Birc5 (baculoviral IAP repeat-containing 5) - Rat Genome Database

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Gene: Birc5 (baculoviral IAP repeat-containing 5) Rattus norvegicus
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Symbol: Birc5
Name: baculoviral IAP repeat-containing 5
RGD ID: 70499
Description: Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein dimerization activity; and small GTPase binding activity. Involved in several processes, including cellular response to ethanol; cellular response to stem cell factor stimulus; and response to glucocorticoid. Located in apical plasma membrane. Used to study endometriosis and pulmonary hypertension. Biomarker of acute pancreatitis (multiple); artery disease (multiple); congestive heart failure; high grade glioma; and stomach carcinoma. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5); PARTICIPATES IN histone modification pathway; colorectal cancer pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AP14; apoptosis inhibitor survivin; baculoviral IAP repeat-containing 5 (survivin); baculoviral IAP repeat-containing protein 5; survivin
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,567,369 - 103,580,069 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10103,572,080 - 103,582,155 (+)EnsemblGRCr8
mRatBN7.210103,072,530 - 103,081,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,073,408 - 103,081,380 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10108,174,435 - 108,182,841 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,637,549 - 107,645,954 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,994,242 - 103,002,165 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,856,097 - 106,864,419 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,856,097 - 106,864,413 (+)Ensemblrn6Rnor6.0
Rnor_5.010106,494,775 - 106,503,097 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera10101,633,441 - 101,641,341 (+)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute megakaryocytic leukemia  (ISO)
acute necrotizing pancreatitis  (IEP)
acute pancreatitis  (IEP)
acute promyelocytic leukemia  (ISO)
adenocarcinoma  (ISO)
adrenocortical carcinoma  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
bladder urothelial carcinoma  (ISO)
brain glioma  (ISO)
Brain Injuries  (IEP)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
chromophobe renal cell carcinoma  (ISO)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (IEP)
COVID-19  (ISO)
ductal carcinoma in situ  (ISO)
endometrial hyperplasia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (IMP)
Experimental Liver Cirrhosis  (IEP)
Experimental Liver Neoplasms  (IEP)
Germ Cell and Embryonal Neoplasms  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (IEP)
Kidney Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant pleural mesothelioma  (ISO)
Mesothelioma  (ISO)
myocardial infarction  (IEP)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic adenocarcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IEP,IMP)
Refractory Anemia  (ISO)
Refractory Anemia with Excess of Blasts  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP,IMP)
small cell carcinoma  (ISO)
squamous cell carcinoma  (ISO)
stomach carcinoma  (IEP)
Stomach Neoplasms  (ISO)
Testicular Germ Cell Tumor  (ISO)
thymoma  (ISO)
thyroid gland carcinoma  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (ISO)
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(-)-noscapine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP,ISO)
1-monopalmitoylglycerol  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-Dihydroxychalcone  (ISO)
2,5-dimethylcelecoxib  (ISO)
2-acetamidofluorene  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methoxyethanol  (EXP)
2-methylcholine  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
2-trans,6-trans-farnesyl diphosphate  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3'-diindolylmethane  (ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alvocidib  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
Antrocin  (ISO)
aprepitant  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
ATP  (ISO)
atrazine  (ISO)
azadirachtin A  (ISO)
azathioprine  (ISO)
Azoxymethane  (ISO)
baicalein  (ISO)
barium sulfate  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoic acid  (ISO)
Berbamine  (ISO)
berberine  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
betulin  (ISO)
betulinic acid  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
budesonide  (ISO)
Bufotalin  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capillarisin  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
ceric oxide  (EXP)
chlorambucil  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chromium(6+)  (ISO)
chrysazin  (ISO)
chrysene  (ISO)
ciclopirox  (ISO)
ciglitazone  (ISO)
Cinobufagin  (ISO)
Cirsimarin  (ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
coumarins  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
crocin-1  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
dacarbazine  (ISO)
dactolisib  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
