Grpel1 (GrpE-like 1, mitochondrial) - Rat Genome Database

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Gene: Grpel1 (GrpE-like 1, mitochondrial) Rattus norvegicus
Analyze
Symbol: Grpel1
Name: GrpE-like 1, mitochondrial
RGD ID: 70947
Description: Enables ATPase activator activity; ATPase binding activity; and identical protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in mitochondrial matrix. Predicted to be part of PAM complex, Tim23 associated import motor. Biomarker of middle cerebral artery infarction. Orthologous to human GRPEL1 (GrpE like 1, mitochondrial); PARTICIPATES IN presequence pathway of mitochondrial protein import; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2-nitrofluorene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: grpE protein homolog 1, mitochondrial; GrpE#1; GrpE1; mt-GrpE#1; stress-inducible chaperone mt-GrpE#1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,517,049 - 78,522,868 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1478,517,052 - 78,522,861 (-)EnsemblGRCr8
mRatBN7.21474,292,023 - 74,298,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1474,292,023 - 74,298,200 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1478,734,419 - 78,740,226 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01479,975,292 - 79,981,099 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01476,420,265 - 76,426,072 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01479,458,951 - 79,464,782 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1479,458,963 - 79,464,770 (-)Ensemblrn6Rnor6.0
Rnor_5.01479,097,953 - 79,103,777 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41479,873,191 - 79,878,998 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1473,230,590 - 73,236,397 (-)NCBICelera
RGSC_v3.11479,875,225 - 79,881,387 (-)NCBI
Cytogenetic Map14q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
adenine  (ISO)
aflatoxin B1  (EXP)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
hydroxyurea  (ISO)
isobutanol  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
limonene  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
omeprazole  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of a human mitochondrial homologue of the bacterial co-chaperone GrpE. Choglay AA, etal., Gene 2001 Apr 4;267(1):125-34.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Isolation and characterisation of a cDNA encoding rat mitochondrial GrpE, a stress-inducible nucleotide-exchange factor of ubiquitous appearance in mammalian organs. Naylor DJ, etal., FEBS Lett 1996 Nov 4;396(2-3):181-8.
7. Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members. Naylor DJ, etal., J Biol Chem. 1998 Aug 14;273(33):21169-77.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Unlocking the presequence import pathway. Schulz C, etal., Trends Cell Biol. 2015 May;25(5):265-75. doi: 10.1016/j.tcb.2014.12.001. Epub 2014 Dec 23.
13. Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat. Tamura S, etal., Brain Res 2003 Jan 17;960(1-2):277-81.
Additional References at PubMed
PMID:11311562   PMID:12477932   PMID:14651853   PMID:18614015   PMID:25002582  


Genomics

Comparative Map Data
Grpel1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81478,517,049 - 78,522,868 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1478,517,052 - 78,522,861 (-)EnsemblGRCr8
mRatBN7.21474,292,023 - 74,298,243 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1474,292,023 - 74,298,200 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1478,734,419 - 78,740,226 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01479,975,292 - 79,981,099 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01476,420,265 - 76,426,072 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01479,458,951 - 79,464,782 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1479,458,963 - 79,464,770 (-)Ensemblrn6Rnor6.0
Rnor_5.01479,097,953 - 79,103,777 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41479,873,191 - 79,878,998 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1473,230,590 - 73,236,397 (-)NCBICelera
RGSC_v3.11479,875,225 - 79,881,387 (-)NCBI
Cytogenetic Map14q21NCBI
GRPEL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3847,058,895 - 7,068,064 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl47,058,643 - 7,068,145 (-)Ensemblhg38GRCh38
GRCh3747,060,622 - 7,069,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3647,112,681 - 7,120,701 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3447,179,851 - 7,187,872NCBI
Celera46,965,198 - 6,973,219 (-)NCBICelera
Cytogenetic Map4p16.1NCBI
HuRef46,989,046 - 6,997,061 (-)NCBIHuRef
CHM1_147,060,163 - 7,068,180 (-)NCBICHM1_1
T2T-CHM13v2.047,030,735 - 7,039,901 (-)NCBIT2T-CHM13v2.0
Grpel1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39536,622,529 - 36,631,421 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl536,622,342 - 36,631,424 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38536,465,185 - 36,474,077 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl536,464,998 - 36,474,080 (+)Ensemblmm10GRCm38
MGSCv37536,807,834 - 36,816,726 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36536,782,280 - 36,791,172 (+)NCBIMGSCv36mm8
Celera533,946,160 - 33,955,052 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map519.14NCBI
Grpel1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555143,459,774 - 3,467,279 (+)Ensembl
ChiLan1.0NW_0049555143,459,774 - 3,467,279 (+)NCBIChiLan1.0ChiLan1.0
GRPEL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v237,326,364 - 7,334,615 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan147,255,405 - 7,263,644 (-)NCBINHGRI_mPanPan1
PanPan1.147,126,043 - 7,135,388 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl47,126,043 - 7,135,388 (-)EnsemblpanPan2panpan1.1
GRPEL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1359,124,116 - 59,131,541 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl359,124,613 - 59,131,977 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha361,770,979 - 61,778,423 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0359,595,959 - 59,603,388 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl359,595,274 - 59,603,595 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1359,093,027 - 59,100,454 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0359,294,915 - 59,302,364 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0359,649,262 - 59,656,689 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grpel1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528565,181,864 - 65,189,477 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647718,880,736 - 18,891,110 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647718,883,556 - 18,891,108 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRPEL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.183,797,310 - 3,813,725 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.283,397,261 - 3,413,692 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRPEL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12743,173,664 - 43,182,015 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2743,174,467 - 43,181,783 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604790,028,597 - 90,036,905 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grpel1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475523,270,910 - 23,280,264 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475523,273,253 - 23,280,328 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Grpel1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11168,634,913 - 68,641,137 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grpel1
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:462
Count of miRNA genes:245
Interacting mature miRNAs:292
Transcripts:ENSRNOT00000008932
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143802371083023710Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1459848686104848686Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1477914838104348525Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143900944484009444Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)147297021087582095Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1433424686102238540Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1474255551109089856Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147764007196755654Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143802371083023710Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1462398852107398852Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1477640071100078267Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1460854936105854936Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1474255551109089856Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147764007196755654Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1459848686104848686Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147764007196755654Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143802371083023710Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144261625899224555Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)146592028399224555Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143941117087582095Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143802371083023710Rat

