Ppp1r9b (protein phosphatase 1, regulatory subunit 9B) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ppp1r9b (protein phosphatase 1, regulatory subunit 9B) Rattus norvegicus
Analyze
Symbol: Ppp1r9b
Name: protein phosphatase 1, regulatory subunit 9B
RGD ID: 632281
Description: Enables several functions, including D2 dopamine receptor binding activity; enzyme binding activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; pallium development; and positive regulation of protein localization to cell periphery. Located in several cellular components, including dendritic spine; growth cone; and neuronal cell body. Is active in glutamatergic synapse; postsynaptic density; and spine apparatus. Is extrinsic component of postsynaptic membrane. Biomarker of Parkinson's disease. Orthologous to human PPP1R9B (protein phosphatase 1 regulatory subunit 9B); INTERACTS WITH (S)-amphetamine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Neb2; neurabin 2; neurabin-2; neurabin-II; neural tissue-specific F-actin-binding protein II; nuerabin 2; p130; PP1bp134; spinophilin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,434,888 - 80,450,919 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1080,434,900 - 80,450,919 (+)EnsemblGRCr8
mRatBN7.21079,938,055 - 79,954,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,938,066 - 79,954,083 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1084,887,200 - 84,903,206 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,385,269 - 84,401,276 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,778,362 - 79,794,325 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,800,704 - 82,816,735 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,800,704 - 82,816,731 (+)Ensemblrn6Rnor6.0
Rnor_5.01082,616,223 - 82,632,356 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41083,674,797 - 83,690,639 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1078,712,214 - 78,727,757 (+)NCBICelera
RGSC_v3.11083,689,166 - 83,705,009 (+)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA)
actin filament depolymerization  (IEP)
actin filament organization  (IBA,ISO)
calcium-mediated signaling  (IBA,ISO)
cell differentiation  (IEA)
cell migration  (IEA,ISO,ISS)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to estradiol stimulus  (IEP)
cellular response to morphine  (IEA,ISO,ISS)
cellular response to peptide  (IEP)
cellular response to xenobiotic stimulus  (IEP)
cerebral cortex development  (IEP)
dendrite development  (ISO)
developmental process involved in reproduction  (IEP)
filopodium assembly  (IEA,ISO,ISS)
hippocampus development  (IEP)
learning  (IEP)
male mating behavior  (IEP)
negative regulation of cell growth  (IEA,ISO)
nervous system development  (IEA)
neuron projection development  (IBA)
positive regulation of protein localization  (IDA)
positive regulation of protein localization to actin cortical patch  (IMP)
positive regulation of protein localization to plasma membrane  (IDA)
protein localization to actin cytoskeleton  (IMP)
protein localization to cell periphery  (IMP)
regulation of opioid receptor signaling pathway  (IEA,ISO,ISS)
regulation of postsynapse assembly  (IEA,ISO)
regulation of protein phosphorylation  (ISO)
reproductive system development  (IEP)
response to amino acid  (IEP)
response to amphetamine  (IEP)
response to estradiol  (IEP)
response to immobilization stress  (IEP)
response to kainic acid  (IEP)
response to L-phenylalanine derivative  (IEP)
response to nicotine  (IEP)
response to prostaglandin E  (IEP)
response to steroid hormone  (IEP)
response to xenobiotic stimulus  (IEP)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Low expression of the putative tumour suppressor spinophilin is associated with higher proliferative activity and poor prognosis in patients with hepatocellular carcinoma. Aigelsreiter A, etal., Br J Cancer. 2013 May 14;108(9):1830-7. doi: 10.1038/bjc.2013.165. Epub 2013 Apr 16.
2. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines. Allen PB, etal., Proc Natl Acad Sci U S A 1997 Sep 2;94(18):9956-61.
3. Serotonin mediates CA1 spine density but is not crucial for ovarian steroid regulation of synaptic plasticity in the adult rat dorsal hippocampus. Alves SE, etal., Synapse. 2002 Aug;45(2):143-51.
