Psmc5 (proteasome 26S subunit, ATPase 5) - Rat Genome Database

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Gene: Psmc5 (proteasome 26S subunit, ATPase 5) Rattus norvegicus
Analyze
Symbol: Psmc5
Name: proteasome 26S subunit, ATPase 5
RGD ID: 708376
Description: Enables ATP hydrolysis activity and TBP-class protein binding activity. Involved in positive regulation of inclusion body assembly and regulation of AMPA receptor activity. Located in inclusion body and synaptic vesicle. Part of cytosolic proteasome complex; nuclear proteasome complex; and proteasome accessory complex. Orthologous to human PSMC5 (proteasome 26S subunit, ATPase 5); PARTICIPATES IN retinoic acid signaling pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; 26S proteasome regulatory subunit 8; for proteasomal ATPase (SUG1); LOC81827; p45/SUG; peptidase (prosome, macropain) 26S subunit, ATPase 5; protease (prosome, macropain) 26S subunit, ATPase 5; proteasomal ATPase (SUG1); proteasome (prosome, macropain) 26S subunit, ATPase, 5; proteasome 26S subunit ATPase 5; proteasome p45/SUG; proteasome subunit p45; Sug1; thyroid hormone receptor-interacting protein 1; TRIP1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,687,553 - 91,693,487 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1091,686,295 - 91,695,921 (+)EnsemblGRCr8
mRatBN7.21091,187,763 - 91,193,697 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,187,743 - 91,213,135 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1096,242,456 - 96,248,389 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,705,625 - 95,711,558 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,116,202 - 91,122,136 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1094,840,187 - 94,846,120 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1095,571,065 - 95,576,998 (+)NCBILyon_Normotensive
Lyon_Hypertensive1097,016,669 - 97,022,602 (+)NCBILyon_Hypertensive
F344_StmMcwi1097,121,505 - 97,127,439 (+)NCBIF344_StmMcwi
Rnor_6.01094,445,877 - 94,451,811 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,445,877 - 94,451,811 (+)Ensemblrn6Rnor6.0
Rnor_5.01094,197,179 - 94,203,113 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41095,650,987 - 95,656,921 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1089,863,649 - 89,869,583 (+)NCBICelera
RGSC_v3.11095,665,356 - 95,671,291 (+)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
ciguatoxin CTX1B  (ISO)
clobetasol  (ISO)
clofibrate  (EXP)
clozapine  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
fenthion  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
imidacloprid  (EXP)
isoprenaline  (EXP)
ivermectin  (ISO)
L-ethionine  (EXP)
L-methionine  (EXP)
leflunomide  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
omeprazole  (EXP)
ozone  (EXP)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
Propiverine  (EXP)
quinoline  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
Soman  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
tolcapone  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. cDNA cloning of a new putative ATPase subunit p45 of the human 26S proteasome, a homolog of yeast transcriptional factor Sug1p. Akiyama K, etal., FEBS Lett 1995 Apr 17;363(1-2):151-6.
2. Phosphorylation of Rpt6 regulates synaptic strength in hippocampal neurons. Djakovic SN, etal., J Neurosci. 2012 Apr 11;32(15):5126-31. doi: 10.1523/JNEUROSCI.4427-11.2012.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Gene coding for the transcription factor, SUG/proteasome, p45 is located nearly 40 kb downstream from the rat growth hormone gene. Kazahari K, etal., Gene 1997 Oct 1;198(1-2):323-7.
5. Structures of the rat proteasomal ATPases: determination of highly conserved structural motifs and rules for their spacing. Makino Y, etal., Biochem Biophys Res Commun 1996 Mar 27;220(3):1049-54.
6. Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120. Makino Y, etal., Genes Cells. 1999 Sep;4(9):529-39.
7. SUG1, a component of the 26 S proteasome, is an ATPase stimulated by specific RNAs. Makino Y, etal., J Biol Chem. 1997 Sep 12;272(37):23201-5.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). Rochette-Egly C and Germain P, Nucl Recept Signal. 2009 May 8;7:e005.
13. Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones. Rousseau E, etal., J Biol Chem. 2009 Jan 16;284(3):1917-29. doi: 10.1074/jbc.M806256200. Epub 2008 Nov 5.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses. Sun C, etal., Science. 2023 May 26;380(6647):eadf2018. doi: 10.1126/science.adf2018. Epub 2023 May 26.
16. Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1. vom Baur E, etal., EMBO J 1996 Jan 2;15(1):110-24.
17. Mammalian Sug1 and c-Fos in the nuclear 26S proteasome. Wang W, etal., Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8236-40.
