Hadh (hydroxyacyl-CoA dehydrogenase) - Rat Genome Database

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Gene: Hadh (hydroxyacyl-CoA dehydrogenase) Rattus norvegicus
Analyze
Symbol: Hadh
Name: hydroxyacyl-CoA dehydrogenase
RGD ID: 69321
Description: Enables 3-hydroxyacyl-CoA dehydrogenase activity. Involved in several processes, including fatty acid beta-oxidation; negative regulation of insulin secretion; and response to insulin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in mitochondrion. Biomarker of myocardial infarction and obesity. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 4. Orthologous to human HADH (hydroxyacyl-CoA dehydrogenase); PARTICIPATES IN fatty acid beta degradation pathway; 2-aminoadipic 2-oxoadipic aciduria pathway; 3-hydroxyacyl-CoA dehydrogenase deficiency pathway; INTERACTS WITH (+)-schisandrin B; (R)-adrenaline; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Hadhsc; HCDH; hydroxyacyl-Coenzyme A dehydrogenase; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; hydroxylacyl-Coenzyme A dehydrogenase; hydroxylacyl-Coenzyme A dehydrogenase short chain; hydroxylacyl-Coenzyme A dehydrogenase, short chain; L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain; medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase; medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; short chain 3-hydroxyacyl-CoA dehydrogenase; short-chain 3-hydroxyacyl-CoA dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82222,462,049 - 222,504,446 (-)NCBIGRCr8
mRatBN7.22219,787,935 - 219,830,335 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2219,787,927 - 219,830,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2227,444,166 - 227,486,582 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02225,343,838 - 225,386,248 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02220,201,461 - 220,243,878 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02236,353,445 - 236,395,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2236,353,445 - 236,395,067 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02254,902,140 - 254,944,001 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42228,698,545 - 228,751,691 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12228,685,284 - 228,738,431 (-)NCBI
Celera2212,044,254 - 212,086,368 (-)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-adrenaline  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
acrolein  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenamidone  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (EXP)
GW 4064  (ISO)
GW 7647  (ISO)
indinavir  (ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
microcystin-LR  (ISO)
milrinone  (EXP)
Muraglitazar  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
oleic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
PhIP  (EXP)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
progesterone  (ISO)
propan-2-ol  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
saquinavir  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tauroursodeoxycholic acid  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
zaragozic acid A  (EXP,ISO)
zidovudine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
mitochondrial matrix  (IEA)
mitochondrion  (IBA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. High intensity training-induced changes in skeletal muscle antioxidant enzyme activity. Criswell D, etal., Med Sci Sports Exerc. 1993 Oct;25(10):1135-40.
2. Different forms of obesity as a function of diet composition. Dourmashkin JT, etal., Int J Obes (Lond). 2005 Nov;29(11):1368-78.
3. Fenofibrate improves insulin sensitivity in connection with intramuscular lipid content, muscle fatty acid-binding protein, and beta-oxidation in skeletal muscle. Furuhashi M, etal., J Endocrinol. 2002 Aug;174(2):321-9.
4. Purification and properties of 3-hydroxyacyl coenzyme A dehydrogenase-binding protein from rat liver mitochondria. Furuta S and Hashimoto T, J Biochem. 1995 Oct;118(4):810-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Identity of heart and liver L-3-hydroxyacyl coenzyme A dehydrogenase. He XY, etal., Biochim Biophys Acta 1999 Feb 25;1437(2):119-23.
8. Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT. Hirai T, etal., J Nucl Cardiol. 2001 Jul-Aug;8(4):472-81.
9. Effects of streptozotocin diabetes, insulin treatment, and training on the diaphragm. Ianuzzo CD, etal., J Appl Physiol. 1982 Jun;52(6):1471-5.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. Specificity in beta cell expression of L-3-hydroxyacyl-CoA dehydrogenase, short chain, and potential role in down-regulating insulin release. Martens GA, etal., J Biol Chem. 2007 Jul 20;282(29):21134-44. Epub 2007 May 9.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Familial hyperinsulinemic hypoglycemia caused by a defect in the SCHAD enzyme of mitochondrial fatty acid oxidation. Molven A, etal., Diabetes. 2004 Jan;53(1):221-7.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis. Schulz N, etal., Endocrinology. 2011 Dec;152(12):4641-51. doi: 10.1210/en.2011-1547. Epub 2011 Oct 11.