4. Nicotine-induced anxiety-like behavior in a rat model of the novelty-seeking phenotype is associated with long-lasting neuropeptidergic and neuroplastic adaptations in the amygdala: effects of the cannabinoid receptor 1 antagonist AM251. Aydin C, etal., Neuropharmacology. 2012 Dec;63(8):1335-45. doi: 10.1016/j.neuropharm.2012.08.016. Epub 2012 Aug 31.
5. The identification of a second actin-binding region in spinophilin/neurabin II. Barnes AP, etal., Brain Res Mol Brain Res. 2004 May 19;124(2):105-13.
6. A sensitizing D-amphetamine dose regimen induces long-lasting spinophilin and VGLUT1 protein upregulation in the rat diencephalon. Boikess SR, etal., Neurosci Lett. 2010 Jan 18;469(1):49-54. doi: 10.1016/j.neulet.2009.11.042. Epub 2009 Nov 20.
7. Dopamine depletion alters phosphorylation of striatal proteins in a model of Parkinsonism. Brown AM, etal., Eur J Neurosci. 2005 Jul;22(1):247-56.
8. Association of protein phosphatase 1 gamma 1 with spinophilin suppresses phosphatase activity in a Parkinson disease model. Brown AM, etal., J Biol Chem. 2008 May 23;283(21):14286-94. doi: 10.1074/jbc.M801377200. Epub 2008 Mar 26.
9. Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin. Buchsbaum RJ, etal., J Biol Chem 2003 May 23;278(21):18833-41. Epub 2003 Jan 16.
10. Exploration of prostanoid receptor subtype regulating estradiol and prostaglandin E2 induction of spinophilin in developing preoptic area neurons. Burks SR, etal., Neuroscience. 2007 May 25;146(3):1117-27. Epub 2007 Apr 6.
11. Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton. Burnett PE, etal., Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8351-6.
12. Selective targeting of the gamma1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin. Carmody LC, etal., FASEB J. 2008 Jun;22(6):1660-71. doi: 10.1096/fj.07-092841. Epub 2008 Jan 23.
13. Clozapine and haloperidol differentially regulate dendritic spine formation and synaptogenesis in rat hippocampal neurons. Critchlow HM, etal., Mol Cell Neurosci. 2006 Aug;32(4):356-65. Epub 2006 Jul 17.
14. Prostaglandin E2 stimulates estradiol synthesis in the cerebellum postnatally with associated effects on Purkinje neuron dendritic arbor and electrophysiological properties. Dean SL, etal., Endocrinology. 2012 Nov;153(11):5415-27. doi: 10.1210/en.2012-1350. Epub 2012 Oct 9.
15. Spinophilin loss correlates with poor patient prognosis in advanced stages of colon carcinoma. Estevez-Garcia P, etal., Clin Cancer Res. 2013 Jul 15;19(14):3925-35. doi: 10.1158/1078-0432.CCR-13-0057. Epub 2013 May 31.
16. Spinophilin loss contributes to tumorigenesis in vivo. Ferrer I, etal., Cell Cycle. 2011 Jun 15;10(12):1948-55. Epub 2011 Jun 15.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Goel M, etal., Pflugers Arch. 2005 Oct;451(1):87-98. Epub 2005 Jul 16.
20. Methamphetamine enhances paced mating behaviors and neuroplasticity in the medial amygdala of female rats. Holder MK and Mong JA, Horm Behav. 2010 Aug;58(3):519-25. doi: 10.1016/j.yhbeh.2010.04.006. Epub 2010 Apr 24.
21. Phosphorylation of spinophilin modulates its interaction with actin filaments. Hsieh-Wilson LC, etal., J Biol Chem 2003 Jan 10;278(2):1186-94. Epub 2002 Nov 1.
22. Interaction of rat lin-10 with brain-enriched F-actin-binding protein, neurabin-II/spinophilin. Ide N, etal., Biochem Biophys Res Commun. 1998 Mar 6;244(1):258-62.
23. Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC. Ladurelle N, etal., Psychopharmacology (Berl). 2012 Jun;221(3):493-509. doi: 10.1007/s00213-011-2597-5. Epub 2011 Dec 8.
24. Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines. Law AJ, etal., Am J Psychiatry. 2004 Oct;161(10):1848-55.
25. Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1). Ma P, etal., PLoS One. 2015 Mar 18;10(3):e0119496. doi: 10.1371/journal.pone.0119496. eCollection 2015.
26. Brain actin-associated protein phosphatase 1 holoenzymes containing spinophilin, neurabin, and selected catalytic subunit isoforms. MacMillan LB, etal., J Biol Chem. 1999 Dec 10;274(50):35845-54.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Down-regulation of spinophilin in lung tumours contributes to tumourigenesis. Molina-Pinelo S, etal., J Pathol. 2011 Sep;225(1):73-82. doi: 10.1002/path.2905. Epub 2011 May 19.
29. Neurabin: a novel neural tissue-specific actin filament-binding protein involved in neurite formation. Nakanishi H, etal., J Cell Biol 1997 Nov 17;139(4):951-61.
30. Wistar rats subjected to chronic restraint stress display increased hippocampal spine density paralleled by increased expression levels of synaptic scaffolding proteins. Orlowski D, etal., Stress. 2012 Sep;15(5):514-23. doi: 10.3109/10253890.2011.643516. Epub 2012 Jan 10.
31. Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment. Ottis P, etal., PLoS One. 2013 Sep 19;8(9):e75112. doi: 10.1371/journal.pone.0075112. eCollection 2013.
32. RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes. Palavicini JP, etal., Cell Death Dis. 2013 Jun 13;4:e667. doi: 10.1038/cddis.2013.183.
33. The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Penzes P, etal., Neuron. 2001 Jan;29(1):229-42.
34. Flexibility in the PP1:spinophilin holoenzyme. Ragusa MJ, etal., FEBS Lett. 2011 Jan 3;585(1):36-40. doi: 10.1016/j.febslet.2010.11.022. Epub 2010 Nov 19.
35. Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites. Ragusa MJ, etal., Nat Struct Mol Biol. 2010 Apr;17(4):459-64. doi: 10.1038/nsmb.1786. Epub 2010 Mar 21.
36. GOA pipeline RGD automated data pipeline
37. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Neurabin-II/spinophilin. An actin filament-binding protein with one pdz domain localized at cadherin-based cell-cell adhesion sites. Satoh A, etal., J Biol Chem 1998 Feb 6;273(6):3470-5.
40. GnRH receptor gene expression in the developing rat hippocampus: transcriptional regulation and potential roles in neuronal plasticity. Schang AL, etal., Endocrinology. 2011 Feb;152(2):568-80. doi: 10.1210/en.2010-0840. Epub 2010 Dec 1.
41. Structure-function analysis of the filamentous actin binding domain of the neuronal scaffolding protein spinophilin. Schüler H and Peti W, FEBS J. 2008 Jan;275(1):59-68. doi: 10.1111/j.1742-4658.2007.06171.x. Epub 2007 Nov 20.
42. Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein. Smith FD, etal., J Biol Chem 1999 Jul 9;274(28):19894-900.
43. Gene expression profiling of nasal polyps associated with chronic sinusitis and aspirin-sensitive asthma. Stankovic KM, etal., Laryngoscope. 2008 May;118(5):881-9. doi: 10.1097/MLG.0b013e31816b4b6f.
44. In vivo dynamics of the F-actin-binding protein neurabin-II. Stephens DJ and Banting G, Biochem J. 2000 Jan 15;345 Pt 2:185-94.
45. Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin. Stephens DJ and Banting G, J Biol Chem. 1999 Oct 15;274(42):30080-6.
46. The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. Terry-Lorenzo RT, etal., J Biol Chem 2002 Aug 2;277(31):27716-24.
47. Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton. Terry-Lorenzo RT, etal., J Biol Chem 2002 Nov 29;277(48):46535-43. Epub 2002 Sep 21.
48. Glutamate AMPA/kainate receptors, not GABA(A) receptors, mediate estradiol-induced sex differences in the hypothalamus. Todd BJ, etal., Dev Neurobiol. 2007 Feb 15;67(3):304-15.