Additional References at PubMed
PMID:7776974   PMID:7870181   PMID:8833236   PMID:9173976   PMID:9464850   PMID:9927201   PMID:10657252   PMID:10816420   PMID:11818503   PMID:12110588   PMID:15489334   PMID:15885686  
PMID:16857966   PMID:17323924   PMID:17565987   PMID:19056867   PMID:19638347   PMID:19946888   PMID:20178748   PMID:20498273   PMID:21630459   PMID:22486777   PMID:22516433   PMID:24482233  
PMID:25002582   PMID:30053369   PMID:30545799   PMID:31904090   PMID:32731408   PMID:32770803   PMID:35352799   PMID:38124005  


Genomics

Comparative Map Data
Psmc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,687,553 - 91,693,487 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1091,686,295 - 91,695,921 (+)EnsemblGRCr8
mRatBN7.21091,187,763 - 91,193,697 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,187,743 - 91,213,135 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1096,242,456 - 96,248,389 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,705,625 - 95,711,558 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,116,202 - 91,122,136 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1094,840,187 - 94,846,120 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1095,571,065 - 95,576,998 (+)NCBILyon_Normotensive
Lyon_Hypertensive1097,016,669 - 97,022,602 (+)NCBILyon_Hypertensive
F344_StmMcwi1097,121,505 - 97,127,439 (+)NCBIF344_StmMcwi
Rnor_6.01094,445,877 - 94,451,811 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,445,877 - 94,451,811 (+)Ensemblrn6Rnor6.0
Rnor_5.01094,197,179 - 94,203,113 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41095,650,987 - 95,656,921 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1089,863,649 - 89,869,583 (+)NCBICelera
RGSC_v3.11095,665,356 - 95,671,291 (+)NCBI
Cytogenetic Map10q32.1NCBI
PSMC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,827,431 - 63,832,019 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,827,152 - 63,832,244 (+)Ensemblhg38GRCh38
GRCh371761,904,791 - 61,909,379 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,258,542 - 59,263,119 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341759,258,541 - 59,263,118NCBI
Celera1756,292,931 - 56,297,508 (+)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,272,832 - 57,277,449 (+)NCBIHuRef
CHM1_11761,969,121 - 61,973,738 (+)NCBICHM1_1
T2T-CHM13v2.01764,697,992 - 64,702,868 (+)NCBIT2T-CHM13v2.0
Psmc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,147,011 - 106,153,938 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,146,980 - 106,153,946 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811106,256,185 - 106,263,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,256,154 - 106,263,120 (+)Ensemblmm10GRCm38
MGSCv3711106,117,499 - 106,124,426 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611106,072,275 - 106,079,202 (+)NCBIMGSCv36mm8
Celera11117,986,618 - 117,993,566 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.89NCBI
Psmc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,996,902 - 8,002,183 (-)Ensembl
ChiLan1.0NW_0049554787,996,902 - 8,002,183 (-)NCBIChiLan1.0ChiLan1.0
PSMC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21979,998,638 - 80,003,642 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,816,490 - 84,821,109 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01757,906,934 - 57,911,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,051,050 - 63,055,911 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,051,050 - 63,055,907 (+)EnsemblpanPan2panpan1.1
PSMC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,783,422 - 11,787,624 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,783,466 - 11,787,617 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha912,743,141 - 12,747,321 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0913,444,521 - 13,448,701 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,444,569 - 13,448,699 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,391,162 - 12,395,338 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,136,575 - 15,140,755 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,139,318 - 15,143,495 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Psmc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,719,365 - 14,724,442 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365414,470,205 - 4,476,015 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365414,470,210 - 4,475,233 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,101,859 - 15,106,213 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11215,101,946 - 15,106,326 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,092,253 - 15,096,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11657,457,670 - 57,462,321 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1657,457,720 - 57,462,249 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607728,066,027 - 28,070,940 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,349,720 - 1,354,775 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248491,349,787 - 1,354,776 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Psmc5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1972,857,877 - 72,863,803 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Psmc5
33 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:60
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000013997
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108101207791729860Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109090424595604677Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108306123692869129Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108780775896620484Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)109112727095604677Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1081012077101828297Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)9090424595604677Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)9090424595604677Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)109090424595604677Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)109090424595604677Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)109090424595604677Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)108890050196620484Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108450348796432422Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108450348796432422Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
M60510  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,194,082 - 91,194,158 (+)MAPPERmRatBN7.2
Rnor_6.01094,452,197 - 94,452,272NCBIRnor6.0
Rnor_5.01094,203,499 - 94,203,574UniSTSRnor5.0
RGSC_v3.41095,657,307 - 95,657,382UniSTSRGSC3.4
Celera1089,869,969 - 89,870,044UniSTS
Cytogenetic Map10q32.1UniSTS
RH136975  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81091,693,209 - 91,693,478 (+)Marker Load Pipeline
mRatBN7.21091,193,419 - 91,193,688 (+)MAPPERmRatBN7.2
Rnor_6.01094,451,534 - 94,451,802NCBIRnor6.0
Rnor_5.01094,202,836 - 94,203,104UniSTSRnor5.0
RGSC_v3.41095,656,644 - 95,656,912UniSTSRGSC3.4
Celera1089,869,306 - 89,869,574UniSTS
Cytogenetic Map10q32.1UniSTS
MARC_4113-4114:991938380:3  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81091,687,557 - 91,688,238 (+)Marker Load Pipeline
mRatBN7.21091,187,767 - 91,188,448 (+)MAPPERmRatBN7.2
Rnor_6.01094,445,882 - 94,446,562NCBIRnor6.0
Rnor_5.01094,197,184 - 94,197,864UniSTSRnor5.0
RGSC_v3.41095,650,992 - 95,651,672UniSTSRGSC3.4
Celera1089,863,654 - 89,864,334UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 16 12 150 249 91 90 65 139 59 22 485 331 11 228 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013997   ⟹   ENSRNOP00000013997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1091,687,755 - 91,693,489 (+)Ensembl
mRatBN7.2 Ensembl1091,187,743 - 91,213,135 (+)Ensembl
Rnor_6.0 Ensembl1094,445,877 - 94,451,811 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113357   ⟹   ENSRNOP00000090060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1091,687,532 - 91,695,921 (+)Ensembl
mRatBN7.2 Ensembl1091,187,746 - 91,193,694 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118001   ⟹   ENSRNOP00000079284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1091,686,295 - 91,695,921 (+)Ensembl
mRatBN7.2 Ensembl1091,187,773 - 91,196,129 (+)Ensembl
RefSeq Acc Id: NM_031149   ⟹   NP_112411
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81091,687,553 - 91,693,487 (+)NCBI
mRatBN7.21091,187,763 - 91,193,697 (+)NCBI
Dahl_SR_JrHsd1094,840,187 - 94,846,120 (+)NCBI
Lyon_Normotensive1095,571,065 - 95,576,998 (+)NCBI
Lyon_Hypertensive1097,016,669 - 97,022,602 (+)NCBI
F344_StmMcwi1097,121,505 - 97,127,439 (+)NCBI
Rnor_6.01094,445,877 - 94,451,811 (+)NCBI
Rnor_5.01094,197,179 - 94,203,113 (+)NCBI
RGSC_v3.41095,650,987 - 95,656,921 (+)RGD
Celera1089,863,649 - 89,869,583 (+)RGD
Sequence:
RefSeq Acc Id: NP_112411   ⟸   NM_031149
- UniProtKB: P62198 (UniProtKB/Swiss-Prot),   A0A8L2Q7I4 (UniProtKB/TrEMBL),   A6HK17 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013997   ⟸   ENSRNOT00000013997
Ensembl Acc Id: ENSRNOP00000090060   ⟸   ENSRNOT00000113357
Ensembl Acc Id: ENSRNOP00000079284   ⟸   ENSRNOT00000118001
Protein Domains
AAA+ ATPase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P62198-F1-model_v2 AlphaFold P62198 1-406 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697839
Promoter ID:EPDNEW_R8364
Type:multiple initiation site
Name:Psmc5_1
Description:proteasome 26S subunit, ATPase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01094,445,855 - 94,445,915EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708376 AgrOrtholog
BioCyc Gene G2FUF-22957 BioCyc
Ensembl Genes ENSRNOG00000010038 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013997 ENTREZGENE
  ENSRNOT00000118001.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot
  2.40.50.140 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6891005 IMAGE-MGC_LOAD
InterPro 26S_Proteasome_ATPase UniProtKB/Swiss-Prot
  AAA+_ATPase UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  ATPase_AAA_core UniProtKB/Swiss-Prot
  ATPase_AAA_CS UniProtKB/Swiss-Prot
  NA-bd_OB-fold UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Prot_ATP_ID_OB UniProtKB/Swiss-Prot
KEGG Report rno:81827 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72780 IMAGE-MGC_LOAD
NCBI Gene 81827 ENTREZGENE
PANTHER 26S PROTEASOME REGULATORY SUBUNIT UniProtKB/Swiss-Prot
Pfam AAA UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  Prot_ATP_ID_OB UniProtKB/Swiss-Prot
PhenoGen Psmc5 PhenoGen
PROSITE AAA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010038 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I6GIK7_RAT UniProtKB/TrEMBL
  A0A8L2Q7I4 ENTREZGENE, UniProtKB/TrEMBL
  A6HK17 ENTREZGENE, UniProtKB/TrEMBL
  A6HK18_RAT UniProtKB/TrEMBL
  A6HK19_RAT UniProtKB/TrEMBL
  A6HK20_RAT UniProtKB/TrEMBL
  A6HK21_RAT UniProtKB/TrEMBL
  A6HK22_RAT UniProtKB/TrEMBL
  P62198 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O35051 UniProtKB/Swiss-Prot
  P47210 UniProtKB/Swiss-Prot
  P52915 UniProtKB/Swiss-Prot
  P52916 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-19 Psmc5  proteasome 26S subunit, ATPase 5  Psmc5  proteasome (prosome, macropain) 26S subunit, ATPase, 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Psmc5  proteasome (prosome, macropain) 26S subunit, ATPase, 5  Psmc5  protease (prosome, macropain) 26S subunit, ATPase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Psmc5  protease (prosome, macropain) 26S subunit, ATPase 5  Psmc5  peptidase (prosome, macropain) 26S subunit, ATPase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Psmc5  peptidase (prosome, macropain) 26S subunit, ATPase 5  LOC81827  for proteasomal ATPase (SUG1)  Symbol and Name updated 1299863 APPROVED