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Gene: Aadac (arylacetamide deacetylase) Rattus norvegicus

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Symbol:

Aadac

Name:

arylacetamide deacetylase

RGD ID:

631440

Description:

Predicted to enable deacetylase activity; serine hydrolase activity; and triacylglycerol lipase activity. Predicted to be involved in positive regulation of triglyceride catabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human AADAC (arylacetamide deacetylase); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Aada; arylacetamide deacetylase (esterase)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	AADAC (arylacetamide deacetylase)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Aadac (arylacetamide deacetylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	AADAC (arylacetamide deacetylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	AADAC (arylacetamide deacetylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Aadac (arylacetamide deacetylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC100623616 (arylacetamide deacetylase-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	AADAC (arylacetamide deacetylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Aadac (arylacetamide deacetylase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	AADACL2 (arylacetamide deacetylase like 2)	HGNC	OrthoDB
Homo sapiens (human):	TMEM254 (transmembrane protein 254)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Aadac (arylacetamide deacetylase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	AADAC (arylacetamide deacetylase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	aadac (arylacetamide deacetylase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	nceh-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	trcs-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	T09B9.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	aadac	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	aadac	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	146,293,449 - 146,351,061 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	146,313,279 - 146,324,525 (+)	Ensembl				GRCr8
mRatBN7.2	2	144,163,436 - 144,186,086 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	144,135,319 - 144,174,734 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	150,817,634 - 150,828,867 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	148,941,093 - 148,952,355 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	143,573,547 - 143,584,789 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	150,146,234 - 150,157,480 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	150,146,234 - 150,157,480 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	169,573,785 - 169,590,476 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	149,348,935 - 149,360,181 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	138,576,394 - 138,587,634 (+)	NCBI		Celera
RGSC_v3.1	2	149,298,897 - 149,310,144 (+)	NCBI
Cytogenetic Map	2	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital merosin-deficient muscular dystrophy 1A (ISO)

Experimental Liver Cirrhosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

beta-naphthoflavone (ISO)

bis-4-nitrophenyl phosphate (ISO)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

cefaloridine (EXP)

Clofop (ISO)

cocaine (EXP)

copper atom (EXP)

copper(0) (EXP)

cyclosporin A (ISO)

desferrioxamine B (ISO)

dexamethasone (ISO)

Diallyl sulfide (ISO)

dicrotophos (ISO)

dieldrin (EXP)

diisopropyl fluorophosphate (ISO)

dimethyl sulfoxide (ISO)

drometrizole (ISO)

endosulfan (EXP)

fenofibrate (ISO)

flutamide (EXP,ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

glafenine (EXP)

glyphosate (ISO)

hexadecanoic acid (ISO)

malonaldehyde (ISO)

methotrexate (ISO)

methylisothiazolinone (ISO)

N-nitrosodimethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

ochratoxin A (EXP)

ozone (ISO)

paracetamol (ISO)

paricalcitol (ISO)

phenacetin (EXP,ISO)

phenylmethanesulfonyl fluoride (ISO)

phosphorus atom (ISO)

phosphorus(.) (ISO)

physostigmine (ISO)

piperonyl butoxide (EXP)

pirinixic acid (ISO)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

rac-lactic acid (ISO)

rifabutin (ISO)

rifampicin (ISO)

rifapentine (ISO)

rotenone (EXP)

silicon dioxide (ISO)

sodium arsenite (EXP,ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

tetrachloromethane (EXP,ISO)

tetracycline (ISO)

thioacetamide (EXP)

tolcapone (EXP)

trichloroethene (EXP)

Triptolide (ISO)

troglitazone (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vancomycin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

lipid metabolic process (IEA)

positive regulation of triglyceride catabolic process (IBA,IEA,ISO)

Cellular Component

endoplasmic reticulum membrane (IBA,IEA,ISO,ISS)

membrane (IEA)

Molecular Function

carboxylic ester hydrolase activity (IEA)

catalytic activity (IEA)

deacetylase activity (IEA,ISO,ISS)

hydrolase activity (IEA)

protein binding (ISO)

serine hydrolase activity (IBA,IEA,ISO)

triacylglycerol lipase activity (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation.	Trickett JI, etal., J Biol Chem 2001 Oct 26;276(43):39522-32.