Markers in Region
RH129769  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21474,292,066 - 74,292,260 (+)MAPPERmRatBN7.2
Rnor_6.01479,458,650 - 79,458,843NCBIRnor6.0
Rnor_5.01479,097,652 - 79,097,845UniSTSRnor5.0
RGSC_v3.41479,872,878 - 79,873,071UniSTSRGSC3.4
Celera1473,230,277 - 73,230,470UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000008932   ⟹   ENSRNOP00000008930
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1474,292,023 - 74,298,200 (-)Ensembl
Rnor_6.0 Ensembl1479,458,963 - 79,464,770 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082180   ⟹   ENSRNOP00000070967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1478,517,052 - 78,522,861 (-)Ensembl
mRatBN7.2 Ensembl1474,292,371 - 74,298,180 (-)Ensembl
Rnor_6.0 Ensembl1479,459,057 - 79,462,080 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104564   ⟹   ENSRNOP00000093798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1474,292,023 - 74,295,055 (-)Ensembl
RefSeq Acc Id: NM_024487   ⟹   NP_077813
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,517,061 - 78,522,868 (-)NCBI
mRatBN7.21474,292,380 - 74,298,187 (-)NCBI
Rnor_6.01479,458,963 - 79,464,770 (-)NCBI
Rnor_5.01479,097,953 - 79,103,777 (-)NCBI
RGSC_v3.41479,873,191 - 79,878,998 (-)RGD
Celera1473,230,590 - 73,236,397 (-)RGD
Sequence:
RefSeq Acc Id: XM_063273663   ⟹   XP_063129733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81478,517,049 - 78,520,125 (-)NCBI
Protein Sequences
Protein RefSeqs NP_077813 (Get FASTA)   NCBI Sequence Viewer  
  XP_063129733 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53534 (Get FASTA)   NCBI Sequence Viewer  
  AAH97312 (Get FASTA)   NCBI Sequence Viewer  
  EDM00047 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000008930.3
  ENSRNOP00000070967
GenBank Protein P97576 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077813   ⟸   NM_024487
- Peptide Label: precursor
- UniProtKB: Q4QRA3 (UniProtKB/Swiss-Prot),   P97576 (UniProtKB/Swiss-Prot),   A6IJY3 (UniProtKB/TrEMBL),   A0A8I6AMG9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000008930   ⟸   ENSRNOT00000008932
Ensembl Acc Id: ENSRNOP00000070967   ⟸   ENSRNOT00000082180
Ensembl Acc Id: ENSRNOP00000093798   ⟸   ENSRNOT00000104564
RefSeq Acc Id: XP_063129733   ⟸   XM_063273663
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JZA2 (UniProtKB/TrEMBL),   A0A8I6AMG9 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P97576-F1-model_v2 AlphaFold P97576 1-217 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699384
Promoter ID:EPDNEW_R9909
Type:multiple initiation site
Name:Grpel1_1
Description:GrpE-like 1, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01479,464,781 - 79,464,841EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70947 AgrOrtholog
Ensembl Genes ENSRNOG00000006593 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008932.6 UniProtKB/Swiss-Prot
  ENSRNOT00000082180 ENTREZGENE
Gene3D-CATH 2.30.22.10 UniProtKB/Swiss-Prot
  3.90.20.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7387647 IMAGE-MGC_LOAD
InterPro GrpE UniProtKB/Swiss-Prot
  GrpE_coiled_coil UniProtKB/Swiss-Prot
  GrpE_head UniProtKB/Swiss-Prot
KEGG Report rno:79563 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114309 IMAGE-MGC_LOAD
NCBI Gene 79563 ENTREZGENE
PANTHER GRPE PROTEIN HOMOLOG 1, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR21237 UniProtKB/Swiss-Prot
Pfam GrpE UniProtKB/Swiss-Prot
PhenoGen Grpel1 PhenoGen
PRINTS GRPEPROTEIN UniProtKB/Swiss-Prot
PROSITE GRPE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000006593 RatGTEx
Superfamily-SCOP SSF51064 UniProtKB/Swiss-Prot
  SSF58014 UniProtKB/Swiss-Prot
UniProt A0A0G2JZA2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMG9 ENTREZGENE
  A6IJY3 ENTREZGENE, UniProtKB/TrEMBL
  GRPE1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q4QRA3 ENTREZGENE
UniProt Secondary Q4QRA3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Grpel1  GrpE-like 1, mitochondrial      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process enhances the ATPase activity of the mitochondrial Hsp70 68707
gene_regulation expression only marginally increased in response to the proline analog L-azetidine 2-carboxylic acid 70756