Hadh (hydroxyacyl-CoA dehydrogenase) - Rat Genome Database

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Gene: Hadh (hydroxyacyl-CoA dehydrogenase) Rattus norvegicus
Analyze
Symbol: Hadh
Name: hydroxyacyl-CoA dehydrogenase
RGD ID: 69321
Description: Enables 3-hydroxyacyl-CoA dehydrogenase activity. Involved in several processes, including fatty acid beta-oxidation; negative regulation of insulin secretion; and response to insulin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in mitochondrion. Biomarker of myocardial infarction and obesity. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 4. Orthologous to human HADH (hydroxyacyl-CoA dehydrogenase); PARTICIPATES IN fatty acid beta degradation pathway; 2-aminoadipic 2-oxoadipic aciduria pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; INTERACTS WITH (+)-schisandrin B; (R)-adrenaline; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hadhsc; HCDH; hydroxyacyl-Coenzyme A dehydrogenase; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; hydroxylacyl-Coenzyme A dehydrogenase; hydroxylacyl-Coenzyme A dehydrogenase short chain; hydroxylacyl-Coenzyme A dehydrogenase, short chain; L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain; medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase; medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; short chain 3-hydroxyacyl-CoA dehydrogenase; short-chain 3-hydroxyacyl-CoA dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82222,462,049 - 222,504,446 (-)NCBIGRCr8
mRatBN7.22219,787,935 - 219,830,335 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2219,787,927 - 219,830,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2227,444,166 - 227,486,582 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02225,343,838 - 225,386,248 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02220,201,461 - 220,243,878 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02236,353,445 - 236,395,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2236,353,445 - 236,395,067 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02254,902,140 - 254,944,001 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42228,698,545 - 228,751,691 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12228,685,284 - 228,738,431 (-)NCBI
Celera2212,044,254 - 212,086,368 (-)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
HadhRatCongenital Hyperinsulinism  ISOHADH (Homo sapiens)2306664DNA:deletion:cds (human)RGD 
HadhRatExperimental Diabetes Mellitus  IEP 2302232 RGD 
HadhRatmyocardial infarction  IEP 2302229 RGD 
HadhRatobesity  IEP 2302228protein:increased expression:skeletal muscleRGD 
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Object Symbol
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Reference
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Original Reference(s)
HadhRat3-Hydroxyacyl-CoA Dehydrogenase Deficiency  ISOHADH (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
HadhRatfamilial hyperinsulinemic hypoglycemia 4  ISOHADH (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
HadhRatobesity  ISOHADH (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20882379
HadhRatpre-malignant neoplasm  ISOHADH (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21472284
Object Symbol
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Original Reference(s)
HadhRat3-Hydroxyacyl-CoA Dehydrogenase Deficiency  ISOHADH (Homo sapiens)7240710 OMIM 
HadhRatfamilial hyperinsulinemic hypoglycemia 4  ISOHADH (Homo sapiens)7240710 OMIM 

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Object Symbol
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Original Reference(s)
HadhRat(+)-dexrazoxane decreases expressionISOHadh (Mus musculus)6480464Dexrazoxane results in decreased expression of HADH mRNACTDPMID:26873546
HadhRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of HADH mRNA]CTDPMID:31150632
HadhRat(1->4)-beta-D-glucan multiple interactionsISOHadh (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of HADH mRNACTDPMID:36331819
HadhRat(R)-adrenaline multiple interactionsEXP 6480464[Epinephrine co-treated with Xanthine co-treated with XDH] results in decreased expression of HADH proteinCTDPMID:19464573
HadhRat1,2-dimethylhydrazine multiple interactionsISOHadh (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of HADH mRNACTDPMID:22206623
HadhRat1,2-dimethylhydrazine decreases expressionISOHadh (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of HADH mRNACTDPMID:22206623
HadhRat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of HADH mRNACTDPMID:30723492
HadhRat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of HADH mRNACTDPMID:16174780
HadhRat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of HADH mRNACTDPMID:26865667
HadhRat17beta-estradiol increases oxidationISOHADH (Homo sapiens)6480464HADH protein results in increased oxidation of EstradiolCTDPMID:10600649
HadhRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of HADH proteinCTDPMID:32145629
HadhRat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in decreased expression of HADH mRNACTDPMID:26496021
HadhRat17beta-estradiol multiple interactionsISOHADH (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in increased expression of HADH mRNACTDPMID:20660070
HadhRat17beta-estradiol decreases expressionISOHadh (Mus musculus)6480464Estradiol results in decreased expression of HADH mRNACTDPMID:19484750 and PMID:39298647
HadhRat17beta-estradiol increases expressionISOHADH (Homo sapiens)6480464Estradiol results in increased expression of HADH mRNACTDPMID:16474171 and PMID:19167446
HadhRat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOHADH (Homo sapiens)64804642 more ...CTDPMID:31675489
HadhRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOHadh (Mus musculus)6480464[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of HADH mRNACTDPMID:16214954
HadhRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of HADH mRNACTDPMID:21724226
HadhRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOHADH (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of HADH mRNACTDPMID:20106945 and PMID:21632981
HadhRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOHadh (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of HADH mRNACTDPMID:17949056 more ...

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Biological Process
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Original Reference(s)
HadhRatcell differentiation involved_inIEAUniProtKB-KW:KW-02211600115GO_REF:0000043UniProtGO_REF:0000043
HadhRatfatty acid beta-oxidation  IMP 2302227 RGD 
HadhRatfatty acid beta-oxidation involved_inIBAPANTHER:PTN005169479 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HadhRatfatty acid beta-oxidation involved_inIEAUniProtKB:Q16836 and ensembl:ENSP000003122881600115GO_REF:0000107EnsemblGO_REF:0000107
HadhRatfatty acid beta-oxidation involved_inISOHADH (Sus scrofa)1624291 PMID:2817332RGDPMID:2817332
HadhRatfatty acid beta-oxidation involved_inISOHADH (Homo sapiens)1624291 PMID:11489939RGDPMID:11489939
HadhRatfatty acid beta-oxidation involved_inISSUniProtKB:Q168361600115GO_REF:0000024UniProtGO_REF:0000024
HadhRatfatty acid beta-oxidation involved_inIEAUniPathway:UPA006591600115GO_REF:0000041UniProtGO_REF:0000041
HadhRatfatty acid metabolic process involved_inIEAInterPro:IPR006108 more ...1600115GO_REF:0000002InterProGO_REF:0000002
HadhRatfatty acid metabolic process involved_inIEAUniProtKB-KW:KW-02761600115GO_REF:0000043UniProtGO_REF:0000043
HadhRatlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
HadhRatnegative regulation of insulin secretion  IMP 2302227 RGD 
HadhRatpositive regulation of cold-induced thermogenesis involved_inISSUniProtKB:Q6142513673794PMID:21990309YuBioLab 
HadhRatpositive regulation of cold-induced thermogenesis involved_inISOHadh (Mus musculus)1624291 PMID:21990309RGDPMID:21990309
HadhRatpositive regulation of cold-induced thermogenesis involved_inIEAUniProtKB:Q61425 and ensembl:ENSMUSP000000296101600115GO_REF:0000107EnsemblGO_REF:0000107
HadhRatregulation of insulin secretion involved_inISSUniProtKB:Q614251600115GO_REF:0000024UniProtGO_REF:0000024
HadhRatregulation of insulin secretion involved_inIEAUniProtKB:Q61425 and ensembl:ENSMUSP000000296101600115GO_REF:0000107EnsemblGO_REF:0000107
HadhRatregulation of insulin secretion involved_inISOHadh (Mus musculus)1624291 PMID:20670938RGDPMID:20670938
HadhRatresponse to activity  IDA 2302231 RGD 
HadhRatresponse to hormone  IEP 2302226 RGD 
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Cellular Component
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Original Reference(s)
HadhRatcytoplasm located_inISOHADH (Homo sapiens)1624291 RGDGO_REF:0000054
HadhRatcytoplasm located_inIEAUniProtKB:Q16836 and ensembl:ENSP000003122881600115GO_REF:0000107EnsemblGO_REF:0000107
HadhRatmitochondrial matrix located_inIEAUniProtKB-SubCell:SL-01701600115GO_REF:0000044UniProtGO_REF:0000044
HadhRatmitochondrion located_inISOHADH (Homo sapiens) more ...1624291 RGDGO_REF:0000052
HadhRatmitochondrion located_inIEAUniProtKB:Q61425 and ensembl:ENSMUSP000000296101600115GO_REF:0000107EnsemblGO_REF:0000107
HadhRatmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
HadhRatmitochondrion located_inIEAUniProtKB:Q16836 and ensembl:ENSP000003122881600115GO_REF:0000107EnsemblGO_REF:0000107
HadhRatmitochondrion located_inIEAUniProtKB:A0A140VK76 and ensembl:ENSP000003122881600115GO_REF:0000107EnsemblGO_REF:0000107
HadhRatmitochondrion is_active_inIBAMGI:96009 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HadhRatmitochondrion located_inISOHadh (Mus musculus)1624291 PMID:26767982RGDPMID:26767982
HadhRatnucleoplasm located_inISOHADH (Homo sapiens) more ...1624291 RGDGO_REF:0000052
HadhRatnucleoplasm located_inIEAUniProtKB:Q16836 and ensembl:ENSP000003122881600115GO_REF:0000107EnsemblGO_REF:0000107
HadhRatnucleoplasm located_inIEAUniProtKB:A0A140VK76 and ensembl:ENSP000003122881600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
HadhRat3-hydroxyacyl-CoA dehydrogenase activity  IMP 2302227 RGD 
HadhRat3-hydroxyacyl-CoA dehydrogenase activity enablesIEARHEA:224321600115GO_REF:0000116RHEAGO_REF:0000116
HadhRat3-hydroxyacyl-CoA dehydrogenase activity enablesIEAUniProtKB:Q61425 and ensembl:ENSMUSP000000296101600115GO_REF:0000107EnsemblGO_REF:0000107
HadhRat3-hydroxyacyl-CoA dehydrogenase activity enablesIEAUniProtKB:Q16836 and ensembl:ENSP000003122881600115GO_REF:0000107EnsemblGO_REF:0000107
HadhRat3-hydroxyacyl-CoA dehydrogenase activity enablesISOHadh (Mus musculus)1624291 PMID:15240869RGDPMID:15240869
HadhRat3-hydroxyacyl-CoA dehydrogenase activity enablesIBAMGI:96009 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
HadhRat3-hydroxyacyl-CoA dehydrogenase activity enablesIEAEC:1.1.1.351600115GO_REF:0000003UniProtGO_REF:0000003
HadhRat3-hydroxyacyl-CoA dehydrogenase activity enablesISSUniProtKB:Q168361600115GO_REF:0000024UniProtGO_REF:0000024
HadhRat3-hydroxyacyl-CoA dehydrogenase activity enablesISOHADH (Sus scrofa)1624291 PMID:2817332RGDPMID:2817332
HadhRat3-hydroxyacyl-CoA dehydrogenase activity enablesISOHADH (Homo sapiens)1624291 PMID:11489939RGDPMID:11489939
HadhRatidentical protein binding enablesISOHADH (Homo sapiens)1624291 PMID:10231530RGDPMID:10231530
HadhRatidentical protein binding enablesIEAUniProtKB:Q16836 and ensembl:ENSP000003122881600115GO_REF:0000107EnsemblGO_REF:0000107
HadhRatidentical protein binding enablesISOHADH (Sus scrofa)1624291 PMID:9593854RGDPMID:9593854
HadhRatidentical protein binding enablesISSUniProtKB:Q168361600115GO_REF:0000024UniProtGO_REF:0000024
HadhRatNAD+ binding enablesISSUniProtKB:Q168361600115GO_REF:0000024UniProtGO_REF:0000024
HadhRatNAD+ binding enablesIEAInterPro:IPR006176 and InterPro:IPR0226941600115GO_REF:0000002InterProGO_REF:0000002
HadhRatNAD+ binding enablesIEAUniProtKB:Q16836 and ensembl:ENSP000003122881600115GO_REF:0000107EnsemblGO_REF:0000107
HadhRatNAD+ binding enablesISOHADH (Homo sapiens)1624291 PMID:10840044RGDPMID:10840044
HadhRatoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
HadhRatoxidoreductase activity enablesIEAInterPro:IPR006108 and InterPro:IPR0061801600115GO_REF:0000002InterProGO_REF:0000002
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RGD Manual Annotations