49. Identification of prostaglandin E2 receptors mediating perinatal masculinization of adult sex behavior and neuroanatomical correlates. Wright CL, etal., Dev Neurobiol. 2008 Oct;68(12):1406-19. doi: 10.1002/dneu.20665.
50. Postpubertal decrease in hippocampal dendritic spines of female rats. Yildirim M, etal., Exp Neurol. 2008 Apr;210(2):339-48. Epub 2007 Nov 21.
51. Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile. Zhao L, etal., J Pharmacol Exp Ther. 2006 Dec;319(3):1124-32. Epub 2006 Sep 1.
Additional References at PubMed
PMID:10194355   PMID:10922077   PMID:11154706   PMID:11278317   PMID:12477932   PMID:15218143   PMID:15228588   PMID:15514983   PMID:15743906   PMID:15793568   PMID:15996550   PMID:16930415  
PMID:17464283   PMID:18439408   PMID:19151759   PMID:19609226   PMID:20124353   PMID:20385205   PMID:24625528   PMID:25750125   PMID:27890541   PMID:28131823   PMID:29383693  


Genomics

Comparative Map Data
Ppp1r9b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81080,434,888 - 80,450,919 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1080,434,900 - 80,450,919 (+)EnsemblGRCr8
mRatBN7.21079,938,055 - 79,954,085 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1079,938,066 - 79,954,083 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1084,887,200 - 84,903,206 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01084,385,269 - 84,401,276 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01079,778,362 - 79,794,325 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01082,800,704 - 82,816,735 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1082,800,704 - 82,816,731 (+)Ensemblrn6Rnor6.0
Rnor_5.01082,616,223 - 82,632,356 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41083,674,797 - 83,690,639 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1078,712,214 - 78,727,757 (+)NCBICelera
RGSC_v3.11083,689,166 - 83,705,009 (+)NCBI
Cytogenetic Map10q26NCBI
PPP1R9B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381750,133,737 - 50,150,677 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1750,133,737 - 50,150,703 (-)Ensemblhg38GRCh38
GRCh371748,211,101 - 48,228,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361745,566,100 - 45,582,876 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341745,567,694 - 45,582,873NCBI
Celera1744,671,218 - 44,687,998 (-)NCBICelera
Cytogenetic Map17q21.33NCBI
HuRef1743,578,978 - 43,595,756 (-)NCBIHuRef
CHM1_11748,275,419 - 48,292,198 (-)NCBICHM1_1
T2T-CHM13v2.01751,000,814 - 51,017,737 (-)NCBIT2T-CHM13v2.0
Ppp1r9b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,882,038 - 94,897,724 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1194,881,861 - 94,897,725 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381194,991,212 - 95,006,898 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,991,035 - 95,006,899 (+)Ensemblmm10GRCm38
MGSCv371194,852,526 - 94,868,212 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361194,807,302 - 94,822,974 (+)NCBIMGSCv36mm8
Celera11104,604,585 - 104,620,251 (+)NCBICelera
Cytogenetic Map11DNCBI
cM Map1159.01NCBI
Ppp1r9b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,516,548 - 11,530,830 (+)Ensembl
ChiLan1.0NW_00495545111,516,548 - 11,530,263 (+)NCBIChiLan1.0ChiLan1.0
PPP1R9B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21966,322,412 - 66,339,660 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11771,128,896 - 71,146,153 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01744,224,007 - 44,240,906 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11749,098,089 - 49,129,659 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1749,098,089 - 49,126,932 (-)EnsemblpanPan2panpan1.1
PPP1R9B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,135,982 - 26,152,303 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,137,464 - 26,151,810 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha925,529,124 - 25,544,951 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0926,930,469 - 26,946,307 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl926,930,469 - 26,946,307 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1925,698,261 - 25,714,094 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0925,956,940 - 25,972,777 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0926,086,858 - 26,102,695 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppp1r9b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,560,948 - 25,577,086 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649011,502,206 - 11,512,595 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649011,497,389 - 11,514,191 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R9B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,319,124 - 26,336,562 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11226,319,123 - 26,337,089 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,358,245 - 26,375,863 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R9B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,188,400 - 43,205,621 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1643,188,022 - 43,205,680 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607713,904,402 - 13,921,606 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r9b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247956,124,159 - 6,137,955 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247956,124,273 - 6,137,776 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppp1r9b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1959,375,111 - 59,391,102 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppp1r9b
78 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:144
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000005498
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076951790107713808Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1079272424102982300Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1073599825107713808Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395464802Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107870758585720738Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)107369533997272278Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107304965694495280Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)107369533983061459Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)107369533983061459Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313384503487Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107395020983959619Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107674313395604677Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072724423107713808Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107395035396620293Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1076128947107713808Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
BF405560  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,935,928 - 79,936,106 (+)MAPPERmRatBN7.2
Rnor_6.01082,798,567 - 82,798,744NCBIRnor6.0
Rnor_5.01082,614,086 - 82,614,263UniSTSRnor5.0
RGSC_v3.41083,672,660 - 83,672,837UniSTSRGSC3.4
Celera1078,709,633 - 78,709,810UniSTS
RH 3.4 Map10720.3UniSTS
Cytogenetic Map10q31UniSTS
BE117171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,944,130 - 79,944,307 (+)MAPPERmRatBN7.2
Rnor_6.01082,806,781 - 82,806,957NCBIRnor6.0
Rnor_5.01082,622,402 - 82,622,578UniSTSRnor5.0
RGSC_v3.41083,680,945 - 83,681,121UniSTSRGSC3.4
Celera1078,717,804 - 78,717,980UniSTS
RH 3.4 Map10719.0UniSTS
Cytogenetic Map10q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000089497   ⟹   ENSRNOP00000074026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1080,434,900 - 80,450,919 (+)Ensembl
mRatBN7.2 Ensembl1079,938,066 - 79,954,083 (+)Ensembl
Rnor_6.0 Ensembl1082,800,704 - 82,816,731 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000143817   ⟹   ENSRNOP00000099109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1080,434,900 - 80,450,919 (+)Ensembl
RefSeq Acc Id: NM_053474   ⟹   NP_445926
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,434,900 - 80,450,919 (+)NCBI
mRatBN7.21079,938,066 - 79,954,085 (+)NCBI
Rnor_6.01082,800,704 - 82,816,735 (+)NCBI
Rnor_5.01082,616,223 - 82,632,356 (+)NCBI
RGSC_v3.41083,674,797 - 83,690,639 (+)RGD
Celera1078,712,214 - 78,727,757 (+)RGD
Sequence:
RefSeq Acc Id: XM_039086990   ⟹   XP_038942918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81080,434,888 - 80,449,403 (+)NCBI
mRatBN7.21079,938,055 - 79,952,554 (+)NCBI
Protein Sequences
Protein RefSeqs NP_445926 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942918 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB72005 (Get FASTA)   NCBI Sequence Viewer  
  AAC05183 (Get FASTA)   NCBI Sequence Viewer  
  AAI60878 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074026
  ENSRNOP00000074026.1
GenBank Protein O35274 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445926   ⟸   NM_053474
- UniProtKB: O35274 (UniProtKB/Swiss-Prot),   B1H262 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074026   ⟸   ENSRNOT00000089497
RefSeq Acc Id: XP_038942918   ⟸   XM_039086990
- Peptide Label: isoform X1
- UniProtKB: B1H262 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000099109   ⟸   ENSRNOT00000143817
Protein Domains
PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35274-F1-model_v2 AlphaFold O35274 1-817 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697614
Promoter ID:EPDNEW_R8139
Type:initiation region
Name:Ppp1r9b_1
