Hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1) - Rat Genome Database

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Gene: Hmgcs1 (3-hydroxy-3-methylglutaryl-CoA synthase 1) Rattus norvegicus
Analyze
Symbol: Hmgcs1
Name: 3-hydroxy-3-methylglutaryl-CoA synthase 1
RGD ID: 70970
Description: Enables hydroxymethylglutaryl-CoA synthase activity; isomerase activity; and organic acid binding activity. Involved in several processes, including cellular response to cholesterol; cellular response to follicle-stimulating hormone stimulus; and response to vitamin E. Predicted to be located in cytoplasm. Biomarker of obesity. Orthologous to human HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1); PARTICIPATES IN alendronate pharmacodynamics pathway; cholesterol biosynthetic pathway; cholesterol ester storage disease pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; 1,3,4-thiadiazole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase 1; hydroxymethylglutaryl-CoA synthase, cytoplasmic
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8253,379,457 - 53,399,807 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl253,382,643 - 53,399,802 (+)EnsemblGRCr8
mRatBN7.2251,649,368 - 51,667,100 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl251,649,497 - 51,667,100 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx258,768,758 - 58,786,285 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0256,827,479 - 56,845,007 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0251,761,458 - 51,778,967 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0252,427,351 - 52,445,082 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl252,431,601 - 52,445,055 (+)Ensemblrn6Rnor6.0
Rnor_5.0270,791,035 - 70,809,191 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4251,737,090 - 51,754,583 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera247,304,535 - 47,322,038 (+)NCBICelera
RGSC_v3.1251,665,322 - 51,682,816 (+)NCBI
Cytogenetic Map2q15NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,4-thiadiazole  (EXP)
1-(3-(trifluoromethyl)phenyl)piperazine  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-D  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
22-Hydroxycholesterol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
amiodarone  (EXP)
amitriptyline  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
Archazolid B  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
betulin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
bupropion  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
citalopram  (ISO)
clofibrate  (EXP)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (EXP)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (EXP)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
difenoconazole  (ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP,ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (ISO)
dipentyl phthalate  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP,ISO)
enilconazole  (ISO)
enniatin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
fenarimol  (EXP)
fenofibrate  (ISO)
fentin chloride  (EXP)
fenvalerate  (EXP)
fingolimod hydrochloride  (ISO)
fluoranthene  (ISO)
fluoxetine  (ISO)
flusilazole  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
furfural  (ISO)
gamma-hexachlorocyclohexane  (ISO)
Ganoderic acid A  (ISO)
gedunin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (EXP,ISO)
imipramine  (ISO)
indometacin  (EXP,ISO)
iron dichloride  (ISO)
isobutanol  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (ISO)
lucanthone  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
mirtazapine  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
morphine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrates  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (ISO)
octocrylene  (ISO)
olanzapine  (ISO)
oleic acid  (ISO)
organophosphorus compound  (EXP)
oxybenzone  (ISO)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorobutanesulfonic acid  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanesulfonamide  (ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoropentanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
phytosterols  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
prednisolone  (ISO)
progesterone  (ISO)
propamocarb  (ISO)
propanal  (ISO)
propanil  (ISO)
propiconazole  (EXP,ISO)
prostaglandin A1  (ISO)
pyrazinecarboxamide  (EXP)
pyrethrins  (EXP)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulfluramid  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topiramate  (EXP)
topotecan  (ISO)
triadimefon  (EXP,ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
triphenylstannane  (EXP)
Triptolide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
Yessotoxin  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (ISO)
zileuton  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
ziprasidone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Lipogenic potential in liver of the preweanling rat: influence of dietary cholesterol. Auestad N, etal., FASEB J. 1988 Dec;2(15):3108-12.
2. Nucleotide sequence of a rat liver cDNA encoding the cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Ayte J, etal., Nucleic Acids Res 1990 Jun 25;18(12):3642.
3. Regulation of cholesterol synthesis in rat adrenal gland through coordinate control of 3-hydroxy-3-methylglutaryl coenzyme A synthase and reductase activities. Balasubramaniam S, etal., Proc Natl Acad Sci U S A. 1977 Apr;74(4):1421-5.
4. Alpha-tocopherol affects androgen metabolism in male rat. Barella L, etal., Ann N Y Acad Sci. 2004 Dec;1031:334-6.
5. Formation of intranuclear crystalloids and proliferation of the smooth endoplasmic reticulum in schwann cells induced by tellurium treatment: association with overexpression of HMG CoA reductase and HMG CoA synthase mRNA. Berciano MT, etal., Glia. 2000 Feb 1;29(3):246-59.
6. Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway. Clarke CF, etal., Mol Cell Biol 1987 Sep;7(9):3138-46.
7. Actein activates stress- and statin-associated responses and is bioavailable in Sprague-Dawley rats. Einbond LS, etal., Fundam Clin Pharmacol. 2009 Jun;23(3):311-21.
8. Correlation between protein accumulation profiles and conventional toxicological findings using a model antiandrogenic compound, flutamide. Friry-Santini C, etal., Toxicol Sci. 2007 May;97(1):81-93. Epub 2007 Feb 20.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Inhibition of 3-hydroxy-3-methylglutaryl-CoA synthase and cholesterol biosynthesis by beta-lactone inhibitors and binding of these inhibitors to the enzyme. Greenspan MD, etal., Biochem J. 1993 Feb 1;289 ( Pt 3):889-95.
12. Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis. Hegardt FG Biochimie. 1998 Oct;80(10):803-6.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Proteomic and transcriptomic analysis for streptozotocin-induced diabetic rat pancreas in response to fungal polysaccharide treatments. Kim SW, etal., Proteomics. 2008 Jun;8(11):2344-61.
15. FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Liu Z, etal., Mol Endocrinol. 2009 May;23(5):649-61. Epub 2009 Feb 5.
16. The course of ketosis and the activity of key enzymes of ketogenesis and ketone-body utilization during development of the postnatal rat. Lockwood EA and Bailey E, Biochem J. 1971 Aug;124(1):249-54.
17. Gene Data Set MGD Curation, June 12, 2002
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins. Morikawa S, etal., J Atheroscler Thromb. 2005;12(3):121-31.
20. Cerebral ketone body metabolism. Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytes. Post SM, etal., Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):3064-70.
26. GOA pipeline RGD automated data pipeline
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Diurnal rhythm of rat liver cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase. Royo T, etal., Biochem J. 1991 Nov 15;280 ( Pt 1):61-4.
29. Regulation of cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase mRNA levels by L-tri-iodothyronine. Royo T, etal., Biochem J. 1993 Jan 15;289 ( Pt 2):557-60.
30. Cytosolic 3-hydroxy-3-methyl glutaryl coenzyme a synthase in rat brain: properties and developmental change. Shah SN Neurochem Res. 1982 Nov;7(11):1359-66.
31. Tissue-specific transcriptional regulation of the cholesterol biosynthetic pathway leads to accumulation of testis meiosis-activating sterol (T-MAS). Tacer KF, etal., J Lipid Res. 2002 Jan;43(1):82-9.
32. Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Tomoda H, etal., Biochim Biophys Acta. 2004 Feb 27;1636(1):22-8.
33. The effects of the intestinal glucosidase inhibitor acarbose on cholesterogenesis in corpulent rats. Tulp OL, etal., Comp Biochem Physiol A Comp Physiol. 1991;100(3):763-8.
34. Regulation of luteinizing hormone/chorionic gonadotropin receptor messenger ribonucleic acid expression in the rat ovary: relationship to cholesterol metabolism. Wang L and Menon KM, Endocrinology. 2005 Jan;146(1):423-31. Epub 2004 Sep 30.
35. The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome. Wang Y, etal., J Proteome Res. 2008 Apr;7(4):1606-14. Epub 2008 Feb 28.
36. Defects of cholesterol biosynthesis. Waterham HR FEBS Lett. 2006 Oct 9;580(23):5442-9. Epub 2006 Jul 20.
37. Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity. Wu L, etal., Org Lett. 2007 Sep 27;9(20):3877-80. Epub 2007 Sep 1.
38. Proteomic profiling of proteins in rat spinal cord induced by contusion injury. Yan X, etal., Neurochem Int. 2010 Jul;56(8):971-83. Epub 2010 Apr 24.
Additional References at PubMed
PMID:20346956   PMID:27671501  


Genomics

Comparative Map Data
Hmgcs1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8253,379,457 - 53,399,807 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl253,382,643 - 53,399,802 (+)EnsemblGRCr8
mRatBN7.2251,649,368 - 51,667,100 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl251,649,497 - 51,667,100 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx258,768,758 - 58,786,285 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0256,827,479 - 56,845,007 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0251,761,458 - 51,778,967 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0252,427,351 - 52,445,082 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl252,431,601 - 52,445,055 (+)Ensemblrn6Rnor6.0
Rnor_5.0270,791,035 - 70,809,191 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4251,737,090 - 51,754,583 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera247,304,535 - 47,322,038 (+)NCBICelera
RGSC_v3.1251,665,322 - 51,682,816 (+)NCBI
Cytogenetic Map2q15NCBI
HMGCS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38543,287,470 - 43,313,412 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl543,287,470 - 43,313,512 (-)Ensemblhg38GRCh38
GRCh37543,287,572 - 43,313,514 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36543,325,250 - 43,349,352 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34543,325,254 - 43,349,241NCBI
Celera543,180,430 - 43,204,721 (-)NCBICelera
Cytogenetic Map5p12NCBI
HuRef543,238,000 - 43,264,043 (-)NCBIHuRef
CHM1_1543,288,873 - 43,314,913 (-)NCBICHM1_1
T2T-CHM13v2.0543,540,305 - 43,566,247 (-)NCBIT2T-CHM13v2.0
Hmgcs1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913120,151,887 - 120,169,796 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13120,151,915 - 120,169,796 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3813119,690,351 - 119,708,260 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13119,690,379 - 119,708,260 (+)Ensemblmm10GRCm38
Celera13124,068,495 - 124,086,131 (+)NCBICelera
Cytogenetic Map13D2.3NCBI
cM Map1366.0NCBI
Hmgcs1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544618,978,102 - 18,998,951 (+)Ensembl
ChiLan1.0NW_00495544618,978,261 - 18,996,794 (+)NCBIChiLan1.0ChiLan1.0
HMGCS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2467,019,050 - 67,043,912 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1565,172,676 - 65,197,538 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0567,067,001 - 67,091,786 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1572,116,304 - 72,141,050 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl572,116,228 - 72,141,050 (+)EnsemblpanPan2panpan1.1
HMGCS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1466,633,706 - 66,654,005 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl466,633,572 - 66,652,196 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha466,394,617 - 66,415,022 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0467,130,232 - 67,144,820 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl467,123,795 - 67,144,508 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1466,884,796 - 66,905,197 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0467,014,391 - 67,034,791 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0467,551,264 - 67,571,669 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hmgcs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213209,925,788 - 209,946,119 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648018,862,238 - 18,882,616 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648018,862,288 - 18,882,614 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGCS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1627,936,218 - 27,957,193 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11627,936,225 - 27,957,261 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21629,432,931 - 29,452,429 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMGCS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1442,083,523 - 42,107,410 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl442,080,949 - 42,107,409 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607132,560,062 - 32,583,929 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmgcs1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475911,826,876 - 11,847,111 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475911,826,793 - 11,847,111 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hmgcs1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v13177,207,664 - 177,225,430 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hmgcs1
134 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:129
Interacting mature miRNAs:148
Transcripts:ENSRNOT00000023554
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21332504158325041Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22411781369117813Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23675034481750344Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)23561408353462005Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21605188361051883Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22203804467038044Rat
731166Mamtr2Mammary tumor resistance QTL 20.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2962358154623581Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22888999173889991Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)21436870759368707Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24490435585286097Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266683465677Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21822713763227137Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23686864381868643Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)24490435589904355Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)23326999678269996Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22865266673652666Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000023554   ⟹   ENSRNOP00000023554
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl251,649,497 - 51,667,097 (+)Ensembl
Rnor_6.0 Ensembl252,431,601 - 52,445,055 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095351   ⟹   ENSRNOP00000092234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl253,382,643 - 53,399,802 (+)Ensembl
mRatBN7.2 Ensembl251,649,497 - 51,667,097 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100742   ⟹   ENSRNOP00000093563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl253,382,643 - 53,399,802 (+)Ensembl
mRatBN7.2 Ensembl251,649,937 - 51,667,100 (+)Ensembl
RefSeq Acc Id: NM_017268   ⟹   NP_058964
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,382,304 - 53,399,807 (+)NCBI
mRatBN7.2251,649,596 - 51,667,100 (+)NCBI
Rnor_6.0252,427,579 - 52,445,082 (+)NCBI
Rnor_5.0270,791,035 - 70,809,191 (+)NCBI
RGSC_v3.4251,737,090 - 51,754,583 (+)RGD
Celera247,304,535 - 47,322,038 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231959   ⟹   XP_006232021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,382,184 - 53,399,807 (+)NCBI
mRatBN7.2251,649,368 - 51,667,098 (+)NCBI
Rnor_6.0252,427,351 - 52,445,080 (+)NCBI
Rnor_5.0270,791,035 - 70,809,191 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102122   ⟹   XP_038958050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8253,379,457 - 53,399,807 (+)NCBI
mRatBN7.2251,649,673 - 51,667,100 (+)NCBI
RefSeq Acc Id: NP_058964   ⟸   NM_017268
- UniProtKB: P17425 (UniProtKB/Swiss-Prot),   A6I5W9 (UniProtKB/TrEMBL),   A0A8I6AH54 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232021   ⟸   XM_006231959
- Peptide Label: isoform X2
- UniProtKB: P17425 (UniProtKB/Swiss-Prot),   A6I5W9 (UniProtKB/TrEMBL),   A0A8I6AH54 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023554   ⟸   ENSRNOT00000023554
RefSeq Acc Id: XP_038958050   ⟸   XM_039102122
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AX76 (UniProtKB/TrEMBL),   A6I5W7 (UniProtKB/TrEMBL),   A0A8I6AH54 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093563   ⟸   ENSRNOT00000100742
Ensembl Acc Id: ENSRNOP00000092234   ⟸   ENSRNOT00000095351
Protein Domains
Hydroxymethylglutaryl-coenzyme A synthase C-   Hydroxymethylglutaryl-coenzyme A synthase N-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17425-F1-model_v2 AlphaFold P17425 1-520 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70970 AgrOrtholog
BioCyc Gene G2FUF-54276 BioCyc
BioCyc Pathway PWY-922 [mevalonate pathway I (eukaryotes and bacteria)] BioCyc
  PWY66-367 [ketogenesis] BioCyc
BioCyc Pathway Image PWY-922 BioCyc
  PWY66-367 BioCyc
Ensembl Genes ENSRNOG00000016552 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023554.7 UniProtKB/Swiss-Prot
  ENSRNOT00000095351 ENTREZGENE
  ENSRNOT00000100742 ENTREZGENE
Gene3D-CATH 3.40.47.10 UniProtKB/Swiss-Prot
InterPro HMG_CoA_synt_AS UniProtKB/Swiss-Prot
  HMG_CoA_synt_C_dom UniProtKB/Swiss-Prot
  HMG_CoA_synth_N UniProtKB/Swiss-Prot
  HMG_CoA_synthase_euk UniProtKB/Swiss-Prot
  Thiolase-like UniProtKB/Swiss-Prot
KEGG Report rno:29637 UniProtKB/Swiss-Prot
NCBI Gene 29637 ENTREZGENE
PANTHER 3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE UniProtKB/Swiss-Prot
  HYDROXYMETHYLGLUTARYL-COA SYNTHASE, CYTOPLASMIC UniProtKB/Swiss-Prot
Pfam HMG_CoA_synt_C UniProtKB/Swiss-Prot
  HMG_CoA_synt_N UniProtKB/Swiss-Prot
PhenoGen Hmgcs1 PhenoGen
PROSITE HMG_COA_SYNTHASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016552 RatGTEx
Superfamily-SCOP SSF53901 UniProtKB/Swiss-Prot
UniProt A0A8I6AH54 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AX76 ENTREZGENE, UniProtKB/TrEMBL
  A6I5W7 ENTREZGENE, UniProtKB/TrEMBL
  A6I5W9 ENTREZGENE, UniProtKB/TrEMBL
  HMCS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-02 Hmgcs1  3-hydroxy-3-methylglutaryl-CoA synthase 1  Hmgcs1  3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Hmgcs1  3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)  Hmgcs1  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Hmgcs1  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)  Hmgcs1  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Hmgcs1  3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference