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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70927 Species: Rattus norvegicus RGD Object: Gene Symbol: Mgst1 Name: microsomal glutathione S-transferase 1

Acc ID: CHEBI:41879 Term: dexamethasone Definition: A fluorinated steroid that has formula C22H29FO5. CasRN: 50-02-2 Chemical ID: MESH:D003907

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:734278	6480464	CTD	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA] Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of MGST1 mRNA]	PMID:16054899
increases expression	ISO	RGD:734278	6480464	CTD	Dexamethasone results in increased expression of MGST1 mRNA	PMID:18723825