Description:protein phosphatase 1, regulatory subunit 9B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01082,800,655 - 82,800,715EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:632281 AgrOrtholog
BIND 130595
  130600
BioCyc Gene G2FUF-23572 BioCyc
Ensembl Genes ENSRNOG00000052113 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000089497 ENTREZGENE
  ENSRNOT00000089497.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7376917 IMAGE-MGC_LOAD
InterPro Neurabin-1/2_PDZ UniProtKB/Swiss-Prot
  Neurabin-like UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
KEGG Report rno:84686 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188268 IMAGE-MGC_LOAD
NCBI Gene 84686 ENTREZGENE
PANTHER PTHR16154 UniProtKB/Swiss-Prot
  PTHR16154:SF24 UniProtKB/Swiss-Prot
Pfam PDZ UniProtKB/Swiss-Prot
  PDZ_5 UniProtKB/Swiss-Prot
PhenoGen Ppp1r9b PhenoGen
PROSITE PDZ UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000052113 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot
UniProt A0ABK0LCN3_RAT UniProtKB/TrEMBL
  B1H262 ENTREZGENE, UniProtKB/TrEMBL
  NEB2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ppp1r9b  protein phosphatase 1, regulatory subunit 9B  Neb2  nuerabin 2  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized in the PSD (post-synaptic density) 625568
gene_cellular_localization localized in the PSD (post-synaptic density) 625590
gene_cellular_localization localized in the PSD (post-synaptic density) 625591
gene_cellular_localization localized in the PSD (post-synaptic density) 625592
gene_domains contains a PSD95/DLG/zo-1(PDZ) domain 625568
gene_domains contains a PSD95/DLG/zo-1(PDZ) domain 625590
gene_domains contains a PSD95/DLG/zo-1(PDZ) domain 625591
gene_domains contains a PSD95/DLG/zo-1(PDZ) domain 625592
gene_expression purified from rat brain neural tissues 625592
gene_function binds to protein phosphatase1 625568
gene_function binds to protein phosphatase1 625590
gene_function binds to protein phosphatase1 625591
gene_function binds to protein phosphatase1 625592
gene_function binds to actin filaments 625568
gene_function binds to actin filaments 625590
gene_function binds to actin filaments 625591
gene_function binds to actin filaments 625592
gene_physical_interaction interacts with protein phosphatase type 1 alpha and type 1 gamma isoform 1 to regulate synaptic transmission 625568
gene_physical_interaction interacts with protein phosphatase type 1 alpha and type 1 gamma isoform 1 to regulate synaptic transmission 625590
gene_physical_interaction interacts with protein phosphatase type 1 alpha and type 1 gamma isoform 1 to regulate synaptic transmission 625591
gene_physical_interaction interacts with protein phosphatase type 1 alpha and type 1 gamma isoform 1 to regulate synaptic transmission 625592
gene_physical_interaction binds to protein phosphatase1  
gene_process regulates synaptic activity by binding to protein phosphatase type 1 alpha and gamma isoform 1 present in the PSD 625568
gene_process regulates synaptic activity by binding to protein phosphatase type 1 alpha and gamma isoform 1 present in the PSD 625591
gene_process involved in vesicular trafficking in developing and developed neurons and formation and maintenance of synaptic junctions 625568
gene_process involved in vesicular trafficking in developing and developed neurons and formation and maintenance of synaptic junctions 625590
gene_process involved in vesicular trafficking in developing and developed neurons and formation and maintenance of synaptic junctions 625591
gene_process involved in vesicular trafficking in developing and developed neurons and formation and maintenance of synaptic junctions 625592
gene_process interacts with protein phosphatase type 1 alpha and type 1 gamma isoform 1 to regulate synaptic transmission  
gene_product 4.6 kb in size 625568
gene_product 4.6 kb in size 625590
gene_product 4.6 kb in size 625591
gene_product 4.6 kb in size 625592
gene_regulation phosphorylated by PKA 625568
gene_regulation phosphorylated by PKA 625591
gene_regulation regulates synaptic activity by binding to protein phosphatase type 1 alpha and gamma isoform 1 present in the PSD and can be phosphorylated by PKA 625568
gene_regulation regulates synaptic activity by binding to protein phosphatase type 1 alpha and gamma isoform 1 present in the PSD and can be phosphorylated by PKA 625590
gene_regulation regulates synaptic activity by binding to protein phosphatase type 1 alpha and gamma isoform 1 present in the PSD and can be phosphorylated by PKA 625591
gene_regulation regulates synaptic activity by binding to protein phosphatase type 1 alpha and gamma isoform 1 present in the PSD and can be phosphorylated by PKA 625592