Nherf1 (NHERF family PDZ scaffold protein 1) - Rat Genome Database

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Gene: Nherf1 (NHERF family PDZ scaffold protein 1) Rattus norvegicus
Analyze
Symbol: Nherf1
Name: NHERF family PDZ scaffold protein 1
RGD ID: 708538
Description: Enables several functions, including PDZ domain binding activity; myosin II binding activity; and transmembrane transporter binding activity. Contributes to gamma-aminobutyric acid transmembrane transporter activity. Involved in gamma-aminobutyric acid import; import across plasma membrane; and positive regulation of monoatomic ion transmembrane transport. Located in apical plasma membrane; cytoplasm; and microvillus membrane. Part of plasma membrane protein complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in hypophosphatemic nephrolithiasis/osteoporosis 2. Orthologous to human NHERF1 (NHERF family PDZ scaffold protein 1); PARTICIPATES IN eicosanoid signaling pathway; parathyroid hormone signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EBP50; ERM-binding phosphoprotein; ezrin-radixin-moesin-binding phosphoprotein 50; LOC59114; na(+)/H(+) exchange regulatory cofactor NHE-RF1; NHERF-1; regulatory cofactor of Na(+)/H(+) exchanger; SLC9A3 regulator 1; Slc9a3r1; sodium-hydrogen exchanger regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1; solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; solute carrier family 9 isoform A3 regulatory factor 1; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810100,902,165 - 100,919,265 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10100,901,227 - 100,919,579 (+)EnsemblGRCr8
mRatBN7.210100,403,189 - 100,420,290 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,403,069 - 100,420,598 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10105,463,056 - 105,480,181 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010104,926,121 - 104,943,248 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,324,177 - 100,341,277 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010103,713,045 - 103,730,145 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,713,045 - 103,730,145 (+)Ensemblrn6Rnor6.0
Rnor_5.010104,573,624 - 104,590,426 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410105,237,637 - 105,254,750 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1098,979,637 - 98,995,900 (+)NCBICelera
RGSC_v3.110105,252,140 - 105,269,254 (+)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dibromoethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-methylcholine  (ISO)
2-nitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetonitrile  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
bromobenzene  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
folpet  (ISO)
FR900359  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glycidol  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nickel atom  (ISO)
Nutlin-3  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salmeterol xinafoate  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
adenylate cyclase-activating dopamine receptor signaling pathway  (ISO)
auditory receptor cell stereocilium organization  (ISO)
bile acid secretion  (ISO,ISS)
cerebrospinal fluid circulation  (ISO)
cilium organization  (ISO)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment of Golgi localization  (ISO)
gamma-aminobutyric acid import  (IGI)
gland morphogenesis  (ISO)
glutathione transport  (ISO,ISS)
import across plasma membrane  (IGI)
intracellular phosphate ion homeostasis  (ISO)
intracellular protein localization  (ISO)
maintenance of epithelial cell apical/basal polarity  (ISO)
microvillus assembly  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell motility  (ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of mitotic cell cycle  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO,ISS)
negative regulation of platelet-derived growth factor receptor signaling pathway  (ISO,ISS)
negative regulation of sodium ion transport  (ISO)
nuclear migration  (ISO)
phospholipase C-activating dopamine receptor signaling pathway  (ISO)
plasma membrane organization  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of monoatomic ion transmembrane transport  (IDA)
protein localization to plasma membrane  (IBA,ISO)
regulation of cell shape  (ISO)
regulation of cell size  (ISO)
regulation of protein kinase activity  (ISO,ISS)
regulation of renal phosphate excretion  (ISO)
renal absorption  (ISO,ISS)
renal phosphate ion absorption  (ISO,ISS)
renal sodium ion transport  (ISO)
sensory perception of sound  (ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A role of intestine in hypertension: mechanism of suppression of intestinal Na-H exchanger isoform-3 in spontaneously hypertensive rats. Abu-Ghefreh A and Khan I, Clin Exp Hypertens. 2013;35(7):543-9. doi: 10.3109/10641963.2013.764888. Epub 2013 Feb 12.
2. EBP50 is involved in the regulation of vascular smooth muscle cell migration and cytokinesis. Baeyens N, etal., J Cell Biochem. 2011 Sep;112(9):2574-84. doi: 10.1002/jcb.23183.
3. Polarity and developmental regulation of two PDZ proteins in the retinal pigment epithelium. Bonilha VL and Rodriguez-Boulan E, Invest Ophthalmol Vis Sci. 2001 Dec;42(13):3274-82.
4. Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1. Deval E, etal., J Biol Chem. 2006 Jan 20;281(3):1796-807. Epub 2005 Oct 17.
5. Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) self-association through PDZ-PDZ interactions. Fouassier L, etal., J Biol Chem 2000 Aug 11;275(32):25039-45.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli. Giral H, etal., J Biol Chem. 2012 Oct 12;287(42):35047-56. doi: 10.1074/jbc.M112.392415. Epub 2012 Aug 17.