Additional References at PubMed

PMID:9665742	PMID:10318829	PMID:12477932	PMID:15152005	PMID:17936933	PMID:19339378	PMID:19654421

Genomics

Comparative Map Data

Aadac
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	146,293,449 - 146,351,061 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	146,313,279 - 146,324,525 (+)	Ensembl				GRCr8
mRatBN7.2	2	144,163,436 - 144,186,086 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	144,135,319 - 144,174,734 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	150,817,634 - 150,828,867 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	148,941,093 - 148,952,355 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	143,573,547 - 143,584,789 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	150,146,234 - 150,157,480 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	150,146,234 - 150,157,480 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	169,573,785 - 169,590,476 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	149,348,935 - 149,360,181 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	138,576,394 - 138,587,634 (+)	NCBI		Celera
RGSC_v3.1	2	149,298,897 - 149,310,144 (+)	NCBI
Cytogenetic Map	2	q31	NCBI

AADAC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	151,814,116 - 151,828,488 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	151,813,931 - 151,828,917 (+)	Ensembl			hg38	GRCh38
GRCh37	3	151,531,904 - 151,546,276 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	153,014,551 - 153,028,966 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	3	153,014,563 - 153,028,972	NCBI
Celera	3	149,949,986 - 149,964,402 (+)	NCBI		Celera
Cytogenetic Map	3	q25.1	ENTREZGENE
HuRef	3	148,922,978 - 148,937,379 (+)	NCBI		HuRef
CHM1_1	3	151,494,887 - 151,509,289 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	154,563,474 - 154,596,308 (+)	NCBI		T2T-CHM13v2.0

Aadac
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	59,939,209 - 59,947,578 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	59,933,138 - 59,947,581 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	60,031,788 - 60,040,157 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	60,025,717 - 60,040,160 (+)	Ensembl			mm10	GRCm38
MGSCv37	3	59,835,710 - 59,844,079 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	60,119,717 - 60,128,086 (+)	NCBI		MGSCv36	mm8
Celera	3	59,714,308 - 59,729,435 (+)	NCBI		Celera
Cytogenetic Map	3	D	NCBI
cM Map	3	29.17	NCBI

AADAC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	149,709,407 - 149,724,824 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	149,714,142 - 149,729,559 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	148,820,706 - 148,853,422 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	156,409,104 - 156,423,847 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	156,408,950 - 156,423,847 (+)	Ensembl			panPan2	panpan1.1

AADAC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	46,339,282 - 46,364,588 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	46,339,466 - 46,363,588 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	46,203,086 - 46,229,054 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	46,968,020 - 46,992,389 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	46,968,171 - 46,992,376 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	46,555,091 - 46,582,165 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	46,609,758 - 46,635,722 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	46,887,325 - 46,911,691 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Aadac
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	89,772,492 - 89,784,330 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004937349	52,605 - 62,840 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100623616
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	92,017,548 - 92,042,938 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	13	92,017,495 - 92,042,944 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

AADAC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	38,855,753 - 38,870,748 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	38,855,348 - 38,870,649 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666041	11,619,884 - 11,634,795 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Aadac
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	95,057,219 - 95,068,268 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Aadac
318 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	330
Count of miRNA genes:	195
Interacting mature miRNAs:	232
Transcripts:	ENSRNOT00000018761, ENSRNOT00000074684
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2293671	Bss44	Bone structure and strength QTL 44	10.97	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	2	105628029	150628029	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1358360	Sradr2	Stress Responsive Adrenal Weight QTL 2	10.24		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	2	124103798	154505346	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	138595962	205135428	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	124537199	209621565	Rat
1581578	Cm49	Cardiac mass QTL 49	4.9	0.01	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	145807215	220931416	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	122597372	215234002	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	145807215	190807215	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	143565208	188565208	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	139067258	192287892	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1582257	Gluco21	Glucose level QTL 21	3.1	0.0035	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	120039407	159440891	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	144882354	205135428	Rat
8662836	Vetf8	Vascular elastic tissue fragility QTL 8	0.66		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	106869825	151869825	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
5135226	Leukc2	Leukocyte quantity QTL 2			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	2	120039407	151869825	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	139067258	184067258	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	143746578	205135428	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	145306936	212705578	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
7488933	Bp368	Blood pressure QTL 368		0.004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	104957381	149957381	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
738007	Anxrr7	Anxiety related response QTL 7	4.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	120339555	165339555	Rat
9685068	Swd7	Spike wave discharge measurement QTL 7	3.2	0.01	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge rate (CMO:0001739)	2	143806628	149738646	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
1581552	Pur12	Proteinuria QTL 12	5.19	0.0009	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	2	114032149	150226270	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
1558653	Prcr1	Prostate cancer resistance QTL 1	5		prostate integrity trait (VT:0010571)	area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)	2	114440891	159440891	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1354594	Despr10	Despair related QTL 10		2e-06	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	2	116804572	161804572	Rat
152025206	Hrtrt23	Heart rate QTL 23	5.98		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat
6903312	Bw112	Body weight QTL 112	3.2	0.0013	body mass (VT:0001259)	body weight (CMO:0000012)	2	145807215	173074435	Rat
152025204	Hrtrt22	Heart rate QTL 22	5.6		heart pumping trait (VT:2000009)		2	30219200	171802126	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
14	3	3	26	68	70	57	10	57	6	166	20	14	72	44	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_020538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282424	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005500357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010063658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC111231	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF182426	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF264017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ209437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000018761 ⟹ ENSRNOP00000018761

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	146,313,279 - 146,324,525 (+)	Ensembl
mRatBN7.2 Ensembl	2	144,163,488 - 144,174,734 (+)	Ensembl
Rnor_6.0 Ensembl	2	150,146,234 - 150,157,480 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110465 ⟹ ENSRNOP00000089619

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	144,135,319 - 144,174,734 (+)	Ensembl

RefSeq Acc Id:

NM_020538 ⟹ NP_065413

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	146,313,279 - 146,324,525 (+)	NCBI
mRatBN7.2	2	144,163,488 - 144,174,734 (+)	NCBI
Rnor_6.0	2	150,146,234 - 150,157,480 (+)	NCBI
Rnor_5.0	2	169,573,785 - 169,590,476 (+)	NCBI
RGSC_v3.4	2	149,348,935 - 149,360,181 (+)	RGD
Celera	2	138,576,394 - 138,587,634 (+)	RGD

Sequence:

