Bbc3 (Bcl-2 binding component 3) - Rat Genome Database

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Gene: Bbc3 (Bcl-2 binding component 3) Rattus norvegicus
Analyze
Symbol: Bbc3
Name: Bcl-2 binding component 3
RGD ID: 631434
Description: Predicted to enable ATPase binding activity. Involved in positive regulation of intrinsic apoptotic signaling pathway. Predicted to be located in lysosome. Predicted to be active in mitochondrion. Biomarker of intermittent claudication and transient cerebral ischemia. Orthologous to human BBC3 (BCL2 binding component 3); PARTICIPATES IN intrinsic apoptotic pathway; Huntington's disease pathway; measles pathway; INTERACTS WITH 1,3-dinitrobenzene; 4-hydroxynon-2-enal; 4-phenylbutylamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bcl-2-binding component 3; p53 up-regulated modulator of apoptosis; Puma
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,141,450 - 86,150,666 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl186,141,603 - 86,150,666 (+)EnsemblGRCr8
mRatBN7.2177,013,281 - 77,022,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,014,543 - 77,022,509 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx182,388,489 - 82,396,486 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0190,952,521 - 90,960,521 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,143,587 - 84,151,585 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,261,491 - 78,267,802 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0179,520,749 - 79,521,829 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera171,503,438 - 71,511,180 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (ISO)
(S)-amphetamine  (ISO)
(S)-naringenin  (ISO)
1,1-dichloroethene  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-methylthioamphetamine  (ISO)
4-phenylbutylamine  (EXP)
4-phenylbutyric acid  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-methoxypsoralen  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-O-methylguanine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
9,10-phenanthroquinone  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
actinomycin D  (ISO)
afatinib  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bortezomib  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
carboxin  (ISO)
celecoxib  (ISO)
chlorambucil  (ISO)
chloroacetaldehyde  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crystal violet  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cytarabine  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
Dictamnine  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
dioscin  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (ISO)
epichlorohydrin  (ISO)
erdosteine  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenthion  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fostriecin  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
Gingerenone A  (ISO)
glucose  (ISO)
glyphosate  (ISO)
gossypol  (ISO)
GSK690693  (ISO)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hydroxyurea  (ISO)
indometacin  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
iron(III) nitrilotriacetate  (EXP)
ivermectin  (ISO)
juglone  (ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lipoic acid  (ISO)
LY294002  (EXP,ISO)
maneb  (ISO)
melatonin  (ISO)
menadione  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylphenidate  (EXP)
methylseleninic acid  (ISO)
metiram  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
morphine  (ISO)
motexafin gadolinium  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
N-phosphocreatine  (EXP)
nefazodone  (ISO)
nickel dichloride  (EXP,ISO)
niclosamide  (ISO)
nicotinamide  (ISO)
nitric oxide  (ISO)
nitrogen dioxide  (ISO)
Nonidet P-40  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
pemetrexed  (ISO)
perfluorooctanoic acid  (ISO)
pevonedistat  (ISO)
PF-4708671  (ISO)
phenobarbital  (ISO)
phosphoramide mustard  (EXP)
pifithrin-alpha hydrobromide  (EXP,ISO)
pinostrobin  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
potassium dichromate  (EXP)
propylparaben  (ISO)
resveratrol  (ISO)
rutin  (EXP)
ruxolitinib  (ISO)
S63845  (ISO)
Salinomycin  (ISO)
sanguinarine  (ISO)
selinexor  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thapsigargin  (ISO)
thiram  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (EXP)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
vemurafenib  (ISO)
venetoclax  (ISO)
vorinostat  (ISO)
VX nerve agent  (ISO)
xanthohumol  (ISO)
zerumbone  (ISO)
zinc acetate  (ISO)
zinc dichloride  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
lysosome  (ISO)
mitochondrion  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cai D, etal., Cell Death Dis. 2016 Mar 31;7:e2161. doi: 10.1038/cddis.2016.67.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
5. Mild hypothermia diminishes oxidative DNA damage and pro-death signaling events after cerebral ischemia: a mechanism for neuroprotection. Ji X, etal., Front Biosci. 2007 Jan 1;12:1737-47.
6. p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Li YZ, etal., Mol Cell Biol. 2008 Jan;28(2):564-74. Epub 2007 Nov 12.
7. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
8. Over-expression of PUMA correlates with the apoptosis of spinal cord cells in rat neuropathic intermittent claudication model. Ma B, etal., PLoS One. 2013 May 2;8(5):e56580. doi: 10.1371/journal.pone.0056580. Print 2013.
9. Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia. Niizuma K, etal., Stroke. 2009 Feb;40(2):618-25. Epub 2008 Dec 18.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. Reimertz C, etal., J Cell Biol 2003 Aug 18;162(4):587-97.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Janus Kinase 2 (JAK2) Dissociates Hepatosteatosis from Hepatocellular Carcinoma in Mice. Shi SY, etal., J Biol Chem. 2017 Mar 3;292(9):3789-3799. doi: 10.1074/jbc.M116.752519. Epub 2017 Jan 18.
15. Postnatal developmental regulation of Bcl-2 family proteins in brain mitochondria. Soane L, etal., J Neurosci Res. 2008 May 1;86(6):1267-76.
16. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Storozhuk Y, etal., Br J Cancer. 2013 May 28;108(10):2021-32. doi: 10.1038/bjc.2013.187. Epub 2013 Apr 30.
Additional References at PubMed
PMID:11463391   PMID:11463392   PMID:14500851   PMID:16151013   PMID:16286009   PMID:16399862   PMID:16407291   PMID:16705087   PMID:16832056   PMID:17024184   PMID:17289999   PMID:20421300  
PMID:20810912   PMID:20818388   PMID:21041309   PMID:21159964   PMID:21570442   PMID:22021910   PMID:22761832   PMID:23716698   PMID:24567336   PMID:25891762   PMID:26043893   PMID:26212789  
PMID:27117005   PMID:31878844   PMID:37088760   PMID:39305937  


Genomics

Comparative Map Data
Bbc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,141,450 - 86,150,666 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl186,141,603 - 86,150,666 (+)EnsemblGRCr8
mRatBN7.2177,013,281 - 77,022,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl177,014,543 - 77,022,509 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx182,388,489 - 82,396,486 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0190,952,521 - 90,960,521 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0184,143,587 - 84,151,585 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0178,261,491 - 78,267,802 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0179,520,749 - 79,521,829 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera171,503,438 - 71,511,180 (+)NCBICelera
Cytogenetic Map1q21NCBI
BBC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381947,220,824 - 47,232,860 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1947,220,822 - 47,233,019 (-)Ensemblhg38GRCh38
GRCh371947,724,081 - 47,735,924 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361952,415,924 - 52,426,291 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341952,415,923 - 52,426,291NCBI
Celera1944,527,934 - 44,539,878 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1944,148,994 - 44,171,276 (-)NCBIHuRef
CHM1_11947,726,482 - 47,738,433 (-)NCBICHM1_1
T2T-CHM13v2.01950,046,144 - 50,058,334 (-)NCBIT2T-CHM13v2.0
Bbc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,042,307 - 16,052,130 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl716,042,318 - 16,052,130 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38716,308,398 - 16,318,334 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,308,393 - 16,318,205 (+)Ensemblmm10GRCm38
MGSCv37716,894,932 - 16,903,683 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36715,468,160 - 15,476,856 (+)NCBIMGSCv36mm8
Celera713,504,637 - 13,513,389 (+)NCBICelera
Cytogenetic Map7A2NCBI
cM Map78.85NCBI
Bbc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555741,167,242 - 1,174,966 (-)Ensembl
ChiLan1.0NW_0049555741,167,790 - 1,174,966 (-)NCBIChiLan1.0ChiLan1.0
BBC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22053,361,167 - 53,374,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11955,232,535 - 55,245,609 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01944,203,517 - 44,215,860 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11952,727,826 - 52,738,535 (-)NCBIPanPan1.1PanPan1.1panPan2
BBC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11108,742,793 - 108,750,832 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1108,741,713 - 108,749,946 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1108,222,131 - 108,231,165 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01109,267,089 - 109,276,129 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1109,271,046 - 109,275,144 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11108,934,859 - 108,943,893 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01108,578,770 - 108,587,804 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01109,447,382 - 109,456,419 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bbc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934919,343,021 - 19,354,349 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936664962,115 - 966,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BBC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl653,037,104 - 53,045,685 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1653,037,103 - 53,046,902 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2648,411,044 - 48,420,848 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BBC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,560,550 - 40,572,428 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl640,561,274 - 40,567,853 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607320,284,513 - 20,296,281 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bbc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248326,470,475 - 6,476,754 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248326,467,716 - 6,476,754 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bbc3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12172,743,801 - 172,752,099 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bbc3
54 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:111
Count of miRNA genes:84
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000071296
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat

Markers in Region
RH70710  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,022,115 - 77,022,240 (+)MAPPERmRatBN7.2
Rnor_6.0178,267,409 - 78,267,533NCBIRnor6.0
Rnor_5.0179,521,436 - 79,521,560UniSTSRnor5.0
Celera171,510,787 - 71,510,911UniSTS
BBC3_3813  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2177,021,640 - 77,022,501 (+)MAPPERmRatBN7.2
Rnor_6.0178,266,934 - 78,267,794NCBIRnor6.0
Rnor_5.0179,520,961 - 79,521,821UniSTSRnor5.0
Celera171,510,312 - 71,511,172UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 67 138 95 11 51 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000096062   ⟹   ENSRNOP00000092134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl186,143,487 - 86,150,666 (+)Ensembl
mRatBN7.2 Ensembl177,015,350 - 77,022,509 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101734   ⟹   ENSRNOP00000076660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl186,141,603 - 86,150,666 (+)Ensembl
mRatBN7.2 Ensembl177,014,543 - 77,022,509 (+)Ensembl
RefSeq Acc Id: NM_173837   ⟹   NP_776209
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,142,701 - 86,150,666 (+)NCBI
mRatBN7.2177,014,543 - 77,022,509 (+)NCBI
Rnor_6.0178,261,491 - 78,267,802 (+)NCBI
Rnor_5.0179,520,749 - 79,521,829 (+)NCBI
Celera171,503,438 - 71,511,180 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080914   ⟹   XP_038936842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,141,450 - 86,146,901 (+)NCBI
mRatBN7.2177,013,281 - 77,018,740 (+)NCBI
RefSeq Acc Id: XM_039080919   ⟹   XP_038936847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,143,492 - 86,150,666 (+)NCBI
mRatBN7.2177,015,343 - 77,022,509 (+)NCBI
RefSeq Acc Id: XM_039080925   ⟹   XP_038936853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8186,143,491 - 86,150,666 (+)NCBI
mRatBN7.2177,015,344 - 77,022,509 (+)NCBI
RefSeq Acc Id: NP_776209   ⟸   NM_173837
- UniProtKB: Q80ZG6 (UniProtKB/Swiss-Prot),   A6J8A5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038936842   ⟸   XM_039080914
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936847   ⟸   XM_039080919
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AHA0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936853   ⟸   XM_039080925
- Peptide Label: isoform X3
- UniProtKB: Q80ZG6 (UniProtKB/Swiss-Prot),   A6J8A5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092134   ⟸   ENSRNOT00000096062
Ensembl Acc Id: ENSRNOP00000076660   ⟸   ENSRNOT00000101734

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80ZG6-F1-model_v2 AlphaFold Q80ZG6 1-193 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631434 AgrOrtholog
BioCyc Gene G2FUF-60613 BioCyc
Ensembl Genes ENSRNOG00000062473 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000096062 ENTREZGENE
  ENSRNOT00000101734.1 UniProtKB/Swiss-Prot
InterPro Bbc3 UniProtKB/Swiss-Prot
KEGG Report rno:317673 UniProtKB/Swiss-Prot
NCBI Gene 317673 ENTREZGENE
PANTHER BCL-2-BINDING COMPONENT 3, ISOFORMS 3/4 UniProtKB/Swiss-Prot
  PTHR28639 UniProtKB/Swiss-Prot
Pfam PUMA UniProtKB/Swiss-Prot
PhenoGen Bbc3 PhenoGen
RatGTEx ENSRNOG00000062473 RatGTEx
UniProt A0A8I6AHA0 ENTREZGENE, UniProtKB/TrEMBL
  A6J8A5 ENTREZGENE, UniProtKB/TrEMBL
  BBC3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Bbc3  Bcl-2 binding component 3      Symbol and Name status set to approved 625702 APPROVED