TrEMBL),   A6HAH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239911   ⟸   XM_006239849
- Peptide Label: isoform X1
- UniProtKB: P21932 (UniProtKB/Swiss-Prot),   G3V6I2 (UniProtKB/TrEMBL),   A6HAH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239910   ⟸   XM_006239848
- Peptide Label: isoform X1
- UniProtKB: P21932 (UniProtKB/Swiss-Prot),   G3V6I2 (UniProtKB/TrEMBL),   A6HAH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239912   ⟸   XM_006239850
- Peptide Label: isoform X2
- UniProtKB: P21932 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006239909   ⟸   XM_006239847
- Peptide Label: isoform X1
- UniProtKB: P21932 (UniProtKB/Swiss-Prot),   G3V6I2 (UniProtKB/TrEMBL),   A6HAH1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005389   ⟸   ENSRNOT00000005389
RefSeq Acc Id: XP_038968804   ⟸   XM_039112876
- Peptide Label: isoform X1
- UniProtKB: P21932 (UniProtKB/Swiss-Prot),   G3V6I2 (UniProtKB/TrEMBL),   A6HAH1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118515   ⟸   XM_063262445
- Peptide Label: isoform X2
Protein Domains
Guanylate cyclase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21932-F1-model_v2 AlphaFold P21932 1-1144 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71009 AgrOrtholog
BioCyc Gene G2FUF-38279 BioCyc
Ensembl Genes ENSRNOG00000003999 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005389 ENTREZGENE
  ENSRNOT00000005389.7 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.1230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A/G_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A/G_cyclase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adcy UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide_cyclase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64508 ENTREZGENE
PANTHER ADENYLATE CYCLASE TYPE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADENYLATE CYCLASE TYPE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AC_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Guanylate_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Adcy3 PhenoGen
PIRSF Ade_cyc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GUANYLATE_CYCLASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GUANYLATE_CYCLASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003999 RatGTEx
SMART CYCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55073 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HAH1 ENTREZGENE, UniProtKB/TrEMBL
  ADCY3_RAT UniProtKB/Swiss-Prot
  G3V6I2 ENTREZGENE, UniProtKB/TrEMBL
  P21932 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Adcy3  adenylate cyclase 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process mediates odorant detection (possibly) via modulation of intracellular cAMP concentration 724707