Destruxin B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazene  (ISO)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
digitoxin  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioscin  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
epoxomicin  (ISO)
erlotinib hydrochloride  (ISO)
escitalopram  (EXP,ISO)
etacrynic acid  (ISO)
ethanol  (ISO)
etodolac  (ISO)
etoposide  (ISO)
everolimus  (ISO)
Evodiamine  (ISO)
fangchinoline  (ISO)
farnesyl diphosphate  (ISO)
fenhexamid  (ISO)
fenpyroximate  (ISO)
fisetin  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
fucoidan  (ISO)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP,ISO)
furosemide  (EXP)
gamma-aminobutyric acid  (EXP)
gamma-tocopherol  (ISO)
gedunin  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
gingerol  (ISO)
glycochenodeoxycholic acid  (EXP)
gossypol  (ISO)
guggulsterone  (ISO)
GW 7647  (ISO)
Hexamethonium  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
inuviscolide  (ISO)
irinotecan  (ISO)
isoflurane  (EXP)
isotretinoin  (ISO)
Jatrorrhizine  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
lapatinib  (ISO)
LCL161  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
leptomycin B  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lidocaine  (EXP)
linderalactone  (ISO)
lithium atom  (EXP)
lithium chloride  (EXP,ISO)
lithium hydride  (EXP)
lonafarnib  (ISO)
lovastatin  (ISO)
lucanthone  (ISO)
LY294002  (EXP,ISO)
magnesium oxide  (ISO)
malathion  (EXP)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
melatonin  (EXP,ISO)
melphalan  (ISO)
memantine  (ISO)
menadione  (ISO)
menaquinone  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methoxsalen  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
mitoxantrone  (ISO)
MK-2206  (ISO)
ML-7  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
morin  (ISO)
motexafin gadolinium  (ISO)
Myrtucommulone A  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (ISO)
navitoclax  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel ferrite  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nimodipine  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
nocodazole  (ISO)
o-anisidine  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olaparib  (ISO)
oleanolic acid  (ISO)
oridonin  (ISO)
osimertinib  (ISO)
osthole  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
palmatine  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
PD173074  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
picropodophyllotoxin  (ISO)
pifithrin-alpha hydrobromide  (ISO)
pinosylvin  (ISO)
pirfenidone  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
potassium iodide  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
prodigiosin  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
puerarin  (ISO)
pyrethrins  (ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-galactopyranoside  (ISO)
rac-1-monopalmitoylglycerol  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (ISO)
ritonavir  (ISO)
romidepsin  (ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
ruxolitinib  (ISO)
Salinomycin  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sclareol  (ISO)
selenium atom  (ISO)
semilicoisoflavone B  (ISO)
sepantronium  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sorafenib  (ISO)
stattic  (ISO)
staurosporine  (ISO)
sulfadimethoxine  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
syringin  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
terameprocol  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
thymoquinone  (EXP,ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
Tomentosin  (ISO)
topotecan  (EXP,ISO)
trans-pinosylvin  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
tyrphostin B42  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
venetoclax  (ISO)
verteporfin  (ISO)
vinyl carbamate  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
Withanone  (ISO)
wortmannin  (ISO)
XMU-MP-1  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Myocardial expression of survivin, an apoptosis inhibitor, in aging and heart failure. An experimental study in the spontaneously hypertensive rat. Abbate A, etal., Int J Cardiol. 2006 Aug 28;111(3):371-6. Epub 2005 Oct 27.
2. Autoantibodies to survivin in the sera of patients with infiltrating ductal carcinoma of the breast. Al-Joudi FS and Iskandar ZA, Med J Malaysia. 2006 Aug;61(3):302-6.
3. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Ambrosini G, etal., Nat Med 1997 Aug;3(8):917-21.
4. The prognostic significance of COX-2 and survivin expression in ovarian cancer. Athanassiadou P, etal., Pathol Res Pract. 2008;204(4):241-9. Epub 2008 Jan 2.
5. Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence. Barnes N, etal., Br J Cancer. 2006 Jan 30;94(2):253-8.
6. Altered Cytoplasmic-to-Nuclear Ratio of Survivin Is a Prognostic Indicator in Breast Cancer. Brennan DJ, etal., Clin Cancer Res. 2008 May 1;14(9):2681-9.
7. Expression of inhibitor of apoptosis family proteins in human oral squamous cell carcinogenesis. Chen YK, etal., Head Neck. 2011 Jul;33(7):985-98. doi: 10.1002/hed.21582. Epub 2010 Oct 21.