show sequence

CAAAGTAGAAAGAGCAGAAGGAAACATGGGAAGAACTATTTTTCTTCTCATCTCTGTGGTGCTT
GTAGCTTATTATATTTATATACCTCTCCCAGATGATATTGAAGAGCCTTGGAAAATAATATTGG
GAAATACACTTCTAAAACTTGGAGGAGATTTGGCTTCTTTTGGTGAACTTTTGGGACTCAATCA
TTTCATGGACACGGTACAGTTATTTATGAGATTTCAAGTTGTCCCACCCACTTCTGATGAGAAT
GTCACTGTGATGGAGACAGATTTCAACAGTGTTCCTGTTCGCATATATATACCCAAAAGGAAGT
CAACGACGCTCAGGAGGGGCTTGTTTTTTATTCATGGTGGTGGCTGGTGTCTGGGGAGTGCTGC
TTACTTCATGTATGACACTCTGTCAAGACGGACTGCCCATAGACTTGATGCCGTTGTTGTGTCA
ACTGACTATGGCTTAGCCCCAAAATACCATTTTCCAAAACAGTTTGAAGATGTATATCATAGTT
TACGATGGTTCTTACAAGAGGACATTCTTGAAAAATATGGTGTAGATCCTAGAAGAGTTGGTGT
GTCTGGGGACAGTGCTGGTGGAAACTTAACTGCAGCTGTGACACAACAGATTCTACAGGATCCA
GATGTCAAGATCAAACTCAAGGTCCAAGCTTTAATATATCCTGCCCTTCAGGCTCTTGATATGA
ATGTACCATCACAACAAGAAAATTCACAATACCCACTTTTAACCAGGTCATTATTGATCCGTTT
CTGGAGTGAATACTTTACTACAGACCGAGACCTTGAGAAAGCCATGCTTCTCAACCAACATGTA
CCTGTGGAATTCAGCCATTTGTTACAATTTGTGAATTGGAGTTCCTTGCTCCCTCAGAGATATA
AGAAAGGTTACTTTTATAAAACTCCCACTCCTGGTAGTTTGGAGCTGGCTCAAAAGTACCCAGG
GTTCACAGATGTAAAGGCATGCCCTCTGTTGGCCAATGACAGTATATTACATCATTTACCTATG
ACCTATATTATCACTTGTCAGTATGATGTTCTAAGAGATGACGGACTCATGTATGTCAAGCGGC
TTCAGAATACTGGAGTTCATGTGACTCATCACCATATTGAAGATGGATTCCATGGAGCACTTAC
CTTACCTGGTTTGAAAATTACATACAGGATGCAAAATCAGTACTTGAATTGGCTTCACAAAAAT
CTGTAGCAAAATCTATAAAATGGTTTATTGAAGATATATAAACACCAAAATAAGAAATAAACTA
GTAAACATGGTTTTGAGGTTTCACATAAATCATTTGTTGTTTCTAATGAGCTGATAGCTTCCAC
ATTTTGTTACTTTTATTATTAGCAAACATTTTTTTTCATTCCTTATTCCGCATTTACCTACAGA
CTCATCTTCCAAACAAGAGTTTTATGTGGGTACTGACAATCCAAATTCATGTGTGCATGCTTAT
GAAATGGGCACTTTATCAATTATCACCATGTACAAATTCCATAACAATTCTGTAGTGCACTTTT
ATTACCCATTATTATTTTACACATAAGAAAAAGTGAACTTAAATAAGTGAAGTAATAAAATATG
TCCTAAATCTAGTACTGTTGGAATAAACATTCATTGTAAGTTTCT

hide sequence

RefSeq Acc Id:

XM_063282424 ⟹ XP_063138494

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	146,293,449 - 146,324,170 (+)	NCBI

RefSeq Acc Id:

XR_005500357

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	146,313,249 - 146,335,446 (+)	NCBI
mRatBN7.2	2	144,163,436 - 144,186,086 (+)	NCBI

RefSeq Acc Id:

XR_010063658

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	146,313,249 - 146,351,061 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_065413	(Get FASTA)	NCBI Sequence Viewer
	XP_063138494	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD56394	(Get FASTA)	NCBI Sequence Viewer
	AAF74757	(Get FASTA)	NCBI Sequence Viewer
	AAH88143	(Get FASTA)	NCBI Sequence Viewer
	EDM14838	(Get FASTA)	NCBI Sequence Viewer
	EDM14839	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000018761
GenBank Protein	Q9QZH8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_065413 ⟸ NM_020538

- UniProtKB:

