PDGFC (platelet derived growth factor C) - Rat Genome Database

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Gene: PDGFC (platelet derived growth factor C) Pan paniscus
Analyze
Symbol: PDGFC
Name: platelet derived growth factor C
RGD ID: 11691323
Description: ENCODES a protein that exhibits growth factor activity (inferred); platelet-derived growth factor receptor binding (inferred); protein homodimerization activity (inferred); INVOLVED IN animal organ morphogenesis (ortholog); bone development (ortholog); cellular response to amino acid stimulus (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); Mesothelioma (ortholog); FOUND IN cell surface (inferred); cytosol (inferred); extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: platelet-derived growth factor C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23154,652,310 - 154,863,474 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14155,007,121 - 155,219,104 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04149,105,330 - 149,317,254 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14160,921,353 - 161,132,308 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4160,922,827 - 161,131,960 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PDGFC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23154,652,310 - 154,863,474 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14155,007,121 - 155,219,104 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04149,105,330 - 149,317,254 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14160,921,353 - 161,132,308 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4160,922,827 - 161,131,960 (-)Ensemblpanpan1.1panPan2
PDGFC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384156,760,454 - 156,971,799 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4156,760,454 - 156,971,799 (-)EnsemblGRCh38hg38GRCh38
GRCh374157,681,606 - 157,892,951 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364157,902,214 - 158,111,996 (-)NCBINCBI36Build 36hg18NCBI36
Build 344158,040,368 - 158,250,151NCBI
Celera4155,025,774 - 155,235,563 (-)NCBICelera
Cytogenetic Map4q32.1NCBI
HuRef4153,433,623 - 153,643,623 (-)NCBIHuRef
CHM1_14157,660,122 - 157,869,922 (-)NCBICHM1_1
T2T-CHM13v2.04160,106,105 - 160,317,463 (-)NCBIT2T-CHM13v2.0
Pdgfc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39380,943,723 - 81,121,347 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl380,943,723 - 81,121,347 (+)EnsemblGRCm39 Ensembl
GRCm38381,036,416 - 81,214,040 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl381,036,416 - 81,214,040 (+)EnsemblGRCm38mm10GRCm38
MGSCv37380,840,338 - 81,017,953 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36381,122,343 - 81,299,958 (+)NCBIMGSCv36mm8
Celera381,066,860 - 81,242,401 (+)NCBICelera
Cytogenetic Map3E3NCBI
cM Map335.73NCBI
Pdgfc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82168,613,409 - 168,791,575 (+)NCBIGRCr8
mRatBN7.22166,316,870 - 166,493,449 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2166,316,803 - 166,493,433 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2173,505,985 - 173,680,955 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02171,520,356 - 171,702,464 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02166,129,200 - 166,311,291 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02179,952,227 - 180,126,897 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2179,952,227 - 180,128,283 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02199,362,291 - 199,537,365 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42172,635,732 - 172,811,004 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12172,585,837 - 172,761,110 (+)NCBI
Celera2160,357,528 - 160,531,962 (+)NCBICelera
Cytogenetic Map2q33-q34NCBI
Pdgfc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547110,418,455 - 10,500,668 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547110,318,683 - 10,500,624 (+)NCBIChiLan1.0ChiLan1.0
PDGFC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11554,143,637 - 54,239,962 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1554,145,381 - 54,345,830 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1554,484,878 - 54,682,918 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01554,865,056 - 55,063,272 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1554,865,080 - 55,064,935 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11554,105,044 - 54,303,114 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01554,213,698 - 54,411,745 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01554,528,725 - 54,726,824 (-)NCBIUU_Cfam_GSD_1.0
Pdgfc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530135,991,126 - 36,189,515 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365763,357,424 - 3,554,890 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365763,357,399 - 3,555,828 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDGFC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl845,578,002 - 45,808,748 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1845,579,065 - 45,808,789 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2847,676,639 - 47,817,552 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDGFC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17103,345,122 - 103,562,961 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7103,344,895 - 103,562,962 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603783,027,150 - 83,244,526 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pdgfc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248481,484,947 - 1,674,641 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248481,484,904 - 1,674,410 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000055295   ⟹   ENSPPAP00000032427
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4160,922,827 - 161,131,960 (-)Ensembl
RefSeq Acc Id: XM_003822558   ⟹   XP_003822606
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23154,652,310 - 154,863,375 (-)NCBI
NHGRI_mPanPan14155,007,121 - 155,219,104 (-)NCBI
Mhudiblu_PPA_v04149,105,659 - 149,317,254 (-)NCBI
PanPan1.14160,921,353 - 161,132,308 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034959316   ⟹   XP_034815207
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23154,652,310 - 154,863,474 (-)NCBI
NHGRI_mPanPan14155,007,121 - 155,218,669 (-)NCBI
Mhudiblu_PPA_v04149,105,330 - 149,316,724 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003822606 (Get FASTA)   NCBI Sequence Viewer  
  XP_034815207 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000032427
  ENSPPAP00000032427.1
Reference Protein Sequences
RefSeq Acc Id: XP_003822606   ⟸   XM_003822558
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BRW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034815207   ⟸   XM_034959316
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000032427   ⟸   ENSPPAT00000055295
Protein Domains
CUB   Platelet-derived growth factor (PDGF) family


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039103 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000055295.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/TrEMBL
InterPro CUB_dom UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  PDGF/VEGF_dom UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100982459 UniProtKB/TrEMBL
NCBI Gene PDGFC ENTREZGENE
PANTHER PLATELET-DERIVED GROWTH FACTOR UniProtKB/TrEMBL
  PTHR11633:SF5 UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  PDGF UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  PDGF_2 UniProtKB/TrEMBL
SMART CUB UniProtKB/TrEMBL
  PDGF UniProtKB/TrEMBL
Superfamily-SCOP SSF49854 UniProtKB/TrEMBL
  SSF57501 UniProtKB/TrEMBL
UniProt A0A2R9BRW3 ENTREZGENE, UniProtKB/TrEMBL