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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70499 Species: Rattus norvegicus RGD Object: Gene Symbol: Birc5 Name: baculoviral IAP repeat-containing 5

Acc ID: CHEBI:15365 Term: acetylsalicylic acid Definition: Benzoic acid carrying an acetoxy group at the 2-position. A non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity. CasRN: 50-78-2 Chemical ID: MESH:D001241

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:737482	6480464	CTD	Aspirin results in increased expression of BIRC5 mRNA	PMID:11906190 PMID:17342322
multiple interactions	ISO	RGD:737482	6480464	CTD	[Aspirin co-treated with TNFSF10 protein] results in decreased expression of BIRC5 protein epoxomicin inhibits the reaction [Aspirin results in decreased expression of BIRC5 protein]	PMID:18483385
multiple interactions	ISO	RGD:737482	6480464	CTD	Aspirin inhibits the reaction [E2F1 protein binds to BIRC5 promoter]	PMID:17848598
decreases expression	ISO	RGD:737482	6480464	CTD	Aspirin results in decreased expression of BIRC5 protein	PMID:18483385 PMID:17848598
decreases expression	ISO	RGD:737482	6480464	CTD	Aspirin results in decreased expression of BIRC5 mRNA	PMID:17848598
increases expression	ISO	RGD:737482	6480464	CTD	Aspirin results in increased expression of BIRC5 mRNA	PMID:11906190
increases expression	ISO	RGD:737482	6480464	CTD	Aspirin results in increased expression of BIRC5 mRNA	PMID:17342322 PMID:11906190
decreases expression	ISO	RGD:737482	6480464	CTD	Aspirin results in decreased expression of BIRC5 protein	PMID:17848598 PMID:18483385