Hadh (hydroxyacyl-CoA dehydrogenase) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Hadh (hydroxyacyl-CoA dehydrogenase) Rattus norvegicus
Analyze
Symbol: Hadh
Name: hydroxyacyl-CoA dehydrogenase
RGD ID: 69321
Description: Enables (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity. Involved in several processes, including fatty acid beta-oxidation; negative regulation of insulin secretion; and response to insulin. Predicted to be located in mitochondrial matrix and nucleoplasm. Predicted to be active in mitochondrion. Biomarker of myocardial infarction and obesity. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 4. Orthologous to human HADH (hydroxyacyl-CoA dehydrogenase); PARTICIPATES IN fatty acid beta degradation pathway; 2-aminoadipic 2-oxoadipic aciduria pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; INTERACTS WITH (+)-schisandrin B; (R)-adrenaline; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hadhsc; HCDH; hydroxyacyl-Coenzyme A dehydrogenase; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; hydroxylacyl-Coenzyme A dehydrogenase; hydroxylacyl-Coenzyme A dehydrogenase short chain; hydroxylacyl-Coenzyme A dehydrogenase, short chain; L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain; medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase; medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; short chain 3-hydroxyacyl-CoA dehydrogenase; short-chain 3-hydroxyacyl-CoA dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82222,462,049 - 222,504,446 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2222,462,049 - 222,504,446 (-)EnsemblGRCr8
mRatBN7.22219,787,935 - 219,830,335 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2219,787,927 - 219,830,353 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2227,444,166 - 227,486,582 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02225,343,838 - 225,386,248 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02220,201,461 - 220,243,878 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02236,353,445 - 236,395,067 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2236,353,445 - 236,395,067 (-)Ensemblrn6Rnor6.0
Rnor_5.02254,902,140 - 254,944,001 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42228,698,545 - 228,751,691 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2212,044,254 - 212,086,368 (-)NCBICelera
RGSC_v3.12228,685,284 - 228,738,431 (-)NCBI
Cytogenetic Map2q43NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
acrolein  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
erianin  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (EXP)
GW 4064  (ISO)
GW 7647  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isoniazide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
microcystin-LR  (ISO)
milrinone  (EXP)
Muraglitazar  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
okadaic acid  (ISO)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
propan-2-ol  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
saquinavir  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
zaragozic acid A  (EXP,ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
mitochondrial matrix  (IEA)
mitochondrion  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. High intensity training-induced changes in skeletal muscle antioxidant enzyme activity. Criswell D, etal., Med Sci Sports Exerc. 1993 Oct;25(10):1135-40.
2. Different forms of obesity as a function of diet composition. Dourmashkin JT, etal., Int J Obes (Lond). 2005 Nov;29(11):1368-78.
3. Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle. Furuhashi M, etal., J Endocrinol. 2002 Aug;174(2):321-9.
4. Purification and properties of 3-hydroxyacyl coenzyme A dehydrogenase-binding protein from rat liver mitochondria. Furuta S and Hashimoto T, J Biochem. 1995 Oct;118(4):810-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Identity of heart and liver L-3-hydroxyacyl coenzyme A dehydrogenase. He XY, etal., Biochim Biophys Acta 1999 Feb 25;1437(2):119-23.
8. Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT. Hirai T, etal., J Nucl Cardiol. 2001 Jul-Aug;8(4):472-81.
9. Effects of streptozotocin diabetes, insulin treatment, and training on the diaphragm. Ianuzzo CD, etal., J Appl Physiol. 1982 Jun;52(6):1471-5.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release. Martens GA, etal., J Biol Chem. 2007 Jul 20;282(29):21134-44. Epub 2007 May 9.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidation. Molven A, etal., Diabetes. 2004 Jan;53(1):221-7.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis. Schulz N, etal., Endocrinology. 2011 Dec;152(12):4641-51. doi: 10.1210/en.2011-1547. Epub 2011 Oct 11.
