Cdh2 (cadherin 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Cdh2 (cadherin 2) Rattus norvegicus
Analyze
Symbol: Cdh2
Name: cadherin 2
RGD ID: 69280
Description: Enables beta-catenin binding activity; nitric-oxide synthase binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; regulation of Rho protein signal transduction; and regulation of myelination. Located in several cellular components, including T-tubule; adherens junction; and fascia adherens. Part of protein-containing complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in agenesis of corpus callosum, cardiac, ocular, and genital syndrome; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 14. Orthologous to human CDH2 (cadherin 2); PARTICIPATES IN cadherin mediated signaling pathway; fibroblast growth factor signaling pathway; N-cadherin signaling pathway; INTERACTS WITH (+)-pilocarpine; 1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); cadherin-2; N-cadherin; neural cadherin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,051,097 - 8,265,288 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,051,097 - 8,265,288 (-)EnsemblGRCr8
mRatBN7.2187,776,704 - 7,990,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl187,776,704 - 7,990,167 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,020,068 - 8,240,669 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0188,807,745 - 9,028,345 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,079,330 - 8,299,941 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,146,971 - 8,366,037 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,146,971 - 8,360,684 (-)Ensemblrn6Rnor6.0
Rnor_5.0187,997,533 - 8,218,018 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4188,048,920 - 8,267,974 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera187,938,006 - 8,155,134 (-)NCBICelera
RGSC_v3.1188,048,919 - 8,268,462 (-)NCBI
Cytogenetic Map18p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-Tetrandrine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,1-bis(2-aminoethyl)-2-hydroxy-3-oxotriazane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
9-cis-retinoic acid  (ISO)
[6]-Shogaol  (ISO)
acadesine  (ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acrolein  (EXP)
acrylonitrile  (ISO)
aflatoxin B1  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
ametryn  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
antimycin A  (ISO)
antroquinonol  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
azithromycin  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
biochanin A  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
Bisphenol P  (ISO)
bleomycin A2  (ISO)
Bufotalin  (ISO)
Butylbenzyl phthalate  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcidiol  (EXP)
calciol  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chloroquine  (EXP)
chrysin  (ISO)
cisatracurium  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
DAPT  (EXP)
DDE  (EXP)
DDT  (ISO)
deguelin  (ISO)
delphinidin  (ISO)
deoxynivalenol  (ISO)
Destruxin B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
dimethyl sulfoxide  (ISO)
dimethylselenide  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
doramapimod  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl trans-caffeate  (ISO)
Evodiamine  (ISO)
fenbendazole  (ISO)
fenpyroximate  (ISO)
fisetin  (ISO)
flubendazole  (ISO)
fludioxonil  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
Ginkgoic acid  (ISO)
glafenine  (EXP)
glycyrrhizinic acid  (ISO)
Goe 6976  (EXP)
gossypol  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroxyflutamide  (ISO)
icariside II  (ISO)
indirubin  (ISO)
isoorientin  (ISO)
isoprenaline  (ISO)
isoprene  (ISO)
jaspamide  (ISO)
L-ascorbic acid  (EXP)
L-citrulline  (ISO)
lapatinib  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
loliolide  (ISO)
luteolin  (ISO)
LY294002  (ISO)
lycopene  (ISO)
mebendazole  (ISO)
menadione  (ISO)
mercury dichloride  (EXP)
methapyrilene  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
MK-2206  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
morusin  (ISO)
N(6),N(6)-dimethyladenine  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrogen mustard  (ISO)
NMS-873  (ISO)
Nonylphenol  (EXP,ISO)
NORCANTHARIDIN  (ISO)
novobiocin  (ISO)
Ophiopogonin D  (ISO)
oridonin  (ISO)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-cresol  (EXP)
p-tert-Amylphenol  (EXP,ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
patulin  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP,ISO)
phenol red  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
plerixafor  (ISO)
potassium iodide  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propofol  (ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
ridaforolimus  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
Salidroside  (ISO)
Salinomycin  (ISO)
sanguinarine  (ISO)
SB 290157  (ISO)
SB 431542  (ISO)
Shikonin  (ISO)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
sinensetin  (ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
solasodine  (ISO)
Soman  (EXP)
sorafenib  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
taraxasterol  (ISO)
tauroursodeoxycholic acid  (EXP)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
ubiquinone-0  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin D  (EXP)
vitamin E  (EXP)
withaferin A  (ISO)
wortmannin  (ISO)
WP1066  (ISO)
XAV939  (ISO)
zardaverine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction organization  (IBA)
blood vessel morphogenesis  (ISO)
brain morphogenesis  (ISO)
calcium-dependent cell-cell adhesion  (IBA,IEA,IMP,ISO)
cell adhesion  (IEA,ISO)
cell migration  (IBA,ISO)
cell morphogenesis  (IBA)
cell-cell adhesion  (IDA,IEA,ISO)
cell-cell adhesion mediated by cadherin  (IBA,IEA,ISO,ISS)
cell-cell junction assembly  (IBA,IEA,ISO,ISS)
cerebral cortex development  (ISO)
glial cell differentiation  (IEA,ISO,ISS)
heterophilic cell-cell adhesion  (ISO)
homeostasis of number of cells  (ISO)
homophilic cell-cell adhesion  (IEA,ISO)
mesenchymal cell migration  (ISO)
modulation of chemical synaptic transmission  (EXP,IDA)
negative regulation of canonical Wnt signaling pathway  (ISO)
neural crest cell development  (IEA,ISO,ISS)
neuroepithelial cell differentiation  (ISO)
neuroligin clustering involved in postsynaptic membrane assembly  (IEA,ISO)
neuronal stem cell population maintenance  (IEA,ISO,ISS)
positive regulation of MAPK cascade  (ISO)
positive regulation of synaptic vesicle clustering  (IEA,ISO)
radial glial cell differentiation  (ISO)
regulation of axonogenesis  (IEA,IMP)
regulation of myelination  (IMP)
regulation of oligodendrocyte progenitor proliferation  (ISO)
regulation of postsynaptic density protein 95 clustering  (IEA,ISO)
regulation of protein localization  (IMP)
regulation of Rho protein signal transduction  (IMP)
striated muscle cell differentiation  (ISO)
synapse assembly  (IBA,IEA,IMP)
synaptic vesicle clustering  (IEA,ISO,ISS)
telencephalon development  (ISO)
type B pancreatic cell development  (IEA,ISO,ISS)

Cellular Component
adherens junction  (IBA,IDA,IEA,ISO)
anchoring junction  (IEA)
apical part of cell  (IBA)
apical plasma membrane  (IEA,ISO)
apicolateral plasma membrane  (IEA,ISO)
basolateral plasma membrane  (IEA,ISO)
catenin complex  (IBA,IEA,ISO)
cell junction  (IEA,ISO)
cell surface  (IEA,ISO,ISS)
cell-cell junction  (IEA,ISO)
cortical actin cytoskeleton  (IEA,ISO)
cytoplasm  (IBA,IEA,ISO)
desmosome  (IDA,IEA,ISO,ISS)
fascia adherens  (IDA,IEA,ISO)
glutamatergic synapse  (EXP,IDA)
intercalated disc  (IBA,IDA,IEA,ISO)
lamellipodium  (IBA,IEA,ISO)
membrane  (IEA)
neuron projection  (IBA)
plasma membrane  (IDA,IEA,ISO,ISS)
plasma membrane raft  (IEA,ISO)
presynapse  (IEA)
protein-containing complex  (IDA)
sarcolemma  (IEA,ISO)
synapse  (IDA,IEA,ISO)
T-tubule  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Bakkaloglu B, etal., Am J Hum Genet. 2008 Jan;82(1):165-73. doi: 10.1016/j.ajhg.2007.09.017.
2. Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites, and required for potentiation. Bozdagi O, etal., Neuron. 2000 Oct;28(1):245-59.
3. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Chen YM, etal., Biol Reprod. 2003 Aug;69(2):656-72. Epub 2003 Apr 16.
4. Rat testicular N-cadherin: its complementary deoxyribonucleic acid cloning and regulation. Chung SS, etal., Endocrinology 1998 Apr;139(4):1853-62.