8. Expression of the Na+/H+ exchanger regulatory protein family in genetically hypertensive rats. Kobayashi K, etal., J Hypertens. 2004 Sep;22(9):1723-30.
9. Subcellular redistribution of NHERF1 in response to dehydroepiandrosterone (DHEA) administration in endometrial glands of Wistar rats. Kreimann EL and Cabrini RL, Reprod Sci. 2013 Jan;20(1):103-11. doi: 10.1177/1933719112451148. Epub 2012 Aug 7.
10. Ezrin and EBP50 redistribute apically in rat uterine epithelial cells at the time of implantation and in response to cell contact. Lecce L, etal., Cell Tissue Res. 2011 Feb;343(2):445-53. doi: 10.1007/s00441-010-1088-z. Epub 2010 Dec 1.
11. NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. Li M, etal., J Biol Chem. 2010 Jun 18;285(25):19299-307. doi: 10.1074/jbc.M109.096081. Epub 2010 Apr 19.
12. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Mahon MJ Curr Drug Targets. 2012 Jan;13(1):116-28.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Na+-H+ exchanger regulatory factor 1 (NHERF1) PDZ scaffold binds an internal binding site in the scavenger receptor megalin. Slattery C, etal., Cell Physiol Biochem. 2011;27(2):171-8. doi: 10.1159/000325219. Epub 2011 Feb 11.
20. Assembly of Taurine Transporter (Slc6a6) with Na+-H+ Exchanger Regulatory Factor 1 (Slc9a3r1) Improves GABA Transport Activity by Increasing the Maximum Transport Velocity. Tachikawa M, etal., Biol Pharm Bull. 2018;41(3):338-341. doi: 10.1248/bpb.b17-00664.
21. Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. Takeda T, etal., J Clin Invest 2001 Jul;108(2):289-301.
22. Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis. Tanimura A, etal., J Med Invest. 2011 Feb;58(1-2):140-7.
Additional References at PubMed
PMID:9560162   PMID:12169661   PMID:12586353   PMID:12881487   PMID:12952857   PMID:14996907   PMID:15591354   PMID:15878350   PMID:16160858   PMID:16236806   PMID:16249272   PMID:16456542  
PMID:16641100   PMID:16987995   PMID:17110338   PMID:17242191   PMID:17895247   PMID:18055461   PMID:18190691   PMID:18784102   PMID:19056867   PMID:19188335   PMID:19190083   PMID:19199708  
PMID:19857202   PMID:20012548   PMID:20124415   PMID:20200151   PMID:20458337   PMID:20736378   PMID:20843475   PMID:20926777   PMID:20937695   PMID:21079987   PMID:21832055   PMID:21976599  
PMID:22855531   PMID:22871113   PMID:23376485   PMID:23482569   PMID:23533145   PMID:24862762   PMID:24920589   PMID:25775275   PMID:26173747   PMID:28392297   PMID:28515088   PMID:28669731  


Genomics

Comparative Map Data
Nherf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810100,902,165 - 100,919,265 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10100,901,227 - 100,919,579 (+)EnsemblGRCr8
mRatBN7.210100,403,189 - 100,420,290 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,403,069 - 100,420,598 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10105,463,056 - 105,480,181 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010104,926,121 - 104,943,248 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,324,177 - 100,341,277 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010103,713,045 - 103,730,145 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10103,713,045 - 103,730,145 (+)Ensemblrn6Rnor6.0
Rnor_5.010104,573,624 - 104,590,426 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.410105,237,637 - 105,254,750 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1098,979,637 - 98,995,900 (+)NCBICelera
RGSC_v3.110105,252,140 - 105,269,254 (+)NCBI
Cytogenetic Map10q32.1NCBI
NHERF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381774,748,628 - 74,769,353 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1774,748,619 - 74,769,360 (+)Ensemblhg38GRCh38
GRCh371772,744,767 - 72,765,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,256,373 - 70,277,089 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341770,256,378 - 70,277,089NCBI
Celera1769,337,944 - 69,358,679 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,155,124 - 68,175,866 (+)NCBIHuRef
CHM1_11772,809,571 - 72,830,338 (+)NCBICHM1_1
T2T-CHM13v2.01775,640,506 - 75,661,228 (+)NCBIT2T-CHM13v2.0
Nherf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,054,138 - 115,072,009 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,054,167 - 115,072,007 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811115,163,341 - 115,181,178 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,163,341 - 115,181,181 (+)Ensemblmm10GRCm38
MGSCv3711115,024,655 - 115,042,492 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611114,979,493 - 115,014,684 (+)NCBIMGSCv36mm8
Celera11126,928,560 - 126,946,416 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.65NCBI
Nherf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555531,639,267 - 1,656,850 (+)Ensembl
ChiLan1.0NW_0049555531,639,267 - 1,656,850 (+)NCBIChiLan1.0ChiLan1.0
NHERF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21990,785,997 - 90,806,905 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11795,608,707 - 95,629,599 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01768,694,468 - 68,715,157 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11774,250,406 - 74,271,234 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1774,250,406 - 74,271,234 (+)EnsemblpanPan2panpan1.1
NHERF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,661,792 - 5,679,783 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,662,464 - 5,679,570 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha96,341,827 - 6,358,910 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.096,333,687 - 6,351,685 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl96,333,688 - 6,351,686 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.196,371,237 - 6,388,311 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.096,481,877 - 6,498,929 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.096,542,206 - 6,559,311 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nherf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056026,275,339 - 6,292,156 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594119,770 - 136,789 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936594119,808 - 136,620 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NHERF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,466,121 - 6,483,548 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1126,466,138 - 6,483,539 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2126,455,107 - 6,472,510 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NHERF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,889,454 - 46,910,776 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,888,942 - 46,910,842 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607717,675,824 - 17,696,157 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nherf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248014,612,849 - 4,630,451 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248014,612,890 - 4,630,454 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nherf1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1968,921,622 - 68,939,130 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nherf1
53 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:325
Count of miRNA genes:184
Interacting mature miRNAs:204
Transcripts:ENSRNOT00000004351
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat

Markers in Region
RH132852  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210100,401,733 - 100,401,935 (+)MAPPERmRatBN7.2
Rnor_6.010103,711,590 - 103,711,791NCBIRnor6.0
Rnor_5.010104,591,680 - 104,591,881UniSTSRnor5.0
RGSC_v3.410105,236,182 - 105,236,383UniSTSRGSC3.4
Celera1098,978,181 - 98,978,382UniSTS
Cytogenetic Map10q32.2UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 159 91 90 59 92 59 6 356 192 11 138 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000004351   ⟹   ENSRNOP00000004351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10100,902,050 - 100,919,579 (+)Ensembl
mRatBN7.2 Ensembl10100,403,069 - 100,420,598 (+)Ensembl
Rnor_6.0 Ensembl10103,713,045 - 103,730,145 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170226   ⟹   ENSRNOP00000103366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10100,901,227 - 100,919,579 (+)Ensembl
RefSeq Acc Id: NM_021594   ⟹   NP_067605
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810100,902,165 - 100,919,265 (+)NCBI
mRatBN7.210100,403,189 - 100,420,290 (+)NCBI
Rnor_6.010103,713,045 - 103,730,145 (+)NCBI
Rnor_5.010104,573,624 - 104,590,426 (-)NCBI
RGSC_v3.410105,237,637 - 105,254,750 (+)RGD
Celera1098,979,637 - 98,995,900 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_067605 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF73258 (Get FASTA)   NCBI Sequence Viewer  
  EDM06563 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004351.1
  ENSRNOP00000103366
GenBank Protein Q9JJ19 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067605   ⟸   NM_021594
- UniProtKB: Q9JJ19 (UniProtKB/Swiss-Prot),   A6HKK8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004351   ⟸   ENSRNOT00000004351
Ensembl Acc Id: ENSRNOP00000103366   ⟸   ENSRNOT00000170226
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJ19-F1-model_v2 AlphaFold Q9JJ19 1-356 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708538 AgrOrtholog
BioCyc Gene G2FUF-22697 BioCyc
Ensembl Genes ENSRNOG00000003232 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004351.5 UniProtKB/Swiss-Prot
  ENSRNOT00000170226 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
InterPro EBP50_C-term UniProtKB/Swiss-Prot
  NHER UniProtKB/Swiss-Prot
  NHERF-1/NHERF-2 UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
KEGG Report rno:59114 UniProtKB/Swiss-Prot
NCBI Gene 59114 ENTREZGENE
PANTHER PDZ DOMAIN CONTAINING PROTEIN UniProtKB/Swiss-Prot
  PTHR14191:SF7 UniProtKB/Swiss-Prot
Pfam EBP50_C UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
PhenoGen Nherf1 PhenoGen
PIRSF EBP50 UniProtKB/Swiss-Prot
PROSITE PDZ UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003232 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot
UniProt A6HKK8 ENTREZGENE, UniProtKB/TrEMBL
  NHRF1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-11-28 Nherf1  NHERF family PDZ scaffold protein 1  Slc9a3r1  SLC9A3 regulator 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-24 Slc9a3r1  SLC9A3 regulator 1  Slc9a3r1  solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Slc9a3r1  solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1  Slc9a3r1  solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-31 Slc9a3r1  solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1  Slc9a3r1  solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc9a3r1  solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1    ERM-binding phosphoprotein  Name updated 1299863 APPROVED
2004-09-10 Slc9a3r1  ERM-binding phosphoprotein  LOC59114    Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference