AADAC (arylacetamide deacetylase)

Gene: AADAC (arylacetamide deacetylase) Chlorocebus sabaeus

Analyze

Symbol:

AADAC

Name:

arylacetamide deacetylase

RGD ID:

18608129

Description:

ENCODES a protein that exhibits deacetylase activity (ortholog); INVOLVED IN positive regulation of triglyceride catabolic process (inferred); ASSOCIATED WITH congenital merosin-deficient muscular dystrophy 1A (ortholog); Experimental Liver Cirrhosis (ortholog); Primary Ovarian Failure (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	38,855,753 - 38,870,748 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	38,855,348 - 38,870,649 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	11,619,884 - 11,634,795 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital merosin-deficient muscular dystrophy 1A (ISO)

Experimental Liver Cirrhosis (ISO)

Primary Ovarian Failure (ISO)

primary ovarian insufficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of triglyceride catabolic process (IEA)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

Molecular Function

carboxylic ester hydrolase activity (IEA)

deacetylase activity (ISO)

hydrolase activity (IEA)

protein binding (ISO)

serine hydrolase activity (IEA)

triglyceride lipase activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

AADAC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	38,855,753 - 38,870,748 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	38,855,348 - 38,870,649 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	11,619,884 - 11,634,795 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

AADAC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	151,814,116 - 151,828,488 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	151,814,073 - 151,828,488 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	151,531,904 - 151,546,276 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	153,014,551 - 153,028,966 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	153,014,563 - 153,028,972	NCBI
Celera	3	149,949,986 - 149,964,402 (+)	NCBI		Celera
Cytogenetic Map	3	q25.1	ENTREZGENE
HuRef	3	148,922,978 - 148,937,379 (+)	NCBI		HuRef
CHM1_1	3	151,494,887 - 151,509,289 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	154,563,474 - 154,596,308 (+)	NCBI		T2T-CHM13v2.0

Aadac
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	59,939,209 - 59,947,578 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	59,933,138 - 59,947,581 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	60,031,788 - 60,040,157 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	60,025,717 - 60,040,160 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	59,835,710 - 59,844,079 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	60,119,717 - 60,128,086 (+)	NCBI		MGSCv36	mm8
Celera	3	59,714,308 - 59,729,435 (+)	NCBI		Celera
Cytogenetic Map	3	D	NCBI
cM Map	3	29.17	NCBI

Aadac
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	146,293,449 - 146,351,061 (+)	NCBI		GRCr8
mRatBN7.2	2	144,163,436 - 144,186,086 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	144,135,319 - 144,174,734 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	150,817,634 - 150,828,867 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	148,941,093 - 148,952,355 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	143,573,547 - 143,584,789 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	150,146,234 - 150,157,480 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	150,146,234 - 150,157,480 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	169,573,785 - 169,590,476 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	149,348,935 - 149,360,181 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	149,298,897 - 149,310,144 (+)	NCBI
Celera	2	138,576,394 - 138,587,634 (+)	NCBI		Celera
Cytogenetic Map	2	q31	NCBI

AADAC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	149,709,407 - 149,724,824 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	149,714,142 - 149,729,559 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	148,820,706 - 148,853,422 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	156,409,104 - 156,423,847 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	156,408,950 - 156,423,847 (+)	Ensembl	panpan1.1		panPan2

AADAC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	46,339,282 - 46,364,588 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	23	46,339,466 - 46,363,588 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	46,203,086 - 46,229,054 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	46,968,020 - 46,992,389 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	23	46,968,171 - 46,992,376 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	23	46,555,091 - 46,582,165 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	46,609,758 - 46,635,722 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	46,887,325 - 46,911,691 (+)	NCBI		UU_Cfam_GSD_1.0

Aadac
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	89,772,492 - 89,784,330 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004937349	52,605 - 62,840 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100623616
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	92,017,548 - 92,042,938 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	92,017,495 - 92,042,944 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	4		1
Low	13	10	3
Below cutoff	4	8	25

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008008693	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000010027 ⟹ ENSCSAP00000008129

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	15	38,855,348 - 38,870,649 (-)	Ensembl

RefSeq Acc Id:

XM_008008693 ⟹ XP_008006884

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	15	38,855,753 - 38,870,748 (-)	NCBI
Vero_WHO_p1.0	NW_023666041	11,619,884 - 11,634,795 (-)	NCBI