22. Growth hormone and heart failure: oxidative stress and energetic metabolism in rats. Seiva FR, etal., Growth Horm IGF Res. 2008 Aug;18(4):275-83. Epub 2008 Jan 10.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12865426   PMID:14651853   PMID:15240869   PMID:18614015   PMID:26316108   PMID:26767982   PMID:29476059  


Genomics

Comparative Map Data
Hadh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82222,462,049 - 222,504,446 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2222,462,049 - 222,504,446 (-)EnsemblGRCr8
mRatBN7.22219,787,935 - 219,830,335 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2219,787,927 - 219,830,353 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2227,444,166 - 227,486,582 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02225,343,838 - 225,386,248 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02220,201,461 - 220,243,878 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02236,353,445 - 236,395,067 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2236,353,445 - 236,395,067 (-)Ensemblrn6Rnor6.0
Rnor_5.02254,902,140 - 254,944,001 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42228,698,545 - 228,751,691 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2212,044,254 - 212,086,368 (-)NCBICelera
RGSC_v3.12228,685,284 - 228,738,431 (-)NCBI
Cytogenetic Map2q43NCBI
HADH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384107,989,889 - 108,035,171 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4107,989,714 - 108,035,241 (+)Ensemblhg38GRCh38
GRCh374108,911,045 - 108,956,327 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364109,130,389 - 109,175,780 (+)NCBIBuild 36Build 36hg18NCBI36
Celera4106,205,689 - 106,251,144 (+)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4104,642,283 - 104,687,973 (+)NCBIHuRef
CHM1_14108,887,327 - 108,932,780 (+)NCBICHM1_1
T2T-CHM13v2.04111,292,223 - 111,337,508 (+)NCBIT2T-CHM13v2.0
Hadh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393131,027,068 - 131,065,750 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3131,027,068 - 131,065,750 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm383131,233,419 - 131,272,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3131,233,419 - 131,272,101 (-)Ensemblmm10GRCm38
MGSCv373130,936,342 - 130,974,955 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363131,222,610 - 131,261,182 (-)NCBIMGSCv36mm8
Celera3137,754,696 - 137,793,253 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map360.86NCBI
Hadh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554961,835,034 - 1,861,407 (-)Ensembl
ChiLan1.0NW_0049554961,835,034 - 1,861,410 (-)NCBIChiLan1.0ChiLan1.0
HADH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23106,088,578 - 106,133,957 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14106,383,480 - 106,428,851 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04100,495,205 - 100,540,589 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14111,067,537 - 111,112,945 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4111,067,336 - 111,113,868 (+)EnsemblpanPan2panpan1.1
HADH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13228,460,445 - 28,506,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3228,460,193 - 28,531,280 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3213,516,288 - 13,562,132 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03228,689,480 - 28,735,351 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3228,689,484 - 28,780,497 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13228,682,743 - 28,728,360 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03228,427,283 - 28,473,178 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03211,383,587 - 11,429,427 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hadh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530112,605,927 - 12,654,203 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936818575,023 - 623,568 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936818575,272 - 623,496 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HADH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8113,950,034 - 114,005,511 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18113,952,561 - 114,005,510 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28122,212,898 - 122,265,850 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HADH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1755,919,499 - 55,965,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl755,919,623 - 55,964,857 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603734,546,087 - 34,591,597 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hadh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248301,426,775 - 1,451,440 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248301,429,989 - 1,451,447 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Hadh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1327,599,367 - 27,641,703 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hadh
242 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:57
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000014658
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2219814164239320906Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2205135267225627153Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
1302789Stl26Serum triglyceride level QTL 263.10.0035blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)2206613059226891081Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221088977243501206Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
1359019Hrtrt19Heart rate QTL 192.9heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221270493228950743Rat

Markers in Region
RH130220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,787,950 - 219,788,156 (+)MAPPERmRatBN7.2
Rnor_6.02234,628,608 - 234,628,813NCBIRnor6.0
Rnor_6.02236,353,461 - 236,353,666NCBIRnor6.0
Rnor_5.02254,902,156 - 254,902,361UniSTSRnor5.0
Rnor_5.02253,948,833 - 253,949,038UniSTSRnor5.0
RGSC_v3.42228,698,561 - 228,698,766UniSTSRGSC3.4
Celera2212,044,270 - 212,044,475UniSTS
RH 3.4 Map21547.5UniSTS
Cytogenetic Map2q43UniSTS
RH143628  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,830,486 - 219,830,588 (+)MAPPERmRatBN7.2
Rnor_6.02236,395,219 - 236,395,320NCBIRnor6.0
Rnor_5.02254,944,153 - 254,944,254UniSTSRnor5.0
RGSC_v3.42228,751,843 - 228,751,944UniSTSRGSC3.4
Celera2212,086,520 - 212,086,621UniSTS
RH 3.4 Map21549.1UniSTS
Cytogenetic Map2q43UniSTS
RH137095  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,788,003 - 219,788,190 (+)MAPPERmRatBN7.2
Rnor_6.02234,628,661 - 234,628,847NCBIRnor6.0
Rnor_6.02236,353,514 - 236,353,700NCBIRnor6.0
Rnor_5.02254,902,209 - 254,902,395UniSTSRnor5.0
Rnor_5.02253,948,886 - 253,949,072UniSTSRnor5.0
RGSC_v3.42228,698,614 - 228,698,800UniSTSRGSC3.4
Celera2212,044,323 - 212,044,509UniSTS
RH 3.4 Map21549.4UniSTS
Cytogenetic Map2q43UniSTS
BQ195950  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,813,422 - 219,813,610 (+)MAPPERmRatBN7.2
Rnor_6.02236,378,932 - 236,379,119NCBIRnor6.0
Rnor_5.02254,927,627 - 254,927,814UniSTSRnor5.0
RGSC_v3.42228,724,032 - 228,724,219UniSTSRGSC3.4
Celera2212,069,769 - 212,069,956UniSTS
RH 3.4 Map21547.5UniSTS
Cytogenetic Map2q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000014658   ⟹   ENSRNOP00000014658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2222,462,049 - 222,504,446 (-)Ensembl
mRatBN7.2 Ensembl2219,787,927 - 219,830,353 (-)Ensembl
Rnor_6.0 Ensembl2236,353,445 - 236,395,067 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000133475   ⟹   ENSRNOP00000103762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2222,462,049 - 222,504,446 (-)Ensembl
RefSeq Acc Id: NM_057186   ⟹   NP_476534
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82222,462,049 - 222,504,446 (-)NCBI
mRatBN7.22219,787,935 - 219,830,335 (-)NCBI
Rnor_6.02236,353,445 - 236,395,067 (-)NCBI
Rnor_5.02254,902,140 - 254,944,001 (-)NCBI
RGSC_v3.42228,698,545 - 228,751,691 (-)RGD
Celera2212,044,254 - 212,086,368 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476534 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD42162 (Get FASTA)   NCBI Sequence Viewer  
  EDL82212 (Get FASTA)   NCBI Sequence Viewer  
  EDL82213 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014658
  ENSRNOP00000014658.1
GenBank Protein Q9WVK7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476534   ⟸   NM_057186
- Peptide Label: precursor
- UniProtKB: Q9WVK7 (UniProtKB/Swiss-Prot),   A6HVS6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014658   ⟸   ENSRNOT00000014658
Ensembl Acc Id: ENSRNOP00000103762   ⟸   ENSRNOT00000133475
Protein Domains
3-hydroxyacyl-CoA dehydrogenase C-terminal   3-hydroxyacyl-CoA dehydrogenase NAD binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVK7-F1-model_v2 AlphaFold Q9WVK7 1-314 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691760
Promoter ID:EPDNEW_R2283
Type:initiation region
Name:Hadh_1
Description:hydroxyacyl-CoA dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02236,395,059 - 236,395,119EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69321 AgrOrtholog
BioCyc Gene G2FUF-51209 BioCyc
BioCyc Pathway PWY-7948 [4-oxopentanoate degradation] BioCyc
BioCyc Pathway Image PWY-7948 BioCyc
Ensembl Genes ENSRNOG00000010697 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014658 ENTREZGENE
  ENSRNOT00000014658.3 UniProtKB/Swiss-Prot
Gene3D-CATH N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2 UniProtKB/Swiss-Prot
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot
InterPro 3-OHacyl-CoA_DH UniProtKB/Swiss-Prot
  3-OHacyl-CoA_DH_CS UniProtKB/Swiss-Prot
  3-OHacyl-CoA_DH_NAD-bd UniProtKB/Swiss-Prot
  3HC_DH_C UniProtKB/Swiss-Prot
  6-PGluconate_DH-like_C_sf UniProtKB/Swiss-Prot
  6PGD_dom2 UniProtKB/Swiss-Prot
  Mito_3-hydroxyacyl-CoA_DH UniProtKB/Swiss-Prot
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:113965 UniProtKB/Swiss-Prot
NCBI Gene 113965 ENTREZGENE
PANTHER HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR43561 UniProtKB/Swiss-Prot
Pfam 3HCDH UniProtKB/Swiss-Prot
  3HCDH_N UniProtKB/Swiss-Prot
PhenoGen Hadh PhenoGen
PIRSF HCDH UniProtKB/Swiss-Prot
PROSITE 3HCDH UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010697 RatGTEx
Superfamily-SCOP SSF48179 UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
TIGR TC228833
UniProt A0ABK0LJQ8_RAT UniProtKB/TrEMBL
  A6HVS6 ENTREZGENE, UniProtKB/TrEMBL
  HCDH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Hadh  hydroxyacyl-CoA dehydrogenase  Hadh  hydroxyacyl-Coenzyme A dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Hadh  hydroxyacyl-Coenzyme A dehydrogenase  Hadhsc  L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hadhsc  L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in heart and liver 68799