8. NSAIDs enhance proteasomic degradation of survivin, a mechanism of gastric epithelial cell injury and apoptosis. Chiou SK and Mandayam S, Biochem Pharmacol. 2007 Nov 15;74(10):1485-95. Epub 2007 Jul 22.
9. Death receptor 5 (DR5) and a 5-gene apoptotic biomarker panel with significant differential diagnostic potential in colorectal cancer. Devetzi M, etal., Sci Rep. 2016 Nov 9;6:36532. doi: 10.1038/srep36532.
10. Expression of survivin, PTEN and p27 in normal, hyperplastic, and carcinomatous endometrium. Erkanli S, etal., Int J Gynecol Cancer. 2006 May-Jun;16(3):1412-8.
11. Zhonghua zhong liu za zhi [Chinese journal of oncology] Feng ZB, etal., Zhonghua Zhong Liu Za Zhi. 2007 Sep;29(9):662-5.
12. Angiogenic signal triggered by ischemic stress induces myocardial repair in rat during chronic infarction. Fukuda S, etal., J Mol Cell Cardiol. 2004 Apr;36(4):547-59.
13. Transcriptional expression of survivin and its splice variants in cervical carcinomas. Futakuchi H, etal., Int J Gynecol Cancer. 2007 Sep-Oct;17(5):1092-8.
14. Prostate-derived Ets transcription factor as a favorable prognostic marker in ovarian cancer patients. Ghadersohi A, etal., Int J Cancer. 2008 Sep 15;123(6):1376-84.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Expression patterns of inhibitor of apoptosis proteins in malignant pleural mesothelioma. Gordon GJ, etal., J Pathol. 2007 Mar;211(4):447-54. doi: 10.1002/path.2121.
17. Gene Data File Integration of LocusLink data, October 12, 2001
18. Expression of survivin in fetal and adult normal tissues of rat. Iskandar ZA and Al-Joudi FS, Malays J Pathol. 2006 Dec;28(2):101-5.
19. Expression of human telomerase reverse transcriptase and survivin gene in patients with myelodysplastic syndrome Jiao XL, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Apr;16(2):294-8.
20. Detection of autoantibodies to survivin in cervical mucus from patients with human papillomavirus-associated cervical cancer and precursor lesions. Jimenez LG, etal., Autoimmunity. 2007 Feb;40(1):66-72.
21. Cell-specific upregulation of survivin after experimental traumatic brain injury in rats. Johnson EA, etal., J Neurotrauma. 2004 Sep;21(9):1183-95.
22. Survivin is a key factor in the differential susceptibility of gastric endothelial and epithelial cells to alcohol-induced injury. Jones MK, etal., J Physiol Pharmacol. 2010 Jun;61(3):253-64.
23. Survivin expression in patients with non-muscle-invasive urothelial cell carcinoma of the bladder. Karam JA, etal., Urology. 2007 Sep;70(3):482-6.
24. Intracranial stereotaxic cannulation for development of orthotopic glioblastoma allograft in Sprague-Dawley rats and histoimmunopathological characterization of the brain tumor. Karmakar S, etal., Neurochem Res. 2007 Dec;32(12):2235-42. Epub 2007 Aug 15.
25. Gene Expression of Survivin and Its Spliced Isoforms Associated with Proliferation and Aggressive Phenotypes of Prostate Cancer. Koike H, etal., Urology. 2008 Mar 10;.
26. Survivin and b7-h1 are collaborative predictors of survival and represent potential therapeutic targets for patients with renal cell carcinoma. Krambeck AE, etal., Clin Cancer Res. 2007 Mar 15;13(6):1749-56.
27. The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney. Lechler P, etal., Am J Pathol. 2007 Nov;171(5):1483-98.
28. Survivin determines cardiac function by controlling total cardiomyocyte number. Levkau B, etal., Circulation. 2008 Mar 25;117(12):1583-93. Epub 2008 Mar 10.
29. [Expression of survivin gene in a rat model of acute pancreatitis]. Li ZD, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jun;29(6):1141-3.
30. Nimesulide inhibits the growth of human esophageal carcinoma cells by inactivating the JAK2/STAT3 pathway. Liu JR, etal., Pathol Res Pract. 2015 Jun;211(6):426-34. doi: 10.1016/j.prp.2015.01.007. Epub 2015 Jan 24.
31. [Effect of hypoxic preconditioning on the learning and memory ability and expressions of survivin and HSP-70 proteins in rats with focal cerebral ischemia/reperfusion injury] Lu N, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2007 Dec;27(12):1856-9.
32. Distinct in vivo expression patterns of survivin splice variants in renal cell carcinomas. Mahotka C, etal., Int J Cancer. 2002 Jul 1;100(1):30-6.
33. Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats. Marsillach J, etal., Mol Cell Biochem. 2008 Jan;308(1-2):101-9. Epub 2007 Oct 16.
34. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. McMurtry MS, etal., J Clin Invest. 2005 Jun;115(6):1479-91.
35. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
36. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Nakahara T, etal., Cancer Res. 2007 Sep 1;67(17):8014-21.
37. Survivin and caspase-3 expression in breast cancer: correlation with prognostic parameters, proliferation, angiogenesis, and outcome. Nassar A, etal., Appl Immunohistochem Mol Morphol. 2008 Mar;16(2):113-20.
38. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
39. Functional pathway characterized by gene expression analysis of supraclavicular lymph node metastasis-positive breast cancer. Oishi Y, etal., J Hum Genet. 2007;52(3):271-9. Epub 2007 Feb 7.
40. Intravenous administration of bone marrow stromal cells increases survivin and Bcl-2 protein expression and improves sensorimotor function following ischemia in rats. Okazaki T, etal., Neurosci Lett. 2008 Jan 10;430(2):109-14. Epub 2007 Nov 6.
41. Expression of antiapoptotic survivin and aven genes in rat heart tissue after traumatic brain injury. Ozisik K, etal., Transplant Proc. 2006 Nov;38(9):2784-7.
42. Readout of epigenetic modifications. Patel DJ and Wang Z, Annu Rev Biochem. 2013;82:81-118. doi: 10.1146/annurev-biochem-072711-165700.
43. Detection of survivin mRNA in urine of patients with superficial urothelial cell carcinomas. Pina-Cabral L, etal., Clin Transl Oncol. 2007 Nov;9(11):731-6.
44. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
45. GOA pipeline RGD automated data pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Comprehensive gene review and curation RGD comprehensive gene curation
49. Differential expression of testin and survivin in breast cancer subtypes. Sarti M, etal., Oncol Rep. 2013 Aug;30(2):824-32. doi: 10.3892/or.2013.2502. Epub 2013 May 28.
50. Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Singh RP, etal., Clin Cancer Res. 2008 Jan 1;14(1):300-8.
51. Inhibitor of apoptosis protein (IAP) survivin is upregulated by oncogenic c-H-Ras. Sommer KW, etal., Oncogene 2003 Jul 3;22(27):4266-80.
52. The survivin:fas ratio in pediatric renal tumors. Takamizawa S, etal., J Pediatr Surg. 2001 Jan;36(1):37-42.
53. Expression of survivin after acute necrohemorrhagic pancreatitis in rats. Tashiro M, etal., Pancreas. 2003 Mar;26(2):160-5.
54. Chemopreventive effects of silymarin and silibinin on N-butyl-N-(4-hydroxybutyl) nitrosamine induced urinary bladder carcinogenesis in male ICR mice. Tyagi A, etal., Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3248-55.
55. Expression and prognostic significance of survivin in the progression of bladder transitional cell cancer. Wang Y, etal., J Huazhong Univ Sci Technolog Med Sci. 2007 Aug;27(4):444-7.
56. Survivin expression in rat testis is upregulated by stem-cell factor. Wang Y, etal., Mol Cell Endocrinol. 2004 Apr 15;218(1-2):165-74.
57. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine / Zhongguo Zhong xi yi jie he xue hui, Zhongguo Zhong yi yan jiu yuan zhu ban Wei SB, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Feb;28(2):139-41.
58. Analysis of molecular pathological factors of unfavorable prognosis for young cervical cancer patients. Yi L, etal., Onkologie. 2007 Oct;30(10):502-6. Epub 2007 Sep 21.
59. Detection of Survivin-expressing circulating cancer cells in the peripheral blood of breast cancer patients by a RT-PCR ELISA. Yie SM, etal., Clin Exp Metastasis. 2006;23(5-6):279-89. Epub 2006 Nov 3.
60. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Yin RT, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Mar;38(2):243-5.
61. Expression of survivin in human gastric carcinoma and gastric carcinoma model of rats. Zhu XD, etal., World J Gastroenterol. 2003 Jul;9(7):1435-8.
62. Diagnosis of bladder cancer by urine survivin, an inhibitor of apoptosis: a preliminary report. Ziaee SA, etal., Urol J. 2006 Summer;3(3):150-3.
Additional References at PubMed
PMID:9859993   PMID:10626797   PMID:10876248   PMID:10949039   PMID:11069302   PMID:11084331   PMID:11516652   PMID:12679106   PMID:12773388   PMID:12805209   PMID:15260989   PMID:15665297  
PMID:16049172   PMID:16239925   PMID:16291752   PMID:16322459   PMID:17099693   PMID:17428462   PMID:18086682   PMID:18358624   PMID:18591255   PMID:19018973   PMID:19035263   PMID:19073407  
PMID:19576024   PMID:19644667   PMID:20514400   PMID:20564420   PMID:20627126   PMID:20826784   PMID:20887644   PMID:21252625   PMID:21364656   PMID:21536684   PMID:21706383   PMID:21708067  
PMID:21976248   PMID:22139302   PMID:22819929   PMID:22883038   PMID:23251006   PMID:23658701   PMID:23884942   PMID:24935577   PMID:25318914   PMID:25323860   PMID:25539851   PMID:25744839  
PMID:25778398   PMID:25816072   PMID:25843524   PMID:25856227   PMID:26347229   PMID:26464661   PMID:26818429   PMID:27046449   PMID:27539959   PMID:28218735   PMID:30251448   PMID:33568044  
PMID:34783140   PMID:35202039  


Genomics

Comparative Map Data
Birc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,567,369 - 103,580,069 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl10103,572,080 - 103,582,155 (+)EnsemblGRCr8
mRatBN7.210103,072,530 - 103,081,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10103,073,408 - 103,081,380 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx10108,174,435 - 108,182,841 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,637,549 - 107,645,954 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,994,242 - 103,002,165 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,856,097 - 106,864,419 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,856,097 - 106,864,413 (+)Ensemblrn6Rnor6.0
Rnor_5.010106,494,775 - 106,503,097 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera10101,633,441 - 101,641,341 (+)NCBICelera
Cytogenetic Map10q32.2NCBI
BIRC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,214,253 - 78,225,635 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,214,186 - 78,225,636 (+)Ensemblhg38GRCh38
GRCh371776,210,334 - 76,221,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,721,872 - 73,733,311 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341773,721,871 - 73,733,310NCBI
Celera1772,806,306 - 72,817,744 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,634,433 - 71,645,847 (+)NCBIHuRef
CHM1_11776,274,801 - 76,286,240 (+)NCBICHM1_1
T2T-CHM13v2.01779,108,345 - 79,119,727 (+)NCBIT2T-CHM13v2.0
Birc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,740,063 - 117,746,569 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,740,077 - 117,746,569 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3811117,849,237 - 117,855,743 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,849,251 - 117,855,743 (+)Ensemblmm10GRCm38
MGSCv3711117,710,551 - 117,717,057 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3611117,665,327 - 117,671,833 (+)NCBIMGSCv36mm8
Celera11129,594,259 - 129,600,765 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
BIRC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,265,019 - 94,276,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,094,471 - 99,105,679 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,292,332 - 72,303,493 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11777,842,724 - 77,854,159 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,842,724 - 77,854,159 (+)EnsemblpanPan2panpan1.1
BIRC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,930,308 - 2,959,307 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,613,921 - 3,619,074 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.093,608,303 - 3,613,418 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.193,631,386 - 3,636,494 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,755,584 - 3,761,556 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,836,949 - 3,842,103 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Birc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,591,620 - 3,599,727 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,812,238 - 2,820,636 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365942,812,165 - 2,820,618 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BIRC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,747,279 - 3,755,215 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1123,747,276 - 3,755,214 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BIRC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11670,226,824 - 70,237,000 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607741,335,707 - 41,347,619 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Birc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248017,727,093 - 7,735,940 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248017,727,084 - 7,735,946 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Birc5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1966,204,836 - 66,212,679 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Birc5
83 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:434
Count of miRNA genes:240
Interacting mature miRNAs:286
Transcripts:ENSRNOT00000072387
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093723381107556066Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1089039175107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1097202388107556066Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096620293107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087807758107713808Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1091127270107556066Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091727883107713808Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1097202388107556066Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000072387   ⟹   ENSRNOP00000065784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,572,080 - 103,580,064 (+)Ensembl
mRatBN7.2 Ensembl10103,073,408 - 103,081,380 (+)Ensembl
Rnor_6.0 Ensembl10106,856,097 - 106,864,413 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096623   ⟹   ENSRNOP00000076513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,073,408 - 103,078,854 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106040   ⟹   ENSRNOP00000095300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,572,080 - 103,582,155 (+)Ensembl
mRatBN7.2 Ensembl10103,073,476 - 103,081,380 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158416   ⟹   ENSRNOP00000109972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl10103,572,080 - 103,578,357 (+)Ensembl
RefSeq Acc Id: NM_022274   ⟹   NP_071610
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,572,146 - 103,580,069 (+)NCBI
mRatBN7.210103,073,459 - 103,081,382 (+)NCBI
Rnor_6.010106,856,097 - 106,864,419 (+)NCBI
Rnor_5.010106,494,775 - 106,503,097 (+)NCBI
Celera10101,633,441 - 101,641,341 (+)RGD
Sequence:
RefSeq Acc Id: XM_063269805   ⟹   XP_063125875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,567,369 - 103,580,067 (+)NCBI
RefSeq Acc Id: NP_071610   ⟸   NM_022274
- UniProtKB: Q9JHY7 (UniProtKB/Swiss-Prot),   A6HL35 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065784   ⟸   ENSRNOT00000072387
Ensembl Acc Id: ENSRNOP00000076513   ⟸   ENSRNOT00000096623
Ensembl Acc Id: ENSRNOP00000095300   ⟸   ENSRNOT00000106040
RefSeq Acc Id: XP_063125875   ⟸   XM_063269805
- Peptide Label: isoform X1
- UniProtKB: Q9JHY7 (UniProtKB/Swiss-Prot),   M0R8I8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000109972   ⟸   ENSRNOT00000158416

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHY7-F1-model_v2 AlphaFold Q9JHY7 1-142 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697934
Promoter ID:EPDNEW_R8459
Type:multiple initiation site
Name:Birc5_1
Description:baculoviral IAP repeat-containing 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010106,856,074 - 106,856,134EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70499 AgrOrtholog
BioCyc Gene G2FUF-22534 BioCyc
Ensembl Genes ENSRNOG00000050819 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000072387 ENTREZGENE
Gene3D-CATH Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A UniProtKB/Swiss-Prot
InterPro Baculoviral_IAP UniProtKB/Swiss-Prot
  BIR_rpt UniProtKB/Swiss-Prot
KEGG Report rno:64041 UniProtKB/Swiss-Prot
NCBI Gene 64041 ENTREZGENE
PANTHER BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 5 UniProtKB/Swiss-Prot
  DETERIN UniProtKB/Swiss-Prot
Pfam BIR UniProtKB/Swiss-Prot
PhenoGen Birc5 PhenoGen
PROSITE BIR_REPEAT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050819 RatGTEx
SMART BIR UniProtKB/Swiss-Prot
Superfamily-SCOP Inhibitor of apoptosis (IAP) repeat UniProtKB/Swiss-Prot
UniProt A0A8I6GLK0_RAT UniProtKB/TrEMBL
  A0ABK0LX32_RAT UniProtKB/TrEMBL
  A6HL35 ENTREZGENE, UniProtKB/TrEMBL
  A6HL36_RAT UniProtKB/TrEMBL
  A6HL37_RAT UniProtKB/TrEMBL
  BIRC5_RAT UniProtKB/Swiss-Prot
  M0R8I8 ENTREZGENE, UniProtKB/TrEMBL
  Q9JHY7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Birc5  baculoviral IAP repeat-containing 5    baculoviral IAP repeat-containing 5 (survivin)  Name updated 1299863 APPROVED
2002-06-10 Birc5  baculoviral IAP repeat-containing 5 (survivin)      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in transformed cell lines and lung, colon, pancreas, prostate and breast cancer tissue 70286