Mgst1 (microsomal glutathione S-transferase 1) - Rat Genome Database

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Gene: Mgst1 (microsomal glutathione S-transferase 1) Rattus norvegicus
Analyze
Symbol: Mgst1
Name: microsomal glutathione S-transferase 1
RGD ID: 70927
Description: Enables glutathione binding activity; glutathione transferase activity; and identical protein binding activity. Involved in Leydig cell differentiation; response to lipopolysaccharide; and response to xenobiotic stimulus. Located in apical part of cell; bounding membrane of organelle; and endoplasmic reticulum. Is active in endoplasmic reticulum membrane and mitochondrion. Orthologous to human MGST1 (microsomal glutathione S-transferase 1); PARTICIPATES IN glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC72699; microsomal GST-1; microsomal GST-I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84172,760,930 - 172,776,157 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4172,760,886 - 172,776,875 (+)EnsemblGRCr8
mRatBN7.24171,029,666 - 171,044,893 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4171,029,630 - 171,044,892 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4177,324,703 - 177,339,950 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04173,108,869 - 173,124,108 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04171,729,410 - 171,744,649 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04172,119,382 - 172,134,609 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4172,119,331 - 172,134,607 (+)Ensemblrn6Rnor6.0
Rnor_5.04236,372,225 - 236,387,452 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44175,248,654 - 175,263,881 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4159,602,240 - 159,617,460 (+)NCBICelera
RGSC_v3.14175,493,783 - 175,509,005 (+)NCBI
RH 3.4 Map41032.9RGD
Cytogenetic Map4q44NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(E)-cinnamyl alcohol  (ISO)
(S)-amphetamine  (EXP)
1,1'-azobis(N,N-dimethylformamide)  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dithiothreitol  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-bromohexadecanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aconitine  (EXP)
acrolein  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antimonite  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
Azaspiracid  (ISO)
Bandrowski's base  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bongkrekic acid  (EXP)
bosentan  (ISO)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chlorogenic acid  (EXP)
cinnamyl alcohol  (ISO)
ciprofibrate  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cumene hydroperoxide  (EXP)
curcumin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dichloromethane  (ISO)
dicyclanil  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (EXP)
emamectin benzoate  (ISO)
endosulfan  (EXP)
ethoxyquin  (ISO)
eugenol  (ISO)
ferric oxide  (EXP)
flutamide  (ISO)
folic acid  (ISO)
furan  (EXP)
furfural  (ISO)
gallic acid  (EXP)
gardiquimod  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glutathione  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hemin  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (ISO)
inulin  (ISO)
iron trichloride  (EXP)
isoeugenol  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
kojic acid  (EXP)
L-1,4-dithiothreitol  (EXP)
L-ascorbic acid  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
leukotriene A4  (EXP)
leukotriene B4  (EXP)
leukotriene C4  (EXP)
leukotriene D4  (EXP)
leukotriene E4  (EXP)
lipopolysaccharide  (EXP)
lutein  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
methimazole  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
morin  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
O-acetyl-L-carnitine  (EXP)
ochratoxin A  (EXP,ISO)
oleanolic acid  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
peroxynitrous acid  (EXP)
phenobarbital  (EXP)
PhIP  (EXP)
phlorizin  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
pyrimidin-2-amine  (EXP)
quercetin  (EXP)
rac-1,2-dichloropropane  (ISO)
reactive oxygen species  (EXP)
retinyl acetate  (ISO)
rotenone  (EXP,ISO)
S-nitroso-L-cysteine  (EXP)
S-nitrosoglutathione  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
spironolactone  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP,ISO)
tolcapone  (EXP)
Tolmetin glucuronide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-caffeic acid  (EXP)
trans-isoeugenol  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triethylenediamine  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zileuton  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. DD-RT-PCR identifies 7-dehydrocholesterol reductase as a key marker of early Leydig cell steroidogenesis. Anbalagan M, etal., Mol Cell Endocrinol. 2004 Apr 30;219(1-2):37-45.
2. [Rat microsomal glutathione S-transferase 1 alters cytotoxic effects of chlorambucil on PC-3, K562, HepG2 and P388D1 cell lines] Chen Z, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2007 May;36(3):236-40.
3. Gene expression of rat and human microsomal glutathione S-transferases. DeJong JL, etal., J Biol Chem 1988 Jun 15;263(17):8430-6.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Structural basis for detoxification and oxidative stress protection in membranes. Holm PJ, etal., J Mol Biol. 2006 Jul 28;360(5):934-45. Epub 2006 Jun 5.
7. Insights into the membrane proteome of rat liver peroxisomes: microsomal glutathione-S-transferase is shared by both subcellular compartments. Islinger M, etal., Proteomics. 2006 Feb;6(3):804-16.
8. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
9. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
10. Novel function of glutathione transferase in rat liver mitochondrial membrane: role for cytochrome c release from mitochondria. Lee KK, etal., Toxicol Appl Pharmacol. 2008 Oct 1;232(1):109-18. Epub 2008 Jun 25.
11. Observation of an intact noncovalent homotrimer of detergent-solubilized rat microsomal glutathione transferase-1 by electrospray mass spectrometry. Lengqvist J, etal., J Biol Chem. 2004 Apr 2;279(14):13311-6. Epub 2004 Jan 14.
12. Gene Data Set MGD Curation, June 12, 2002
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Microsomal glutathione S-transferase. Purification, initial characterization and demonstration that it is not identical to the cytosolic glutathione S-transferases A, B and C. Morgenstern R, etal., Eur J Biochem. 1982 Nov;128(1):243-8.
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. Purification and properties of glutathione S-transferase from outer mitochondrial membrane of rat liver. Nishino H and Ito A, Biochem Int. 1990;20(6):1059-66.
17. Immunolocalization of microsomal glutathione S-transferase in rat tissues. Otieno MA, etal., Drug Metab Dispos. 1997 Jan;25(1):12-20.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Molecular basis for the dual subcellular distribution of microsomal glutathione transferase 1. Shimoji M, etal., Biochim Biophys Acta Biomembr. 2017 Feb;1859(2):238-244. doi: 10.1016/j.bbamem.2016.11.014. Epub 2016 Nov 30.
22. The role of glutathione-S-transferase in anti-cancer drug resistance. Townsend DM and Tew KD, Oncogene 2003 Oct 20;22(47):7369-75.
Additional References at PubMed
PMID:3932348   PMID:6439207   PMID:10767383   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15236595   PMID:15489334   PMID:16314419   PMID:16899233   PMID:19111564   PMID:20727966  
PMID:21216258   PMID:21851097   PMID:24419913   PMID:28801553  


Genomics

Comparative Map Data
Mgst1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84172,760,930 - 172,776,157 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4172,760,886 - 172,776,875 (+)EnsemblGRCr8
mRatBN7.24171,029,666 - 171,044,893 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4171,029,630 - 171,044,892 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4177,324,703 - 177,339,950 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04173,108,869 - 173,124,108 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04171,729,410 - 171,744,649 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04172,119,382 - 172,134,609 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4172,119,331 - 172,134,607 (+)Ensemblrn6Rnor6.0
Rnor_5.04236,372,225 - 236,387,452 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44175,248,654 - 175,263,881 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4159,602,240 - 159,617,460 (+)NCBICelera
RGSC_v3.14175,493,783 - 175,509,005 (+)NCBI
RH 3.4 Map41032.9RGD
Cytogenetic Map4q44NCBI
MGST1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381216,347,115 - 16,593,331 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1216,347,115 - 16,609,259 (+)Ensemblhg38GRCh38
GRCh371216,500,049 - 16,530,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361216,391,343 - 16,408,611 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341216,391,342 - 16,408,610NCBI
Celera1221,643,859 - 21,661,125 (+)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1216,268,374 - 16,298,400 (+)NCBIHuRef
CHM1_11216,465,087 - 16,495,133 (+)NCBICHM1_1
T2T-CHM13v2.01216,224,568 - 16,466,967 (+)NCBIT2T-CHM13v2.0
Mgst1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396138,117,525 - 138,133,753 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6138,117,314 - 138,133,753 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm386138,140,527 - 138,156,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6138,140,316 - 138,156,755 (+)Ensemblmm10GRCm38
MGSCv376138,089,058 - 138,105,273 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366138,104,733 - 138,120,948 (+)NCBIMGSCv36mm8
Celera6141,204,105 - 141,221,034 (+)NCBICelera
Cytogenetic Map6G1NCBI
cM Map668.4NCBI
Mgst1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541312,989,935 - 13,007,761 (+)Ensembl
ChiLan1.0NW_00495541312,989,935 - 13,005,203 (+)NCBIChiLan1.0ChiLan1.0
MGST1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21021,793,489 - 21,823,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11221,790,250 - 21,819,884 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01216,347,737 - 16,383,776 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11216,743,739 - 16,773,290 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1216,743,739 - 16,773,290 (+)EnsemblpanPan2panpan1.1
MGST1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12730,370,588 - 30,391,898 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2730,370,594 - 30,391,778 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2716,055,808 - 16,077,100 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02730,690,546 - 30,712,016 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2730,690,548 - 30,711,952 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12730,541,771 - 30,563,263 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02730,537,988 - 30,559,272 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02715,775,516 - 15,796,781 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mgst1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494591,542,405 - 91,559,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365871,269,184 - 1,287,150 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365871,270,030 - 1,287,130 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MGST1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl556,259,557 - 56,283,965 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1556,259,566 - 56,283,823 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MGST1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11116,270,588 - 16,300,446 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1116,277,434 - 16,287,171 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606919,006,137 - 19,023,047 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mgst1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475221,720,012 - 21,737,809 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475221,722,593 - 21,737,826 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mgst1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1611,308,623 - 11,324,047 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mgst1
272 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:205
Count of miRNA genes:147
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000010579
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4160623982184426481Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat

Markers in Region
RH142292  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24171,044,542 - 171,044,729 (+)MAPPERmRatBN7.2
Rnor_6.04172,134,259 - 172,134,445NCBIRnor6.0
Rnor_5.04236,387,102 - 236,387,288UniSTSRnor5.0
RGSC_v3.44175,263,531 - 175,263,717UniSTSRGSC3.4
Celera4159,617,110 - 159,617,296UniSTS
RH 3.4 Map41032.9UniSTS
Cytogenetic Map4q44UniSTS
BI277057  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24171,044,355 - 171,044,564 (+)MAPPERmRatBN7.2
Rnor_6.04172,134,072 - 172,134,280NCBIRnor6.0
Rnor_5.04236,386,915 - 236,387,123UniSTSRnor5.0
RGSC_v3.44175,263,344 - 175,263,552UniSTSRGSC3.4
Celera4159,616,923 - 159,617,131UniSTS
RH 3.4 Map41045.0UniSTS
Cytogenetic Map4q44UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_134349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC063150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP494884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB711033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ179404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000010579   ⟹   ENSRNOP00000010579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4172,760,886 - 172,776,875 (+)Ensembl
mRatBN7.2 Ensembl4171,029,630 - 171,044,892 (+)Ensembl
Rnor_6.0 Ensembl4172,119,331 - 172,134,607 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110483   ⟹   ENSRNOP00000094357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4172,760,886 - 172,772,354 (+)Ensembl
mRatBN7.2 Ensembl4171,029,630 - 171,041,090 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110698   ⟹   ENSRNOP00000091759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4172,762,050 - 172,776,875 (+)Ensembl
mRatBN7.2 Ensembl4171,030,786 - 171,044,892 (+)Ensembl
RefSeq Acc Id: NM_134349   ⟹   NP_599176
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,760,930 - 172,776,157 (+)NCBI
mRatBN7.24171,029,666 - 171,044,893 (+)NCBI
Rnor_6.04172,119,382 - 172,134,609 (+)NCBI
Rnor_5.04236,372,225 - 236,387,452 (+)NCBI
RGSC_v3.44175,248,654 - 175,263,881 (+)RGD
Celera4159,602,240 - 159,617,460 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_599176 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41281 (Get FASTA)   NCBI Sequence Viewer  
  AAH63150 (Get FASTA)   NCBI Sequence Viewer  
  ACI32121 (Get FASTA)   NCBI Sequence Viewer  
  EDM01574 (Get FASTA)   NCBI Sequence Viewer  
  EDM01575 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010579
  ENSRNOP00000010579.4
GenBank Protein P08011 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_599176   ⟸   NM_134349
- UniProtKB: P08011 (UniProtKB/Swiss-Prot),   B6DYQ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010579   ⟸   ENSRNOT00000010579
Ensembl Acc Id: ENSRNOP00000094357   ⟸   ENSRNOT00000110483
Ensembl Acc Id: ENSRNOP00000091759   ⟸   ENSRNOT00000110698

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08011-F1-model_v2 AlphaFold P08011 1-155 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693474
Promoter ID:EPDNEW_R3997
Type:initiation region
Name:Mgst1_1
Description:microsomal glutathione S-transferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04172,119,388 - 172,119,448EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70927 AgrOrtholog
BioCyc Gene G2FUF-42563 BioCyc
BioCyc Pathway PWY-4061 [glutathione-mediated detoxification I] BioCyc
  PWY-7112 [4-hydroxy-2-nonenal detoxification] BioCyc
BioCyc Pathway Image PWY-4061 BioCyc
  PWY-7112 BioCyc
Ensembl Genes ENSRNOG00000007743 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010579 ENTREZGENE
  ENSRNOT00000010579.8 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.550 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6922267 IMAGE-MGC_LOAD
InterPro MAPEG-like_dom_sf UniProtKB/Swiss-Prot
  Membr-assoc_MAPEG UniProtKB/Swiss-Prot
  MGST1-like UniProtKB/Swiss-Prot
KEGG Report rno:171341 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72699 IMAGE-MGC_LOAD
NCBI Gene 171341 ENTREZGENE
PANTHER MICROSOMAL GLUTATHIONE S-TRANSFERASE 1 UniProtKB/Swiss-Prot
  PTHR10689 UniProtKB/Swiss-Prot
Pfam MAPEG UniProtKB/Swiss-Prot
PhenoGen Mgst1 PhenoGen
RatGTEx ENSRNOG00000007743 RatGTEx
Superfamily-SCOP SSF161084 UniProtKB/Swiss-Prot
UniProt A0A8I6ACC0_RAT UniProtKB/TrEMBL
  A0A8I6ALY9_RAT UniProtKB/TrEMBL
  A6IML5_RAT UniProtKB/TrEMBL
  B6DYQ4 ENTREZGENE, UniProtKB/TrEMBL
  MGST1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Mgst1  microsomal glutathione S-transferase 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 154 amino acids 70791