22. Growth hormone and heart failure: oxidative stress and energetic metabolism in rats. Seiva FR, etal., Growth Horm IGF Res. 2008 Aug;18(4):275-83. Epub 2008 Jan 10.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:12865426   PMID:14651853   PMID:15240869   PMID:18614015   PMID:26316108   PMID:26767982   PMID:29476059  


Genomics

Comparative Map Data
Hadh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82222,462,049 - 222,504,446 (-)NCBIGRCr8
mRatBN7.22219,787,935 - 219,830,335 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2219,787,927 - 219,830,353 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2227,444,166 - 227,486,582 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02225,343,838 - 225,386,248 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02220,201,461 - 220,243,878 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02236,353,445 - 236,395,067 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2236,353,445 - 236,395,067 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02254,902,140 - 254,944,001 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42228,698,545 - 228,751,691 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12228,685,284 - 228,738,431 (-)NCBI
Celera2212,044,254 - 212,086,368 (-)NCBICelera
Cytogenetic Map2q43NCBI
HADH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384107,989,889 - 108,035,171 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4107,989,714 - 108,035,241 (+)EnsemblGRCh38hg38GRCh38
GRCh374108,911,045 - 108,956,327 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364109,130,389 - 109,175,780 (+)NCBINCBI36Build 36hg18NCBI36
Celera4106,205,689 - 106,251,144 (+)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4104,642,283 - 104,687,973 (+)NCBIHuRef
CHM1_14108,887,327 - 108,932,780 (+)NCBICHM1_1
T2T-CHM13v2.04111,292,223 - 111,337,508 (+)NCBIT2T-CHM13v2.0
Hadh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393131,027,068 - 131,065,750 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3131,027,068 - 131,065,750 (-)EnsemblGRCm39 Ensembl
GRCm383131,233,419 - 131,272,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3131,233,419 - 131,272,101 (-)EnsemblGRCm38mm10GRCm38
MGSCv373130,936,342 - 130,974,955 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363131,222,610 - 131,261,182 (-)NCBIMGSCv36mm8
Celera3137,754,696 - 137,793,253 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map360.86NCBI
Hadh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554961,835,034 - 1,861,407 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554961,835,034 - 1,861,410 (-)NCBIChiLan1.0ChiLan1.0
HADH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23106,088,578 - 106,133,957 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14106,383,480 - 106,428,851 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04100,495,205 - 100,540,589 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14111,067,537 - 111,112,945 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4111,067,336 - 111,113,868 (+)Ensemblpanpan1.1panPan2
HADH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13228,460,445 - 28,506,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3228,460,193 - 28,531,280 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3213,516,288 - 13,562,132 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03228,689,480 - 28,735,351 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3228,689,484 - 28,780,497 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13228,682,743 - 28,728,360 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03228,427,283 - 28,473,178 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03211,383,587 - 11,429,427 (-)NCBIUU_Cfam_GSD_1.0
Hadh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530112,605,927 - 12,654,203 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936818575,023 - 623,568 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936818575,272 - 623,496 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HADH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8113,950,034 - 114,005,511 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18113,952,561 - 114,005,510 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28122,212,898 - 122,265,850 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HADH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1755,919,499 - 55,965,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl755,919,623 - 55,964,857 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603734,546,087 - 34,591,597 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hadh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248301,426,775 - 1,451,440 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248301,429,989 - 1,451,447 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hadh
239 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:57
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000014658
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
1359019Hrtrt19Heart rate QTL 192.9heart pumping trait (VT:2000009)heart rate (CMO:0000002)2219753301226277316Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat

Markers in Region
RH130220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,787,950 - 219,788,156 (+)MAPPERmRatBN7.2