5. [Dynamic assembly of intercalated disc during postnatal development in the rat myocardium]. Dou JP, etal., Sheng Li Xue Bao. 2014 Oct 25;66(5):569-74.
6. Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS. Fasen K, etal., J Neuropathol Exp Neurol 2002 Oct;61(10):903-13.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Gorski JA, etal., Mol Biol Cell. 2005 Aug;16(8):3574-90. Epub 2005 Jun 1.
10. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Hermiston ML and Gordon JI, Science 1995 Nov 17;270(5239):1203-7.
11. N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes. Hertig CM, etal., J Cell Sci. 1996 Jan;109 ( Pt 1):11-20.
12. Multiple cadherin superfamily members with unique expression profiles are produced in rat testis. Johnson KJ, etal., Endocrinology 2000 Feb;141(2):675-83.
13. N-cadherin upregulation and function in response of smooth muscle cells to arterial injury. Jones M, etal., Arterioscler Thromb Vasc Biol 2002 Dec 1;22(12):1972-7.
14. Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase. Kwon YT, etal., Curr Biol. 2000 Apr 6;10(7):363-72.
15. Is the cadherin/catenin complex a functional unit of cell-cell actin-based adherens junctions in the rat testis? Lee NP, etal., Biol Reprod. 2003 Feb;68(2):489-508.
16. Regulation of Sertoli-germ cell adherens junction dynamics in the testis via the nitric oxide synthase (NOS)/cGMP/protein kinase G (PRKG)/beta-catenin (CATNB) signaling pathway: an in vitro and in vivo study. Lee NP, etal., Biol Reprod. 2005 Sep;73(3):458-71. Epub 2005 Apr 27.
17. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
18. N-cadherin signals through Rac1 determine the localization of connexin 43 in cardiac myocytes. Matsuda T, etal., J Mol Cell Cardiol. 2006 Apr;40(4):495-502. Epub 2006 Mar 2.
19. Identification of Cadherin 2 (CDH2) Mutations in Arrhythmogenic Right Ventricular Cardiomyopathy. Mayosi BM, etal., Circ Cardiovasc Genet. 2017 Apr;10(2). pii: CIRCGENETICS.116.001605. doi: 10.1161/CIRCGENETICS.116.001605.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
21. Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Mohler PJ, etal., Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17533-8. Epub 2004 Dec 3.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25. N-cadherin regulates ingrowth and laminar targeting of thalamocortical axons. Poskanzer K, etal., J Neurosci 2003 Mar 15;23(6):2294-305.
26. Endothelial-to-mesenchymal transition in pulmonary hypertension. Ranchoux B, etal., Circulation. 2015 Mar 17;131(11):1006-18. doi: 10.1161/CIRCULATIONAHA.114.008750. Epub 2015 Jan 15.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43). Sato M, etal., J Biol Chem. 2009 Nov 6;284(45):31431-40. doi: 10.1074/jbc.M109.014068. Epub 2009 Sep 1.
31. Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc. Sato PY, etal., Circ Res. 2011 Jul 8;109(2):193-201. Epub 2011 May 26.
32. N-cadherin is involved in axon-oligodendrocyte contact and myelination. Schnadelbach O, etal., Mol Cell Neurosci. 2001 Jun;17(6):1084-93.
33. Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure. Shan W, etal., J Neurosci Res 2002 Aug 1;69(3):292-304.
34. Comparative expression patterns of T-, N-, E-cadherins, beta-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development: implications for the nature of Kolliker's organ. Simonneau L, etal., J Comp Neurol 2003 Apr 28;459(2):113-26.
35. A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation. Tang L, etal., Neuron. 1998 Jun;20(6):1165-75.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Whole exome sequencing with genomic triangulation implicates CDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy. Turkowski KL, etal., Congenit Heart Dis. 2017 Mar;12(2):226-235. doi: 10.1111/chd.12462. Epub 2017 Mar 21.
38. Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. Xia W, etal., J Biol Chem. 2006 Jun 16;281(24):16799-813. Epub 2006 Apr 13.
