PSMC5 (proteasome 26S subunit, ATPase 5) - Rat Genome Database

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Gene: PSMC5 (proteasome 26S subunit, ATPase 5) Canis lupus familiaris
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Symbol: PSMC5
Name: proteasome 26S subunit, ATPase 5
RGD ID: 12294407
Description: ENCODES a protein that exhibits ATP hydrolysis activity (ortholog); TBP-class protein binding (ortholog); INVOLVED IN modulation of chemical synaptic transmission (ortholog); negative regulation of DNA-templated transcription (ortholog); positive regulation of inclusion body assembly (ortholog); PARTICIPATES IN retinoic acid signaling pathway; ASSOCIATED WITH genetic disease (ortholog); human immunodeficiency virus infectious disease (ortholog); Stevens-Johnson syndrome (ortholog); FOUND IN cytosolic proteasome complex (ortholog); inclusion body (ortholog); nuclear proteasome complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 26S protease regulatory subunit 8; 26S proteasome regulatory subunit 8; proteasome (prosome, macropain) 26S subunit, ATPase, 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,783,422 - 11,787,624 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,783,466 - 11,787,617 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,743,141 - 12,747,321 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0913,444,521 - 13,448,701 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,444,569 - 13,448,699 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,391,162 - 12,395,338 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,136,575 - 15,140,755 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,139,318 - 15,143,495 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PSMC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,783,422 - 11,787,624 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,783,466 - 11,787,617 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,743,141 - 12,747,321 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0913,444,521 - 13,448,701 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl913,444,569 - 13,448,699 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,391,162 - 12,395,338 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0915,136,575 - 15,140,755 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0915,139,318 - 15,143,495 (-)NCBIUU_Cfam_GSD_1.0
PSMC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381763,827,431 - 63,832,019 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1763,827,152 - 63,832,026 (+)EnsemblGRCh38hg38GRCh38
GRCh371761,904,791 - 61,909,379 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,258,542 - 59,263,119 (+)NCBINCBI36Build 36hg18NCBI36
Build 341759,258,541 - 59,263,118NCBI
Celera1756,292,931 - 56,297,508 (+)NCBICelera
Cytogenetic Map17q23.3NCBI
HuRef1757,272,832 - 57,277,449 (+)NCBIHuRef
CHM1_11761,969,121 - 61,973,738 (+)NCBICHM1_1
T2T-CHM13v2.01764,697,992 - 64,702,868 (+)NCBIT2T-CHM13v2.0
Psmc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,147,011 - 106,153,938 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,146,980 - 106,153,946 (+)EnsemblGRCm39 Ensembl
GRCm3811106,256,185 - 106,263,112 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,256,154 - 106,263,120 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711106,117,499 - 106,124,426 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611106,072,275 - 106,079,202 (+)NCBIMGSCv36mm8
Celera11117,986,618 - 117,993,566 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.89NCBI
Psmc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81091,687,553 - 91,693,487 (+)NCBIGRCr8
mRatBN7.21091,187,763 - 91,193,697 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,187,743 - 91,213,135 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,242,456 - 96,248,389 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01095,705,625 - 95,711,558 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,116,202 - 91,122,136 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01094,445,877 - 94,451,811 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1094,445,877 - 94,451,811 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,197,179 - 94,203,113 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,650,987 - 95,656,921 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11095,665,356 - 95,671,291 (+)NCBI
Celera1089,863,649 - 89,869,583 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Psmc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,996,902 - 8,002,183 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554787,996,902 - 8,002,183 (-)NCBIChiLan1.0ChiLan1.0
PSMC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21979,998,638 - 80,003,642 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11784,816,490 - 84,821,109 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01757,906,934 - 57,911,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,051,050 - 63,055,911 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,051,050 - 63,055,907 (+)Ensemblpanpan1.1panPan2
Psmc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,719,365 - 14,724,442 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365414,470,210 - 4,475,233 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1215,101,859 - 15,106,213 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11215,101,946 - 15,106,326 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,092,253 - 15,096,632 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PSMC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11657,457,670 - 57,462,321 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1657,457,720 - 57,462,249 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607728,066,027 - 28,070,940 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,349,720 - 1,354,775 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248491,349,787 - 1,354,776 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PSMC5
43 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000020231   ⟹   ENSCAFP00000018768
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl911,783,466 - 11,787,617 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845036755   ⟹   ENSCAFP00845028777
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl913,444,569 - 13,448,699 (+)Ensembl
RefSeq Acc Id: XM_038485153   ⟹   XP_038341081
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1912,391,162 - 12,395,338 (+)NCBI
RefSeq Acc Id: XM_038546905   ⟹   XP_038402833
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0915,139,318 - 15,143,495 (-)NCBI
RefSeq Acc Id: XM_038610876   ⟹   XP_038466804
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0915,136,575 - 15,140,755 (-)NCBI
RefSeq Acc Id: XM_038675992   ⟹   XP_038531920
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0913,444,521 - 13,448,701 (+)NCBI
RefSeq Acc Id: XM_537597   ⟹   XP_537597
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1911,783,422 - 11,787,624 (+)NCBI
Dog10K_Boxer_Tasha912,743,141 - 12,747,321 (+)NCBI
Sequence:
RefSeq Acc Id: XP_537597   ⟸   XM_537597
- Peptide Label: isoform X1
- UniProtKB: A0A8C0Z0G3 (UniProtKB/TrEMBL),   A0A8C0LM49 (UniProtKB/TrEMBL),   A0A8I3S1Z6 (UniProtKB/TrEMBL),   A0A8P0NEG7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000018768   ⟸   ENSCAFT00000020231
RefSeq Acc Id: XP_038341081   ⟸   XM_038485153
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038466804   ⟸   XM_038610876
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038531920   ⟸   XM_038675992
- Peptide Label: isoform X1
- UniProtKB: A0A8C0Z0G3 (UniProtKB/TrEMBL),   A0A8C0LM49 (UniProtKB/TrEMBL),   A0A8I3S1Z6 (UniProtKB/TrEMBL),   A0A8P0NEG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038402833   ⟸   XM_038546905
- Peptide Label: isoform X1
- UniProtKB: A0A8C0LM49 (UniProtKB/TrEMBL),   A0A8C0Z0G3 (UniProtKB/TrEMBL),   A0A8I3S1Z6 (UniProtKB/TrEMBL),   A0A8P0NEG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845028777   ⟸   ENSCAFT00845036755
Protein Domains
AAA+ ATPase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000012741 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013865 UniProtKB/TrEMBL
  ENSCAFG00040017209 UniProtKB/TrEMBL
  ENSCAFG00845020751 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000020231.5 UniProtKB/TrEMBL
  ENSCAFT00000099434.1 UniProtKB/TrEMBL
  ENSCAFT00030025668.1 UniProtKB/TrEMBL
  ENSCAFT00040031834.1 UniProtKB/TrEMBL
  ENSCAFT00845036755 ENTREZGENE
  ENSCAFT00845036755.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  ATPase_AAA_CS UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Prot_ATP_ID_OB UniProtKB/TrEMBL
KEGG Report cfa:480478 UniProtKB/TrEMBL
NCBI Gene PSMC5 ENTREZGENE
PANTHER 26S PROTEASOME REGULATORY SUBUNIT UniProtKB/TrEMBL
  26S PROTEASOME REGULATORY SUBUNIT 8 UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/TrEMBL
  Prot_ATP_ID_OB UniProtKB/TrEMBL
PROSITE AAA UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0LM49 ENTREZGENE
  A0A8C0Z0G3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S1Z6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NEG7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0TJF0_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:111670 ENTREZGENE