Sequence:

show sequence

CAGAAGAGCAAGATAAAGCTTTTGGGTGGAGCTGAAGCACACTGCTTATTAAAGTACACTATTC
AGGCACATCATGTAAGTTAATTTCTGTGTTTCTAGAGACCAAGAAGCAGGACGTACACCATGGG
AAGAAAATCACTGTACCTTCTGATTGGGGGGATCCTCATAGCTTATTATATTTATACACCTCTC
TCAGATAACATTGAGGAGCCATGGAGATTGATGTGGATAAACGCACATCTGAAAACTATAGAAA
ATGTGGCTACATTTGTGGAGCTGCTGGGACTTCACCACATTATGGATTCTTTGAAGGTTGTATG
GAGCTTTTATGAAGTCCCACCAACCTCAGATGAAAATGTCACTGTGACTGAGACAAAATTCAAC
AACATTCCTGTTCGAGTATATGTGCCAAAGAGAAAGTCTGAAGTACTAAGAAGGGGGTTGTTTT
ACATCCATGGTGGAGGCTGGTGCATGGGAAGTGCTGCTGTAAATGATTACGACTTGCTGTCAAG
ATGGACAGCAGACCGACTTGATGCTGTCGTCATATCAACCAACTACAGATTAGCACCTAAGTAT
CATTTCCCAATTCAATTTGAAGATGTATATAACGCCTTAAAGTGGTTCTTACGTAAAACAGTTC
TTGCAAAATACGGTGTGAACCCTGAGAGAATCGGTATTTCTGGAGATAGTGCAGGAGGGAATTT
AGCTGCAGCAGTGACTCAACAGCTCCTTGATGACCCAGATGTCAAGATCAAACTCAAGATCCAG
GCTTTAATTTATCCTGCCCTTCAGCCTCTTGATGTAGATTTACCATCATATCAAGAAAATTCAA
ATTTTCTACTTCTATCCAAATCACTCATGGTCAGATTCTGGAGTGAATATTTTACCACTGATAG
ATCACTTGAAAAAGCCATGCTTTCCAGACAACATGTACCTGTGGAATCAAGTCATCTCTTCAAA
TTTGTTAATTGGAGTTCCCTGCTCCCTGAGAGGTTTATAAAAGGACATGTTTATAACAACCCAA
ATTATGGCAGTTCTGAGCTGGCTAAAAAATATCCAGGGTTCCTAGATGTGAGGGCAGCCCCTTT
GTTGGCTGATGACAAAAAATTACATAGTTTACCCCTGACCTATGTCATCACCTGTCAATATGAT
CCCTTAAGAGATGATGGACTCATGTATGTCACCCGACTTCGCAACGCTGGAGTTCAGGTTACTC
ATAACCATGTTGAGGATGGATTCCATGGAGCATTTTCAATTCTGGAACTTAAAATTAGTCACAG
ACTTATAAATCAGTATATTGAGTGGCTAAAGGAAAATCTATAGTAAAACATGTAGCTATATTTT
TTAAAATAAAGTAAATCTCAAAACCTCAGAAAATTTGCATTAGAAATTGGCCTTTCTTAGAATG
GTCTAATTAAGTTCCACATGTAGCATAATTCTTAAATAGTCACTTTTCTGTTTTTTTTCTTATT
GTGGGATTTCATTTCAATTTTCTACATTGTCTATCTGCTTTTTCTGAAATTTTCCTTCTTACAC
TGTTAATCTTATTTTTAAAAATATTACATTCTTGTATACTTTATTTTTGTGTGTTGGCTACTAT
TTACAATGCAGGAGAATAAGTGTGAGCAAATATTGCCTGTCTGAATAATGTCAAGATTTTAATC
AATGTTCATTTACAACCTGAAACATTCCTAATCACAGATATGAATTAAATGCCAATTCTTTTCA
AAAGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008006884	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000008129
	ENSCSAP00000008129.1

RefSeq Acc Id:	XP_008006884 ⟸ XM_008008693
- UniProtKB:	A0A0D9RHP0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000008129 ⟸ ENSCSAT00000010027

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000011936	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000010027.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1820	UniProtKB/TrEMBL
InterPro	AB_hydrolase	UniProtKB/TrEMBL
	AB_hydrolase_3	UniProtKB/TrEMBL
	Arylacetamide_deacetylase	UniProtKB/TrEMBL
	Lipase_GDXG_put_SER_AS	UniProtKB/TrEMBL
KEGG Report	csab:103241459	UniProtKB/TrEMBL
NCBI Gene	AADAC	ENTREZGENE
PANTHER	ARYLACETAMIDE DEACETYLASE	UniProtKB/TrEMBL
	ARYLACETAMIDE DEACETYLASE	UniProtKB/TrEMBL
Pfam	Abhydrolase_3	UniProtKB/TrEMBL
PIRSF	Arylacetamide_deacetylase	UniProtKB/TrEMBL
PROSITE	LIPASE_GDXG_SER	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53474	UniProtKB/TrEMBL
UniProt	A0A0D9RHP0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD