Dll3 (delta like canonical Notch ligand 3) - Rat Genome Database

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Gene: Dll3 (delta like canonical Notch ligand 3) Rattus norvegicus
Analyze
Symbol: Dll3
Name: delta like canonical Notch ligand 3
RGD ID: 70953
Description: Enables Notch binding activity. Involved in negative regulation of Notch signaling pathway; negative regulation of astrocyte differentiation; and positive regulation of neurogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis 1. Orthologous to human DLL3 (delta like canonical Notch ligand 3); PARTICIPATES IN altered Notch signaling pathway; altered Notch signaling pathway involving the main players; Notch signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: delta (Drosophila)-like 3; delta-like 3 (Drosophila); delta-like protein 3; delta3; drosophila Delta homolog 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,689,577 - 92,698,125 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,689,577 - 92,697,406 (-)EnsemblGRCr8
mRatBN7.2183,562,011 - 83,570,008 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,562,014 - 83,569,750 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,973,668 - 88,982,023 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,431,999 - 97,440,363 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,729,526 - 90,737,881 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,485,875 - 85,493,683 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,485,289 - 85,493,685 (+)Ensemblrn6Rnor6.0
Rnor_5.0186,697,034 - 86,704,826 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,373,482 - 83,381,219 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,961,035 - 77,968,719 (-)NCBICelera
RGSC_v3.1183,451,593 - 83,459,330 (-)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Bulman MP, etal., Nat Genet. 2000 Apr;24(4):438-41.
2. Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Dunwoodie SL, etal., Development. 2002 Apr;129(7):1795-806.
3. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells. Irvin DK, etal., J Neurosci Res 2004 Feb 1;75(3):330-43.
7. The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. Ladi E, etal., J Cell Biol. 2005 Sep 12;170(6):983-92. Epub 2005 Sep 6.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Information Derived from GenBank Report RGD, Sept. 2003
18. Diverse requirements for Notch signalling in mammals. Sparrow DB, etal., Int J Dev Biol 2002;46(4):365-74.
Additional References at PubMed
PMID:9272948   PMID:12001066   PMID:15170697  


Genomics

Comparative Map Data
Dll3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,689,577 - 92,698,125 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,689,577 - 92,697,406 (-)EnsemblGRCr8
mRatBN7.2183,562,011 - 83,570,008 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,562,014 - 83,569,750 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,973,668 - 88,982,023 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,431,999 - 97,440,363 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,729,526 - 90,737,881 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0185,485,875 - 85,493,683 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl185,485,289 - 85,493,685 (+)Ensemblrn6Rnor6.0
Rnor_5.0186,697,034 - 86,704,826 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,373,482 - 83,381,219 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,961,035 - 77,968,719 (-)NCBICelera
RGSC_v3.1183,451,593 - 83,459,330 (-)NCBI
Cytogenetic Map1q21NCBI
DLL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,498,947 - 39,508,469 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,498,895 - 39,508,481 (+)Ensemblhg38GRCh38
GRCh371939,989,587 - 39,999,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361944,681,427 - 44,690,949 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341944,681,426 - 44,690,948NCBI
Celera1936,791,266 - 36,800,828 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,435,871 - 36,445,452 (+)NCBIHuRef
CHM1_11939,990,197 - 39,999,736 (+)NCBICHM1_1
T2T-CHM13v2.01942,303,204 - 42,312,726 (+)NCBIT2T-CHM13v2.0
Dll3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,992,980 - 28,001,210 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,992,978 - 28,001,663 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38728,293,555 - 28,301,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,293,553 - 28,302,238 (-)Ensemblmm10GRCm38
MGSCv37729,078,574 - 29,086,804 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36728,002,336 - 28,010,544 (-)NCBIMGSCv36mm8
Celera722,855,195 - 22,863,426 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.67NCBI
Dll3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546871,004 - 78,827 (-)Ensembl
ChiLan1.0NW_00495546870,714 - 78,831 (-)NCBIChiLan1.0ChiLan1.0
DLL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22045,794,577 - 45,804,191 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11947,665,162 - 47,674,775 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01936,597,420 - 36,607,021 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,144,641 - 45,154,854 (+)NCBIPanPan1.1PanPan1.1panPan2
DLL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,737,662 - 113,745,936 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,141,459 - 113,149,451 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01114,338,412 - 114,346,404 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,338,408 - 114,346,328 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,897,659 - 113,905,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,530,679 - 113,538,682 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,525,073 - 114,533,065 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dll3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,893,682 - 13,904,131 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,322,531 - 2,329,953 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,322,531 - 2,330,150 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DLL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,147,635 - 48,155,292 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1648,135,738 - 48,155,373 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,998,228 - 44,008,477 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DLL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,102,433 - 34,114,558 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,103,854 - 34,114,103 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607312,125,291 - 12,136,981 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dll3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479412,806,868 - 12,815,582 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479412,806,299 - 12,816,048 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Dll3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12167,715,019 - 167,723,396 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dll3
29 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:150
Interacting mature miRNAs:165
Transcripts:ENSRNOT00000026182
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat

Markers in Region
RH140770  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,562,752 - 83,562,904 (-)MAPPERmRatBN7.2
Rnor_6.0185,492,792 - 85,492,943NCBIRnor6.0
Rnor_5.0186,703,935 - 86,704,086UniSTSRnor5.0
RGSC_v3.4183,374,222 - 83,374,373UniSTSRGSC3.4
Celera177,961,775 - 77,961,926UniSTS
Cytogenetic Map1q21UniSTS
RH141257  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8192,689,697 - 92,690,157 (+)Marker Load Pipeline
mRatBN7.2183,562,133 - 83,562,593 (-)MAPPERmRatBN7.2
Rnor_6.0185,493,103 - 85,493,562NCBIRnor6.0
Rnor_5.0186,704,246 - 86,704,705UniSTSRnor5.0
RGSC_v3.4183,373,603 - 83,374,062UniSTSRGSC3.4
Celera177,961,156 - 77,961,615UniSTS
RH 3.4 Map1839.2UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 11 41 131 63 62 31 54 31 6 201 118 1 111 32 68 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000026182   ⟹   ENSRNOP00000026182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,689,577 - 92,697,316 (-)Ensembl
mRatBN7.2 Ensembl183,562,014 - 83,569,750 (-)Ensembl
Rnor_6.0 Ensembl185,485,289 - 85,493,685 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl185,490,587 - 85,491,231 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000149953   ⟹   ENSRNOP00000110429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,689,577 - 92,697,406 (-)Ensembl
RefSeq Acc Id: NM_053666   ⟹   NP_446118
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,689,577 - 92,697,316 (-)NCBI
mRatBN7.2183,562,013 - 83,569,750 (-)NCBI
Rnor_6.0185,485,945 - 85,493,683 (+)NCBI
Rnor_5.0186,697,034 - 86,704,826 (+)NCBI
RGSC_v3.4183,373,482 - 83,381,219 (-)RGD
Celera177,961,035 - 77,968,719 (-)RGD
Sequence:
RefSeq Acc Id: XM_006228611   ⟹   XP_006228673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,689,577 - 92,698,125 (-)NCBI
mRatBN7.2183,562,011 - 83,570,008 (-)NCBI
Rnor_6.0185,485,875 - 85,493,683 (+)NCBI
Rnor_5.0186,697,034 - 86,704,826 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_446118 (Get FASTA)   NCBI Sequence Viewer  
  XP_006228673 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC33303 (Get FASTA)   NCBI Sequence Viewer  
  EDM07908 (Get FASTA)   NCBI Sequence Viewer  
  EDM07909 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026182
GenBank Protein O88671 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446118   ⟸   NM_053666
- Peptide Label: precursor
- UniProtKB: O88671 (UniProtKB/Swiss-Prot),   F1M9P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228673   ⟸   XM_006228611
- Peptide Label: isoform X1
- UniProtKB: O88671 (UniProtKB/Swiss-Prot),   A6J9H5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026182   ⟸   ENSRNOT00000026182
Ensembl Acc Id: ENSRNOP00000110429   ⟸   ENSRNOT00000149953
Protein Domains
DSL   EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88671-F1-model_v2 AlphaFold O88671 1-589 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70953 AgrOrtholog
BioCyc Gene G2FUF-60257 BioCyc
Ensembl Genes ENSRNOG00000019338 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000026182 ENTREZGENE
Gene3D-CATH 2.60.40.3510 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_CS UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  Notch_ligand_N UniProtKB/Swiss-Prot
KEGG Report rno:114125 UniProtKB/Swiss-Prot
NCBI Gene 114125 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2 UniProtKB/Swiss-Prot
  UNINFLATABLE, ISOFORM C UniProtKB/Swiss-Prot
Pfam EGF UniProtKB/Swiss-Prot
  hEGF UniProtKB/Swiss-Prot
  MNNL UniProtKB/Swiss-Prot
PhenoGen Dll3 PhenoGen
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019338 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
UniProt A0ABK0LVU0_RAT UniProtKB/TrEMBL
  A6J9H5 ENTREZGENE, UniProtKB/TrEMBL
  A6J9H6_RAT UniProtKB/TrEMBL
  DLL3_RAT UniProtKB/Swiss-Prot
  F1M9P5 ENTREZGENE, UniProtKB/TrEMBL
  O88671 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-20 Dll3  delta like canonical Notch ligand 3  Dll3  delta-like 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Dll3  delta-like 3 (Drosophila)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the proliferative EGL (external granule layer) of the brain during the first week of postnatal development, possibly suggesting communication between adjacent Dll3-expressing and Notch2-expressing cells 1304491
gene_expression expressed in sparsely distributed cells within the ventricular germinal zones during the late embryonic stage and at relatively very low levels during the first week postnatal 1304491