RGD Reference Report - Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT. - Rat Genome Database

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Serial evaluation of fatty acid metabolism in rats with myocardial infarction by pinhole SPECT.

Authors: Hirai, T  Nohara, R  Ogoh, S  Chen, LG  Kataoka, K  Li, XH  Fujita, M  Matsumori, A  Taguchi, S  Sasayama, S 
Citation: Hirai T, etal., J Nucl Cardiol. 2001 Jul-Aug;8(4):472-81.
RGD ID: 2302229
Pubmed: PMID:11481570   (View Abstract at PubMed)
DOI: DOI:10.1067/mnc.2001.114519   (Journal Full-text)

BACKGROUND: Iodine 123-labeled 15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) is mainly trapped in the myocardium as triglyceride, depending on the adenosine triphosphate level. Ten percent to 20% of it is metabolized through alpha-oxidation after beta-oxidation; however, the precise mechanism of the regulatory pathways of BMIPP is yet to be clarified. METHODS AND RESULTS: A brief left coronary artery occlusion (10-30 minutes) was performed in 28 male Wistar-Kyoto rats. Dual single photon emission computed tomography images of BMIPP and thallium 201 were obtained 3 days and 24 days after the operation. The activities of 3-hydroxyacyl-coenzyme A dehydrogenase (HAD), citrate synthase (CS), and alpha-glycerol-phosphate dehydrogenase (GPD) were then measured in both ischemic and nonischemic regions. BMIPP and Tl-201 chloride severity scores were also evaluated conventionally. CS and HAD levels were significantly lower in the ischemic region than in the nonischemic region in the chronic group (CS, 102.9 +/- 28.1 vs 138.7 +/- 33.7 micromol/g/min, respectively, P =.0051; HAD, 54.7 +/- 20.1 vs 78.6 +/- 18.7 micromol/g/min, respectively, P =.0031). There was no difference in GPD between the ischemic and nonischemic regions. The BMIPP severity score had closer inverse relations with HAD (acute, r = -0.82; chronic, r = -0.80) and CS (acute, r = -0.87; chronic, r = -0.81), but not with GPD, than did Tl-201 chloride severity score. CONCLUSIONS: BMIPP imaging correlates well with the activities of HAD and CS, suggesting that a decrease in BMIPP uptake reflects deterioration of both fatty acid metabolism and citrate cycle and shows information other than regional myocardial perfusion.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
myocardial infarction  ISOHadh (Rattus norvegicus)2302229; 2302229 RGD 
myocardial infarction  IEP 2302229 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hadh  (hydroxyacyl-CoA dehydrogenase)

Genes (Mus musculus)
Hadh  (hydroxyacyl-Coenzyme A dehydrogenase)

Genes (Homo sapiens)
HADH  (hydroxyacyl-CoA dehydrogenase)


Additional Information