39. AMD3100 inhibits epithelial-mesenchymal transition, cell invasion, and metastasis in the liver and the lung through blocking the SDF-1α/CXCR4 signaling pathway in prostate cancer. Zhu WB, etal., J Cell Physiol. 2019 Jul;234(7):11746-11759. doi: 10.1002/jcp.27831. Epub 2018 Dec 7.
Additional References at PubMed
PMID:7650039   PMID:8270638   PMID:9531566   PMID:9655503   PMID:11732910   PMID:12052883   PMID:12203715   PMID:12695331   PMID:12738802   PMID:14561752   PMID:14622577   PMID:14657280  
PMID:15383621   PMID:15389538   PMID:15569714   PMID:15691707   PMID:15741167   PMID:15750591   PMID:15809310   PMID:16580782   PMID:16831887   PMID:16886205   PMID:16892058   PMID:16955247  
PMID:16973135   PMID:17028923   PMID:17188238   PMID:17884088   PMID:17959753   PMID:17988630   PMID:18064706   PMID:18067145   PMID:18239929   PMID:18617695   PMID:19075000   PMID:19101069  
PMID:19377287   PMID:19546590   PMID:19830702   PMID:20160094   PMID:20190754   PMID:20333303   PMID:20457910   PMID:20534458   PMID:20623533   PMID:20638445   PMID:20668183   PMID:20848607  
PMID:20881055   PMID:21056983   PMID:21250828   PMID:21257918   PMID:21296051   PMID:21300292   PMID:21414924   PMID:21423176   PMID:21520058   PMID:21572446   PMID:21720156   PMID:21720765  
PMID:21947081   PMID:22199283   PMID:22328515   PMID:22354041   PMID:22467863   PMID:22489706   PMID:22698587   PMID:22735489   PMID:22871113   PMID:23271561   PMID:23292232   PMID:23376485  
PMID:23392350   PMID:24046456   PMID:24223993   PMID:24338362   PMID:24412534   PMID:24891510   PMID:24952463   PMID:25100583   PMID:25232112   PMID:25512490   PMID:25724647   PMID:26187182  
PMID:26345922   PMID:26403541   PMID:26545901   PMID:27559042   PMID:27816814   PMID:28008617   PMID:28169360   PMID:28213972   PMID:28641114   PMID:29131030   PMID:29133434   PMID:29238079  
PMID:29257288   PMID:29768261   PMID:35352799   PMID:37654026   PMID:38127465   PMID:38169592  


Genomics

Comparative Map Data
Cdh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,051,097 - 8,265,288 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl188,051,097 - 8,265,288 (-)EnsemblGRCr8
mRatBN7.2187,776,704 - 7,990,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl187,776,704 - 7,990,167 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx188,020,068 - 8,240,669 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0188,807,745 - 9,028,345 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0188,079,330 - 8,299,941 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0188,146,971 - 8,366,037 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,146,971 - 8,360,684 (-)Ensemblrn6Rnor6.0
Rnor_5.0187,997,533 - 8,218,018 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4188,048,920 - 8,267,974 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera187,938,006 - 8,155,134 (-)NCBICelera
RGSC_v3.1188,048,919 - 8,268,462 (-)NCBI
Cytogenetic Map18p13NCBI
CDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381827,932,879 - 28,177,130 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1827,932,879 - 28,177,946 (-)Ensemblhg38GRCh38
GRCh371825,530,930 - 25,757,094 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361823,784,933 - 24,011,189 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341823,784,933 - 24,011,189NCBI
Celera1822,342,317 - 22,568,868 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1822,383,072 - 22,579,896 (-)NCBIHuRef
CHM1_11825,458,398 - 25,684,881 (-)NCBICHM1_1
T2T-CHM13v2.01828,127,759 - 28,372,130 (-)NCBIT2T-CHM13v2.0
Cdh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391816,721,934 - 16,942,303 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1816,721,934 - 16,942,303 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381816,588,877 - 16,809,246 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1816,588,877 - 16,809,246 (-)Ensemblmm10GRCm38
MGSCv371816,747,386 - 16,967,558 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361816,732,027 - 16,952,264 (-)NCBIMGSCv36mm8