Q9QZH8 (UniProtKB/Swiss-Prot), A0A9K3Y8C2 (UniProtKB/TrEMBL), F7F0B9 (UniProtKB/TrEMBL), Q5I0N0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGRTIFLLISVVLVAYYIYIPLPDDIEEPWKIILGNTLLKLGGDLASFGELLGLNHFMDTVQLF
MRFQVVPPTSDENVTVMETDFNSVPVRIYIPKRKSTTLRRGLFFIHGGGWCLGSAAYFMYDTLS
RRTAHRLDAVVVSTDYGLAPKYHFPKQFEDVYHSLRWFLQEDILEKYGVDPRRVGVSGDSAGGN
LTAAVTQQILQDPDVKIKLKVQALIYPALQALDMNVPSQQENSQYPLLTRSLLIRFWSEYFTTD
RDLEKAMLLNQHVPVEFSHLLQFVNWSSLLPQRYKKGYFYKTPTPGSLELAQKYPGFTDVKACP
LLANDSILHHLPMTYIITCQYDVLRDDGLMYVKRLQNTGVHVTHHHIEDGFHGALTLPGLKITY
RMQNQYLNWLHKNL

hide sequence

Ensembl Acc Id:

ENSRNOP00000018761 ⟸ ENSRNOT00000018761

Ensembl Acc Id:

ENSRNOP00000089619 ⟸ ENSRNOT00000110465

RefSeq Acc Id:	XP_063138494 ⟸ XM_063282424
- Peptide Label:	isoform X1

Protein Domains

Alpha/beta hydrolase fold-3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9QZH8-F1-model_v2	AlphaFold	Q9QZH8	1-398	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:631440	AgrOrtholog
BioCyc Gene	G2FUF-52976	BioCyc
Ensembl Genes	ENSRNOG00000013950	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000018761	ENTREZGENE
Gene3D-CATH	3.40.50.1820	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7323135	IMAGE-MGC_LOAD
InterPro	AB_hydrolase	UniProtKB/Swiss-Prot
	AB_hydrolase_3	UniProtKB/Swiss-Prot
	Arylacetamide_deacetylase	UniProtKB/Swiss-Prot
	GDXG_lipolytic_enzyme	UniProtKB/Swiss-Prot
	Lipase_GDXG_HIS_AS	UniProtKB/Swiss-Prot
	Lipase_GDXG_put_SER_AS	UniProtKB/Swiss-Prot
KEGG Report	rno:57300	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108701	IMAGE-MGC_LOAD
NCBI Gene	57300	ENTREZGENE
PANTHER	AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C	UniProtKB/Swiss-Prot
	ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN	UniProtKB/Swiss-Prot
Pfam	Abhydrolase_3	UniProtKB/Swiss-Prot
PhenoGen	Aadac	PhenoGen
PIRSF	Arylacetamide_deacetylase	UniProtKB/Swiss-Prot
PROSITE	LIPASE_GDXG_HIS	UniProtKB/Swiss-Prot
	LIPASE_GDXG_SER	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000013950	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/Swiss-Prot
UniProt	A0A9K3Y8C2	ENTREZGENE, UniProtKB/TrEMBL
	A6JVL4_RAT	UniProtKB/TrEMBL
	AAAD_RAT	UniProtKB/Swiss-Prot
	F7F0B9	ENTREZGENE
	Q5I0N0	ENTREZGENE, UniProtKB/TrEMBL
	Q9QZH8	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-07-18	Aadac	arylacetamide deacetylase	Aadac	arylacetamide deacetylase (esterase)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Aadac	arylacetamide deacetylase (esterase)			Symbol and Name status set to approved	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	microsomal in hepatocytes	70567
gene_domains	HGGG box of lipases present	70567
gene_expression	mRNA is expressed in hepatocytes, intestinal mucosal cells, pancreas, adrenal gland, and probably enterocytes	70567
gene_function	lipase exhibiting esterase activity during very low density lipoprotein (VLDL) assembly	70567
gene_process	may be active in promoting the mobilization of lipids from intracellular stores and in the liver for assembling VLDL	70567
gene_product	45 kDa protein	70567
gene_transcript	5 exons with 1.1 kb retroposon insertion at 4th exon	70567

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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