Pdgfc (platelet derived growth factor C) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Pdgfc (platelet derived growth factor C) Rattus norvegicus
Analyze
Symbol: Pdgfc
Name: platelet derived growth factor C
RGD ID: 68410
Description: Predicted to enable platelet-derived growth factor receptor binding activity and protein homodimerization activity. Predicted to be involved in several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including bone development; cellular response to amino acid stimulus; and positive regulation of fibroblast proliferation. Predicted to be located in cell surface and extracellular region. Predicted to be active in extracellular space. Orthologous to human PDGFC (platelet derived growth factor C); PARTICIPATES IN platelet-derived growth factor signaling pathway; melanoma pathway; prostate cancer pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: fallotein; PDGF-C; platelet-derived growth factor C; platelet-derived growth factor, C polypeptide; rScdfg; SCDGF; spinal cord-derived growth factor; VEGF-E
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82168,613,409 - 168,791,575 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2168,614,353 - 168,791,573 (+)EnsemblGRCr8
mRatBN7.22166,316,870 - 166,493,449 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2166,316,803 - 166,493,433 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2173,505,985 - 173,680,955 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02171,520,356 - 171,702,464 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02166,129,200 - 166,311,291 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02179,952,227 - 180,126,897 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2179,952,227 - 180,128,283 (+)Ensemblrn6Rnor6.0
Rnor_5.02199,362,291 - 199,537,365 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42172,635,732 - 172,811,004 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2160,357,528 - 160,531,962 (+)NCBICelera
RGSC_v3.12172,585,837 - 172,761,110 (+)NCBI
Cytogenetic Map2q33-q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)
Mesothelioma  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
divanadium pentaoxide  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
etoposide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (ISO)
cytosol  (IEA,ISO)
extracellular region  (IEA,ISO)
extracellular space  (IBA,ISO)
membrane  (IEA)
nucleus  (IEA)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC). Breitkopf K, etal., Cytokine. 2005 Sep 7;31(5):349-57.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein. Hamada T, etal., Biochem Biophys Res Commun 2001 Jan 26;280(3):733-7.
4. The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system. Hamada T, etal., Mech Dev 2002 Mar;112(1-2):161-4.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat. Seki T, etal., Nat Commun. 2016 Aug 5;7:12152. doi: 10.1038/ncomms12152.
Additional References at PubMed
PMID:10806482   PMID:11940581   PMID:15234987   PMID:15247255   PMID:15361870   PMID:15372073   PMID:18272536   PMID:19199708   PMID:19213942   PMID:19249599   PMID:20548288   PMID:22565577  
PMID:23376485   PMID:23938297   PMID:28338461  


Genomics

Comparative Map Data
Pdgfc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82168,613,409 - 168,791,575 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2168,614,353 - 168,791,573 (+)EnsemblGRCr8
mRatBN7.22166,316,870 - 166,493,449 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2166,316,803 - 166,493,433 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2173,505,985 - 173,680,955 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02171,520,356 - 171,702,464 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02166,129,200 - 166,311,291 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02179,952,227 - 180,126,897 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2179,952,227 - 180,128,283 (+)Ensemblrn6Rnor6.0
Rnor_5.02199,362,291 - 199,537,365 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42172,635,732 - 172,811,004 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2160,357,528 - 160,531,962 (+)NCBICelera
RGSC_v3.12172,585,837 - 172,761,110 (+)NCBI
Cytogenetic Map2q33-q34NCBI
PDGFC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384156,760,454 - 156,971,799 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4156,760,454 - 156,971,799 (-)Ensemblhg38GRCh38
GRCh374157,681,606 - 157,892,951 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364157,902,214 - 158,111,996 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344158,040,368 - 158,250,151NCBI
Celera4155,025,774 - 155,235,563 (-)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4153,433,623 - 153,643,623 (-)NCBIHuRef
CHM1_14157,660,122 - 157,869,922 (-)NCBICHM1_1
T2T-CHM13v2.04160,106,105 - 160,317,463 (-)NCBIT2T-CHM13v2.0
Pdgfc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39380,943,723 - 81,121,347 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl380,943,723 - 81,121,347 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38381,036,416 - 81,214,040 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl381,036,416 - 81,214,040 (+)Ensemblmm10GRCm38
MGSCv37380,840,338 - 81,017,953 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36381,122,343 - 81,299,958 (+)NCBIMGSCv36mm8
Celera381,066,860 - 81,242,401 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map335.73NCBI
Pdgfc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547110,418,455 - 10,500,668 (+)Ensembl
ChiLan1.0NW_00495547110,318,683 - 10,500,624 (+)NCBIChiLan1.0ChiLan1.0
PDGFC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23154,652,310 - 154,863,474 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14155,007,121 - 155,219,104 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04149,105,330 - 149,317,254 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14160,921,353 - 161,132,308 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4160,922,827 - 161,131,960 (-)EnsemblpanPan2panpan1.1
PDGFC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11554,143,637 - 54,239,962 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1554,145,381 - 54,345,830 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1554,484,878 - 54,682,918 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01554,865,056 - 55,063,272 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1554,865,080 - 55,064,935 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11554,105,044 - 54,303,114 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01554,213,698 - 54,411,745 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01554,528,725 - 54,726,824 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Pdgfc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530135,991,126 - 36,189,515 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365763,357,424 - 3,554,890 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365763,357,399 - 3,555,828 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDGFC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl845,578,002 - 45,808,748 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1845,579,065 - 45,808,789 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2847,676,639 - 47,817,552 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDGFC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17103,345,122 - 103,562,961 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7103,344,895 - 103,562,962 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603783,027,150 - 83,244,526 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdgfc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248481,484,947 - 1,674,641 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248481,484,904 - 1,674,410 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pdgfc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1372,320,097 - 72,500,390 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pdgfc
1001 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000015081
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149806826170653323Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2145807215173074435Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat

Markers in Region
D2Chm24  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22166,334,196 - 166,334,439 (+)MAPPERmRatBN7.2
Rnor_6.02179,969,364 - 179,969,608NCBIRnor6.0
Rnor_5.02199,379,428 - 199,379,672UniSTSRnor5.0
RGSC_v3.42172,652,869 - 172,653,113UniSTSRGSC3.4
Celera2160,374,661 - 160,374,905UniSTS
Cytogenetic Map2q33UniSTS
BM384420  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22166,403,059 - 166,403,237 (+)MAPPERmRatBN7.2
Rnor_6.02180,038,703 - 180,038,880NCBIRnor6.0
Rnor_5.02199,448,835 - 199,449,012UniSTSRnor5.0
RGSC_v3.42172,721,667 - 172,721,844UniSTSRGSC3.4
Celera2160,443,548 - 160,443,725UniSTS
RH 3.4 Map21078.8UniSTS
Cytogenetic Map2q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 50 59 6 314 150 11 140 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000015081   ⟹   ENSRNOP00000015081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2168,614,353 - 168,791,573 (+)Ensembl
mRatBN7.2 Ensembl2166,316,803 - 166,493,433 (+)Ensembl
Rnor_6.0 Ensembl2179,952,227 - 180,126,897 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082273   ⟹   ENSRNOP00000068678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2168,675,032 - 168,791,571 (+)Ensembl
mRatBN7.2 Ensembl2166,376,803 - 166,493,433 (+)Ensembl
Rnor_6.0 Ensembl2180,012,414 - 180,128,283 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133774   ⟹   ENSRNOP00000104834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2168,614,353 - 168,791,034 (+)Ensembl
RefSeq Acc Id: NM_031317   ⟹   NP_112607
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82168,615,168 - 168,790,184 (+)NCBI
mRatBN7.22166,317,060 - 166,492,058 (+)NCBI
Rnor_6.02179,952,227 - 180,126,897 (+)NCBI
Rnor_5.02199,362,291 - 199,537,365 (+)NCBI
RGSC_v3.42172,635,732 - 172,811,004 (+)RGD
Celera2160,357,528 - 160,531,962 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103196   ⟹   XP_038959124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82168,613,409 - 168,791,575 (+)NCBI
mRatBN7.22166,316,870 - 166,493,449 (+)NCBI
RefSeq Acc Id: XM_039103197   ⟹   XP_038959125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82168,615,484 - 168,791,575 (+)NCBI
mRatBN7.22166,317,368 - 166,493,449 (+)NCBI
RefSeq Acc Id: XM_039103198   ⟹   XP_038959126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82168,615,484 - 168,791,575 (+)NCBI
mRatBN7.22166,317,370 - 166,493,449 (+)NCBI
RefSeq Acc Id: NP_112607   ⟸   NM_031317
- Peptide Label: precursor
- UniProtKB: Q8K429 (UniProtKB/Swiss-Prot),   Q9EQX6 (UniProtKB/Swiss-Prot),   A6J5T2 (UniProtKB/TrEMBL),   A0A0G2JTE4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068678   ⟸   ENSRNOT00000082273
Ensembl Acc Id: ENSRNOP00000015081   ⟸   ENSRNOT00000015081
RefSeq Acc Id: XP_038959124   ⟸   XM_039103196
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038959125   ⟸   XM_039103197
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038959126   ⟸   XM_039103198
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000104834   ⟸   ENSRNOT00000133774
Protein Domains
CUB   Platelet-derived growth factor (PDGF) family

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQX6-F1-model_v2 AlphaFold Q9EQX6 1-345 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68410 AgrOrtholog
BioCyc Gene G2FUF-52704 BioCyc
Ensembl Genes ENSRNOG00000010695 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015081 ENTREZGENE
  ENSRNOT00000015081.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
  2.60.120.290 UniProtKB/Swiss-Prot
InterPro CUB_dom UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  PDGF/VEGF_dom UniProtKB/Swiss-Prot
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:79429 UniProtKB/Swiss-Prot
NCBI Gene 79429 ENTREZGENE
PANTHER PLATELET-DERIVED GROWTH FACTOR UniProtKB/Swiss-Prot
  PTHR11633:SF5 UniProtKB/Swiss-Prot
Pfam CUB UniProtKB/Swiss-Prot
  PDGF UniProtKB/Swiss-Prot
PhenoGen Pdgfc PhenoGen
PROSITE CUB UniProtKB/Swiss-Prot
  PDGF_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010695 RatGTEx
SMART CUB UniProtKB/Swiss-Prot
  PDGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49854 UniProtKB/Swiss-Prot
  SSF57501 UniProtKB/Swiss-Prot
UniProt A0A0G2JTE4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LSP3_RAT UniProtKB/TrEMBL
  A6J5T2 ENTREZGENE, UniProtKB/TrEMBL
  PDGFC_RAT UniProtKB/Swiss-Prot
  Q8K429 ENTREZGENE
  Q9EQX6 ENTREZGENE
UniProt Secondary Q8K429 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-08-29 Pdgfc  platelet derived growth factor C  Pdgfc  platelet-derived growth factor, C polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pdgfc  platelet-derived growth factor, C polypeptide      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference