GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bbc3 | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of BBC3 mRNA; Doxorubicin results in increased expression of BBC3 protein | PMID:18775851 PMID:27181935 PMID:34047412 PMID:34713381 | Bbc3 | multiple interactions | EXP | | 6480464 | CTD | Curcumin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein]; Fungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of BBC3 mRNA]; pifithrin inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein]; U 0126 inhibits the reaction [Doxorubicin results in increased expression of BBC3 protein] | PMID:18775851 PMID:27181935 PMID:34047412 | Bbc3 | affects expression | ISO | Bbc3 (Mus musculus) | 6480464 | CTD | Doxorubicin affects the expression of BBC3 mRNA | PMID:29653124 | Bbc3 | increases expression | ISO | Bbc3 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased expression of BBC3 mRNA | PMID:16018998 PMID:34713381 | Bbc3 | increases expression | ISO | BBC3 (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of BBC3 mRNA; Doxorubicin results in increased expression of BBC3 protein | PMID:16439685 PMID:20856197 PMID:24816189 PMID:34126102 PMID:36634904 | Bbc3 | multiple interactions | ISO | Bbc3 (Mus musculus) | 6480464 | CTD | zinc chloride promotes the reaction [Doxorubicin results in increased expression of BBC3 mRNA] | PMID:19714248 | Bbc3 | multiple interactions | ISO | BBC3 (Homo sapiens) | 6480464 | CTD | [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of BBC3 protein; [Doxorubicin co-treated with PI103] results in increased expression of BBC3 protein; [Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of BBC3 mRNA; cobaltous chloride inhibits the reaction [[Doxorubicin results in increased phosphorylation of and results in increased activity of TP53 protein] which results in increased expression of BBC3 mRNA]; Doxorubicin promotes the reaction [[TP53 protein binds to BBC3 promoter] which results in increased expression of BBC3 mRNA]; TP53 protein affects the reaction [Doxorubicin results in increased expression of BBC3 protein]; TP53 protein mutant form affects the reaction [Doxorubicin results in increased expression of BBC3 protein]; TP53 protein promotes the reaction [[Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of BBC3 protein]; TP53 protein promotes the reaction [[Doxorubicin co-treated with PI103] results in increased expression of BBC3 protein] | PMID:19714248 PMID:20856197 PMID:24816189 PMID:34126102 | | ||||||||||||||||||||||
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