Gene:	Ppp3r1 ( Rattus norvegicus ) protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)
Description:	regulatory subunit of the enzyme that catalyzes the calcium-dependent removal of serine- and threonine-bound phosphate groups
Synonyms:	protein phospatase 3, regulatory subunit B, alpha isoform,type 1; protein phospatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I); protein phospatase 3, regulatory subunit b, alpha isoform,type 1; protein phospatase 3 regulatory subunit B alpha isoform (calcineurin B type I);  (details...)
ArrayIDs:	5619213; 5969123; D14425_s_at; 6603385; 5688542; D14568_at; 6432722; 5646824; 1372982_at; 1391213_at; 1369152_at; 5680329; 6575176; 6377113; 5726450; GE21570; A_44_P149148; 6059085; 6272164; 6398039;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: PPP3R1     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Ppp3r1     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Ppp3r1 genome assembly 3.1 14 98079446 - 98118237     Rat Celera Assembly 14 90614429 - 90652365     RGSC genome assembly v3.4 14 98060302 - 98099092     Cytogenetic 14 q22 Mus musculus Ppp3r1 Mouse genome assembly build 36.1 11 17059301 - 17100383     Cytogenetic 11 11 A3.1 Homo sapiens PPP3R1 human genome assembly 2 68317639 - 68391302     Human genome assembly build 36.2 2 68259493 - 68333155     Cytogenetic 2 p15   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Gene Ontology protein binding,  phosphoprotein phosphatase activity (details...)
Biological Process	Gene Ontology heart development,  activation of pro-apoptotic gene products,  protein amino acid dephosphorylation ...  (details...)
Cellular Component	Gene Ontology cytosol (details...)
Disease	Ontology Hypertrophy, Left Ventricular,  Myocardial Ischemia,  Cardiomyopathy, Congestive (details...)
Pathway	Ontology mitogen activated protein kinase signaling pathway,  calcineurin signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: EFh IPI PROSITE: EF_HAND_2 IPI PROSITE: EF_HAND_1 IPI UNIPARC: UPI0001B7A69E IPI UNIPARC: UPI00000012AE IPI UNIPARC: UPI000002A554 IPI KEGG Report: rno:29748 ENTREZGENE HomoloGene Group ID: 68099 ENTREZGENE Germonline: 69230 Pfam: efhand IPI KEGG Pathway: 04360 ENTREZGENE KEGG Pathway: 05010 ENTREZGENE KEGG Pathway: 05014 ENTREZGENE KEGG Pathway: 04210 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 04020 ENTREZGENE KEGG Pathway: 04720 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04650 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 04370 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE InterPro: EF_Hand_1_Ca_BS. IPI InterPro: EF-Hand_type. IPI InterPro: EF_hand_Ca_bd. IPI InterPro: EF_Hand_dom. IPI InterPro: Parvalbumin. IPI InterPro: EF_HAND_2. IPI IPI: IPI00230947 IPI IPI: IPI00206406 IPI IPI: IPI00949307 IPI Ensembl Protein: ENSRNOP00000037143 IPI Ensembl Protein: ENSRNOP00000061429 IPI Ensembl Protein: ENSRNOP00000058834 IPI Gene3D-CATH: EF-Hand_type IPI Entrez Gene: Ppp3r1 ENTREZGENE IMAGE_CLONE: IMAGE:7317429 IMAGE-MGC_LOAD MGC_CLONE: MGC:105458 IMAGE-MGC_LOAD UniProt: CANB1_RAT IPI UniProt: CANB1_RAT IPI Ensembl Genes: ENSRNOG00000043210 IPI PRINTS: PARVALBUMIN. IPI
Sequences	Nucleotide: BC088855 Get FASTA Search GEO Profiles Nucleotide: D14568 Get FASTA Search GEO Profiles Nucleotide: D14425 Get FASTA Search GEO Profiles Nucleotide: L03554 Get FASTA Search GEO Profiles Nucleotide: CH473996 Get FASTA Search GEO Profiles Nucleotide: NM_017309 Get FASTA Search GEO Profiles (View all 6 Nucleotide Accessions) Protein: BAA03422 Get FASTA Protein: P63100 Get FASTA Protein: BAA03318 Get FASTA Protein: AAH88855 Get FASTA Protein: NP_059005 Get FASTA Protein: EDL97906 Get FASTA Protein: EDL97907 Get FASTA Protein: AAA40854 Get FASTA (View all 8 Protein Accessions)
Clusters	UniGene: 42903
References
Curated References	13 references in RGD related to Ppp3r1
Other References	13 other references at PubMed related to Ppp3r1
Database Information
RGD ID	69230
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 01-DEC-05: Pcsk6 protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) Ppp3r1 protein phospatase 3, regulatory subunit B, alpha isoform,type 1 APPROVED Name updated to reflect Human and Mouse nomenclature 1299863 10-JUN-02: Ppp3r1 protein phospatase 3, regulatory subunit B, alpha isoform,type 1 APPROVED Name updated 70584