  
Object Symbol
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Original Reference(s)
HadhRatfatty acid beta degradation pathway   IMP 2302227 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Term
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Evidence
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Reference
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Original Reference(s)
HadhRatbutanoate metabolic pathway  IEA 6907045 KEGGrno:00650
HadhRatfatty acid elongation pathway  IEA 6907045 KEGGrno:00062
HadhRatfatty acid metabolic pathway  IEA 6907045 KEGGrno:00071
HadhRatlysine degradation pathway  IEA 6907045 KEGGrno:00310
HadhRattryptophan metabolic pathway  IEA 6907045 KEGGrno:00380
HadhRatvaline, leucine and isoleucine degradation pathway  IEA 6907045 KEGGrno:00280

Imported Annotations - PID (archival)

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Original Reference(s)
HadhRatforkhead class A signaling pathway  ISOHADH (Homo sapiens)6484113 PIDPID:200087

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#
Reference Title
Reference Citation
1. High intensity training-induced changes in skeletal muscle antioxidant enzyme activity. Criswell D, etal., Med Sci Sports Exerc. 1993 Oct;25(10):1135-40.
2. Different forms of obesity as a function of diet composition. Dourmashkin JT, etal., Int J Obes (Lond). 2005 Nov;29(11):1368-78.
3. Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle. Furuhashi M, etal., J Endocrinol. 2002 Aug;174(2):321-9.
4. Purification and properties of 3-hydroxyacyl coenzyme A dehydrogenase-binding protein from rat liver mitochondria. Furuta S and Hashimoto T, J Biochem. 1995 Oct;118(4):810-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Identity of heart and liver L-3-hydroxyacyl coenzyme A dehydrogenase. He XY, etal., Biochim Biophys Acta 1999 Feb 25;1437(2):119-23.
8. Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT. Hirai T, etal., J Nucl Cardiol. 2001 Jul-Aug;8(4):472-81.
9. Effects of streptozotocin diabetes, insulin treatment, and training on the diaphragm. Ianuzzo CD, etal., J Appl Physiol. 1982 Jun;52(6):1471-5.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release. Martens GA, etal., J Biol Chem. 2007 Jul 20;282(29):21134-44. Epub 2007 May 9.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidation. Molven A, etal., Diabetes. 2004 Jan;53(1):221-7.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:12865426   PMID:14651853   PMID:15240869   PMID:18614015   PMID:26316108   PMID:26767982   PMID:29476059  



Hadh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82222,462,049 - 222,504,446 (-)NCBIGRCr8
mRatBN7.22219,787,935 - 219,830,335 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2219,787,927 - 219,830,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2227,444,166 - 227,486,582 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02225,343,838 - 225,386,248 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02220,201,461 - 220,243,878 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02236,353,445 - 236,395,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2236,353,445 - 236,395,067 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02254,902,140 - 254,944,001 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42228,698,545 - 228,751,691 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12228,685,284 - 228,738,431 (-)NCBI
Celera2212,044,254 - 212,086,368 (-)NCBICelera
Cytogenetic Map2q43NCBI
HADH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384107,989,889 - 108,035,171 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4107,989,714 - 108,035,241 (+)EnsemblGRCh38hg38GRCh38
GRCh374108,911,045 - 108,956,327 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364109,130,389 - 109,175,780 (+)NCBINCBI36Build 36hg18NCBI36
Celera4106,205,689 - 106,251,144 (+)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4104,642,283 - 104,687,973 (+)NCBIHuRef
CHM1_14108,887,327 - 108,932,780 (+)NCBICHM1_1
T2T-CHM13v2.04111,292,223 - 111,337,508 (+)NCBIT2T-CHM13v2.0
Hadh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393131,027,068 - 131,065,750 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3131,027,068 - 131,065,750 (-)EnsemblGRCm39 Ensembl
GRCm383131,233,419 - 131,272,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3131,233,419 - 131,272,101 (-)EnsemblGRCm38mm10GRCm38
MGSCv373130,936,342 - 130,974,955 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363131,222,610 - 131,261,182 (-)NCBIMGSCv36mm8
Celera3137,754,696 - 137,793,253 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map360.86NCBI
Hadh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554961,835,034 - 1,861,407 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554961,835,034 - 1,861,410 (-)NCBIChiLan1.0ChiLan1.0
HADH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23106,088,578 - 106,133,957 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14106,383,480 - 106,428,851 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04100,495,205 - 100,540,589 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14111,067,537 - 111,112,945 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4111,067,336 - 111,113,868 (+)Ensemblpanpan1.1panPan2
HADH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13228,460,445 - 28,506,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3228,460,193 - 28,531,280 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3213,516,288 - 13,562,132 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03228,689,480 - 28,735,351 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3228,689,484 - 28,780,497 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13228,682,743 - 28,728,360 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03228,427,283 - 28,473,178 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03211,383,587 - 11,429,427 (-)NCBIUU_Cfam_GSD_1.0
Hadh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530112,605,927 - 12,654,203 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936818575,023 - 623,568 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936818575,272 - 623,496 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HADH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8113,950,034 - 114,005,511 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18113,952,561 - 114,005,510 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28122,212,898 - 122,265,850 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HADH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1755,919,499 - 55,965,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl755,919,623 - 55,964,857 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603734,546,087 - 34,591,597 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hadh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248301,426,775 - 1,451,440 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248301,429,989 - 1,451,447 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Hadh
239 total Variants

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:57
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000014658
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 44 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat

1 to 10 of 44 rows
RH130220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,787,950 - 219,788,156 (+)MAPPERmRatBN7.2
Rnor_6.02234,628,608 - 234,628,813NCBIRnor6.0
Rnor_6.02236,353,461 - 236,353,666NCBIRnor6.0
Rnor_5.02254,902,156 - 254,902,361UniSTSRnor5.0
Rnor_5.02253,948,833 - 253,949,038UniSTSRnor5.0
RGSC_v3.42228,698,561 - 228,698,766UniSTSRGSC3.4
Celera2212,044,270 - 212,044,475UniSTS
RH 3.4 Map21547.5UniSTS
Cytogenetic Map2q43UniSTS
RH143628  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,830,486 - 219,830,588 (+)MAPPERmRatBN7.2
Rnor_6.02236,395,219 - 236,395,320NCBIRnor6.0
Rnor_5.02254,944,153 - 254,944,254UniSTSRnor5.0
RGSC_v3.42228,751,843 - 228,751,944UniSTSRGSC3.4
Celera2212,086,520 - 212,086,621UniSTS
RH 3.4 Map21549.1UniSTS
Cytogenetic Map2q43UniSTS
RH137095  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,788,003 - 219,788,190 (+)MAPPERmRatBN7.2
Rnor_6.02234,628,661 - 234,628,847NCBIRnor6.0
Rnor_6.02236,353,514 - 236,353,700NCBIRnor6.0
Rnor_5.02254,902,209 - 254,902,395UniSTSRnor5.0
Rnor_5.02253,948,886 - 253,949,072UniSTSRnor5.0
RGSC_v3.42228,698,614 - 228,698,800UniSTSRGSC3.4
Celera2212,044,323 - 212,044,509UniSTS
RH 3.4 Map21549.4UniSTS
Cytogenetic Map2q43UniSTS
BQ195950  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,813,422 - 219,813,610 (+)MAPPERmRatBN7.2
Rnor_6.02236,378,932 - 236,379,119NCBIRnor6.0
Rnor_5.02254,927,627 - 254,927,814UniSTSRnor5.0
RGSC_v3.42228,724,032 - 228,724,219UniSTSRGSC3.4
Celera2212,069,769 - 212,069,956UniSTS
RH 3.4 Map21547.5UniSTS
Cytogenetic Map2q43UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000014658   ⟹   ENSRNOP00000014658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2219,787,927 - 219,830,353 (-)Ensembl
Rnor_6.0 Ensembl2236,353,445 - 236,395,067 (-)Ensembl
RefSeq Acc Id: NM_057186   ⟹   NP_476534
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82222,462,049 - 222,504,446 (-)NCBI
mRatBN7.22219,787,935 - 219,830,335 (-)NCBI
Rnor_6.02236,353,445 - 236,395,067 (-)NCBI
Rnor_5.02254,902,140 - 254,944,001 (-)NCBI
RGSC_v3.42228,698,545 - 228,751,691 (-)RGD
Celera2212,044,254 - 212,086,368 (-)RGD
Sequence:
Protein RefSeqs NP_476534 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD42162 (Get FASTA)   NCBI Sequence Viewer  
  EDL82212 (Get FASTA)   NCBI Sequence Viewer  
  EDL82213 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014658
  ENSRNOP00000014658.1
GenBank Protein Q9WVK7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476534   ⟸   NM_057186
- Peptide Label: precursor
- UniProtKB: Q9WVK7 (UniProtKB/Swiss-Prot),   A6HVS6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014658   ⟸   ENSRNOT00000014658
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVK7-F1-model_v2 AlphaFold Q9WVK7 1-314 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691760
Promoter ID:EPDNEW_R2283
Type:initiation region
Name:Hadh_1
Description:hydroxyacyl-CoA dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02236,395,059 - 236,395,119EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-51209 BioCyc
BioCyc Pathway PWY-7948 [4-oxopentanoate degradation] BioCyc
BioCyc Pathway Image PWY-7948 BioCyc
Ensembl Genes ENSRNOG00000010697 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014658 ENTREZGENE
  ENSRNOT00000014658.3 UniProtKB/Swiss-Prot
Gene3D-CATH N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
InterPro 3-OHacyl-CoA_DH UniProtKB/Swiss-Prot
  3-OHacyl-CoA_DH_CS UniProtKB/Swiss-Prot
  3-OHacyl-CoA_DH_NAD-bd UniProtKB/Swiss-Prot
  3HC_DH_C UniProtKB/Swiss-Prot
  6-PGluconate_DH-like_C_sf UniProtKB/Swiss-Prot
  6PGD_dom2 UniProtKB/Swiss-Prot
  Mito_3-hydroxyacyl-CoA_DH UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:113965 UniProtKB/Swiss-Prot
NCBI Gene 113965 ENTREZGENE
PANTHER HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR43561 UniProtKB/Swiss-Prot
Pfam 3HCDH UniProtKB/Swiss-Prot
  3HCDH_N UniProtKB/Swiss-Prot
PhenoGen Hadh PhenoGen
PIRSF HCDH UniProtKB/Swiss-Prot
PROSITE 3HCDH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010697 RatGTEx
Superfamily-SCOP SSF48179 UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
TIGR TC228833
UniProt A6HVS6 ENTREZGENE, UniProtKB/TrEMBL
  HCDH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Hadh  hydroxyacyl-CoA dehydrogenase  Hadh  hydroxyacyl-Coenzyme A dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Hadh  hydroxyacyl-Coenzyme A dehydrogenase  Hadhsc  L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hadhsc  L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain      Name updated 70584 APPROVED

Note Type Note Reference
gene_expression expressed in heart and liver 68799