Celera1817,099,283 - 17,328,154 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map1810.1NCBI
Cdh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540215,831,110 - 16,049,890 (-)Ensembl
ChiLan1.0NW_00495540215,829,895 - 16,049,874 (-)NCBIChiLan1.0ChiLan1.0
CDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21745,382,669 - 45,608,715 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11831,075,259 - 31,301,025 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01821,210,001 - 21,435,919 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11824,812,019 - 25,008,249 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1824,812,019 - 25,008,325 (-)EnsemblpanPan2panpan1.1
CDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1760,736,760 - 60,950,477 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl760,736,760 - 60,951,034 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha760,142,523 - 60,355,795 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0760,754,899 - 60,968,628 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl760,754,774 - 60,968,438 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1760,431,048 - 60,644,193 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0760,442,612 - 60,655,854 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0760,744,933 - 60,958,801 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cdh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494456,749,166 - 56,930,675 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365506,886,706 - 6,945,056 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365506,885,484 - 7,067,001 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6112,396,721 - 112,628,432 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16112,396,713 - 112,629,073 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26105,317,507 - 105,518,900 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11852,426,381 - 52,652,986 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1852,426,077 - 52,654,828 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605027,147,394 - 27,374,174 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247704,334,202 - 4,545,470 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247704,333,643 - 4,540,817 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Cdh2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11527,138,853 - 27,350,424 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cdh2
1380 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:109
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000021170
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
2301409Cm70Cardiac mass QTL 700.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)18706572852065728Rat
12904716Am21Aortic mass QTL 210.005aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)18706572852065728Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18126032889Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18144930869Rat
12904714Cm131Cardiac mass QTL 1310.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)18706572852065728Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18125022372Rat
12904715Cm132Cardiac mass QTL 1320.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)18706572852065728Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)18125071266Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18115642423Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18381190230809809Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134566578Rat
6903345Bp349Blood pressure QTL 3493.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18126032889Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18131610627Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18448264849482648Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18546045542690191Rat
6903349Bp351Blood pressure QTL 3513.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18154490981Rat