Rnor_6.02234,628,608 - 234,628,813NCBIRnor6.0
Rnor_6.02236,353,461 - 236,353,666NCBIRnor6.0
Rnor_5.02254,902,156 - 254,902,361UniSTSRnor5.0
Rnor_5.02253,948,833 - 253,949,038UniSTSRnor5.0
RGSC_v3.42228,698,561 - 228,698,766UniSTSRGSC3.4
Celera2212,044,270 - 212,044,475UniSTS
RH 3.4 Map21547.5UniSTS
Cytogenetic Map2q43UniSTS
RH143628  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,830,486 - 219,830,588 (+)MAPPERmRatBN7.2
Rnor_6.02236,395,219 - 236,395,320NCBIRnor6.0
Rnor_5.02254,944,153 - 254,944,254UniSTSRnor5.0
RGSC_v3.42228,751,843 - 228,751,944UniSTSRGSC3.4
Celera2212,086,520 - 212,086,621UniSTS
RH 3.4 Map21549.1UniSTS
Cytogenetic Map2q43UniSTS
RH137095  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,788,003 - 219,788,190 (+)MAPPERmRatBN7.2
Rnor_6.02234,628,661 - 234,628,847NCBIRnor6.0
Rnor_6.02236,353,514 - 236,353,700NCBIRnor6.0
Rnor_5.02254,902,209 - 254,902,395UniSTSRnor5.0
Rnor_5.02253,948,886 - 253,949,072UniSTSRnor5.0
RGSC_v3.42228,698,614 - 228,698,800UniSTSRGSC3.4
Celera2212,044,323 - 212,044,509UniSTS
RH 3.4 Map21549.4UniSTS
Cytogenetic Map2q43UniSTS
BQ195950  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,813,422 - 219,813,610 (+)MAPPERmRatBN7.2
Rnor_6.02236,378,932 - 236,379,119NCBIRnor6.0
Rnor_5.02254,927,627 - 254,927,814UniSTSRnor5.0
RGSC_v3.42228,724,032 - 228,724,219UniSTSRGSC3.4
Celera2212,069,769 - 212,069,956UniSTS
RH 3.4 Map21547.5UniSTS
Cytogenetic Map2q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000014658   ⟹   ENSRNOP00000014658
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2219,787,927 - 219,830,353 (-)Ensembl
Rnor_6.0 Ensembl2236,353,445 - 236,395,067 (-)Ensembl
RefSeq Acc Id: NM_057186   ⟹   NP_476534
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82222,462,049 - 222,504,446 (-)NCBI
mRatBN7.22219,787,935 - 219,830,335 (-)NCBI
Rnor_6.02236,353,445 - 236,395,067 (-)NCBI
Rnor_5.02254,902,140 - 254,944,001 (-)NCBI
RGSC_v3.42228,698,545 - 228,751,691 (-)RGD
Celera2212,044,254 - 212,086,368 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476534 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD42162 (Get FASTA)   NCBI Sequence Viewer  
  EDL82212 (Get FASTA)   NCBI Sequence Viewer  
  EDL82213 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014658.1
  ENSRNOP00055014662
  ENSRNOP00060032592
  ENSRNOP00065018745
GenBank Protein Q9WVK7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476534   ⟸   NM_057186
- Peptide Label: precursor
- UniProtKB: Q9WVK7 (UniProtKB/Swiss-Prot),   A6HVS6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014658   ⟸   ENSRNOT00000014658
Protein Domains
3-hydroxyacyl-CoA dehydrogenase C-terminal   3-hydroxyacyl-CoA dehydrogenase NAD binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVK7-F1-model_v2 AlphaFold Q9WVK7 1-314 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691760
Promoter ID:EPDNEW_R2283
Type:initiation region
Name:Hadh_1
Description:hydroxyacyl-CoA dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02236,395,059 - 236,395,119EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69321 AgrOrtholog
BioCyc Gene G2FUF-51209 BioCyc
BioCyc Pathway PWY-7948 [4-oxopentanoate degradation] BioCyc
BioCyc Pathway Image PWY-7948 BioCyc
Ensembl Genes ENSRNOG00000010697 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055010800 UniProtKB/Swiss-Prot
  ENSRNOG00060022720 UniProtKB/Swiss-Prot
  ENSRNOG00065014559 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014658.3 UniProtKB/Swiss-Prot
  ENSRNOT00055018253 UniProtKB/Swiss-Prot
  ENSRNOT00060039400 UniProtKB/Swiss-Prot
  ENSRNOT00065024043 UniProtKB/Swiss-Prot
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 3-OHacyl-CoA_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3-OHacyl-CoA_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3-OHacyl-CoA_DH_NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3HC_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6-PGluconate_DH-like_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6PGD_dom2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mito_3-hydroxyacyl-CoA_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:113965 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 113965 ENTREZGENE
PANTHER HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43561 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 3HCDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3HCDH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hadh PhenoGen
PIRSF HCDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 3HCDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010697 RatGTEx
  ENSRNOG00055010800 RatGTEx
  ENSRNOG00060022720 RatGTEx
  ENSRNOG00065014559 RatGTEx
Superfamily-SCOP 6-phosphogluconate dehydrogenase C-terminal domain-like UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-fold domains UniProtKB/TrEMBL
  SSF48179 UniProtKB/Swiss-Prot
  SSF51735 UniProtKB/Swiss-Prot
TIGR TC228833
UniProt A6HVS6 ENTREZGENE, UniProtKB/TrEMBL
  HCDH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Hadh  hydroxyacyl-CoA dehydrogenase  Hadh  hydroxyacyl-Coenzyme A dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Hadh  hydroxyacyl-Coenzyme A dehydrogenase  Hadhsc  L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Hadhsc  L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in heart and liver 68799