6903351Bp352Blood pressure QTL 3523.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)18391722648917226Rat
11565454Kidm59Kidney mass QTL 590.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)18706572852065728Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134566578Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)18430735449307354Rat

Markers in Region
D18Got6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,939,002 - 7,939,178 (+)MAPPERmRatBN7.2
Rnor_6.0188,309,243 - 8,309,418NCBIRnor6.0
Rnor_5.0188,161,224 - 8,161,399UniSTSRnor5.0
RGSC_v3.4188,211,177 - 8,211,405RGDRGSC3.4
RGSC_v3.4188,211,180 - 8,211,355UniSTSRGSC3.4
Celera188,099,385 - 8,099,560UniSTS
RGSC_v3.1188,211,180 - 8,211,355RGD
RH 3.4 Map1866.1RGD
RH 3.4 Map1866.1UniSTS
Cytogenetic Map18p13UniSTS
D18Chm84  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,866,120 - 7,866,271 (+)MAPPERmRatBN7.2
Rnor_6.0188,236,422 - 8,236,572NCBIRnor6.0
Rnor_5.0188,088,405 - 8,088,555UniSTSRnor5.0
RGSC_v3.4188,138,359 - 8,138,509UniSTSRGSC3.4
Celera188,026,453 - 8,026,603UniSTS
Cytogenetic Map18p13UniSTS
D18Wox24  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8188,051,280 - 8,051,437 (+)Marker Load Pipeline
mRatBN7.2187,776,887 - 7,777,044 (+)MAPPERmRatBN7.2
Rnor_6.0188,147,155 - 8,147,311NCBIRnor6.0
Rnor_5.0187,997,717 - 7,997,873UniSTSRnor5.0
RGSC_v3.4188,049,104 - 8,049,260UniSTSRGSC3.4
Cytogenetic Map18p13UniSTS
RH130775  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,777,618 - 7,777,813 (+)MAPPERmRatBN7.2
Rnor_6.0188,147,886 - 8,148,080NCBIRnor6.0
Rnor_5.0187,998,448 - 7,998,642UniSTSRnor5.0
RGSC_v3.4188,049,835 - 8,050,029UniSTSRGSC3.4
Celera187,938,903 - 7,939,097UniSTS
RH 3.4 Map1868.0UniSTS
Cytogenetic Map18p13UniSTS
BF387008  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,859,971 - 7,860,169 (+)MAPPERmRatBN7.2
Rnor_6.0188,230,273 - 8,230,470NCBIRnor6.0
Rnor_5.0188,082,256 - 8,082,453UniSTSRnor5.0
RGSC_v3.4188,132,210 - 8,132,407UniSTSRGSC3.4
Celera188,020,304 - 8,020,501UniSTS
RH 3.4 Map1882.31UniSTS
Cytogenetic Map18p13UniSTS
BF396900  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,932,939 - 7,933,165 (+)MAPPERmRatBN7.2
Rnor_6.0188,303,180 - 8,303,405NCBIRnor6.0
Rnor_5.0188,155,161 - 8,155,386UniSTSRnor5.0
RGSC_v3.4188,205,117 - 8,205,342UniSTSRGSC3.4
Celera188,093,321 - 8,093,546UniSTS
RH 3.4 Map1866.41UniSTS
Cytogenetic Map18p13UniSTS
AU046659  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,895,010 - 7,895,134 (+)MAPPERmRatBN7.2
Rnor_6.0188,265,309 - 8,265,435NCBIRnor6.0
Rnor_5.0188,117,292 - 8,117,418UniSTSRnor5.0
RGSC_v3.4188,167,246 - 8,167,372UniSTSRGSC3.4
Cytogenetic Map18p13UniSTS
RH134928  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8188,230,794 - 8,230,985 (+)Marker Load Pipeline
mRatBN7.2187,956,439 - 7,956,630 (+)MAPPERmRatBN7.2
Rnor_6.0188,326,678 - 8,326,868NCBIRnor6.0
Rnor_5.0188,178,659 - 8,178,849UniSTSRnor5.0
RGSC_v3.4188,228,615 - 8,228,805UniSTSRGSC3.4
Celera188,115,783 - 8,115,973UniSTS
RH 3.4 Map1868.0UniSTS
Cytogenetic Map18p13UniSTS
REN16027  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2187,810,266 - 7,810,521 (+)MAPPERmRatBN7.2
Rnor_6.0188,180,549 - 8,180,803NCBIRnor6.0
Rnor_5.0188,031,420 - 8,031,674UniSTSRnor5.0
RGSC_v3.4188,082,486 - 8,082,740UniSTSRGSC3.4
Celera187,971,154 - 7,971,408UniSTS
Cytogenetic Map18p13UniSTS
UniSTS:498368  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8188,051,156 - 8,051,825 (+)Marker Load Pipeline
mRatBN7.2187,776,763 - 7,777,432 (+)MAPPERmRatBN7.2
Rnor_6.0188,147,031 - 8,147,699NCBIRnor6.0
Rnor_5.0187,997,593 - 7,998,261UniSTSRnor5.0
RGSC_v3.4188,048,980 - 8,049,648UniSTSRGSC3.4
Celera187,938,066 - 7,938,716UniSTS
Cytogenetic Map18p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 13 79 183 91 90 59 37 59 6 335 155 18 165 97 92 31 28 28

Sequence


Ensembl Acc Id: ENSRNOT00000021170   ⟹   ENSRNOP00000021170
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,051,097 - 8,265,288 (-)Ensembl
mRatBN7.2 Ensembl187,776,704 - 7,990,167 (-)Ensembl
Rnor_6.0 Ensembl188,146,971 - 8,360,684 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108729   ⟹   ENSRNOP00000084692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,051,097 - 8,167,459 (-)Ensembl
mRatBN7.2 Ensembl187,776,704 - 7,893,134 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115561   ⟹   ENSRNOP00000083478
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,051,097 - 8,132,255 (-)Ensembl
mRatBN7.2 Ensembl187,776,704 - 7,857,840 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118601   ⟹   ENSRNOP00000091203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl188,051,097 - 8,192,482 (-)Ensembl
mRatBN7.2 Ensembl187,776,704 - 7,957,490 (-)Ensembl
RefSeq Acc Id: NM_031333   ⟹   NP_112623
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8188,051,097 - 8,265,288 (-)NCBI
mRatBN7.2187,776,704 - 7,990,934 (-)NCBI
Rnor_6.0188,146,971 - 8,366,037 (-)NCBI
Rnor_5.0187,997,533 - 8,218,018 (-)NCBI
RGSC_v3.4188,048,920 - 8,267,974 (-)RGD
Celera187,938,006 - 8,155,134 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_112623 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC83818 (Get FASTA)   NCBI Sequence Viewer  
  AAF87057 (Get FASTA)   NCBI Sequence Viewer  
  BAA84919 (Get FASTA)   NCBI Sequence Viewer  
  EDL76077 (Get FASTA)   NCBI Sequence Viewer  
  EDL76078 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021170
GenBank Protein Q9Z1Y3 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112623   ⟸   NM_031333
- Peptide Label: precursor
- UniProtKB: Q9Z1Y3 (UniProtKB/Swiss-Prot),   Q9R0T5 (UniProtKB/Swiss-Prot),   G3V803 (UniProtKB/TrEMBL),   A6J2E5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000021170   ⟸   ENSRNOT00000021170
Ensembl Acc Id: ENSRNOP00000083478   ⟸   ENSRNOT00000115561
Ensembl Acc Id: ENSRNOP00000091203   ⟸   ENSRNOT00000118601
Ensembl Acc Id: ENSRNOP00000084692   ⟸   ENSRNOT00000108729
Protein Domains
Cadherin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1Y3-F1-model_v2 AlphaFold Q9Z1Y3 1-906 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700649
Promoter ID:EPDNEW_R11173
Type:multiple initiation site
Name:Cdh2_1
Description:cadherin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0188,360,413 - 8,360,473EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69280 AgrOrtholog
BioCyc Gene G2FUF-8263 BioCyc
Ensembl Genes ENSRNOG00000015602 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000021170 ENTREZGENE
Gene3D-CATH 4.10.900.10 UniProtKB/Swiss-Prot
  Cadherins UniProtKB/Swiss-Prot
InterPro Cadherin UniProtKB/Swiss-Prot
  Cadherin-like_dom UniProtKB/Swiss-Prot
  Cadherin-like_sf UniProtKB/Swiss-Prot
  Cadherin_CS UniProtKB/Swiss-Prot
  Cadherin_cytoplasmic-dom UniProtKB/Swiss-Prot
  Cadherin_pro_dom UniProtKB/Swiss-Prot
  Catenin_binding_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:83501 UniProtKB/Swiss-Prot
NCBI Gene 83501 ENTREZGENE
PANTHER PTHR24027 UniProtKB/Swiss-Prot
  PTHR24027:SF79 UniProtKB/Swiss-Prot
Pfam Cadherin UniProtKB/Swiss-Prot
  Cadherin_C UniProtKB/Swiss-Prot
  Cadherin_pro UniProtKB/Swiss-Prot
PhenoGen Cdh2 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot
  DESMOCOLLIN UniProtKB/Swiss-Prot
PROSITE CADHERIN_1 UniProtKB/Swiss-Prot
  CADHERIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015602 RatGTEx
SMART Cadherin_pro UniProtKB/Swiss-Prot
  SM00112 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot
TIGR TC218644
UniProt A0A8I6A049_RAT UniProtKB/TrEMBL
  A0A8I6ABL6_RAT UniProtKB/TrEMBL
  A6J2E5 ENTREZGENE, UniProtKB/TrEMBL
  CADH2_RAT UniProtKB/Swiss-Prot
  G3V803 ENTREZGENE, UniProtKB/TrEMBL
  Q9R0T5 ENTREZGENE
  Q9Z1Y3 ENTREZGENE
UniProt Secondary Q9R0T5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cdh2  cadherin 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease increased expression occurs after balloon catheter injury of the carotid artery 68759
gene_process may be involved in facilitating germ cell migration during spermatogenesis 68761